ENTRY       M00825            Pathway   Module
NAME        10-membered enediyne core biosynthesis, malonyl-CoA => 3-hydroxyhexadeca-4,6,8,10,12,14-hexaenoyl-ACP => 10-membered enediyne core
DEFINITION  K15314 K21168+K21169+K21170+K21171+K21172+K21173+K21174
ORTHOLOGY   K15314  sgcE; enediyne polyketide synthase [RN:R11435]
            K21168  calE1; enediyne biosynthesis protein CalE1
            K21169  calE2; enediyne biosynthesis protein CalE2
            K21170  calE3; enediyne biosynthesis protein CalE3
            K21171  calE4; enediyne biosynthesis protein CalE4
            K21172  calE5; enediyne biosynthesis protein CalE5
            K21173  calE6; methionine gamma-lyase
            K21174  calE9; enediyne biosynthesis protein CalE9
CLASS       Pathway modules; Biosynthesis of terpenoids and polyketides; Enediyne biosynthesis
PATHWAY     map01059  Biosynthesis of enediyne antibiotics
            map01100  Metabolic pathways
            map01110  Biosynthesis of secondary metabolites
REFERENCE   PMID:12183629
  AUTHORS   Ahlert J, Shepard E, Lomovskaya N, Zazopoulos E, Staffa A, Bachmann BO, Huang K, Fonstein L, Czisny A, Whitwam RE, Farnet CM, Thorson JS
  TITLE     The calicheamicin gene cluster and its iterative type I enediyne PKS.
  JOURNAL   Science 297:1173-6 (2002)
            DOI:10.1126/science.1072105
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