Tie no Home team Score Away team Date
1 Liverpool 0–1 West Bromwich Albion 28 January 1922
2 Preston North End 3–1 Newcastle United 28 January 1922
3 Southampton 1–1 Cardiff City 28 January 1922
Replay Cardiff City 2–0 Southampton 1 February 1922
4 Leicester City 2–0 Fulham 28 January 1922
5 Nottingham Forest 3–0 Hull City 28 January 1922
6 Aston Villa 1–0 Luton Town 28 January 1922
7 Bolton Wanderers 1–3 Manchester City 28 January 1922
8 Swindon Town 0–1 Blackburn Rovers 28 January 1922
9 Tottenham Hotspur 1–0 Watford 28 January 1922
10 Barnsley 3–1 Oldham Athletic 28 January 1922
11 Northampton Town 2–2 Stoke 28 January 1922
Replay Stoke 3–0 Northampton Town 1 February 1922
12 Brighton & Hove Albion 0–0 Huddersfield Town 28 January 1922
Replay Huddersfield Town 2–0 Brighton & Hove Albion 1 February 1922
13 Bradford City 1–1 Notts County 28 January 1922
Replay Notts County 0–0 Bradford City 1 February 1922
Replay Notts County 1–0 Bradford City 6 February 1922
14 Crystal Palace 0–0 Millwall 28 January 1922
Replay Millwall 2–0 Crystal Palace 1 February 1922
15 Southend United 0–1 Swansea Town 28 January 1922
16 Bradford Park Avenue 2–3 Arsenal 28 January 1922