ENTRY       M00943            Pathway   Module
NAME        Reticuline biosynthesis, dopamine + 4HPAA => (S)-reticuline
DEFINITION  K13382 K13383 K13384 K13385 K13386
ORTHOLOGY   K13382  (S)-norcoclaurine synthase [EC:3.5.99.14] [RN:R04305]
            K13383  (RS)-norcoclaurine 6-O-methyltransferase [EC:2.1.1.128] [RN:R05123]
            K13384  (S)-coclaurine-N-methyltransferase [EC:2.1.1.140] [RN:R04692]
            K13385  N-methylcoclaurine 3'-monooxygenase [EC:1.14.14.102] [RN:R05732]
            K13386  3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase [EC:2.1.1.116] [RN:R03832]
CLASS       Pathway modules; Biosynthesis of other secondary metabolites; Biosynthesis of phytochemical compounds
PATHWAY     map00950  Isoquinoline alkaloid biosynthesis
            map01100  Metabolic pathways
            map01110  Biosynthesis of secondary metabolites
REACTION    R04305  C03765 + C03758 -> C06160
            R05123  C06160 -> C06161
            R04692  C06161 -> C05176
            R05732  C05176 -> C05202
            R03832  C05202 -> C02105
COMPOUND    C03765  4-Hydroxyphenylacetaldehyde
            C03758  Dopamine
            C06160  (S)-Norcoclaurine
            C06161  (S)-Coclaurine
            C05176  (S)-N-Methylcoclaurine
            C05202  3'-Hydroxy-N-methyl-(S)-coclaurine
            C02105  (S)-Reticuline
REFERENCE   PMID:24671624
  AUTHORS   Beaudoin GA, Facchini PJ.
  TITLE     Benzylisoquinoline alkaloid biosynthesis in opium poppy.
  JOURNAL   Planta 240:19-32 (2014)
            DOI:10.1007/s00425-014-2056-8
///
