ENTRY       M00642            Signature Module
NAME        Multidrug resistance, efflux pump MexJK-OprM
DEFINITION  K18301 K18302+K18303-K18139
ORTHOLOGY   K18301  mexL; TetR/AcrR family transcriptional regulator, mexJK operon transcriptional repressor
            K18302  mexJ; membrane fusion protein
            K18303  mexK; multidrug efflux pump
            K18139  oprM; outer membrane protein
CLASS       Signature modules; Gene set; Drug resistance
REFERENCE   PMID:12193619
  AUTHORS   Chuanchuen R, Narasaki CT, Schweizer HP
  TITLE     The MexJK efflux pump of Pseudomonas aeruginosa requires OprM for antibiotic efflux but not for efflux of triclosan.
  JOURNAL   J Bacteriol 184:5036-44 (2002)
            DOI:10.1128/JB.184.18.5036-5044.2002
REFERENCE   PMID:17223624
  AUTHORS   Depardieu F, Podglajen I, Leclercq R, Collatz E, Courvalin P
  TITLE     Modes and modulations of antibiotic resistance gene expression.
  JOURNAL   Clin Microbiol Rev 20:79-114 (2007)
            DOI:10.1128/CMR.00015-06
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