Requirements
Make sure to register a user to the clinVar submission portal.
If your organization is not already present in clinVar you should follow the instructions to register a submitting organization to the same portal.
The first time an organization is registered in the ClinVar Submission Portal, the content will be reviewed, so it will take some time before getting approved in order to start a variant submission.
Obtain a submission ID
If the requirements above are fullfilled, you can start a new submission by using the "Upload new file submission" button from the submission page.
This button is a link to a multi-panel (4 panels) submission page. The first panel (submission information) has a precompiled field named "Submission name".
Fill in panel 1 and 2
Fill in submission forms in panel 1 and 2, respectively named "Submission information" and "Organization". In the "Submission format" in panel 1 make sure to select the value "Comma-separated values".
Assemby name fields should be filled in before proceding further with the submission.
Download the files
You'll need to register the Submission Name obtained from Clinvar portal in order to download variants and casedata submission files.
Upload the files to Clinvar
Upload the files obtained above (either the variants .csv file or the variants .csv + the casedata .csv files) in the "Submission Files" field in the third panel of the submission.
The field named "Assertion Criteria File" should be left blank, since the default information is already filled in the "Variants sheet" (ACMG Guidelines, 2015).