{% extends "bootstrap_global.html" %} {% block css %} {{ super() }} {% endblock %} {% block head %} {{ super() }} {% endblock head %} {% block content %} {% if variant_data.var_obj.category in ["snv", "cancer"]%} {% set var_category = 'snv' %} {% else %} {% set var_category = 'sv' %} {% endif %}
  • Start
  • Assertion Criteria
  • Variant Details
  • Inheritance Model
  • Clinical Significance
  • Associated conditions
  • Observation Data

The form present on this page mirrors the fields on the Clinvar submission spreadsheets.
After collecting the required fields, this variant gets saved in an open ClinVar submission object.

{{ variant_data.var_form.csrf_token }} {{ variant_data.var_form.case_id() }} {{ variant_data.var_form.category() }} {{ variant_data.var_form.local_id() }} {{ variant_data.var_form.linking_id() }} {{ variant_data.var_form.ref() }} {{ variant_data.var_form.alt() }} {% if var_category == 'snv' %} {{ variant_data.var_form.chromosome() }} {{ variant_data.var_form.start() }} {{ variant_data.var_form.stop() }} {% endif %}

Assertion Criteria ?

{{variant_data.var_form.last_evaluated.label(class="fw-bold text-dark")}} {{variant_data.var_form.last_evaluated(class="bg-white")}}

{{variant_data.var_form.assertion_method.label(class="fw-bold text-dark")}} {{variant_data.var_form.assertion_method(class="bg-white")}}

{{variant_data.var_form.assertion_method_cit.label(class="fw-bold text-dark")}} {{variant_data.var_form.assertion_method_cit(class="bg-white")}}

Variant Details

{{variant_data.var_form.gene_symbol.label(class="fw-bold, text-dark")}} ? {{variant_data.var_form.gene_symbol(class="bg-white")}}
{% if var_category == 'snv' %}

{{variant_data.var_form.tx_hgvs.label(class="fw-bold, text-dark")}}?

{% for item_row in variant_data.var_form.tx_hgvs | batch(3) %}
{% for item in item_row %}

{{ item() }} {{item.label}}

{% endfor %}
{% endfor %}

{{variant_data.var_form.variations_ids.label(class="fw-bold, text-dark")}} {{variant_data.var_form.variations_ids(class="bg-white")}}
{% else %}
{{variant_data.var_form.sv_type.label(class="fw-bold, text-dark")}} {{variant_data.var_form.sv_type(class="form-control, bg-white")}}

{{variant_data.var_form.ref_copy_number.label(class="fw-bold, text-dark")}} {{variant_data.var_form.ref_copy_number(size=5, class="bg-white")}}

{{variant_data.var_form.copy_number.label(class="fw-bold, text-dark")}} ? {{variant_data.var_form.copy_number(size=5, class="bg-white")}}

{{variant_data.var_form.chromosome.label(class="fw-bold, text-dark")}} {{variant_data.var_form.chromosome(size=5, class="bg-white")}}

{{variant_data.var_form.breakpoint1.label(class="fw-bold, text-dark")}} {{variant_data.var_form.breakpoint1(class="bg-white")}}

{{variant_data.var_form.breakpoint2.label(class="fw-bold, text-dark")}} {{variant_data.var_form.breakpoint2(class="bg-white")}}

{{variant_data.var_form.outer_start.label(class="fw-bold, text-dark")}} {{variant_data.var_form.outer_start(size=20, class="bg-white")}}

{{variant_data.var_form.inner_start.label(class="fw-bold, text-dark")}} {{variant_data.var_form.inner_start(size=20, class="bg-white")}}

{{variant_data.var_form.inner_stop.label(class="fw-bold, text-dark")}} {{variant_data.var_form.inner_stop(size=20, class="bg-white")}}

{{variant_data.var_form.outer_stop.label(class="fw-bold, text-dark")}} {{variant_data.var_form.outer_stop(size=20, class="bg-white")}}
{% endif %}

Inheritance model

The mode of inheritance specific to the variant-disease pair, not generally for the disease

{{variant_data.var_form.inheritance_mode.label(class="fw-bold, text-dark")}} {{variant_data.var_form.inheritance_mode(class="form-control, btn-secondary")}}

Clinical Significance

The interpretation, or clinical significance, of the variant for the submitted condition

Classification in Scout:
{{variant_data.var_obj.classification|replace("_"," ")|upper if variant_data.var_obj.classification else "n.a."}}
{{variant_data.var_form.clinsig.label(class="fw-bold, text-dark")}} * {{variant_data.var_form.clinsig(class="form-control, btn-secondary")}}



{{variant_data.var_form.clinsig_comment.label(class="fw-bold, text-dark")}} ? {{variant_data.var_form.clinsig_comment(class="form-control, bg-white", placeholder="(optional)")}}

{{variant_data.var_form.clinsig_cit.label(class="fw-bold, text-dark")}} {{variant_data.var_form.clinsig_cit(class="form-control, bg-white", placeholder="(optional) e.g. PMID:123456, PMCID:PMC3385229, NBK:56955")}}

Associated Conditions

The condition for which the variant is interpreted. Detailed information about reporting condition is available at https://www.ncbi.nlm.nih.gov/clinvar/docs/faq_submitters/#pheno. If multiple conditions are submitted for a variant, this indicates that the variant was interpreted for the combination of conditions in the same individual(s). i.e. this variant causes both condition A and condition B in the same individual. This scenario is most common for a new disease or syndrome that does not yet have a name and is described by several clinical features. If you want to indicate that the variant has been interpreted for more than one condition, please submit these as separate records. i.e. this variant causes condition A in some individuals and causes disease B in other individuals. Provide only one name or identifier for a condition; do not provide multiple names or identifiers for the same condition."

{{variant_data.var_form.condition_type.label(class="fw-bold, text-dark")}}*

{{variant_data.var_form.conditions.label(class="fw-bold, text-dark")}} *?
{{variant_data.var_form.omim_terms.label(class="fw-bold, text-dark")}}
    {% for term in variant_data.var_form.omim_terms %}
  • {{ term.label }}
  • {% else %} n.a. {% endfor %}


{{variant_data.var_form.hpo_terms.label(class="fw-bold, text-dark")}}
    {% for term in variant_data.var_form.hpo_terms %}
  • {{ term.label }}
  • {% else %} n.a.
{% endfor %}

Observation Data

Information provided by filling in these fields will be used to create the CaseData.csv file. Observations from at least one individuals are required.

    {% for cdata in variant_data.cdata_forms %} {{cdata.linking_id(class="fw-bold, text-dark")}}
  • {{ cdata.include_ind.label(class="fw-bold, text-dark") }} {{ cdata.include_ind() }}
    {{ cdata.individual_id.label(class="fw-bold, text-dark") }} {{ cdata.individual_id(class="form-control, bg-white", readonly=true) }}
    {{ cdata.affected_status.label(class="fw-bold, text-dark") }} {{ cdata.affected_status(class="form-control, btn-secondary") }}
    {{ cdata.allele_of_origin.label(class="fw-bold, text-dark") }} {{ cdata.allele_of_origin(class="form-control, btn-secondary") }}
    {{ cdata.collection_method.label(class="fw-bold, text-dark") }} {{ cdata.collection_method(class="form-control, btn-secondary") }}
  • {% endfor %}
{% endblock %} {% block scripts %} {{ super() }} {% endblock %}