PMID- 24037245
OWN - NLM
STAT- MEDLINE
DCOM- 20131226
LR  - 20181113
IS  - 1548-7105 (Electronic)
IS  - 1548-7091 (Linking)
VI  - 10
IP  - 11
DP  - 2013 Nov
TI  - Exploiting tertiary structure through local folds for crystallographic phasing.
PG  - 1099-101
LID - 10.1038/nmeth.2644 [doi]
AB  - We describe an algorithm for phasing protein crystal X-ray diffraction data that 
      identifies, retrieves, refines and exploits general tertiary structural information 
      from small fragments available in the Protein Data Bank. The algorithm successfully 
      phased, through unspecific molecular replacement combined with density modification, 
      all-helical, mixed alpha-beta, and all-beta protein structures. The method is 
      available as a software implementation: Borges.
FAU - Sammito, Massimo
AU  - Sammito M
AD  - Instituto de Biología Molecular de Barcelona, Consejo Superior de Investigaciones 
      Científicas, Barcelona, Spain.
FAU - Millan, Claudia
AU  - Millan C
FAU - Rodriguez, Dayte D
AU  - Rodriguez DD
FAU - de Ilarduya, Iñaki M
AU  - de Ilarduya IM
FAU - Meindl, Kathrin
AU  - Meindl K
FAU - De Marino, Ivan
AU  - De Marino I
FAU - Petrillo, Giovanna
AU  - Petrillo G
FAU - Buey, Rubén M
AU  - Buey RM
FAU - de Pereda, José M
AU  - de Pereda JM
FAU - Zeth, Kornelius
AU  - Zeth K
FAU - Sheldrick, George M
AU  - Sheldrick GM
FAU - Uson, Isabel
AU  - Uson I
LA  - eng
SI  - PDB/4GDO
SI  - PDB/4GN0
SI  - PDB/4L1H
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130915
PL  - United States
TA  - Nat Methods
JT  - Nature methods
JID - 101215604
SB  - IM
MH  - Algorithms
MH  - Crystallography/*methods
MH  - Databases, Protein
MH  - Models, Molecular
MH  - *Protein Folding
MH  - *Protein Structure, Tertiary
EDAT- 2013/09/17 06:00
MHDA- 2013/12/27 06:00
CRDT- 2013/09/17 06:00
PHST- 2012/10/19 00:00 [received]
PHST- 2013/07/22 00:00 [accepted]
PHST- 2013/09/17 06:00 [entrez]
PHST- 2013/09/17 06:00 [pubmed]
PHST- 2013/12/27 06:00 [medline]
AID - nmeth.2644 [pii]
AID - 10.1038/nmeth.2644 [doi]
PST - ppublish
SO  - Nat Methods. 2013 Nov;10(11):1099-101. doi: 10.1038/nmeth.2644. Epub 2013 Sep 15.