The model.canonical subpackage implements the canonical approach, the
original method to compute elementary modes introduced by Schuster et al.
(see [1], for an overview and implementation details also [2], [3]).
References
-
Schuster, S. and Hilgetag, C., "On elementary flux modes in biochemical
reaction systems at steady state", 1994,
J.Biol. Syst., 2, 165-182.
-
Gagneur, J. and Klamt, S., "Computation of elementary modes: A unifying
framework and the new binary approach", 2004,
BMC Bioinformatics, 5, 175.
- Terzer, M. and Stelling, J., "Large scale computation of elementary flux
modes with bit pattern trees",
Bioinformatics, August 1, 2008,
doi:10.1093/bioinformatics/btn401