ENTRY       M00704            Signature Module
NAME        Tetracycline resistance, efflux pump Tet38
DEFINITION  K18906 K08168
ORTHOLOGY   K18906  mgrA; MarR family transcriptional regulator, multiple gene regulator MgrA [COG:COG1846]
            K08168  tetB; MFS transporter, DHA2 family, metal-tetracycline-proton antiporter [COG:COG0477] [TC:2.A.1.3]
CLASS       Signature modules; Gene set; Drug resistance
COMMENT     Resistance mechanism: limitation of drug accumulation as a result of active drug efflux
REFERENCE   PMID:15774883
  AUTHORS   Truong-Bolduc QC, Dunman PM, Strahilevitz J, Projan SJ, Hooper DC
  TITLE     MgrA is a multiple regulator of two new efflux pumps in Staphylococcus aureus.
  JOURNAL   J Bacteriol 187:2395-405 (2005)
            DOI:10.1128/JB.187.7.2395-2405.2005
REFERENCE   PMID:23034325
  AUTHORS   Fernandez L, Hancock RE
  TITLE     Adaptive and mutational resistance: role of porins and efflux pumps in drug resistance.
  JOURNAL   Clin Microbiol Rev 25:661-81 (2012)
            DOI:10.1128/CMR.00043-12
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