ENTRY       M00102            Pathway   Module
NAME        Ergocalciferol biosynthesis, FPP => ergosterol/ergocalciferol
DEFINITION  K00801 K00511 K01852 K05917 K00222 K07750 K07748 K09827 K00559 K09829 K00227 K09831 K00223
ORTHOLOGY   K00801  farnesyl-diphosphate farnesyltransferase [EC:2.5.1.21] [RN:R00702 R02872]
            K00511  squalene monooxygenase [EC:1.14.14.17] [RN:R02874]
            K01852  lanosterol synthase [EC:5.4.99.7] [RN:R03199]
            K05917  sterol 14alpha-demethylase [EC:1.14.14.154] [RN:R05640]
            K00222  delta14-sterol reductase [EC:1.3.1.70] [RN:R05639]
            K07750  methylsterol monooxygenase [EC:1.14.18.9] [RN:R07509 R12403]
            K07748  sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating) [EC:1.1.1.170] [RN:R07494 R12404]
            K09827  3-keto steroid reductase [EC:1.1.1.270] [RN:R07495 R12405]
            K00559  sterol 24-C-methyltransferase [EC:2.1.1.41] [RN:R04427]
            K09829  C-8 sterol isomerase [EC:5.-.-.-] [RN:R07497]
            K00227  Delta7-sterol 5-desaturase [EC:1.14.19.20] [RN:R07491]
            K09831  sterol 22-desaturase [EC:1.14.19.41] [RN:R07506]
            K00223  Delta24(24(1))-sterol reductase [EC:1.3.1.71] [RN:R05641]
CLASS       Pathway modules; Lipid metabolism; Sterol biosynthesis
PATHWAY     map00100  Steroid biosynthesis
            map01100  Metabolic pathways
            map01110  Biosynthesis of secondary metabolites
REACTION    R00702  C00448 -> C03428
            R02872  C03428 -> C00751
            R02874  C00751 -> C01054
            R03199  C01054 -> C01724	
            R05640  C01724 -> C11455	
            R05639  C11455 -> C05108	
            R07509  C05108 -> C15808	
            R07494  C15808 -> C15816	
            R07495  C15816 -> C05103	
            R12403  C05103 -> C22112	
            R12404  C22112 -> C22136	
            R12405  C22136 -> C05437	
            R04427  C05437 -> C04525	
            R07497  C04525 -> C15777	
            R07491  C15777 -> C15780	
            R07506  C15780 -> C05440	
            R05641  C05440 -> C01694	
            R03677  C01694 -> C05441
COMPOUND    C00448  trans,trans-Farnesyl diphosphate
            C03428  Presqualene diphosphate
            C00751  Squalene
            C01054  (S)-2,3-Epoxysqualene
            C01724  Lanosterol
            C11455  4,4-Dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
            C05108  14-Demethyllanosterol
            C15808  4alpha-Methylzymosterol-4-carboxylate
            C15816  3-Keto-4-methylzymosterol
            C05103  4alpha-Methylzymosterol
            C22112  4alpha-Carboxy-5alpha-cholesta-8,24-dien-3beta-ol
            C22136  Zymosterone
            C05437  Zymosterol
            C04525  Fecosterol
            C15777  Episterol
            C15780  5-Dehydroepisterol
            C05440  Ergosta-5,7,22,24(28)-tetraen-3beta-ol
            C01694  Ergosterol
            C05441  Vitamin D2
REFERENCE   PMID:14554200
  AUTHORS   Veen M, Stahl U, Lang C
  TITLE     Combined overexpression of genes of the ergosterol biosynthetic pathway leads to accumulation of sterols in Saccharomyces cerevisiae.
  JOURNAL   FEMS Yeast Res 4:87-95 (2003)
            DOI:10.1016/S1567-1356(03)00126-0
REFERENCE   PMID:30042199
  AUTHORS   Bhattacharya S, Esquivel BD, White TC
  TITLE     Overexpression or Deletion of Ergosterol Biosynthesis Genes Alters Doubling Time, Response to Stress Agents, and Drug Susceptibility in Saccharomyces cerevisiae.
  JOURNAL   mBio 9:e01291-18 (2018)
            DOI:10.1128/mBio.01291-18
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