The model.nullspace subpackage implements the nullspace approach introduced by Wagner (see [1], for an overview and implementation details also [2], [3]).

References

  1. Wagner, C., "Nullspace approach to determine the elementary modes of chemical reaction systems", 2004,
    J.Phys. Chem. B, 108, 2425-2431.
  2. Gagneur, J. and Klamt, S., "Computation of elementary modes: A unifying framework and the new binary approach", 2004,
    BMC Bioinformatics, 5, 175.
  3. Terzer, M. and Stelling, J., "Large scale computation of elementary flux modes with bit pattern trees",
    Bioinformatics, August 1, 2008, doi:10.1093/bioinformatics/btn401