```python
def region_totals(grid: list, queries: list) -> list:
    if not isinstance(grid, list) or not grid:
        raise ValueError("grid must be a non-empty list of rows")
    width = len(grid[0]) if isinstance(grid[0], list) else 0
    if width == 0:
        raise ValueError("rows must be non-empty lists")
    for row in grid:
        if not isinstance(row, list) or len(row) != width:
            raise ValueError("rows must all share one length")
        for cell in row:
            if isinstance(cell, bool) or not isinstance(cell, int):
                raise ValueError("cells must be integers")
    
    # Build a prefix-sum table over the grid
    prefix_sum = [[0] * (width + 1) for _ in range(len(grid) + 1)]
    for i in range(1, len(grid) + 1):
        for j in range(1, width + 1):
            prefix_sum[i][j] = prefix_sum[i - 1][j] + prefix_sum[i][j - 1] - prefix_sum[i - 1][j - 1] + grid[i - 1][j - 1]
    
    # Validate each query and answer it from the table
    return [prefix_sum[q[2]][q[3]] - prefix_sum[q[0]][q[3]] - prefix_sum[q[2]][q[0]] + prefix_sum[q[0]][q[0]] for q in queries if isinstance(q, list) and len(q) == 4]
```