ENTRY       M00931            Pathway   Module
NAME        Menaquinone biosynthesis, modified futalosine pathway
DEFINITION  K11782 K18285 K18284 K11784 K11785
ORTHOLOGY   K11782  mqnA; chorismate dehydratase [EC:4.2.1.151] [RN:R10666]
            K18285  mqnE; aminodeoxyfutalosine synthase [EC:2.5.1.120] [RN:R10667]
            K18284  K18284; aminodeoxyfutalosine nucleosidase [EC:3.2.2.30] [RN:R10668]
            K11784  mqnC; cyclic dehypoxanthinyl futalosine synthase [EC:1.21.98.1] [RN:R08588]
            K11785  mqnD; 5,8-dihydroxy-2-naphthoate synthase [EC:4.1.99.29] [RN:R08589]
CLASS       Pathway modules; Metabolism of cofactors and vitamins; Cofactor and vitamin metabolism
PATHWAY     map00130  Ubiquinone and other terpenoid-quinone biosynthesis
            map01240  Biosynthesis of cofactors
            map01100  Metabolic pathways
REACTION    R10666  C00251 -> C20772
            R10667  C20772 -> C20773
            R10668  C20773 -> C17010
            R08588  C17010 -> C17017
            R08589  C17017 -> C17018
COMPOUND    C00251  Chorismate
            C20772  3-[(1-Carboxyvinyl)oxy]benzoate
            C20773  6-Amino-6-deoxyfutalosine
            C17010  Dehypoxanthine futalosine
            C17017  Cyclic dehypoxanthine futalosine
            C17018  1,4-Dihydroxy-6-naphthoate
REFERENCE   PMID:30447488
  AUTHORS   Joshi S, Fedoseyenko D, Mahanta N, Manion H, Naseem S, Dairi T, Begley TP
  TITLE     Novel enzymology in futalosine-dependent menaquinone biosynthesis.
  JOURNAL   Curr Opin Chem Biol 47:134-141 (2018)
            DOI:10.1016/j.cbpa.2018.09.015
REFERENCE   PMID:21489995
  AUTHORS   Li X, Apel D, Gaynor EC, Tanner ME
  TITLE     5'-methylthioadenosine nucleosidase is implicated in playing a key role in a modified futalosine pathway for menaquinone biosynthesis in Campylobacter jejuni.
  JOURNAL   J Biol Chem 286:19392-8 (2011)
            DOI:10.1074/jbc.M111.229781
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