ENTRY       M00595            Pathway   Module
NAME        Sulfur oxidation, SOX system, thiosulfate => sulfate
DEFINITION  K17222+K17223+K17224-K17225-K22622+K17226+K17227
ORTHOLOGY   K17222  soxA; sulfur-oxidizing protein SoxA
            K17223  soxX; sulfur-oxidizing protein SoxX
            K17224  soxB; sulfur-oxidizing protein SoxB
            K17225  soxC; S-disulfanyl-L-cysteine oxidoreductase SoxC [EC:1.8.2.6]
            K22622  soxD; S-disulfanyl-L-cysteine oxidoreductase SoxD [EC:1.8.2.6]
            K17226  soxY; sulfur-oxidizing protein SoxY
            K17227  soxZ; sulfur-oxidizing protein SoxZ
CLASS       Pathway modules; Energy metabolism; Sulfur metabolism
PATHWAY     map00920  Sulfur metabolism
            map01320  Sulfur cycle
            map01100  Metabolic pathways
            map01120  Microbial metabolism in diverse environments
REACTION    R10151  C00320 -> C00059
COMPOUND    C00320  Thiosulfate
            C00059  Sulfate
REFERENCE   PMID:22092713
  AUTHORS   Falkenby LG, Szymanska M, Holkenbrink C, Habicht KS, Andersen JS, Miller M, Frigaard NU
  TITLE     Quantitative proteomics of Chlorobaculum tepidum: insights into the sulfur metabolism of a phototrophic green sulfur bacterium.
  JOURNAL   FEMS Microbiol Lett 323:142-50 (2011)
            DOI:10.1111/j.1574-6968.2011.02370.x
REFERENCE   PMID:21147779
  AUTHORS   Zander U, Faust A, Klink BU, de Sanctis D, Panjikar S, Quentmeier A, Bardischewsky F, Friedrich CG, Scheidig AJ
  TITLE     Structural basis for the oxidation of protein-bound sulfur by the sulfur cycle molybdohemo-enzyme sulfane dehydrogenase SoxCD.
  JOURNAL   J Biol Chem 286:8349-60 (2011)
            DOI:10.1074/jbc.M110.193631
REFERENCE   PMID:19616092
  AUTHORS   Ghosh W, Mallick S, DasGupta SK
  TITLE     Origin of the Sox multienzyme complex system in ancient thermophilic bacteria and coevolution of its constituent proteins.
  JOURNAL   Res Microbiol 160:409-20 (2009)
            DOI:10.1016/j.resmic.2009.07.003
REFERENCE   PMID:19645821
  AUTHORS   Ghosh W, Dam B
  TITLE     Biochemistry and molecular biology of lithotrophic sulfur oxidation by taxonomically and ecologically diverse bacteria and archaea.
  JOURNAL   FEMS Microbiol Rev 33:999-1043 (2009)
            DOI:10.1111/j.1574-6976.2009.00187.x
///
