ENTRY       M00621            Pathway   Module
NAME        Glycine cleavage system
DEFINITION  (K00281,K00282+K00283) K00605 K00382
ORTHOLOGY   K00281,K00282+K00283  glycine dehydrogenase (P protein) [EC:1.4.4.2] [RN:R03425 R01221]
            K00605  aminomethyltransferase (T protein) [EC:2.1.2.10] [RN:R04125 R01221]
            K00382  dihydrolipoyl dehydrogenase (L protein) [EC:1.8.1.4] [RN:R03815 R01221]
CLASS       Pathway modules; Amino acid metabolism; Serine and threonine metabolism
PATHWAY     map00260  Glycine, serine and threonine metabolism
            map00630  Glyoxylate and dicarboxylate metabolism
            map00670  One carbon pool by folate
            map00785  Lipoic acid metabolism
            map01200  Carbon metabolism
            map01100  Metabolic pathways
REACTION    R03425  C00037 + C02051 -> C01242 + C00011
            R04125  C01242 + C00101 -> C02972 + C00143 + C00014
            R03815  C02972 -> C02051
            
            R01221  C00037 + C00101 -> C00014 + C00143
COMPOUND    C00037  Glycine
            C02051  [H-protein]-lipoyllysine
            C01242  [H-protein]-S-aminomethyldihydrolipoyllysine
            C00011  CO2
            C00101  Tetrahydrofolate
            C02972  [H-protein]-dihydrolipoyllysine
            C00143  5,10-Methylenetetrahydrofolate
            C00014  Ammonia
COMMENT     Glycine cleavage system contains the non-enzyme H protein (K02437).
REFERENCE   PMID:10966480
  AUTHORS   Perham RN
  TITLE     Swinging arms and swinging domains in multifunctional enzymes: catalytic machines for multistep reactions.
  JOURNAL   Annu Rev Biochem 69:961-1004 (2000)
            DOI:10.1146/annurev.biochem.69.1.961
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