ENTRY       M00063            Pathway   Module
NAME        CMP-3-deoxy-D-manno-octulosonate biosynthesis, ribulose-5P => CMP-KDO
DEFINITION  K06041 K01627 K03270 K00979
ORTHOLOGY   K06041  arabinose-5-phosphate isomerase [EC:5.3.1.13] [RN:R01530]
            K01627  2-dehydro-3-deoxyphosphooctonate aldolase (KDO 8-P synthase) [EC:2.5.1.55] [RN:R03254]
            K03270  3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (KDO 8-P phosphatase) [EC:3.1.3.45] [RN:R03350]
            K00979  3-deoxy-manno-octulosonate cytidylyltransferase (CMP-KDO synthetase) [EC:2.7.7.38] [RN:R03351]
CLASS       Pathway modules; Glycan metabolism; Nucleotide sugar biosynthesis
PATHWAY     map00541  Biosynthesis of various nucleotide sugars
            map01250  Biosynthesis of nucleotide sugars
            map01100  Metabolic pathways
REACTION    R01530  C00199 -> C01112
            R03254  C01112 -> C04478
            R03350  C04478 -> C01187
            R03351  C01187 -> C04121
COMPOUND    C00199  D-Ribulose 5-phosphate
            C01112  D-Arabinose 5-phosphate
            C04478  3-Deoxy-D-manno-octulosonate 8-phosphate
            C01187  3-Deoxy-D-manno-octulosonate
            C04121  CMP-3-deoxy-D-manno-octulosonate
RMODULE     RM042  Nucleotide sugar biosynthesis, type 4
REFERENCE   PMID:24102217
  AUTHORS   Lodowska J, Wolny D, Weglarz L
  TITLE     The sugar 3-deoxy-d-manno-oct-2-ulosonic acid (Kdo) as a characteristic component of bacterial endotoxin -- a review of its biosynthesis, function, and placement in the lipopolysaccharide core.
  JOURNAL   Can J Microbiol 59:645-55 (2013)
            DOI:10.1139/cjm-2013-0490
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