The model.canonical subpackage implements the canonical approach, the original method to compute elementary modes introduced by Schuster et al. (see [1], for an overview and implementation details also [2], [3]).

References

  1. Schuster, S. and Hilgetag, C., "On elementary flux modes in biochemical reaction systems at steady state", 1994,
    J.Biol. Syst., 2, 165-182.
  2. Gagneur, J. and Klamt, S., "Computation of elementary modes: A unifying framework and the new binary approach", 2004,
    BMC Bioinformatics, 5, 175.
  3. Terzer, M. and Stelling, J., "Large scale computation of elementary flux modes with bit pattern trees",
    Bioinformatics, August 1, 2008, doi:10.1093/bioinformatics/btn401