ENTRY       M00065            Pathway   Module
NAME        GPI-anchor biosynthesis, core oligosaccharide
DEFINITION  (K03857+K03859+K03858+K03861+K03860+(K11001,K11002)-K09658) K03434 K05283 (K05284+K07541) K07542 K05285 K05286 (K05288+K05287) (K05310+K05287)
ORTHOLOGY   K03857  PIGA [EC:2.4.1.198] [RN:R05916]
            K03859  PIGC [RN:R05916]
            K03858  PIGH [RN:R05916]
            K03861  PIGP [RN:R05916]
            K03860  PIGQ [RN:R05916]
            K11001  PIGY [RN:R05916]
            K11002  ERI1 [RN:R05916]
            K09658  DPM2 [RN:R05916]
            K03434  PIGL [EC:3.5.1.89] [RN:R05917]
            K05283  PIGW [EC:2.3.-.-] [RN:R05918]
            K05284  PIGM [EC:2.4.1.-] [RN:R05919]
            K07541  PIGX [RN:R05919]
            K07542  PIGV [EC:2.4.1.-] [RN:R12350]
            K05285  PIGN [EC:2.7.-.-] [RN:R12351]
            K05286  PIGB [EC:2.4.1.-] [RN:R05922]
            K05288  PIGO [EC:2.7.-.-] [RN:R08107]
            K05287  PIGF [RN:R08107]
            K05310  PIGG [EC:2.7.-.-] [RN:R12702]
CLASS       Pathway modules; Glycan metabolism; Glycan biosynthesis
PATHWAY     map00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
            map01100  Metabolic pathways
REACTION    R05916  C01194 -> G00143
            R05917  G00143 -> G00144
            R05918  G00144 -> G00145
            R05919  G00145 -> G00146
            R12350  G00146 -> G13128
            R12351  G13128 -> G00148
            R05922  G00148 -> G00149
            R08107  G00149 -> G13044
            R12702  G13044 -> G13152
COMPOUND    C01194  1-Phosphatidyl-D-myo-inositol
            G00143
            G00144
            G00145
            G00146
            G13128
            G00148
            G00149
            G13044
            G13152
REFERENCE   PMID:25509331
  AUTHORS   Kinoshita T
  TITLE     [Biochemistry of glycosylphosphatidylinositol (GPI) anchored proteins].
  JOURNAL   Seikagaku 86:626-36 (2014)
REFERENCE   PMID:32156170
  AUTHORS   Kinoshita T.
  TITLE     Biosynthesis and biology of mammalian GPI-anchored proteins.
  JOURNAL   Open Biol 10:190290 (2020)
            DOI:10.1098/rsob.190290
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