ENTRY       M00921            Pathway   Module
NAME        Cyclooctatin biosynthesis, dimethylallyl-PP + isopentenyl-PP => cyclooctatin
DEFINITION  K13787 K18686 K22997 K22998
ORTHOLOGY   K13787  cotB1; geranylgeranyl diphosphate synthase [EC:2.5.1.1 2.5.1.10 2.5.1.29] [RN:R01658 R02003 R02061]
            K18686  cotB2; cyclooctat-9-en-7-ol synthase [EC:4.2.3.146] [RN:R10763]
            K22997  cotB3; cyclooctat-9-en-7-ol 5-monooxygenase [EC:1.14.99.61] [RN:R12177]
            K22998  cotB4; cyclooctatin synthase [EC:1.14.99.62] [RN:R12178]
CLASS       Pathway modules; Biosynthesis of other secondary metabolites; Biosynthesis of other bacterial compounds
PATHWAY     map00997  Biosynthesis of various other secondary metabolites
            map01100  Metabolic pathways
            map01110  Biosynthesis of secondary metabolites
REACTION    R01658+R02003+R02061  C00129 -> C00353
            R10763  C00353 -> C20834
            R12177  C20834 -> C21978
            R12178  C21978 -> C21979
COMPOUND    C00129  Isopentenyl diphosphate
            C00353  Geranylgeranyl diphosphate
            C20834  Cyclooctat-9-en-7-ol
            C21978  Cyclooctat-9-ene-5,7-diol
            C21979  Cyclooctatin
REFERENCE   PMID:19635410
  AUTHORS   Kim SY, Zhao P, Igarashi M, Sawa R, Tomita T, Nishiyama M, Kuzuyama T
  TITLE     Cloning and heterologous expression of the cyclooctatin biosynthetic gene cluster afford a diterpene cyclase and two p450 hydroxylases.
  JOURNAL   Chem Biol 16:736-43 (2009)
            DOI:10.1016/j.chembiol.2009.06.007
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