ENTRY       M00123            Pathway   Module
NAME        Biotin biosynthesis, pimeloyl-ACP/CoA => biotin
DEFINITION  K00652 ((K00833,K19563) K01935,K19562) K01012
ORTHOLOGY   K00652  bioF; 8-amino-7-oxononanoate synthase [EC:2.3.1.47] [RN:R10124 R03210]
            K00833  bioA; adenosylmethionine---8-amino-7-oxononanoate aminotransferase [EC:2.6.1.62] [RN:R03231]
            K19563  bioA; lysine---8-amino-7-oxononanoate aminotransferase [EC:2.6.1.105] [RN:R10699]
            K19562  BIO3-BIO1; bifunctional dethiobiotin synthetase / adenosylmethionine---8-amino-7-oxononanoate aminotransferase [EC:6.3.3.3 2.6.1.62] [RN:R03231 R03182]
            K01935  bioD; dethiobiotin synthetase [EC:6.3.3.3] [RN:R03182]
            K01012  bioB; biotin synthetase [EC:2.8.1.6] [RN:R01078]
CLASS       Pathway modules; Metabolism of cofactors and vitamins; Cofactor and vitamin metabolism
PATHWAY     map00780  Biotin metabolism
            map01240  Biosynthesis of cofactors
            map01100  Metabolic pathways
REACTION    R10124  C19845 -> C01092
            R03210  C01063 -> C01092
            R03231  C01092 -> C01037
            R10699  C01092 -> C01037
            R03182  C01037 -> C01909
            R01078  C01909 -> C00120
COMPOUND    C19845  Pimeloyl-[acyl-carrier protein]
            C01092  8-Amino-7-oxononanoate
            C01063  Pimeloyl-CoA
            C01037  7,8-Diaminononanoate
            C01909  Dethiobiotin
            C00120  Biotin
REFERENCE   PMID:21437340
  AUTHORS   Lin S, Cronan JE
  TITLE     Closing in on complete pathways of biotin biosynthesis.
  JOURNAL   Mol Biosyst 7:1811-21 (2011)
            DOI:10.1039/c1mb05022b
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