# Exemplary Ordinary Differential Equation (ODE) models

Inflammatory bowel disease (IBD) model targeting IL6R with tocilizumab.

Publication: <br>
*A multiscale model of interleukin-6-mediated immune regulation in Crohn's disease and its application in drug discovery and development.* <br >
Dwivedi G, Fitz L, Hegen M, Martin SW, Harrold J, Heatherington A, Li C.
CPT Pharmacometrics Syst Pharmacol 2014; 3: e89

## Original model

Model [description](https://www.ebi.ac.uk/biomodels/BIOMD0000000537) and [the original version (sbml)](./Dwivedi_Model537_original.xml).

## Model without annotations

Download [here (sbml)](./Dwivedi_Model537_empty.xml).

## Fully annotated model

Download [here (sbml)](./Dwivedi_Model537_annotated.xml).

## IDs of annotations

Download [here (.xlsx)](./model537_mapping.xlsx).
