ENTRY       M00572            Pathway   Module
NAME        Pimeloyl-ACP biosynthesis, BioC-BioH pathway, malonyl-ACP => pimeloyl-ACP
DEFINITION  K02169 (K00647,K09458) K00059 K02372 K00208 (K02170,K09789,K19560,K19561)
ORTHOLOGY   K02169 malonyl-CoA O-methyltransferase [EC:2.1.1.197] [RN:R09543]
            K00647,K09458  3-oxoacyl-[acyl-carrier-protein] synthase [EC:2.3.1.41 2.3.1.179] [RN:R10115 R10119]
            K00059  3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100] [RN:R10116 R10120]
            K02372  3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:4.2.1.59] [RN:R10117 R10121]
            K00208  enoyl-[acyl-carrier protein] reductase [EC:1.3.1.10] [RN:R10118 R10122]
            K02170,K09789,K19560,K19561 pimelyl-[acyl-carrier protein] methyl ester esterase [EC:3.1.1.85] [RN:R09725]
CLASS       Pathway modules; Metabolism of cofactors and vitamins; Cofactor and vitamin metabolism
PATHWAY     map00780  Biotin metabolism
            map01240  Biosynthesis of cofactors
            map01100  Metabolic pathways
REACTION    R09543  C01209 -> C19673
            R10115  C19673 -> C20372
            R10116  C20372 -> C20373
            R10117  C20373 -> C20374
            R10118  C20374 -> C20375
            R10119  C20375 -> C20376
            R10120  C20376 -> C20377
            R10121  C20377 -> C20378
            R10122  C20378 -> C19846
            R09725  C19846 -> C19845
COMPOUND    C01209  Malonyl-[acp]
            C19673  Malonyl-[acp] methyl ester
            C20372  3-Ketoglutaryl-[acp] methyl ester
            C20373  3-Hydroxyglutaryl-[acp] methyl ester
            C20374  Enoylglutaryl-[acp] methyl ester
            C20375  Glutaryl-[acp] methyl ester
            C20376  3-Ketopimeloyl-[acp] methyl ester
            C20377  3-Hydroxypimeloyl-[acp] methyl ester
            C20378  Enoylpimeloyl-[acp] methyl ester
            C19846  Pimelyl-[acp] methyl ester
            C19845  Pimelyl-[acp]
RMODULE     RM021  Fatty acid synthesis using malonyl-CoA
REFERENCE   PMID:21437340
  AUTHORS   Lin S, Cronan JE
  TITLE     Closing in on complete pathways of biotin biosynthesis.
  JOURNAL   Mol Biosyst 7:1811-21 (2011)
            DOI:10.1039/c1mb05022b
REFERENCE   PMID:22965231
  AUTHORS   Lin S, Cronan JE
  TITLE     The BioC O-methyltransferase catalyzes methyl esterification of malonyl-acyl carrier protein, an essential step in biotin synthesis.
  JOURNAL   J Biol Chem 287:37010-20 (2012)
            DOI:10.1074/jbc.M112.410290
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