# PAM250 substitution matrix (generated from Biopython substitution_matrices 'PAM250')
# rows = reference residue, cols = query residue; integer scores
    A   R   N   D   C   Q   E   G   H   I   L   K   M   F   P   S   T   W   Y   V   B   Z   X   *
A   2  -2   0   0  -2   0   0   1  -1  -1  -2  -1  -1  -3   1   1   1  -6  -3   0   0   0   0  -8
R  -2   6   0  -1  -4   1  -1  -3   2  -2  -3   3   0  -4   0   0  -1   2  -4  -2  -1   0  -1  -8
N   0   0   2   2  -4   1   1   0   2  -2  -3   1  -2  -3   0   1   0  -4  -2  -2   2   1   0  -8
D   0  -1   2   4  -5   2   3   1   1  -2  -4   0  -3  -6  -1   0   0  -7  -4  -2   3   3  -1  -8
C  -2  -4  -4  -5  12  -5  -5  -3  -3  -2  -6  -5  -5  -4  -3   0  -2  -8   0  -2  -4  -5  -3  -8
Q   0   1   1   2  -5   4   2  -1   3  -2  -2   1  -1  -5   0  -1  -1  -5  -4  -2   1   3  -1  -8
E   0  -1   1   3  -5   2   4   0   1  -2  -3   0  -2  -5  -1   0   0  -7  -4  -2   3   3  -1  -8
G   1  -3   0   1  -3  -1   0   5  -2  -3  -4  -2  -3  -5   0   1   0  -7  -5  -1   0   0  -1  -8
H  -1   2   2   1  -3   3   1  -2   6  -2  -2   0  -2  -2   0  -1  -1  -3   0  -2   1   2  -1  -8
I  -1  -2  -2  -2  -2  -2  -2  -3  -2   5   2  -2   2   1  -2  -1   0  -5  -1   4  -2  -2  -1  -8
L  -2  -3  -3  -4  -6  -2  -3  -4  -2   2   6  -3   4   2  -3  -3  -2  -2  -1   2  -3  -3  -1  -8
K  -1   3   1   0  -5   1   0  -2   0  -2  -3   5   0  -5  -1   0   0  -3  -4  -2   1   0  -1  -8
M  -1   0  -2  -3  -5  -1  -2  -3  -2   2   4   0   6   0  -2  -2  -1  -4  -2   2  -2  -2  -1  -8
F  -3  -4  -3  -6  -4  -5  -5  -5  -2   1   2  -5   0   9  -5  -3  -3   0   7  -1  -4  -5  -2  -8
P   1   0   0  -1  -3   0  -1   0   0  -2  -3  -1  -2  -5   6   1   0  -6  -5  -1  -1   0  -1  -8
S   1   0   1   0   0  -1   0   1  -1  -1  -3   0  -2  -3   1   2   1  -2  -3  -1   0   0   0  -8
T   1  -1   0   0  -2  -1   0   0  -1   0  -2   0  -1  -3   0   1   3  -5  -3   0   0  -1   0  -8
W  -6   2  -4  -7  -8  -5  -7  -7  -3  -5  -2  -3  -4   0  -6  -2  -5  17   0  -6  -5  -6  -4  -8
Y  -3  -4  -2  -4   0  -4  -4  -5   0  -1  -1  -4  -2   7  -5  -3  -3   0  10  -2  -3  -4  -2  -8
V   0  -2  -2  -2  -2  -2  -2  -1  -2   4   2  -2   2  -1  -1  -1   0  -6  -2   4  -2  -2  -1  -8
B   0  -1   2   3  -4   1   3   0   1  -2  -3   1  -2  -4  -1   0   0  -5  -3  -2   3   2  -1  -8
Z   0   0   1   3  -5   3   3   0   2  -2  -3   0  -2  -5   0   0  -1  -6  -4  -2   2   3  -1  -8
X   0  -1   0  -1  -3  -1  -1  -1  -1  -1  -1  -1  -1  -2  -1   0   0  -4  -2  -1  -1  -1  -1  -8
*  -8  -8  -8  -8  -8  -8  -8  -8  -8  -8  -8  -8  -8  -8  -8  -8  -8  -8  -8  -8  -8  -8  -8   1
