{% extends "layout_bs4.html" %} {% from "utils.html" import comments_panel, activity_panel, pedigree_panel %} {% from "variants/utils.html" import compounds_table %} {% from "variant/utils.html" import modal_causative, rankscore_panel, overlapping_panel, genes_panel, transcripts_panel, proteins_panel, pin_button, causative_button %} {% from "variant/tx_overview.html" import disease_associated, transcripts_overview %} {% from "variant/gene_disease_relations.html" import omim_phenotypes, inheritance_panel, autozygosity_panel, genemodels_panel %} {% from "variant/variant_details.html" import frequencies, gtcall_panel, old_observations, observations_panel, severity_list, conservations, mappability %} {% from "variant/components.html" import alignments, panel_classify, compounds_panel, matching_variants, external_links, clinsig_table %} {% from "variant/sanger.html" import sanger_button, modal_sanger, modal_cancel_sanger %} {% block title %} {{ super() }} - {{ institute.display_name }} - {{ case.display_name }} - {{ variant.display_name }} {% endblock %} {% block css %} {{ super() }} {% endblock %} {% block top_nav %} {{ super() }} {% endblock %} {% block top_nav_right %} {% if config['MAIL_USERNAME'] %} {# Email setting must be setup #} {% endif %} {{ super() }} {% endblock %} {% block content_main %}
{% if variant.missing_data %}
Showing only first 30 genes!
{% endif %}
{{ matching_variants(managed_variant, causatives) }}
{{ panel_classify(variant, institute, case, ACMG_OPTIONS, manual_rank_options, cancer_tier_options, dismiss_variant_options, mosaic_variant_options, evaluations) }} {{ comments_panel(institute, case, current_user, variant.comments, variant_id=variant._id) }} {{ omim_phenotypes(variant) }}
{{ panel_summary() }}
{% if variant.disease_associated_transcripts %}
{{ disease_associated(variant) }}
{% endif %}
{{ transcripts_overview(variant) }}
{{ genemodels_panel(variant) }} {{ inheritance_panel(variant) }} {% if variant.azlength %} {{ autozygosity_panel(variant) }} {% endif %} {{ frequencies(variant) }} {% if config['LOQUSDB_SETTINGS'] %} {{ observations_panel(variant, observations, case) }} {% endif %} {{ old_observations(variant) }} {{ severity_list(variant) }} {{ conservations(variant) }} {{ mappability(variant) }}
{% set has_pedigree = case.madeline_info and case.individuals|length > 1 %} {% if has_pedigree %}
{{ pedigree_panel(case) }}
{% endif %}
{{ gtcall_panel(variant) }}
{% if variant.compounds %}
{{ compounds_panel(institute, case, variant) }}
{% endif %}
{{ rankscore_panel(variant) }}
{{ overlapping_panel(variant, overlapping_vars, case, institute) }}
{{ external_links(case, variant) }}
{{ activity_panel(events|reverse) }}
{% if config['MAIL_USERNAME'] %} {# Email setting must be setup #} {{ modal_sanger(institute, case, variant, current_user) }} {% endif %} {% if config['MAIL_USERNAME'] %} {# Email setting must be setup #} {{ modal_cancel_sanger(institute, case, variant, current_user) }} {% endif %}
{{ modal_causative(case, institute, variant) }} {% endblock %} {% macro panel_summary() %}
Summary
Position: {{ variant.chromosome }}:{{ variant.position }} Change: {% if variant.reference|length > 8 %} {{ variant.reference[:1] }}..{{variant.reference[-1:]}} {% else %} {{ variant.reference }} {% endif %} → {%- if variant.alternative|length > 8 -%} {{ variant.alternative[:1] }}..{{variant.alternative[-1:]}} {% else %} {{ variant.alternative }} {% endif %}
Rank {{ variant.variant_rank }} Rank score {{ variant.rank_score }} CADD score {% if variant.cadd_score %} {{ variant.cadd_score|round(1) }} {% else %} - {% endif %} QUAL {% if variant.quality %} {{ variant.quality|int }} {% else %} - {% endif %}
Matches OMIM inhert. {% if variant.is_matching_inheritance %} Yes {% else %}
No
{% endif %}
Frequency
{{ variant.frequency }}
{{ clinsig_table(variant) }} {% if variant.mitomap_associated_diseases %}
MITOMAP associated diseases {{ variant.mitomap_associated_diseases.split('/')|join('
')|safe }}
{% endif %} {% for gene in variant.genes %} {% endfor %}
Gene Region Function
{{ gene.common.hgnc_symbol if gene.common else gene.hgnc_id }} {{ gene.region_annotation }} {{ gene.functional_annotation|truncate(20, True) }}
{{ alignments(institute, case, variant, current_user, case_groups, config, igv_tracks, splice_junctions_tracks) }} {% if variant.custom %} {% for pair in variant.custom %} {% endfor %}
Custom annotation Value
{{ pair[0] }} {{ pair[1] }}
{% endif %}
{% endmacro %} {% macro acmg_form(selected=None) %}
{% for option in ACMG_OPTIONS %} {% endfor %}
{% endmacro %} {% macro acmg_classification_item(data) %} {% set current_variant = (data.variant_specific == variant._id) %}
  • {{ data.classification.label }} {{ data.classification.short }} {% if not current_variant %} {{ data.case.display_name }} {% endif %}
    {{ data.user_name }} on {{ data.created_at.date() }} {% if current_variant %} {% endif %}
  • {% endmacro %} {% block scripts %} {{ super() }} {% endblock %}