ENTRY       M00746            Signature Module
NAME        Multidrug resistance, repression of porin OmpF
DEFINITION  K13632 K18513 K09476
ORTHOLOGY   K13632  marA; AraC family transcriptional regulator, mar-sox-rob regulon activator [COG:COG2207]
            K18513  micF; small regulatory RNA MicF
            K09476  ompF; outer membrane pore protein F [COG:COG3203] [TC:1.B.1.1.1]
CLASS       Signature modules; Gene set; Drug resistance
COMMENT     Resistance mechanism: decrease in the production of OmpF porin which is involved in the entry of antimicrobial agents
REFERENCE   PMID:11353631
  AUTHORS   Balague C, Vescovi EG
  TITLE     Activation of multiple antibiotic resistance in uropathogenic Escherichia coli strains by aryloxoalcanoic acid compounds.
  JOURNAL   Antimicrob Agents Chemother 45:1815-22 (2001)
            DOI:10.1128/AAC.45.6.1815-1822.2001
REFERENCE   PMID:25788514
  AUTHORS   Li XZ, Plesiat P, Nikaido H
  TITLE     The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria.
  JOURNAL   Clin Microbiol Rev 28:337-418 (2015)
            DOI:10.1128/CMR.00117-14
REFERENCE   PMID:9333027
  AUTHORS   Alekshun MN, Levy SB
  TITLE     Regulation of chromosomally mediated multiple antibiotic resistance: the mar regulon.
  JOURNAL   Antimicrob Agents Chemother 41:2067-75 (1997)
            DOI:10.1128/AAC.41.10.2067
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