ENTRY       M00034            Pathway   Module
NAME        Methionine salvage pathway
DEFINITION  K00789 K01611 K00797 ((K01243,K01244) K00899,(K00772,K05810)) K08963 (K16054,K08964 (K09880,K08965 K08966)) K08967 (K00815,K08969,K23977,K00832,K00838)
ORTHOLOGY   K00789  S-adenosylmethionine synthetase [EC:2.5.1.6] [RN:R00177]
            K01611  S-adenosylmethionine decarboxylase [EC:4.1.1.50] [RN:R00178]
            K00797  spermidine synthase [EC:2.5.1.16] [RN:R01920]
            K01243  S-adenosylhomocysteine nucleosidase [EC:3.2.2.9] [RN:R01401]
            K01244  5'-methylthioadenosine nucleosidase [EC:3.2.2.16] [RN:R01401]
            K00899  5-methylthioribose kinase [EC:2.7.1.100] [RN:R04143]
            K00772,K05810  5'-methylthioadenosine phosphorylase [EC:2.4.2.28] [RN:R01402]
            K08963  methylthioribose-1-phosphate isomerase [EC:5.3.1.23] [RN:R04420]
            K08964,K16054  methylthioribulose-1-phosphate dehydratase [EC:4.2.1.109] [RN:R07392]
            K09880,K16054  enolase-phosphatase E1 [EC:3.1.3.77] [RN:R07395]
            K08965  2,3-diketo-5-methylthiopentyl-1-phosphate enolase [EC:5.3.2.5] [RN:R07393]
            K08966  2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase [EC:3.1.3.87] [RN:R07394]
            K08967  1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase [EC:1.13.11.53] [RN:R07364]
            K00815  tyrosine aminotransferase [EC:2.6.1.5] [RN:R07396]
            K08969,K23977  L-glutamine---4-(methylsulfanyl)-2-oxobutanoate aminotransferase [EC:2.6.1.117] [RN:R12507]
            K00832  aromatic-amino-acid transaminase [EC:2.6.1.57] [RN:R07396]
            K00838  aromatic amino acid aminotransferase  [EC:2.6.1.57] [RN:R07396]
CLASS       Pathway modules; Amino acid metabolism; Cysteine and methionine metabolism
PATHWAY     map00270  Cysteine and methionine metabolism
            map01100  Metabolic pathways
REACTION    R00177  C00073 -> C00019
            R00178  C00019 -> C01137
            R01920  C01137 -> C00170
            R01401  C00170 -> C03089
            R04143  C03089 -> C04188
            R01402  C00170 -> C04188
            R04420  C04188 -> C04582
            R07392  C04582 -> C15650
            R07393  C15650 -> C15651
            R07394  C15651 -> C15606
            R07395  C15650 -> C15606
            R07364  C15606 -> C01180
            R07396,R12507  C01180 -> C00073
COMPOUND    C00073  L-Methionine
            C00019  S-Adenosyl-L-methionine
            C01137  S-Adenosylmethioninamine
            C00170  5'-Methylthioadenosine
            C03089  5-Methylthio-D-ribose
            C04188  S-Methyl-5-thio-D-ribose 1-phosphate
            C04582  S-Methyl-5-thio-D-ribulose 1-phosphate
            C15650  2,3-Diketo-5-methylthiopentyl-1-phosphate
            C15651  2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate
            C15606  1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one
            C01180  4-Methylthio-2-oxobutanoic acid
///
