ENTRY       M00357            Pathway   Module
NAME        Methanogenesis, acetate => methane
DEFINITION  ((K00925 K00625),K01895) (K00193+K00197+K00194) (K00577+K00578+K00579+K00580+K00581-K00582-K00583+K00584) (K00399+K00401+K00402) (K22480+K22481+K22482,K03388+K03389+K03390,K08264+K08265,K03388+K03389+K03390+K14127+(K14126+K14128,K22516+K00125))
ORTHOLOGY   K00925  acetate kinase [EC:2.7.2.1] [RN:R00315]
            K00625  phosphate acetyltransferase [EC:2.3.1.8] [RN:R00230]
            K01895  acetyl-CoA synthetase [EC:6.2.1.1] [RN:R00235]
            K00193+K00197+K00194  acetyl-CoA decarbonylase/synthase complex [EC:2.3.1.-] [RN:R09096]
            K00577+K00578+K00579+K00580+K00581-K00582-K00583+K00584  tetrahydromethanopterin S-methyltransferase [EC:7.2.1.4] [RN:R04347]
            K00399+K00401+K00402  methyl-coenzyme M reductase [EC:2.8.4.1] [RN:R04541]
            K22480+K22481+K22482  heterodisulfide reductase 1 [EC:1.8.7.3] [RN:R11931]
            K03388+K03389+K03390  heterodisulfide reductase 2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6] [RN:R11928 R11931 R11943 R11944]
            K08264+K08265  heterodisulfide reductase [EC:1.8.98.1] [RN:R04540]
            K14126+K14128  F420-non-reducing hydrogenase [EC:1.8.98.5] [RN:R11943]
            K14127  F420-non-reducing hydrogenase iron-sulfur subunit [EC:1.8.98.5 1.8.98.6] [RN:R11943 R11944]
            K22516+K00125  formate dehydrogenase (coenzyme F420) [EC:1.8.98.6] [RN:R11944]
CLASS       Pathway modules; Energy metabolism; Methane metabolism
PATHWAY     map00680  Methane metabolism
            map01200  Carbon metabolism
            map01100  Metabolic pathways
            map01120  Microbial metabolism in diverse environments
REACTION    R00315  C00033 -> C00227
            R00230  C00227 -> C00024
            R00235  C00033 -> C00024
            R09096  C00024 -> C04488
            R04347  C04488 + C03576 -> C03920
            R04541  C03920 + C04628 -> C01438 + C04832
            R11931,R04540,R11928,R11943,R11944  C04832 -> C04628 + C03576
COMPOUND    C00033  Acetate
            C00227  Acetyl phosphate
            C00024  Acetyl-CoA
            C04488  5-Methyl-5,6,7,8-tetrahydromethanopterin
            C03576  Coenzyme M
            C03920  2-(Methylthio)ethanesulfonate
            C04628  Coenzyme B
            C01438  Methane
            C04832  Coenzyme M 7-mercaptoheptanoylthreonine-phosphate heterodisulfide
REFERENCE   PMID:18378594
  AUTHORS   Liu Y, Whitman WB
  TITLE     Metabolic, phylogenetic, and ecological diversity of the methanogenic archaea.
  JOURNAL   Ann N Y Acad Sci 1125:171-89 (2008)
            DOI:10.1196/annals.1419.019
REFERENCE   PMID:16024727
  AUTHORS   Welander PV, Metcalf WW
  TITLE     Loss of the mtr operon in Methanosarcina blocks growth on methanol, but not methanogenesis, and reveals an unknown methanogenic pathway.
  JOURNAL   Proc Natl Acad Sci U S A 102:10664-9 (2005)
            DOI:10.1073/pnas.0502623102
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