Airline Destination(s) Aircraft Scheduled Service Date(s) Comments
Air Florida New York JFK, Tampa, Washington National Boeing 737-200, DC-9-10 JFK: 6/14/79-9/5/79, DCA: 10/26/79-9/30/1982, TPA: 02/1980-9/30/1982 [18]
AirTran Airways Atlanta, Dayton, Orlando Boeing 737-200, DC-9-30, Boeing 717-200 11/14/1996-2/28/1998, 10/3/2000-4/29/2002
Air Wisconsin Akron-Canton, Chicago O'Hare, Cleveland, Columbus, Flint, Fort Wayne, Kalamazoo, Pittsburgh, South Bend BAe 146, BAe ATP, Dash 8-300, Dash 7, Metro III  ?-02/03/1993 Original and operating as United Express.
Allegiant Air* Las Vegas MD-80 12/15/2005-4/24/2006
America West Express Columbus, Flint Beech 1900 Operated by Mesa dba Superior Airlines
American Eagle Airlines* Dallas/Fort Worth ERJ-145 Operated by Simmons Airlines (now American Eagle Airlines) and Chautauqua Airlines (dba AmericanConnection until name change to American Eagle)
Atlantic Coast Airlines Cincinnati Dornier 328JET dba Delta Connection
Atlantic Southeast Airlines Atlanta, Cincinnati ATR 72, CRJ-200, CRJ-700 dba Delta Connection
Beaver Aviation / BAS Airlines [19] Beaver Falls (PA), Detroit City, Youngstown Piper Navajo Early 1980s
Capital Airlines Akron, Chicago, Cleveland, Detroit, Flint, Grand Rapids, Lansing, Muskegon, Pittsburgh, Philadelphia [20] Viscount, DC-3, DC-4 1/8/1948-05-31-1961 * Merged with United. * At the time, 14 flights at startup was the most ever for a new city.[21]
Chicago Express Airlines Chicago Midway, South Bend Jetstream 31, Saab 340 1993-1995, 6/28/2002-1/4/2005 Original and returned as ATA Connection
Chicago and Southern Airlines Deroit, Fort Wayne Merged with Delta
Comair Atlanta, Cincinnati, Columbus, Indianapolis Piper Chieftain, Piper Navajo, EMB-110, Saab 340, EMB-120, Metro III, CRJ-100, CRJ-200, CRJ-700 1979, 01/03/1981-? Original and as Delta Connection
Continental Express Cleveland EMB-120, Beech 1900, Dash-8-200
Delta Air Lines Atlanta, Cincinnati, Dayton, Detroit, Fort Wayne Convair 440, Boeing 727-200, Boeing 737-300, MD-88, DC-9-30
Eastern Airlines Columbus Constellation L-1049G, Locheed Electra, Boeing 727-100, Boeing 727-200, DC-9-30, DC-9-50
Frontier Airlines mk 1 Denver, Detroit Boeing 737-200, MD-80
Liberty Airlines Chicago Midway & O'Hare Convair 440 02/1982-5/16/1983 Plans for CMH, CLE, STL, BUF, & EWR scrapped.[22] Also flew CAK-ORD
Midway Connection Chicago Midway EMB-120, Dornier 228
Mesaba Aviation Detroit, Youngstown Dash 8-200, Fokker 27, Metro III, Saab 340 Original and dba Northwest Airlink
Piedmont Airlines Dayton Boeing 727-200, Boeing 737-200 Merged with USAir
TransMeridian Airlines Las Vegas, Sanford/Orlando Boeing 757-200, Boeing 727-200, MD-80 Filed for Bankruptcy
Trans Midwest Airlines [19] Columbus,[23] Dayton, Detroit Metro, Lima Piper Navajo 1983-1985
Trans World Airlines St. Louis Boeing 727-100, DC-9, Martin 404
United Airlines Chicago O'Hare, Cleveland, Denver, Fort Wayne, Peoria, Saginaw DC-8 series 21, Boeing 727-122, 727-222, Boeing 737-222,Caravelle, Boeing 720, Convair 340, DC-6B
US Airways (USAir/Allegheny) Pittsburgh Convair 580, Boeing 727-200, MD-80, Boeing 737-200/300/400, DC-9-30, BAe 1-11, Fokker 100, Fokker 28
US Airways Express Dayton, Indianapolis, Pittsburgh Metro III, Jetstream 31, Saab 340, Dash 8-100/200, ERJ 145, Dornier 328 Operated by Trans States Airlines, Jetstream Int'l / PSA Airlines, Allegheny Airlines, Chautauqua Airlines, Shuttle America
Vision Airlines Myrtle Beach Boeing 737-400 6/1 - 6/29/2012