ENTRY       M00567            Pathway   Module
NAME        Methanogenesis, CO2 => methane
DEFINITION  (K00200+K00201+K00202+K00203-K11261+(K00205,K11260,K00204)) K00672 K01499 (K00319,K13942) K00320 (K00577+K00578+K00579+K00580+K00581-K00582-K00583+K00584) (K00399+K00401+K00402) (K22480+K22481+K22482,K03388+K03389+K03390,K08264+K08265,K03388+K03389+K03390+K14127+(K14126+K14128,K22516+K00125))
ORTHOLOGY   K00200+K00201+K00202+K00203+K11261 formylmethanofuran dehydrogenase [EC:1.2.99.5] [RN:R03015]
            K00205,K11260,K00204  4Fe-4S ferredoxin
            K00672  formylmethanofuran--tetrahydromethanopterin N-formyltransferase [EC:2.3.1.101] [RN:R03390]
            K01499  methenyltetrahydromethanopterin cyclohydrolase [EC:3.5.4.27] [RN:R03464]
            K00319  methylenetetrahydromethanopterin dehydrogenase [EC:1.5.99.9] [RN:R04456]
            K13942  5,10-methenyltetrahydromethanopterin hydrogenase [EC:1.12.98.2] [RN:R04455]
            K00320  coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase [EC:1.5.99.11] [RN:R04464]
            K00577+K00578+K00579+K00580+K00581+K00582+K00583+K00584  tetrahydromethanopterin S-methyltransferase [EC:7.2.1.4] [RN:R04347]
            K00399+K00401+K00402  methyl-coenzyme M reductase [EC:2.8.4.1] [RN:R04541]
            K22480+K22481+K22482  heterodisulfide reductase 1 [EC:1.8.7.3] [RN:R11931]
            K03388+K03389+K03390  heterodisulfide reductase 2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6] [RN:R11928 R11931 R11943 R11944]
            K08264+K08265  heterodisulfide reductase [EC:1.8.98.1] [RN:R04540]
            K14126+K14128  F420-non-reducing hydrogenase [EC:1.8.98.5] [RN:R11943]
            K14127  F420-non-reducing hydrogenase iron-sulfur subunit [EC:1.8.98.5 1.8.98.6] [RN:R11943 R11944]
            K22516+K00125  formate dehydrogenase (coenzyme F420) [EC1.8.98.6] [RN:R11944]
CLASS       Pathway modules; Energy metabolism; Methane metabolism
PATHWAY     map00680  Methane metabolism
            map01200  Carbon metabolism
            map01100  Metabolic pathways
            map01120  Microbial metabolism in diverse environments
REACTION    R03015  C00011 -> C01001
            R03390  C01001 -> C01274
            R03464  C01274 -> C04330
            R04456,R04455  C04330 -> C04377
            R04464  C04377 -> C04488
            R04347  C04488 + C03576 -> C03920
            R04541  C03920 + C04628 -> C01438 + C04832
            R11931,R04540,R11928,R11943,R11944  C04832 -> C04628 + C03576
COMPOUND    C00011  CO2
            C01001  Formylmethanofuran
            C01274  5-Formyl-5,6,7,8-tetrahydromethanopterin
            C04330  5,10-Methenyltetrahydromethanopterin
            C04377  5,10-Methylenetetrahydromethanopterin
            C04488  5-Methyl-5,6,7,8-tetrahydromethanopterin
            C03576  Coenzyme M
            C03920  2-(Methylthio)ethanesulfonate
            C04628  Coenzyme B
            C01438  Methane
            C04832  Coenzyme M 7-mercaptoheptanoylthreonine-phosphate heterodisulfide
COMMENT     Organism group: methanogenic archaea
REFERENCE   PMID:18378594
  AUTHORS   Liu Y, Whitman WB
  TITLE     Metabolic, phylogenetic, and ecological diversity of the methanogenic archaea.
  JOURNAL   Ann N Y Acad Sci 1125:171-89 (2008)
            DOI:10.1196/annals.1419.019
REFERENCE   PMID:18587410
  AUTHORS   Thauer RK, Kaster AK, Seedorf H, Buckel W, Hedderich R
  TITLE     Methanogenic archaea: ecologically relevant differences in energy conservation.
  JOURNAL   Nat Rev Microbiol 6:579-91 (2008)
            DOI:10.1038/nrmicro1931
REFERENCE   PMID:14657125
  AUTHORS   L'Haridon S, Reysenbach AL, Banta A, Messner P, Schumann P, Stackebrandt E, Jeanthon C
  TITLE     Methanocaldococcus indicus sp. nov., a novel hyperthermophilic methanogen isolated from the Central Indian Ridge.
  JOURNAL   Int J Syst Evol Microbiol 53:1931-5 (2003)
            DOI:10.1099/ijs.0.02700-0
///
