ENTRY       M00643            Signature Module
NAME        Multidrug resistance, efflux pump MexXY-OprM
DEFINITION  K18129 K18094+K18095+K18139
ORTHOLOGY   K18129  mexZ; TetR/AcrR family transcriptional regulator, mexXY operon repressor
            K18094  mexX; membrane fusion protein
            K18095  mexY; multidrug efflux pump
            K18139  oprM; outer membrane protein
CLASS       Signature modules; Gene set; Drug resistance
REFERENCE   PMID:15105137
  AUTHORS   Llanes C, Hocquet D, Vogne C, Benali-Baitich D, Neuwirth C, Plesiat P
  TITLE     Clinical strains of Pseudomonas aeruginosa overproducing MexAB-OprM and MexXY efflux pumps simultaneously.
  JOURNAL   Antimicrob Agents Chemother 48:1797-802 (2004)
            DOI:10.1128/AAC.48.5.1797-1802.2004
REFERENCE   PMID:10952562
  AUTHORS   Masuda N, Sakagawa E, Ohya S, Gotoh N, Tsujimoto H, Nishino T
  TITLE     Contribution of the MexX-MexY-oprM efflux system to intrinsic resistance in Pseudomonas aeruginosa.
  JOURNAL   Antimicrob Agents Chemother 44:2242-6 (2000)
            DOI:10.1128/AAC.44.9.2242-2246.2000
REFERENCE   PMID:21149619
  AUTHORS   Muller C, Plesiat P, Jeannot K
  TITLE     A two-component regulatory system interconnects resistance to polymyxins, aminoglycosides, fluoroquinolones, and beta-lactams in Pseudomonas aeruginosa.
  JOURNAL   Antimicrob Agents Chemother 55:1211-21 (2011)
            DOI:10.1128/AAC.01252-10
REFERENCE   PMID:19589837
  AUTHORS   Yamamoto M, Ueda A, Kudo M, Matsuo Y, Fukushima J, Nakae T, Kaneko T, Ishigatsubo Y
  TITLE     Role of MexZ and PA5471 in transcriptional regulation of mexXY in Pseudomonas aeruginosa.
  JOURNAL   Microbiology 155:3312-21 (2009)
            DOI:10.1099/mic.0.028993-0
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