entry created 1996-02-01 dataset Swiss-Prot modified 2023-02-22 version 175 accession P49282 accession O54903 accession Q3UFV5 accession Q8BJL2 accession Q8BWV3 accession Q8CFA0 accession Q8VCU6 name NRAM2_MOUSE protein recommendedName fullName Natural-resistance-associated-macrophage-protein-2 shortName NRAMP-2 alternativeName fullName Divalent-cation-transporter-1 alternativeName fullName Divalent-metal-transporter-1 shortName DMT-1 alternativeName fullName Solute-carrier-family-11-member-2 gene name type primary Slc11a2 name type synonym Dct1 name type synonym Dmt1 name type synonym Nramp2 organism name type scientific Mus-musculus name type common Mouse dbReference id 10090 type NCBI-Taxonomy lineage taxon Eukaryota taxon Metazoa taxon Chordata taxon Craniata taxon Vertebrata taxon Euteleostomi taxon Mammalia taxon Eutheria taxon Euarchontoglires taxon Glires taxon Rodentia taxon Myomorpha taxon Muroidea taxon Muridae taxon Murinae taxon Mus taxon Mus reference key 1 citation date 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INTERACTION-WITH-NDFIP1;-NDFIP2-AND-WWP2 scope SUBCELLULAR-LOCATION-(ISOFORMS-1-AND-2) scope UBIQUITINATION reference key 13 citation date 2009 first 143 last 154 name Immunity type journal-article volume 30 title The-phagosomal-proteome-in-interferon-gamma-activated-macrophages. authorList person name Trost-M. person name English-L. person name Lemieux-S. person name Courcelles-M. person name Desjardins-M. person name Thibault-P. dbReference id 19144319 type PubMed dbReference id 10.1016/j.immuni.2008.11.006 type DOI scope PHOSPHORYLATION-[LARGE-SCALE-ANALYSIS]-AT-SER-564-AND-SER-567 scope IDENTIFICATION-BY-MASS-SPECTROMETRY-[LARGE-SCALE-ANALYSIS] reference key 14 citation date 2010 first 1174 last 1189 name Cell type journal-article volume 143 title A-tissue-specific-atlas-of-mouse-protein-phosphorylation-and-expression. authorList person name Huttlin-E.L. person name Jedrychowski-M.P. person name Elias-J.E. person name Goswami-T. person name Rad-R. person name Beausoleil-S.A. person name Villen-J. person name Haas-W. person name Sowa-M.E. person name Gygi-S.P. dbReference id 21183079 type PubMed dbReference id 10.1016/j.cell.2010.12.001 type DOI scope PHOSPHORYLATION-[LARGE-SCALE-ANALYSIS]-AT-SER-564-AND-SER-567 scope PHOSPHORYLATION-[LARGE-SCALE-ANALYSIS]-AT-SER-556-(ISOFORM-1) scope PHOSPHORYLATION-[LARGE-SCALE-ANALYSIS]-AT-SER-586-(ISOFORM-3) scope IDENTIFICATION-BY-MASS-SPECTROMETRY-[LARGE-SCALE-ANALYSIS] source tissue Kidney tissue Spleen tissue Testis reference key 15 citation date 2016 first 16011 last 16011 name Cell-Discov. type journal-article volume 2 title Regulation-of-the-divalent-metal-ion-transporter-via-membrane-budding. authorList person name Mackenzie-K. person name Foot-N.J. person name Anand-S. person name Dalton-H.E. person name Chaudhary-N. person name Collins-B.M. person name Mathivanan-S. person name Kumar-S. dbReference id 27462458 type PubMed dbReference id 10.1038/celldisc.2016.11 type DOI scope SUBCELLULAR-LOCATION reference key 16 citation date 1997 first 383 last 386 name Nat.-Genet. type journal-article volume 16 title Microcytic-anaemia-mice-have-a-mutation-in-Nramp2,-a-candidate-iron-transporter-gene. authorList person name Fleming-M.D. person name Trenor-C.C.-III person name Su-M.A. person name Foernzler-D. person name Beier-D.R. person name Dietrich-W.F. person name Andrews-N.C. dbReference id 9241278 type PubMed dbReference id 10.1038/ng0897-383 type DOI scope VARIANT-MK-ARG-185 comment type function text evidence 1-2-6-8 Proton-coupled-metal-ion-symporter-operating-with-a-proton-to-metal-ion-stoichiometry-of-1:1-(PubMed:16475818).-Selectively-transports-various-divalent-metal-cations,-in-decreasing-affinity:-Cd(2+)->-Fe(2+)->-Co(2+),-Mn(2+)->>-Zn(2+),-Ni(2+),-VO(2+)-(By-similarity)-(PubMed:16475818).-Essential-for-maintenance-of-iron-homeostasis-by-modulating-intestinal-absorption-of-dietary-Fe(2+)-and-TF-associated-endosomal-Fe(2+)-transport-in-erythroid-precursors-and-other-cells-(PubMed:11739192).-Enables-Fe(2+)-and-Mn(2+)-ion-entry-into-mitochondria,-and-is-thus-expected-to-promote-mitochondrial-heme-synthesis,-iron-sulfur-cluster-biogenesis-and-antioxidant-defense-(By-similarity).-Can-mediate-uncoupled-fluxes-of-either-protons-or-metal-ions. comment type catalytic-activity molecule Isoform-1 reaction evidence 8 text Fe(2+)(in)-+-H(+)(in)-=-Fe(2+)(out)-+-H(+)(out) dbReference id RHEA:29579 type Rhea dbReference id CHEBI:15378 type ChEBI dbReference id CHEBI:29033 type ChEBI physiologicalReaction direction left-to-right evidence 1 dbReference id RHEA:29580 type Rhea physiologicalReaction direction right-to-left evidence 15 dbReference id RHEA:29581 type Rhea comment type catalytic-activity molecule Isoform-1 reaction evidence 8 text Co(2+)(out)-+-H(+)(out)-=-Co(2+)(in)-+-H(+)(in) dbReference id RHEA:73035 type Rhea dbReference id CHEBI:15378 type ChEBI dbReference id CHEBI:48828 type ChEBI physiologicalReaction direction left-to-right evidence 15 dbReference id RHEA:73036 type Rhea comment type catalytic-activity molecule Isoform-2 reaction evidence 8 text Fe(2+)(in)-+-H(+)(in)-=-Fe(2+)(out)-+-H(+)(out) dbReference id RHEA:29579 type Rhea dbReference id CHEBI:15378 type ChEBI dbReference id CHEBI:29033 type ChEBI physiologicalReaction direction left-to-right evidence 1 dbReference id RHEA:29580 type Rhea physiologicalReaction direction right-to-left evidence 15 dbReference id RHEA:29581 type Rhea comment type catalytic-activity molecule Isoform-2 reaction evidence 8 text Co(2+)(out)-+-H(+)(out)-=-Co(2+)(in)-+-H(+)(in) dbReference id RHEA:73035 type Rhea dbReference id CHEBI:15378 type ChEBI dbReference id CHEBI:48828 type ChEBI physiologicalReaction direction left-to-right evidence 15 dbReference id RHEA:73036 type Rhea comment type catalytic-activity reaction evidence 1 text Cd(2+)(out)-+-H(+)(out)-=-Cd(2+)(in)-+-H(+)(in) dbReference id RHEA:73031 type Rhea dbReference id CHEBI:15378 type ChEBI dbReference id CHEBI:48775 type ChEBI physiologicalReaction direction left-to-right evidence 1 dbReference id RHEA:73032 type Rhea comment type catalytic-activity reaction evidence 1-2 text H(+)(in)-+-Mn(2+)(in)-=-H(+)(out)-+-Mn(2+)(out) dbReference id RHEA:29007 type Rhea dbReference id CHEBI:15378 type ChEBI dbReference id CHEBI:29035 type ChEBI physiologicalReaction direction left-to-right evidence 1 dbReference id RHEA:29008 type Rhea physiologicalReaction direction right-to-left evidence 1-2 dbReference id RHEA:29009 type Rhea comment type catalytic-activity reaction evidence 1-2 text H(+)(out)-+-Zn(2+)(out)-=-H(+)(in)-+-Zn(2+)(in) dbReference id RHEA:71195 type Rhea dbReference id CHEBI:15378 type ChEBI dbReference id CHEBI:29105 type ChEBI physiologicalReaction direction left-to-right evidence 1-2 dbReference id RHEA:71196 type Rhea comment type catalytic-activity reaction evidence 1-2 text H(+)(out)-+-Ni(2+)(out)-=-H(+)(in)-+-Ni(2+)(in) dbReference id RHEA:73039 type Rhea dbReference id CHEBI:15378 type ChEBI dbReference id CHEBI:49786 type ChEBI physiologicalReaction direction left-to-right evidence 1-2 dbReference id RHEA:73040 type Rhea comment type catalytic-activity reaction evidence 2 text H(+)(in)-=-H(+)(out) dbReference id RHEA:34979 type Rhea dbReference id CHEBI:15378 type ChEBI comment type catalytic-activity reaction evidence 2 text Fe(2+)(in)-=-Fe(2+)(out) dbReference id RHEA:28486 type Rhea dbReference id CHEBI:29033 type ChEBI comment type subunit text evidence 2-9 Forms-a-complex-with-NDFIP1-and-NEDD4L,-in-cortical-neurons,-in-response-to-iron-and-cobalt-exposure;-this-interaction-leads-to-SLC11A2-ubiquitination-by-NEDD4L-and-proteasome-dependent-degradation-(By-similarity).-Interacts-with-NDFIP1,-NDFIP2-and-WWP2;-this-interaction-leads-to-SLC11A2-ubiquitination-by-WWP2-and-subsequent-proteasome-dependent-degradation-(PubMed:18776082).-Interacts-with-COX2-and-TOM6-at-the-outer-mitochondrion-membrane-(By-similarity).-Interacts-with-ARRDC1;-this-interaction-regulates-the-incorporation-of-SLC11A2-into-extracellular-vesicles-through-an-ubiquitination-dependent-mechanism-(By-similarity).-Interacts-with-ARRDC4;-controls-the-incorporation-of-SLC11A2-into-extracellular-vesicles-through-an-ubiquitination-dependent-mechanism-(By-similarity). comment type subcellular-location molecule Isoform-1 subcellularLocation location evidence 9 Golgi-apparatus location evidence 9 Trans-Golgi-network-membrane topology evidence 3 Multi-pass-membrane-protein subcellularLocation location evidence 8-9 Early-endosome-membrane topology evidence 3 Multi-pass-membrane-protein subcellularLocation location evidence 8 Recycling-endosome-membrane topology evidence 3 Multi-pass-membrane-protein subcellularLocation location evidence 8 Cell-membrane topology evidence 3 Multi-pass-membrane-protein comment type subcellular-location molecule Isoform-2 subcellularLocation location evidence 9 Golgi-apparatus location evidence 9 Trans-Golgi-network-membrane topology evidence 3 Multi-pass-membrane-protein subcellularLocation location evidence 9 Early-endosome-membrane topology evidence 3 Multi-pass-membrane-protein subcellularLocation location evidence 8 Late-endosome-membrane topology evidence 3 Multi-pass-membrane-protein subcellularLocation location evidence 8 Lysosome-membrane topology evidence 3 Multi-pass-membrane-protein subcellularLocation location evidence 8 Cell-membrane topology evidence 3 Multi-pass-membrane-protein comment type subcellular-location subcellularLocation location evidence 2 Apical-cell-membrane topology evidence 3 Multi-pass-membrane-protein subcellularLocation location evidence 2 Mitochondrion-outer-membrane topology evidence 3 Multi-pass-membrane-protein subcellularLocation location evidence 10 Extracellular-vesicle-membrane topology evidence 3 Multi-pass-membrane-protein comment type alternative-products event type alternative-splicing isoform id P49282-1 name 2 name Non-IRE sequence type displayed isoform id P49282-2 name 1 name IRE sequence ref VSP_003596 type described isoform id P49282-3 name 3 name 1A-IRE sequence ref VSP_038145-VSP_003596 type described isoform id P49282-4 name 4 name 1A-Non-IRE sequence ref VSP_038145 type described comment type tissue-specificity molecule Isoform-1 text evidence 6 Abundantly-expressed-in-erythroid-precursor-cells-(at-protein-level). comment type tissue-specificity molecule Isoform-2 text evidence 5 Expressed-in-duodenum-(at-protein-level). comment type induction molecule Isoform-2 text evidence 5 Up-regulated-under-iron-depletion-conditions-in-the-proximal-portion-of-the-duodenum-where-it-is-abundantly-expressed-in-the-brush-border-of-absorptive-epithelial-cells-(at-protein-level). comment type PTM text evidence 9 Ubiquitinated-by-WWP2. comment type PTM text evidence 2 N-glycosylated. comment type disease text Defects-in-Slc11a2-are-the-cause-of-microcytic-anemia-(mk).-Homozygous-mk/mk-mice-have-hypochromic-microcytic-anemia-due-to-severe-defects-in-intestinal-iron-absorption-and-erythroid-iron-utilization. comment type disruption-phenotype text evidence 7 Mice-display-no-apparent-anatomical-abnormalities.-They-are-however-anemic,-show-progressive-postnatal-growth-retardation,-and-at-birth-have-elevated-liver-iron-stores-compared-with-wild-type-littermates.-None-survive-for-more-than-7-days.-Heterozygotes-appear-normal,-showing-no-significant-hematological-abnormalities.-However,-by-8-weeks,-their-liver-iron-content-is-lower-than-in-wild-type-littermates. comment type miscellaneous text Nifedipine-induces-duodenal-iron-accumulation-and-mobilizes-iron-from-the-liver-of-iron-overloaded-mice. comment type similarity text evidence 14 Belongs-to-the-NRAMP-family. comment evidence 14 type sequence-caution conflict type frameshift sequence id CAD38518 resource EMBL-CDS version 1 dbReference id L33415 type EMBL property type protein-sequence-ID value AAC42051.1 property type molecule-type value mRNA dbReference id AF029758 type EMBL property type protein-sequence-ID value AAC24496.1 property type molecule-type value mRNA dbReference id AK049856 type EMBL property type protein-sequence-ID value BAC33960.1 property type molecule-type value mRNA dbReference id AK083478 type EMBL property type protein-sequence-ID value BAC38930.1 property type molecule-type value mRNA dbReference id AK148276 type EMBL property type protein-sequence-ID value BAE28454.1 property type molecule-type value mRNA dbReference id CH466550 type EMBL property type protein-sequence-ID value EDL04090.1 property type molecule-type value Genomic_DNA dbReference id BC019137 type EMBL property type protein-sequence-ID value AAH19137.1 property type molecule-type value mRNA dbReference id AJ493663 type EMBL property type protein-sequence-ID value CAD38518.1 property type status value ALT_FRAME property type molecule-type value mRNA dbReference id CCDS37211.1 type CCDS molecule id P49282-1 dbReference id CCDS49733.1 type CCDS molecule id P49282-2 dbReference id A56852 type PIR property type entry-name value A56852 dbReference id NP_001139633.1 type RefSeq molecule id P49282-2 property type nucleotide-sequence-ID value NM_001146161.1 dbReference id NP_032758.2 type RefSeq molecule id P49282-1 property type nucleotide-sequence-ID value NM_008732.2 dbReference id XP_006520640.1 type RefSeq molecule id P49282-1 property type nucleotide-sequence-ID value XM_006520577.3 dbReference id XP_006520641.1 type RefSeq molecule id P49282-1 property type nucleotide-sequence-ID value XM_006520578.3 dbReference id XP_011243789.1 type RefSeq molecule id P49282-4 property type nucleotide-sequence-ID value XM_011245487.2 dbReference id P49282 type AlphaFoldDB dbReference id P49282 type SMR dbReference id 10090.ENSMUSP00000023774 type STRING dbReference id P49282 type GlyCosmos property type glycosylation value 2-sites,-No-reported-glycans dbReference id P49282 type GlyGen property type glycosylation value 2-sites dbReference id P49282 type iPTMnet dbReference id P49282 type PhosphoSitePlus dbReference id P49282 type SwissPalm dbReference id P49282 type EPD dbReference id P49282 type jPOST dbReference id P49282 type MaxQB dbReference id P49282 type PaxDb dbReference id P49282 type PeptideAtlas dbReference id 253101 type ProteomicsDB molecule id P49282-1 dbReference id 253102 type ProteomicsDB molecule id P49282-2 dbReference id 253103 type ProteomicsDB molecule id P49282-3 dbReference id 253104 type ProteomicsDB molecule id P49282-4 dbReference id 26282 type Antibodypedia property type antibodies value 380-antibodies-from-31-providers dbReference id 18174 type DNASU dbReference id ENSMUST00000023774.12 type Ensembl property type protein-sequence-ID value ENSMUSP00000023774.6 property type gene-ID value ENSMUSG00000023030.17 dbReference id ENSMUST00000138843.8 type Ensembl molecule id P49282-2 property type protein-sequence-ID value ENSMUSP00000116463.2 property type gene-ID value ENSMUSG00000023030.17 dbReference id 18174 type GeneID dbReference id mmu:18174 type KEGG dbReference id uc007xrc.2 type UCSC molecule id P49282-1 property type organism-name value mouse dbReference id uc007xrd.2 type UCSC molecule id P49282-2 property type organism-name value mouse dbReference id MGI:1345279 type AGR dbReference id 4891 type CTD dbReference id MGI:1345279 type MGI property type gene-designation value Slc11a2 dbReference id HostDB:ENSMUSG00000023030 type VEuPathDB dbReference id KOG1291 type eggNOG property type taxonomic-scope value Eukaryota dbReference id ENSGT00940000155330 type GeneTree dbReference id CLU_020088_5_2_1 type HOGENOM dbReference id P49282 type InParanoid dbReference id IATFVNS type OMA dbReference id 1093299at2759 type OrthoDB dbReference id P49282 type PhylomeDB dbReference id TF315185 type TreeFam dbReference id R-MMU-425410 type Reactome property type pathway-name value Metal-ion-SLC-transporters dbReference id R-MMU-917937 type Reactome property type pathway-name value Iron-uptake-and-transport dbReference id 18174 type BioGRID-ORCS property type hits value 1-hit-in-77-CRISPR-screens dbReference id 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property type match-status value 1 dbReference id IPR001046 type InterPro property type entry-name value NRAMP_fam dbReference id PTHR11706:SF40 type PANTHER property type entry-name value NATURAL-RESISTANCE-ASSOCIATED-MACROPHAGE-PROTEIN-2 property type match-status value 1 dbReference id PTHR11706 type PANTHER property type entry-name value SOLUTE-CARRIER-PROTEIN-FAMILY-11-MEMBER property type match-status value 1 dbReference id PF01566 type Pfam property type entry-name value Nramp property type match-status value 1 dbReference id PR00447 type PRINTS property type entry-name value NATRESASSCMP dbReference id TIGR01197 type TIGRFAMs property type entry-name value nramp property type match-status value 1 proteinExistence type evidence-at-protein-level keyword id KW-0025 Alternative-splicing keyword id KW-1003 Cell-membrane keyword id KW-0225 Disease-variant keyword id KW-0967 Endosome keyword id KW-0325 Glycoprotein keyword id KW-0333 Golgi-apparatus keyword id KW-0406 Ion-transport keyword id KW-0408 Iron keyword id KW-0410 Iron-transport keyword id KW-0458 Lysosome keyword id KW-0472 Membrane keyword id KW-0496 Mitochondrion keyword id KW-1000 Mitochondrion-outer-membrane keyword id KW-0597 Phosphoprotein keyword id KW-1185 Reference-proteome keyword id KW-0769 Symport keyword id KW-0812 Transmembrane keyword id KW-1133 Transmembrane-helix keyword id KW-0813 Transport keyword id KW-0832 Ubl-conjugation feature description Natural-resistance-associated-macrophage-protein-2 id PRO_0000212595 type chain location begin position 1 end position 568 feature description Cytoplasmic evidence 3 type topological-domain location begin position 1 end position 69 feature description Helical evidence 3 type transmembrane-region location begin position 70 end position 90 feature description Extracellular evidence 3 type topological-domain location begin position 91 end position 95 feature description Helical evidence 3 type transmembrane-region location begin position 96 end position 117 feature description Cytoplasmic evidence 3 type topological-domain location begin position 118 end position 154 feature description Helical evidence 3 type transmembrane-region location begin position 155 end position 175 feature description Extracellular evidence 3 type topological-domain location begin position 176 end position 179 feature description Helical evidence 3 type transmembrane-region location begin position 180 end position 194 feature description Cytoplasmic evidence 3 type topological-domain location begin position 195 end position 208 feature description Helical evidence 3 type transmembrane-region location begin position 209 end position 229 feature description Extracellular evidence 3 type topological-domain location begin position 230 end position 255 feature description Helical evidence 3 type transmembrane-region location begin position 256 end position 276 feature description Cytoplasmic evidence 3 type topological-domain location begin position 277 end position 301 feature description Helical evidence 3 type transmembrane-region location begin position 302 end position 322 feature description Extracellular evidence 3 type topological-domain location begin position 323 end position 360 feature description Helical evidence 3 type transmembrane-region location begin position 361 end position 381 feature description Cytoplasmic evidence 3 type topological-domain location begin position 382 end position 408 feature description Helical evidence 3 type transmembrane-region location begin position 409 end position 429 feature description Extracellular evidence 3 type topological-domain location begin position 430 end position 440 feature description Helical evidence 3 type transmembrane-region location begin position 441 end position 461 feature description Cytoplasmic evidence 3 type topological-domain location begin position 462 end position 482 feature description Helical evidence 3 type transmembrane-region location begin position 483 end position 503 feature description Extracellular evidence 3 type topological-domain location begin position 504 end position 506 feature description Helical evidence 3 type transmembrane-region location begin position 507 end position 527 feature description Cytoplasmic evidence 3 type topological-domain location begin position 528 end position 568 feature description Disordered evidence 4 type region-of-interest location begin position 1 end position 45 feature description Required-for-early-endosome-targeting evidence 2 type region-of-interest location begin position 555 end position 559 feature description Basic-and-acidic-residues evidence 4 type compositionally-biased-region location begin position 1 end position 15 feature description Polar-residues evidence 4 type compositionally-biased-region location begin position 26 end position 45 feature description Phosphoserine evidence 16-17 type modified-residue location position position 564 feature description Phosphoserine evidence 16-17 type modified-residue location position position 567 feature description N-linked-(GlcNAc...)-asparagine evidence 3 type glycosylation-site location position position 336 feature description N-linked-(GlcNAc...)-asparagine evidence 3 type glycosylation-site location position position 349 feature description In-isoform-3-and-isoform-4. evidence 14 id VSP_038145 type splice-variant original M variation MGKKQPRAAAAAPNCELKSYSKSTDPQVSTM location position position 1 feature description In-isoform-1-and-isoform-3. evidence 12-13 id VSP_003596 type splice-variant original YRLGLTAQPELYLLNTVDADSVVSR variation VSISKVLLSEDTSGGNIK location begin position 544 end position 568 feature description In-microcytic-anemia. evidence 11 type sequence-variant original G variation R location position position 185 feature description In-Ref.-3;-BAE28454-and-6;-CAD38518. evidence 14 ref 3-6 type sequence-conflict original K variation E location position position 6 feature description In-Ref.-2;-AAC24496. evidence 14 ref 2 type sequence-conflict original R variation S location position position 68 feature description In-Ref.-6;-CAD38518. evidence 14 ref 6 type sequence-conflict location begin position 69 end position 70 feature description In-Ref.-3;-BAC38930. evidence 14 ref 3 type sequence-conflict original P variation R location position position 142 feature description In-Ref.-1;-AAC42051. evidence 14 ref 1 type sequence-conflict original L variation V location position position 182 feature description Phosphoserine evidence 17 type modified-residue location sequence P49282-2 position position 556 feature description Phosphoserine evidence 17 type modified-residue location sequence P49282-3 position position 586 evidence key 1 type ECO:0000250 source dbReference id O54902 type UniProtKB evidence key 2 type ECO:0000250 source dbReference id P49281 type UniProtKB evidence key 3 type ECO:0000255 evidence key 4 type ECO:0000256 source dbReference id MobiDB-lite type SAM evidence key 5 type ECO:0000269 source dbReference id 10361139 type PubMed evidence key 6 type ECO:0000269 source dbReference id 11739192 type PubMed evidence key 7 type ECO:0000269 source dbReference id 15849611 type PubMed evidence key 8 type ECO:0000269 source dbReference id 16475818 type PubMed evidence key 9 type ECO:0000269 source dbReference id 18776082 type PubMed evidence key 10 type ECO:0000269 source dbReference id 27462458 type PubMed evidence key 11 type ECO:0000269 source dbReference id 9241278 type PubMed evidence key 12 type ECO:0000303 source dbReference id 16141072 type PubMed evidence key 13 type ECO:0000303 source ref 2 evidence key 14 type ECO:0000305 evidence key 15 type ECO:0000305 source dbReference id 16475818 type PubMed evidence key 16 type ECO:0007744 source ref 4319 evidence key 17 type ECO:0007744 source ref 3079 sequence checksum 603AAF697AAD3C74 length 568 mass 62368 modified 2009-09-22 version 2 MVLDPKEKMPDDGASGDHGDSASLGAINPAYSNSSLPHSTGDSEEPFTTYFDEKIPIPEEEYSCFSFRKLWAFTGPGFLMSIAYLDPGNIESDLQSGAVAGFKLLWVLLLATIVGLLLQRLAARLGVVTGLHLAEVCHRQYPKVPRIILWLMVELAIIGSDMQEVIGSAIAINLLSAGRVPLWGGVLITIADTFVFLFLDKYGLRKLEAFFGFLITIMALTFGYEYITVKPSQSQVLRGMFVPSCPGCRTPQVEQAVGIVGAVIMPHNMYLHSALVKSRQVNRANKQEVREANKYFFIESCIALFVSFIINVFVVSVFAEAFFEKTNKQVVEVCKNNSSPHADLFPSDNSTLAVDIYKGGVVLGCYFGPAALYIWAVGILAAGQSSTMTGTYSGQFVMEGFLNLKWSRFARVILTRSIAIIPTLLVAVFQDVEHLTGMNDFLNVLQSLQLPFALIPILTFTSLRPVMSEFSNGIGWRIAGGILVLIVCSINMYFVVVYVQELGHVALYVVAAVVSVAYLTFVFYLGWQCLIALGLSFLDCGRSYRLGLTAQPELYLLNTVDADSVVSR 
entry created 1990-01-01 dataset Swiss-Prot modified 2023-02-22 version 225 accession P14211 accession Q3TVD2 name CALR_MOUSE protein recommendedName fullName Calreticulin alternativeName fullName CRP55 alternativeName fullName Calregulin alternativeName fullName Endoplasmic-reticulum-resident-protein-60 shortName ERp60 alternativeName fullName HACBP gene name type primary Calr organism name type scientific Mus-musculus name type common Mouse dbReference id 10090 type NCBI-Taxonomy lineage taxon Eukaryota taxon Metazoa taxon Chordata taxon Craniata taxon Vertebrata taxon Euteleostomi taxon Mammalia taxon Eutheria taxon Euarchontoglires taxon Glires taxon Rodentia taxon Myomorpha taxon Muroidea taxon Muridae taxon Murinae taxon Mus taxon Mus reference key 1 citation date 1989 first 3581 last 3586 name EMBO-J. type journal-article volume 8 title Multiple-zones-in-the-sequence-of-calreticulin-(CRP55,-calregulin,-HACBP),-a-major-calcium-binding-ER/SR-protein. authorList person name Smith-M.J. person name Koch-G.L.E. dbReference id 2583110 type PubMed dbReference id 10.1002/j.1460-2075.1989.tb08530.x type DOI scope NUCLEOTIDE-SEQUENCE-[MRNA] scope PROTEIN-SEQUENCE-OF-18-48-AND-129-161 source strain BALB/cJ tissue Liver reference key 2 citation date 1992 first 217 last 225 name Gene type journal-article volume 120 title Determination-of-the-sequence-of-an-expressible-cDNA-clone-encoding-ERp60/calregulin-by-the-use-of-a-novel-nested-set-method. authorList person name Mazzarella-R.A. person name Gold-P. person name Cunningham-M. person name Green-M. dbReference id 1398135 type PubMed dbReference id 10.1016/0378-1119(92)90096-8 type DOI scope NUCLEOTIDE-SEQUENCE-[MRNA] reference key 3 citation date 2005 first 1559 last 1563 name Science type journal-article volume 309 title The-transcriptional-landscape-of-the-mammalian-genome. authorList person name Carninci-P. person name Kasukawa-T. person name Katayama-S. person name Gough-J. person name Frith-M.C. person name 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person name Furuno-M. person name Futaki-S. person name Gariboldi-M. person name Georgii-Hemming-P. person name Gingeras-T.R. person name Gojobori-T. person name Green-R.E. person name Gustincich-S. person name Harbers-M. person name Hayashi-Y. person name Hensch-T.K. person name Hirokawa-N. person name Hill-D. person name Huminiecki-L. person name Iacono-M. person name Ikeo-K. person name Iwama-A. person name Ishikawa-T. person name Jakt-M. person name Kanapin-A. person name Katoh-M. person name Kawasawa-Y. person name Kelso-J. person name Kitamura-H. person name Kitano-H. person name Kollias-G. person name Krishnan-S.P. person name Kruger-A. person name Kummerfeld-S.K. person name Kurochkin-I.V. person name Lareau-L.F. person name Lazarevic-D. person name Lipovich-L. person name Liu-J. person name Liuni-S. person name McWilliam-S. person name Madan-Babu-M. person name Madera-M. person name Marchionni-L. person name Matsuda-H. person name Matsuzawa-S. person name Miki-H. person name Mignone-F. person name Miyake-S. person name Morris-K. person name Mottagui-Tabar-S. person name Mulder-N. person name Nakano-N. person name Nakauchi-H. person name Ng-P. person name Nilsson-R. person name Nishiguchi-S. person name Nishikawa-S. person name Nori-F. person name Ohara-O. person name Okazaki-Y. person name Orlando-V. person name Pang-K.C. person name Pavan-W.J. person name Pavesi-G. person name Pesole-G. person name Petrovsky-N. person name Piazza-S. person name Reed-J. person name Reid-J.F. person name Ring-B.Z. person name Ringwald-M. person name Rost-B. person name Ruan-Y. person name Salzberg-S.L. person name Sandelin-A. person name Schneider-C. person name Schoenbach-C. person name Sekiguchi-K. person name Semple-C.A. person name Seno-S. person name Sessa-L. person name Sheng-Y. person name Shibata-Y. person name Shimada-H. person name Shimada-K. person name Silva-D. person name Sinclair-B. person name Sperling-S. person name Stupka-E. person name Sugiura-K. person name Sultana-R. person name Takenaka-Y. person name Taki-K. person name Tammoja-K. person name Tan-S.L. person name Tang-S. person name Taylor-M.S. person name Tegner-J. person name Teichmann-S.A. person name Ueda-H.R. person name van-Nimwegen-E. person name Verardo-R. person name Wei-C.L. person name Yagi-K. person name Yamanishi-H. person name Zabarovsky-E. person name Zhu-S. person name Zimmer-A. person name Hide-W. person name Bult-C. person name Grimmond-S.M. person name Teasdale-R.D. person name Liu-E.T. person name Brusic-V. person name Quackenbush-J. person name Wahlestedt-C. person name Mattick-J.S. person name Hume-D.A. person name Kai-C. person name Sasaki-D. person name Tomaru-Y. person name Fukuda-S. person name Kanamori-Katayama-M. person name Suzuki-M. person name Aoki-J. person name Arakawa-T. person name Iida-J. person name Imamura-K. person name Itoh-M. person name Kato-T. person name Kawaji-H. person name Kawagashira-N. person name Kawashima-T. person name Kojima-M. 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person name Lombard-D.B. person name Zhao-Y. dbReference id 23806337 type PubMed dbReference id 10.1016/j.molcel.2013.06.001 type DOI scope ACETYLATION-[LARGE-SCALE-ANALYSIS]-AT-LYS-209 scope IDENTIFICATION-BY-MASS-SPECTROMETRY-[LARGE-SCALE-ANALYSIS] source tissue Embryonic-fibroblast reference evidence 16-17-18 key 13 citation date 2010 first 38612 last 38620 name J.-Biol.-Chem. type journal-article volume 285 title Structural-basis-of-carbohydrate-recognition-by-calreticulin. authorList person name Kozlov-G. person name Pocanschi-C.L. person name Rosenauer-A. person name Bastos-Aristizabal-S. person name Gorelik-A. person name Williams-D.B. person name Gehring-K. dbReference id 20880849 type PubMed dbReference id 10.1074/jbc.m110.168294 type DOI scope X-RAY-CRYSTALLOGRAPHY-(1.95-ANGSTROMS)-OF-18-368-IN-COMPLEXES-WITH-CALCIUM-AND-THE-TETRASACCHARIDE-ALPHA-GLC-(1->3)-ALPHA-MAN-(1->2)-ALPHA-MAN-(1->2)-MAN scope FUNCTION scope IDENTIFICATION-BY-MASS-SPECTROMETRY scope DISULFIDE-BOND reference evidence 19 key 14 citation date 2011 first 27266 last 27277 name J.-Biol.-Chem. type journal-article volume 286 title Structural-and-functional-relationships-between-the-lectin-and-arm-domains-of-calreticulin. authorList person name Pocanschi-C.L. person name Kozlov-G. person name Brockmeier-U. person name Brockmeier-A. person name Williams-D.B. person name Gehring-K. dbReference id 21652723 type PubMed dbReference id 10.1074/jbc.m111.258467 type DOI scope X-RAY-CRYSTALLOGRAPHY-(2.57-ANGSTROMS)-OF-18-368-IN-COMPLEX-WITH-CALCIUM-IONS scope FUNCTION scope DISULFIDE-BOND comment type function text evidence 3-4-5-9-10 Calcium-binding-chaperone-that-promotes-folding,-oligomeric-assembly-and-quality-control-in-the-endoplasmic-reticulum-(ER)-via-the-calreticulin/calnexin-cycle.-This-lectin-interacts-transiently-with-almost-all-of-the-monoglucosylated-glycoproteins-that-are-synthesized-in-the-ER-(PubMed:20880849,-PubMed:21652723).-Interacts-with-the-DNA-binding-domain-of-NR3C1-and-mediates-its-nuclear-export-(By-similarity).-Involved-in-maternal-gene-expression-regulation.-May-participate-in-oocyte-maturation-via-the-regulation-of-calcium-homeostasis-(By-similarity).-Present-in-the-cortical-granules-of-non-activated-oocytes,-is-exocytosed-during-the-cortical-reaction-in-response-to-oocyte-activation-and-might-participate-in-the-block-to-polyspermy-(By-similarity). comment type subunit text evidence 2-3-7-8-11 Monomer.-Interacts-with-GABARAP,-NR3C1,-PDIA3/ERp57-and-TRIM21.-Interacts-(via-P-domain)-with-PDIA5-(By-similarity).-Interacts-with-PPIB-(PubMed:20801878).-Interacts-with-SPACA9-(PubMed:24256100).-Component-of-an-EIF2-complex-at-least-composed-of-CELF1/CUGBP1,-CALR,-CALR3,-EIF2S1,-EIF2S2,-HSP90B1-and-HSPA5-(PubMed:16931514).-Interacts-with-CLCC1-(By-similarity). comment type interaction interactant intactId EBI-644340 id P14211 interactant intactId EBI-78814 id P12023 label App organismsDiffer false experiments 4 comment type interaction interactant intactId EBI-644340 id P14211 interactant intactId EBI-998934 id P57716 label Ncstn organismsDiffer false experiments 2 comment type interaction interactant intactId EBI-644340 id P14211 interactant intactId EBI-990067 id P49769 label Psen1 organismsDiffer false experiments 3 comment type subcellular-location subcellularLocation location evidence 14 Endoplasmic-reticulum-lumen subcellularLocation location evidence 3 Cytoplasm location evidence 3 Cytosol subcellularLocation location evidence 14 Cytolytic-granule subcellularLocation location evidence 3 Secreted location evidence 3 Extracellular-space location evidence 3 Extracellular-matrix subcellularLocation location evidence 3 Cell-surface subcellularLocation location evidence 4 Sarcoplasmic-reticulum-lumen subcellularLocation location Cytoplasmic-vesicle location Secretory-vesicle location Cortical-granule text evidence 3-4-5 Also-found-in-cell-surface-(T-cells),-cytosol-and-extracellular-matrix.-During-oocyte-maturation-and-after-parthenogenetic-activation-accumulates-in-cortical-granules.-In-pronuclear-and-early-cleaved-embryos-localizes-weakly-to-cytoplasm-around-nucleus-and-more-strongly-in-the-region-near-the-cortex-(By-similarity).-In-cortical-granules-of-non-activated-oocytes,-is-exocytosed-during-the-cortical-reaction-in-response-to-oocyte-activation-(By-similarity). comment type domain text evidence 1 Can-be-divided-into-a-N-terminal-globular-domain,-a-proline-rich-P-domain-forming-an-elongated-arm-like-structure-and-a-C-terminal-acidic-domain.-The-P-domain-binds-one-molecule-of-calcium-with-high-affinity,-whereas-the-acidic-C-domain-binds-multiple-calcium-ions-with-low-affinity-(By-similarity). comment type domain text evidence 1 The-interaction-with-glycans-occurs-through-a-binding-site-in-the-globular-lectin-domain. comment type domain text evidence 1 The-zinc-binding-sites-are-localized-to-the-N-domain. comment type domain text evidence 1 Associates-with-PDIA3-through-the-tip-of-the-extended-arm-formed-by-the-P-domain. comment type similarity text evidence 15 Belongs-to-the-calreticulin-family. dbReference id X14926 type EMBL property type protein-sequence-ID value CAA33053.1 property type molecule-type value mRNA dbReference id M92988 type EMBL property type protein-sequence-ID value AAA37569.1 property type molecule-type value mRNA dbReference id AK075605 type EMBL property type protein-sequence-ID value BAC35852.1 property type molecule-type value mRNA dbReference id AK160197 type EMBL property type protein-sequence-ID value BAE35687.1 property type molecule-type value mRNA dbReference id BC003453 type EMBL property type protein-sequence-ID value AAH03453.1 property type molecule-type value mRNA dbReference id CCDS22479.1 type CCDS dbReference id S06763 type PIR property type entry-name value S06763 dbReference id NP_031617.1 type RefSeq property type nucleotide-sequence-ID value NM_007591.3 dbReference id 3O0V type PDB property type method value X-ray property type resolution value 2.30-A property type chains value A=18-206,-A=301-368 dbReference id 3O0W type PDB property type method value X-ray property type resolution value 1.95-A property type chains value A=18-206,-A=301-368 dbReference id 3O0X type PDB property type method value X-ray property type resolution value 2.01-A property type chains value A/B=18-206,-A/B=301-368 dbReference id 3RG0 type 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type PhosphoSitePlus dbReference id P14211 type SwissPalm dbReference id P14211 type COMPLUYEAST-2DPAGE dbReference id IPI00123639 type REPRODUCTION-2DPAGE dbReference id P14211 type REPRODUCTION-2DPAGE dbReference id P14211 type SWISS-2DPAGE dbReference id non-CPTAC-3966 type CPTAC dbReference id P14211 type EPD dbReference id P14211 type jPOST dbReference id P14211 type MaxQB dbReference id P14211 type PaxDb dbReference id P14211 type PeptideAtlas dbReference id 265512 type ProteomicsDB dbReference id P14211 type TopDownProteomics dbReference id 1028 type Antibodypedia property type antibodies value 1170-antibodies-from-47-providers dbReference id 12317 type DNASU dbReference id ENSMUST00000003912.7 type Ensembl property type protein-sequence-ID value ENSMUSP00000003912.7 property type gene-ID value ENSMUSG00000003814.9 dbReference id 12317 type GeneID dbReference id mmu:12317 type KEGG dbReference id uc009mnp.1 type UCSC property type organism-name value mouse dbReference id 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dbReference id 2.10.250.10 type Gene3D property type entry-name value Calreticulin/calnexin,-P-domain property type match-status value 1 dbReference id IPR001580 type InterPro property type entry-name value Calret/calnex dbReference id IPR018124 type InterPro property type entry-name value Calret/calnex_CS dbReference id IPR009169 type InterPro property type entry-name value Calreticulin dbReference id IPR009033 type InterPro property type entry-name value Calreticulin/calnexin_P_dom_sf dbReference id IPR013320 type InterPro property type entry-name value ConA-like_dom_sf dbReference id PTHR11073:SF16 type PANTHER property type entry-name value CALRETICULIN property type match-status value 1 dbReference id PTHR11073 type PANTHER property type entry-name value CALRETICULIN-AND-CALNEXIN property type match-status value 1 dbReference id PF00262 type Pfam property type entry-name value Calreticulin property type match-status value 2 dbReference id PIRSF002356 type PIRSF property type entry-name value Calreticulin property type match-status value 1 dbReference id PR00626 type PRINTS property type entry-name value CALRETICULIN dbReference id SSF49899 type SUPFAM property type entry-name value Concanavalin-A-like-lectins/glucanases property type match-status value 1 dbReference id SSF63887 type SUPFAM property type entry-name value P-domain-of-calnexin/calreticulin property type match-status value 1 dbReference id PS00803 type PROSITE property type entry-name value CALRETICULIN_1 property type match-status value 1 dbReference id PS00804 type PROSITE property type entry-name value CALRETICULIN_2 property type match-status value 1 dbReference id PS00805 type PROSITE property type entry-name value CALRETICULIN_REPEAT property type match-status value 3 dbReference id PS00014 type PROSITE property type entry-name value ER_TARGET property type match-status value 1 proteinExistence type evidence-at-protein-level keyword id KW-0002 3D-structure keyword id KW-0007 Acetylation keyword id KW-0106 Calcium keyword id KW-0143 Chaperone keyword id KW-0963 Cytoplasm keyword id KW-0968 Cytoplasmic-vesicle keyword id KW-0903 Direct-protein-sequencing keyword id KW-1015 Disulfide-bond keyword id KW-0256 Endoplasmic-reticulum keyword id KW-0272 Extracellular-matrix keyword id KW-0379 Hydroxylation keyword id KW-0430 Lectin keyword id KW-0458 Lysosome keyword id KW-0479 Metal-binding keyword id KW-1185 Reference-proteome keyword id KW-0677 Repeat keyword id KW-0703 Sarcoplasmic-reticulum keyword id KW-0964 Secreted keyword id KW-0732 Signal keyword id KW-0862 Zinc feature evidence 12-13 type signal-peptide location begin position 1 end position 17 feature description Calreticulin id PRO_0000004174 type chain location begin position 18 end position 416 feature description 1-1 type repeat location begin position 191 end position 202 feature description 1-2 type repeat location begin position 210 end position 221 feature description 1-3 type repeat location begin position 227 end position 238 feature description 1-4 type repeat location begin position 244 end position 255 feature description 2-1 type repeat location begin position 259 end position 269 feature description 2-2 type repeat location begin position 273 end position 283 feature description 2-3 type repeat location begin position 287 end position 297 feature description N-domain type region-of-interest location begin position 18 end position 197 feature description 4-X-approximate-repeats type region-of-interest location begin position 191 end position 255 feature description Disordered evidence 6 type region-of-interest location begin position 193 end position 278 feature description P-domain type region-of-interest location begin position 198 end position 308 feature description Interaction-with-PPIB evidence 8 type region-of-interest location begin position 237 end position 270 feature description 3-X-approximate-repeats type region-of-interest location begin position 259 end position 297 feature description C-domain type region-of-interest location begin position 309 end position 416 feature description Disordered evidence 6 type region-of-interest location begin position 350 end position 416 feature description Prevents-secretion-from-ER type short-sequence-motif location begin position 413 end position 416 feature description Basic-and-acidic-residues evidence 6 type compositionally-biased-region location begin position 199 end position 254 feature description Basic-and-acidic-residues evidence 6 type compositionally-biased-region location begin position 352 end position 381 feature description Acidic-residues evidence 6 type compositionally-biased-region location begin position 382 end position 416 feature evidence 9 type binding-site location position position 26 ligand name Ca(2+) dbReference id CHEBI:29108 type ChEBI feature evidence 9 type binding-site location position position 62 ligand name Ca(2+) dbReference id CHEBI:29108 type ChEBI feature evidence 9 type binding-site location position position 64 ligand name Ca(2+) dbReference id CHEBI:29108 type ChEBI feature evidence 9-17 type binding-site location position position 109 ligand name an-alpha-D-glucoside dbReference id CHEBI:22390 type ChEBI feature evidence 9-17 type binding-site location position position 111 ligand name an-alpha-D-glucoside dbReference id CHEBI:22390 type ChEBI feature evidence 9-17 type binding-site location position position 128 ligand name an-alpha-D-glucoside dbReference id CHEBI:22390 type ChEBI feature evidence 9-17 type binding-site location position position 135 ligand name an-alpha-D-glucoside dbReference id CHEBI:22390 type ChEBI feature evidence 9-17 type binding-site location position position 317 ligand name an-alpha-D-glucoside dbReference id CHEBI:22390 type ChEBI feature evidence 9 type binding-site location position position 328 ligand name Ca(2+) dbReference id CHEBI:29108 type ChEBI feature description N6-acetyllysine evidence 3 type modified-residue location position position 48 feature description N6-(2-hydroxyisobutyryl)lysine evidence 3 type modified-residue location position position 64 feature description N6-acetyllysine evidence 3 type modified-residue location position position 159 feature description N6-acetyllysine evidence 20 type modified-residue location position position 209 feature evidence 9-10 type disulfide-bond location begin position 105 end position 137 feature description In-Ref.-3;-BAE35687. evidence 15 ref 3 type sequence-conflict original K variation R location position position 272 feature description In-Ref.-3;-BAE35687. evidence 15 ref 3 type sequence-conflict original E variation Q location position position 407 feature evidence 22 type strand location begin position 21 end position 25 feature evidence 22 type helix location begin position 30 end position 35 feature evidence 21 type strand location begin position 37 end position 39 feature evidence 22 type strand location begin position 42 end position 44 feature evidence 22 type strand location begin position 49 end position 52 feature evidence 22 type turn location begin position 60 end position 63 feature evidence 22 type strand location begin position 65 end position 68 feature evidence 22 type strand location begin position 70 end position 84 feature evidence 22 type strand location begin position 91 end position 98 feature evidence 22 type strand location begin position 104 end position 107 feature evidence 22 type strand location begin position 110 end position 113 feature evidence 22 type helix location begin position 119 end position 121 feature evidence 22 type strand location begin position 129 end position 137 feature evidence 22 type turn location begin position 138 end position 140 feature evidence 22 type strand location begin position 141 end position 150 feature evidence 22 type strand location begin position 153 end position 156 feature evidence 22 type strand location begin position 166 end position 176 feature evidence 22 type strand location begin position 180 end position 186 feature evidence 22 type strand location begin position 189 end position 195 feature evidence 22 type helix location begin position 196 end position 199 feature evidence 23 type strand location begin position 206 end position 209 feature evidence 23 type strand location begin position 293 end position 295 feature evidence 22 type turn location begin position 303 end position 306 feature evidence 22 type strand location begin position 311 end position 322 feature evidence 22 type strand location begin position 326 end position 334 feature evidence 22 type helix location begin position 336 end position 345 feature evidence 22 type helix location begin position 347 end position 360 evidence key 1 type ECO:0000250 evidence key 2 type ECO:0000250 source dbReference id P18418 type UniProtKB evidence key 3 type ECO:0000250 source dbReference id P27797 type UniProtKB evidence key 4 type ECO:0000250 source dbReference id P28491 type UniProtKB evidence key 5 type ECO:0000250 source dbReference id Q8K3H7 type UniProtKB evidence key 6 type ECO:0000256 source dbReference id MobiDB-lite type SAM evidence key 7 type ECO:0000269 source dbReference id 16931514 type PubMed evidence key 8 type ECO:0000269 source dbReference id 20801878 type PubMed evidence key 9 type ECO:0000269 source dbReference id 20880849 type PubMed evidence key 10 type ECO:0000269 source dbReference id 21652723 type PubMed evidence key 11 type ECO:0000269 source dbReference id 24256100 type PubMed evidence key 12 type ECO:0000269 source dbReference id 2583110 type PubMed evidence key 13 type ECO:0000269 source dbReference id 7523108 type PubMed evidence key 14 type ECO:0000269 source dbReference id 8418194 type PubMed evidence key 15 type ECO:0000305 evidence key 16 type ECO:0007744 source dbReference id 3O0V type PDB evidence key 17 type ECO:0007744 source dbReference id 3O0W type PDB evidence key 18 type ECO:0007744 source dbReference id 3O0X type PDB evidence key 19 type ECO:0007744 source dbReference id 3RG0 type PDB evidence key 20 type ECO:0007744 source ref 6337 evidence key 21 type ECO:0007829 source dbReference id 3O0V type PDB evidence key 22 type ECO:0007829 source dbReference id 3O0W type PDB evidence key 23 type ECO:0007829 source dbReference id 3RG0 type PDB sequence checksum 24C03B00913408D8 length 416 mass 47995 modified 1990-01-01 precursor true version 1 MLLSVPLLLGLLGLAAADPAIYFKEQFLDGDAWTNRWVESKHKSDFGKFVLSSGKFYGDLEKDKGLQTSQDARFYALSAKFEPFSNKGQTLVVQFTVKHEQNIDCGGGYVKLFPSGLDQKDMHGDSEYNIMFGPDICGPGTKKVHVIFNYKGKNVLINKDIRCKDDEFTHLYTLIVRPDNTYEVKIDNSQVESGSLEDDWDFLPPKKIKDPDAAKPEDWDERAKIDDPTDSKPEDWDKPEHIPDPDAKKPEDWDEEMDGEWEPPVIQNPEYKGEWKPRQIDNPDYKGTWIHPEIDNPEYSPDANIYAYDSFAVLGLDLWQVKSGTIFDNFLITNDEAYAEEFGNETWGVTKAAEKQMKDKQDEEQRLKEEEEDKKRKEEEEAEDKEDDDDRDEDEDEEDEKEEDEEESPGQAKDEL 
