11 years old boy who was born at full term via NSVD following an uneventful pregnancy. His birth growth parameters were weight 2.75 kg and head circumference 31.5 cm. He has a global developmental delay, microcephaly and seizures. Parents are first-degree cousins, and they have another affected son. There is a family history of hearing loss on the maternal side. (14DG0648) A 9 years old boy who was born at full term via NSVD following an uneventful pregnancy. Birth weight was 2.5 kg, and he was noted to have microcephaly. He also has a global developmental delay and seizures. 