ENTRY       M00375            Pathway   Module
NAME        Hydroxypropionate-hydroxybutylate cycle
DEFINITION  (K01964+K15037+K15036) K15017 K15039 K15018 K15019 K15020 K05606 (K01848+K01849) (K15038,K15017) K14465 (K14466,K18861,K25774) K14534 K15016 K00626
ORTHOLOGY   K01964,K15036  acetyl-CoA/propionyl-CoA carboxylase [EC:6.4.1.2 6.4.1.3] [RN:R00742 R01859]
            K15037  biotin carboxyl carrier protein [RN:R00742 R01859]
            K15017  malonyl-CoA reductase (NADPH) [EC:1.2.1.75] [RN:R00740]
            K15039  3-hydroxypropionate dehydrogenase (NADP+) [EC:1.1.1.298] [RN:R09289]
            K15018  3-hydroxypropionyl-coenzyme A synthetase [EC:6.2.1.36] [RN:R09286]
            K15019  3-hydroxypropionyl-coenzyme A dehydratase [EC:4.2.1.116] [RN:R03045]
            K15020  acryloyl-coenzyme A reductase [EC:1.3.1.84] [RN:R00919]
            K05606  methylmalonyl-CoA epimerase [EC:5.1.99.1] [RN:R02765]
            K01848,K01849  methylmalonyl-CoA mutase [EC:5.4.99.2] [RN:R00833]
            K15038,K15017  succinyl-coA reductase [EC:1.2.1.76] [RN:R09280]
            K14465  succinate semialdehyde reductase [EC:1.1.1.-] [RN:R09281]
            K14466,K18861,K25774  4-hydroxybutyrate---CoA ligase (AMP-forming) [EC:6.2.1.40] [RN:R09279]
            K14534  4-hydroxybutyryl-CoA dehydratase / vinylacetyl-CoA-Delta-isomerase [EC:4.2.1.120 5.3.3.3] [RN:R10782]  
            K15016  3-hydroxybutyryl-CoA dehydratase / 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.35] [RN:R03026 R01975]
            K00626  acetyl-CoA C-acetyltransferase [EC:2.3.1.9] [RN:R00238]
CLASS       Pathway modules; Energy metabolism; Carbon fixation
PATHWAY     map00720  Other carbon fixation pathways
            map01200  Carbon metabolism
            map01100  Metabolic pathways
            map01120  Microbial metabolism in diverse environments
REACTION    R00742  C00024 -> C00083
            R00740  C00083 -> C00222
            R09289  C00222 -> C01013
            R09286  C01013 -> C05668
            R03045  C05668 -> C00894
            R00919  C00894 -> C00100
            R01859  C00100 -> C00683
            R02765  C00683 -> C01213
            R00833  C01213 -> C00091
            R09280  C00091 -> C00232
            R09281  C00232 -> C00989
            R09279  C00989 -> C11062
            R10782  C11062 -> C00877
            R03026  C00877 -> C01144
            R01975  C01144 -> C00332
            R00238  C00332 -> C00024
COMPOUND    C00024  Acetyl-CoA
            C00083  Malonyl-CoA
            C00222  3-Oxopropanoate
            C01013  3-Hydroxypropanoate
            C05668  3-Hydroxypropionyl-CoA
            C00894  Propenoyl-CoA
            C00100  Propanoyl-CoA
            C00683  (S)-Methylmalonyl-CoA
            C01213  (R)-Methylmalonyl-CoA
            C00091  Succinyl-CoA
            C00232  Succinate semialdehyde
            C00989  4-Hydroxybutanoic acid
            C11062  4-Hydroxybutyryl-CoA
            C00877  Crotonoyl-CoA
            C01144  (S)-3-Hydroxybutanoyl-CoA
            C00332  Acetoacetyl-CoA
RMODULE     RM019  Acyl-CoA conversion via dicarboxylate semialdehyde
COMMENT     Organism group: crenarchaeota
REFERENCE   PMID:19429610
  AUTHORS   Teufel R, Kung JW, Kockelkorn D, Alber BE, Fuchs G
  TITLE     3-hydroxypropionyl-coenzyme A dehydratase and acryloyl-coenzyme A reductase, enzymes of the autotrophic 3-hydroxypropionate/4-hydroxybutyrate cycle in the Sulfolobales.
  JOURNAL   J Bacteriol 191:4572-81 (2009)
            DOI:10.1128/JB.00068-09
///
