ENTRY       M00117            Pathway   Module
NAME        Ubiquinone biosynthesis, prokaryotes, chorismate (+ polyprenyl-PP) => ubiquinol
DEFINITION  (K03181,K18240) K03179 K03182+K03186 K18800 K00568 K03185 K03183 (K03184,K06134)
ORTHOLOGY   K03181,K18240  ubiC, xanB2; chorismate lyase [EC:4.1.3.40] [RN:R01302]
            K03179  ubiA; 4-hydroxybenzoate polyprenyltransferase [EC:2.5.1.39] [RN:R05000]
            K03182  ubiD; 4-hydroxy-3-polyprenylbenzoate decarboxylase [EC:4.1.1.98] [RN:R04985]
            K03186  ubiX; flavin prenyltransferase [EC:2.5.1.129] [RN:R04985]
            K18800  ubiI; 2-polyprenylphenol 6-hydroxylase [EC:1.14.13.240] [RN:R08768]
            K00568  ubiG; 2-polyprenyl-6-hydroxyphenyl methylase / 3-demethylubiquinone-9 3-methyltransferase [EC:2.1.1.222 2.1.1.64] [RN:R08769 R12657]
            K03185  ubiH; 2-octaprenyl-6-methoxyphenol hydroxylase [EC:1.14.13.-] [RN:R12658]
            K03183  ubiE; 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase [EC:2.1.1.201] [RN:R09737]
            K03184,K06134  ubiF, coq7; 3-demethoxyubiquinol 3-hydroxylase [EC:1.14.99.60] [RN:R12067]
CLASS       Pathway modules; Metabolism of cofactors and vitamins; Cofactor and vitamin metabolism
PATHWAY     map00130  Ubiquinone and other terpenoid-quinone biosynthesis
            map01240  Biosynthesis of cofactors
            map01100  Metabolic pathways
            map01110  Biosynthesis of secondary metabolites
REACTION    R01302  C00251 -> C00156
            R05000  C00156 + C05847 -> C05848
            R04985  C05848 -> C05807
            R08768  C05807 -> C17551
            R08769  C17551 -> C17552
            R12658  C17552 -> C19858
            R09737  C19858 -> C19859
            R12067  C19859 -> C21860
            R12657  C21860 -> C00390
COMPOUND    C00251  Chorismate
            C00156  4-Hydroxybenzoate
            C05847  all-trans-Polyprenyl diphosphate
            C05848  4-Hydroxy-3-polyprenylbenzoate
            C05807  2-Polyprenylphenol
            C17551  2-Polyprenyl-6-hydroxyphenol
            C17552  2-Polyprenyl-6-methoxyphenol
            C19858  2-Methoxy-6-all-trans-polyprenyl-1,4-benzoquinol
            C19859  5-Methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol
            C21860  3-Demethylubiquinol
            C00390  Ubiquinol
REFERENCE   PMID:24480387
  AUTHORS   Aussel L, Pierrel F, Loiseau L, Lombard M, Fontecave M, Barras F
  TITLE     Biosynthesis and physiology of coenzyme Q in bacteria.
  JOURNAL   Biochim Biophys Acta 1837:1004-11 (2014)
            DOI:10.1016/j.bbabio.2014.01.015
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