ENTRY       M00377            Pathway   Module
NAME        Reductive acetyl-CoA pathway (Wood-Ljungdahl pathway)
DEFINITION  K00198 (K05299-K15022,K22015+K25123+K25124) K01938 K01491-K01500 K00297-K25007-K25008 K15023 K14138+K00197+K00194
ORTHOLOGY   K00198  carbon-monoxide dehydrogenase [EC:1.2.7.4] [RN:R07157]
            K05299,K15022  formate dehydrogenase [EC:1.17.1.10] [RN:R00134]
            K22015,K25123,K25124  formate dehydrogenase (hydrogenase) [EC:1.17.98.-] [RN:R12754]
            K01938  formate--tetrahydrofolate ligase [EC:6.3.4.3] [RN:R00943]
            K01491  methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.5 3.5.4.9] [RN:R01655 R01220]
            K01500  methenyltetrahydrofolate cyclohydrolase [EC:3.5.4.9] [RN:R01655]
            K00297,K25007,K25008  methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54] [RN:R07168]
            K15023  5-methyltetrahydrofolate corrinoid/iron sulfur protein methyltransferase [EC:2.1.1.258] [RN:R02289]
            K14138  acetyl-CoA synthase [EC:2.3.1.169] [RN:R08433]
            K00197+K00194  acetyl-CoA decarbonylase/synthase complex [EC:2.3.1.-] [RN:R10243]
CLASS       Pathway modules; Energy metabolism; Carbon fixation
PATHWAY     map00720  Other carbon fixation pathways
            map01200  Carbon metabolism
            map01100  Metabolic pathways
            map01120  Microbial metabolism in diverse environments
REACTION    R07157  C00011 -> C00237
            R00134,R12754  C00011 -> C00058
            R00943  C00058 + C00101 -> C00234
            R01655  C00234 -> C00445
            R01220  C00445 -> C00143
            R07168  C00143 -> C00440
            R02289+R08433,R10243  C00237 + C00440 -> C00101 + C00024
COMPOUND    C00011  CO2
            C00237  CO
            C00058  Formate
            C00101  Tetrahydrofolate
            C00234  10-Formyltetrahydrofolate
            C00445  5,10-Methenyltetrahydrofolate
            C00143  5,10-Methylenetetrahydrofolate
            C00440  5-Methyltetrahydrofolate
            C00024  Acetyl-CoA
REFERENCE   PMID:3096193
  AUTHORS   Ljungdahl LG
  TITLE     The autotrophic pathway of acetate synthesis in acetogenic bacteria.
  JOURNAL   Annu Rev Microbiol 40:415-50 (1986)
            DOI:10.1146/annurev.mi.40.100186.002215
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