PySkein is an extension module for Python 3.0 or higher providing the recently proposed Skein hash algorithms (c.f. Skein website). It is based on the optimized version of the reference implementation written in C by Doug Whiting, allowing efficient hash computations. (On a 2.8 GHz Opteron I get a hashing performance of 373 MB/s for Skein-512-512 as called from Python.)