ENTRY       M00894            Pathway   Module
NAME        Cannabidiol biosynthesis, malonyl-CoA => cannabidiol/dronabinol
DEFINITION  K20503 K20508 K27602 K20502 K20501
ORTHOLOGY   K20503  OLS; 3,5,7-trioxododecanoyl-CoA synthase [EC:2.3.1.206] [RN:R10171]
            K20508  OAC; olivetolic acid cyclase [EC:4.4.1.26] [RN:R10278]
            K27602  PT4; geranyl-pyrophosphate---olivetolic acid geranyltransferase [EC:2.5.1.102] [RN:R10176]
            K20502  CBDAS; cannabidiolic acid synthase [EC:1.21.3.8] [RN:R10160]
            K20501  THCAS; tetrahydrocannabinolic acid synthase [EC:1.21.3.7] [RN:R12101]
CLASS       Pathway modules; Biosynthesis of other secondary metabolites; Biosynthesis of phytochemical compounds
PATHWAY     map00999  Biosynthesis of various plant secondary metabolites
            map01100  Metabolic pathways
            map01110  Biosynthesis of secondary metabolites
REACTION    R10171  C00083 -> C20413
            R10278  C20413 -> C20417
            R10176  C20417 -> C20406
            R10160  C20406 -> C10784
            R12103  C10784 -> C07578
            R12101  C20406 -> C21903
            R12102  C21903 -> C06972
COMPOUND    C00083  Malonyl-CoA
            C20413  3,5,7-Trioxododecanoyl-CoA
            C20417  2,4-Dihydroxy-6-pentylbenzoate
            C20406  Cannabigerolate
            C10784  Cannabidiolic acid
            C07578  Cannabidiol
            C21903  Delta9-Tetrahydrocannabinolate
            C06972  Dronabinol
REFERENCE   PMID:17544411
  AUTHORS   Taura F, Sirikantaramas S, Shoyama Y, Yoshikai K, Shoyama Y, Morimoto S
  TITLE     Cannabidiolic-acid synthase, the chemotype-determining enzyme in the fiber-type Cannabis sativa.
  JOURNAL   FEBS Lett 581:2929-34 (2007)
            DOI:10.1016/j.febslet.2007.05.043
///
