ENTRY       1956              CDS       T01001
SYMBOL      EGFR, ERBB, ERBB1, ERRP, HER1, NISBD2, NNCIS, PIG61, mENA
NAME        (RefSeq) epidermal growth factor receptor isoform a precursor
ORTHOLOGY   K04361  epidermal growth factor receptor [EC:2.7.10.1]
ORGANISM    hsa  Homo sapiens (human)
PATHWAY     hsa01521  EGFR tyrosine kinase inhibitor resistance
            hsa01522  Endocrine resistance
            hsa03272  Virion - Hepatitis viruses
            hsa04010  MAPK signaling pathway
            hsa04012  ErbB signaling pathway
            hsa04014  Ras signaling pathway
            hsa04015  Rap1 signaling pathway
            hsa04020  Calcium signaling pathway
            hsa04066  HIF-1 signaling pathway
            hsa04068  FoxO signaling pathway
            hsa04072  Phospholipase D signaling pathway
            hsa04144  Endocytosis
            hsa04151  PI3K-Akt signaling pathway
            hsa04510  Focal adhesion
            hsa04518  Integrin signaling
            hsa04519  Cadherin signaling
            hsa04520  Adherens junction
            hsa04540  Gap junction
            hsa04630  JAK-STAT signaling pathway
            hsa04810  Regulation of actin cytoskeleton
            hsa04912  GnRH signaling pathway
            hsa04915  Estrogen signaling pathway
            hsa04921  Oxytocin signaling pathway
            hsa04926  Relaxin signaling pathway
            hsa04928  Parathyroid hormone synthesis, secretion and action
            hsa04934  Cushing syndrome
            hsa05120  Epithelial cell signaling in Helicobacter pylori infection
            hsa05131  Shigellosis
            hsa05160  Hepatitis C
            hsa05163  Human cytomegalovirus infection
            hsa05165  Human papillomavirus infection
            hsa05171  Coronavirus disease - COVID-19
            hsa05200  Pathways in cancer
            hsa05205  Proteoglycans in cancer
            hsa05206  MicroRNAs in cancer
            hsa05207  Chemical carcinogenesis - receptor activation
            hsa05208  Chemical carcinogenesis - reactive oxygen species
            hsa05210  Colorectal cancer
            hsa05212  Pancreatic cancer
            hsa05213  Endometrial cancer
            hsa05214  Glioma
            hsa05215  Prostate cancer
            hsa05218  Melanoma
            hsa05219  Bladder cancer
            hsa05223  Non-small cell lung cancer
            hsa05224  Breast cancer
            hsa05225  Hepatocellular carcinoma
            hsa05226  Gastric cancer
            hsa05230  Central carbon metabolism in cancer
            hsa05231  Choline metabolism in cancer
            hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
NETWORK     nt06160  Human T-cell leukemia virus 1 (HTLV-1)
            nt06162  Hepatitis B virus (HBV)
            nt06163  Hepatitis C virus (HCV)
            nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
            nt06165  Epstein-Barr virus (EBV)
            nt06166  Human papillomavirus (HPV)
            nt06167  Human cytomegalovirus (HCMV)
            nt06170  Influenza A virus (IAV)
            nt06180  Pathogenic Escherichia coli
            nt06182  Shigella
            nt06210  ERK signaling (cancer)
            nt06213  Other RAS signaling (cancer)
            nt06214  PI3K signaling (cancer)
            nt06219  JAK-STAT signaling (cancer)
            nt06220  Calcium signaling (cancer)
            nt06260  Colorectal cancer
            nt06261  Gastric cancer
            nt06262  Pancreatic cancer
            nt06263  Hepatocellular carcinoma
            nt06265  Bladder cancer
            nt06266  Non-small cell lung cancer
            nt06268  Melanoma
            nt06270  Breast cancer
            nt06271  Endometrial cancer
            nt06273  Glioma
            nt06274  Thyroid cancer
            nt06276  Chronic myeloid leukemia
            nt06310  CRH-ACTH-cortisol signaling
            nt06360  Cushing syndrome
            nt06526  MAPK signaling
            nt06528  Calcium signaling
            nt06530  PI3K signaling
  ELEMENT   N00001  EGF-EGFR-RAS-ERK signaling pathway
            N00006  Amplified EGFR to RAS-ERK signaling pathway
            N00014  Mutation-activated EGFR to RAS-ERK signaling pathway
            N00021  EGF-ERBB2-RAS-ERK signaling pathway
            N00022  ERBB2-overexpression to RAS-ERK signaling pathway
            N00023  EGF-EGFR-PLCG-ERK signaling pathway
            N00024  Mutation-activated EGFR to PLCG-ERK signaling pathway
            N00026  EGF-EGFR-PLCG-CAMK signaling pathway
            N00027  Amplified EGFR to PLCG-CAMK signaling pathway
            N00030  EGF-EGFR-RAS-PI3K signaling pathway
            N00033  EGF-EGFR-PI3K signaling pathway
            N00034  ERBB2-overexpression to PI3K signaling pathway
            N00035  Amplified EGFR to PI3K signaling pathway
            N00036  Mutation-activated EGFR to PI3K signaling pathway
            N00041  EGFR-overexpression to RAS-ERK signaling pathway
            N00042  EGFR-overexpression to PI3K signaling pathway
            N00094  EGF-Jak-STAT signaling pathway
            N00095  ERBB2-overexpression to EGF-Jak-STAT signaling pathway
            N00096  EGF-EGFR-RAS-RASSF1 signaling pathway
            N00103  EGF-EGFR-RAS-RalGDS signaling pathway
            N00147  EGF-EGFR-PLCG-calcineurin signaling pathway
            N00227  TGFA-EGFR-PLCG-PKC signaling pathway
            N00228  TGFA-overexpression to PLCG-PKC signaling pathway
            N00229  TGFA-EGFR-RAS-ERK signaling pathway
            N00230  TGFA-overexpression to RAS-ERK signaling pathway
            N00231  TGFA-EGFR-PI3K signaling pathway
            N00232  TGFA-overexpression to PI3K signaling pathway
            N00252  Amplified ERBB2 to RAS-ERK signaling pathway
            N00253  Amplified ERBB2 to PI3K signaling pathway
            N00276  EGF-overexpression to RAS-ERK signaling pathway
            N00277  EREG-EGFR-RAS-ERK signaling pathway
            N00278  EREG-overexpression to RAS-ERK signaling pathway
            N00279  AREG-EGFR-RAS-ERK signaling pathway
            N00280  AREG-overexpression to RAS-ERK signaling pathway
            N00281  EGF-overexpression to PI3K signaling pathway
            N00282  EREG-EGFR-PI3K signaling pathway
            N00283  EREG-overexpression to PI3K signaling pathway
            N00284  AREG-EGFR-PI3K signaling pathway
            N00285  AREG-overexpression to PI3K signaling pathway
            N00318  EGFR-ERK-ACTH signaling pathway
            N00319  Mutation-activated USP8 to EGFR-ERK-ACTH signaling pathway
            N00366  HPV E5 to EGFR-PI3K signaling pathway
            N00367  HPV E5 to EGFR-RAS-ERK signaling pathway
            N00390  EGF-EGFR-PI3K-NFKB signaling pathway
            N00391  HCMV gB to EGFR-PI3K-NFKB signaling pathway
            N00392  HCMV gB to EGFR-RAS-ERK signaling pathway
            N00513  Mutation-activated EGFR to RAS-ERK signaling pathway
            N00514  Mutation-activated EGFR to PI3K signaling pathway
            N00542  EGF-EGFR-RAS-JNK signaling pathway
            N01078  EGF-EGFR-Actin signaling pathway
            N01354  BPA to RAS-ERK signaling pathway
            N01355  Arsenic to PI3K signaling pathway
            N01592  GF-RTK-RAS-ERK signaling pathway
            N01599  Regulation of GF-RTK-RAS-ERK signaling, ubiquitination of RTK by CBL
            N01641  RTK-PLCG-ITPR signaling pathway
            N01656  GF-RTK-PI3K signaling pathway
            N01658  GF-RTK-RAS-PI3K signaling pathway
DISEASE     H00014  Non-small cell lung cancer
            H00016  Oral cancer
            H00017  Esophageal cancer
            H00022  Bladder cancer
            H00028  Choriocarcinoma
            H00030  Cervical cancer
            H00031  Breast cancer
            H00042  Glioma
            H00055  Laryngeal cancer
            H01508  Salivary gland cancer
            H01559  Oropharyngeal cancer
            H02467  Neonatal inflammatory skin and bowel disease
DRUG_TARGET Afatinib (DG00717): D09724 D09733<JP/US>
            Amivantamab: D11894<JP/US> D13229<JP/US>
            Aumolertinib (DG03209): D12258 D12259
            Bafisontamab: D12809
            Canertinib dihydrochloride: D03350
            Cetuximab: D03455<JP/US>
            Cetuximab sarotalocan: D11803
            Cetuximab sarotalocan sodium: D11805<JP>
            Dacomitinib (DG01793): D09883 D10514<JP/US>
            Duligotuzumab: D11750
            Erlotinib (DG00711): D04023<JP/US> D07907
            Ficerafusp alfa: D12768
            Firmonertinib (DG03322): D12956 D12957
            Gefitinib: D01977<JP/US>
            Icotinib: D11251
            Imgatuzumab: D10439
            Izalontamab: D13052
            Izalontamab brengitecan: D13053
            Lapatinib (DG00715): D04024<JP/US> D08108
            Lazertinib (DG03205): D11980 D12245<JP/US>
            Lifirafenib (DG03009): D11410 D11411
            Marlotamig: D12709
            Masoprocol: D04862
            Mavelertinib: D11368
            Mifanertinib: D13235
            Mobocertinib (DG03148): D11969 D12001
            Modotuximab: D11125
            Naquotinib (DG03112): D10886 D10958
            Nazartinib (DG03015): D11430 D11434
            Necitumumab: D10018<JP/US>
            Neratinib (DG02303): D08950 D10898<US>
            Olmutinib (DG02916): D10859 D11115
            Osimertinib: D10766<JP/US>
            Pamvatamig: D13156
            Panitumumab: D05350<JP/US>
            Pebezertinib: D12859
            Pelitinib: D05399
            Petosemtamab: D12416
            Poziotinib (DG03196): D12229 D12230
            Rindopepimut: D09660
            Rociletinib: D10858
            Serclutamab: D11872
            Serclutamab talirine: D11874
            Sevabertinib (DG03348): D13098 D13116<US>
            Sunvozertinib: D12506
            Tesevatinib (DG03101): D11772 D11773
            Tigozertinib: D12730
            Tilatamig: D13066
            Tilatamig samrotecan: D13067
            Tuxobertinib: D12457
            Vandetanib: D06407<JP/US>
            Varlitinib (DG01357): D09689 D09690
            Zalutumumab: D10031
            Zipalertinib: D13062
BRITE       KEGG Orthology (KO) [BR:hsa00001]
             09120 Genetic Information Processing
              09125 Information processing in viruses
               03272 Virion - Hepatitis viruses
                1956 (EGFR)
             09130 Environmental Information Processing
              09132 Signal transduction
               04010 MAPK signaling pathway
                1956 (EGFR)
               04012 ErbB signaling pathway
                1956 (EGFR)
               04014 Ras signaling pathway
                1956 (EGFR)
               04015 Rap1 signaling pathway
                1956 (EGFR)
               04630 JAK-STAT signaling pathway
                1956 (EGFR)
               04066 HIF-1 signaling pathway
                1956 (EGFR)
               04068 FoxO signaling pathway
                1956 (EGFR)
               04020 Calcium signaling pathway
                1956 (EGFR)
               04072 Phospholipase D signaling pathway
                1956 (EGFR)
               04151 PI3K-Akt signaling pathway
                1956 (EGFR)
              09133 Signaling molecules and interaction
               04518 Integrin signaling
                1956 (EGFR)
               04519 Cadherin signaling
                1956 (EGFR)
             09140 Cellular Processes
              09141 Transport and catabolism
               04144 Endocytosis
                1956 (EGFR)
              09144 Cellular community - eukaryotes
               04510 Focal adhesion
                1956 (EGFR)
               04520 Adherens junction
                1956 (EGFR)
               04540 Gap junction
                1956 (EGFR)
              09142 Cell motility
               04810 Regulation of actin cytoskeleton
                1956 (EGFR)
             09150 Organismal Systems
              09152 Endocrine system
               04912 GnRH signaling pathway
                1956 (EGFR)
               04915 Estrogen signaling pathway
                1956 (EGFR)
               04921 Oxytocin signaling pathway
                1956 (EGFR)
               04926 Relaxin signaling pathway
                1956 (EGFR)
               04928 Parathyroid hormone synthesis, secretion and action
                1956 (EGFR)
             09160 Human Diseases
              09161 Cancer: overview
               05200 Pathways in cancer
                1956 (EGFR)
               05206 MicroRNAs in cancer
                1956 (EGFR)
               05205 Proteoglycans in cancer
                1956 (EGFR)
               05207 Chemical carcinogenesis - receptor activation
                1956 (EGFR)
               05208 Chemical carcinogenesis - reactive oxygen species
                1956 (EGFR)
               05230 Central carbon metabolism in cancer
                1956 (EGFR)
               05231 Choline metabolism in cancer
                1956 (EGFR)
               05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
                1956 (EGFR)
              09162 Cancer: specific types
               05210 Colorectal cancer
                1956 (EGFR)
               05212 Pancreatic cancer
                1956 (EGFR)
               05225 Hepatocellular carcinoma
                1956 (EGFR)
               05226 Gastric cancer
                1956 (EGFR)
               05214 Glioma
                1956 (EGFR)
               05218 Melanoma
                1956 (EGFR)
               05219 Bladder cancer
                1956 (EGFR)
               05215 Prostate cancer
                1956 (EGFR)
               05213 Endometrial cancer
                1956 (EGFR)
               05224 Breast cancer
                1956 (EGFR)
               05223 Non-small cell lung cancer
                1956 (EGFR)
              09172 Infectious disease: viral
               05160 Hepatitis C
                1956 (EGFR)
               05171 Coronavirus disease - COVID-19
                1956 (EGFR)
               05163 Human cytomegalovirus infection
                1956 (EGFR)
               05165 Human papillomavirus infection
                1956 (EGFR)
              09171 Infectious disease: bacterial
               05120 Epithelial cell signaling in Helicobacter pylori infection
                1956 (EGFR)
               05131 Shigellosis
                1956 (EGFR)
              09167 Endocrine and metabolic disease
               04934 Cushing syndrome
                1956 (EGFR)
              09176 Drug resistance: antineoplastic
               01521 EGFR tyrosine kinase inhibitor resistance
                1956 (EGFR)
               01522 Endocrine resistance
                1956 (EGFR)
             09180 Brite Hierarchies
              09181 Protein families: metabolism
               01001 Protein kinases [BR:hsa01001]
                1956 (EGFR)
              09183 Protein families: signaling and cellular processes
               04147 Exosome [BR:hsa04147]
                1956 (EGFR)
            Enzymes [BR:hsa01000]
             2. Transferases
              2.7  Transferring phosphorus-containing groups
               2.7.10  Protein-tyrosine kinases
                2.7.10.1  receptor protein-tyrosine kinase
                 1956 (EGFR)
            Protein kinases [BR:hsa01001]
             Receptor tyrosine kinases (RTK)
              EGFR family [OT]
               1956 (EGFR)
            Exosome [BR:hsa04147]
             Exosomal proteins
              Exosomal proteins of colorectal cancer cells
               1956 (EGFR)
              Exosomal proteins of pancreatic cancer cells
               1956 (EGFR)
              Exosomal proteins of bladder cancer cells
               1956 (EGFR)
POSITION    7:55019017..55211628
MOTIF       Pfam: PK_Tyr_Ser-Thr Recep_L_domain GF_recep_IV Pkinase Furin-like TM_ErbB1 Kinase-like ABC1 GAPT
DBLINKS     NCBI-GeneID: 1956
            NCBI-ProteinID: NP_005219
            OMIM: 131550
            HGNC: 3236
            Ensembl: ENSP00000275493.2
            UniProt: P00533 Q504U8 F2YGG7
STRUCTURE   PDB
AASEQ       1210
            MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV
            VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA
            VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF
            QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC
            TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV
            VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK
            NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAF
            ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKL
            FGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN
            LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVM
            GENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVV
            ALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGS
            GAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGI
            CLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAA
            RNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSY
            GVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPK
            FRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQ
            QGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTED
            SIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLN
            TVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRV
            APQSSEFIGA
NTSEQ       3633
            atgcgaccctccgggacggccggggcagcgctcctggcgctgctggctgcgctctgcccg
            gcgagtcgggctctggaggaaaagaaagtttgccaaggcacgagtaacaagctcacgcag
            ttgggcacttttgaagatcattttctcagcctccagaggatgttcaataactgtgaggtg
            gtccttgggaatttggaaattacctatgtgcagaggaattatgatctttccttcttaaag
            accatccaggaggtggctggttatgtcctcattgccctcaacacagtggagcgaattcct
            ttggaaaacctgcagatcatcagaggaaatatgtactacgaaaattcctatgccttagca
            gtcttatctaactatgatgcaaataaaaccggactgaaggagctgcccatgagaaattta
            caggaaatcctgcatggcgccgtgcggttcagcaacaaccctgccctgtgcaacgtggag
            agcatccagtggcgggacatagtcagcagtgactttctcagcaacatgtcgatggacttc
            cagaaccacctgggcagctgccaaaagtgtgatccaagctgtcccaatgggagctgctgg
            ggtgcaggagaggagaactgccagaaactgaccaaaatcatctgtgcccagcagtgctcc
            gggcgctgccgtggcaagtcccccagtgactgctgccacaaccagtgtgctgcaggctgc
            acaggcccccgggagagcgactgcctggtctgccgcaaattccgagacgaagccacgtgc
            aaggacacctgccccccactcatgctctacaaccccaccacgtaccagatggatgtgaac
            cccgagggcaaatacagctttggtgccacctgcgtgaagaagtgtccccgtaattatgtg
            gtgacagatcacggctcgtgcgtccgagcctgtggggccgacagctatgagatggaggaa
            gacggcgtccgcaagtgtaagaagtgcgaagggccttgccgcaaagtgtgtaacggaata
            ggtattggtgaatttaaagactcactctccataaatgctacgaatattaaacacttcaaa
            aactgcacctccatcagtggcgatctccacatcctgccggtggcatttaggggtgactcc
            ttcacacatactcctcctctggatccacaggaactggatattctgaaaaccgtaaaggaa
            atcacagggtttttgctgattcaggcttggcctgaaaacaggacggacctccatgccttt
            gagaacctagaaatcatacgcggcaggaccaagcaacatggtcagttttctcttgcagtc
            gtcagcctgaacataacatccttgggattacgctccctcaaggagataagtgatggagat
            gtgataatttcaggaaacaaaaatttgtgctatgcaaatacaataaactggaaaaaactg
            tttgggacctccggtcagaaaaccaaaattataagcaacagaggtgaaaacagctgcaag
            gccacaggccaggtctgccatgccttgtgctcccccgagggctgctggggcccggagccc
            agggactgcgtctcttgccggaatgtcagccgaggcagggaatgcgtggacaagtgcaac
            cttctggagggtgagccaagggagtttgtggagaactctgagtgcatacagtgccaccca
            gagtgcctgcctcaggccatgaacatcacctgcacaggacggggaccagacaactgtatc
            cagtgtgcccactacattgacggcccccactgcgtcaagacctgcccggcaggagtcatg
            ggagaaaacaacaccctggtctggaagtacgcagacgccggccatgtgtgccacctgtgc
            catccaaactgcacctacggatgcactgggccaggtcttgaaggctgtccaacgaatggg
            cctaagatcccgtccatcgccactgggatggtgggggccctcctcttgctgctggtggtg
            gccctggggatcggcctcttcatgcgaaggcgccacatcgttcggaagcgcacgctgcgg
            aggctgctgcaggagagggagcttgtggagcctcttacacccagtggagaagctcccaac
            caagctctcttgaggatcttgaaggaaactgaattcaaaaagatcaaagtgctgggctcc
            ggtgcgttcggcacggtgtataagggactctggatcccagaaggtgagaaagttaaaatt
            cccgtcgctatcaaggaattaagagaagcaacatctccgaaagccaacaaggaaatcctc
            gatgaagcctacgtgatggccagcgtggacaacccccacgtgtgccgcctgctgggcatc
            tgcctcacctccaccgtgcagctcatcacgcagctcatgcccttcggctgcctcctggac
            tatgtccgggaacacaaagacaatattggctcccagtacctgctcaactggtgtgtgcag
            atcgcaaagggcatgaactacttggaggaccgtcgcttggtgcaccgcgacctggcagcc
            aggaacgtactggtgaaaacaccgcagcatgtcaagatcacagattttgggctggccaaa
            ctgctgggtgcggaagagaaagaataccatgcagaaggaggcaaagtgcctatcaagtgg
            atggcattggaatcaattttacacagaatctatacccaccagagtgatgtctggagctac
            ggggtgactgtttgggagttgatgacctttggatccaagccatatgacggaatccctgcc
            agcgagatctcctccatcctggagaaaggagaacgcctccctcagccacccatatgtacc
            atcgatgtctacatgatcatggtcaagtgctggatgatagacgcagatagtcgcccaaag
            ttccgtgagttgatcatcgaattctccaaaatggcccgagacccccagcgctaccttgtc
            attcagggggatgaaagaatgcatttgccaagtcctacagactccaacttctaccgtgcc
            ctgatggatgaagaagacatggacgacgtggtggatgccgacgagtacctcatcccacag
            cagggcttcttcagcagcccctccacgtcacggactcccctcctgagctctctgagtgca
            accagcaacaattccaccgtggcttgcattgatagaaatgggctgcaaagctgtcccatc
            aaggaagacagcttcttgcagcgatacagctcagaccccacaggcgccttgactgaggac
            agcatagacgacaccttcctcccagtgcctgaatacataaaccagtccgttcccaaaagg
            cccgctggctctgtgcagaatcctgtctatcacaatcagcctctgaaccccgcgcccagc
            agagacccacactaccaggacccccacagcactgcagtgggcaaccccgagtatctcaac
            actgtccagcccacctgtgtcaacagcacattcgacagccctgcccactgggcccagaaa
            ggcagccaccaaattagcctggacaaccctgactaccagcaggacttctttcccaaggaa
            gccaagccaaatggcatctttaagggctccacagctgaaaatgcagaatacctaagggtc
            gcgccacaaagcagtgaatttattggagcatga
///
