# NCBI BLAST substitution matrices
# Source: https://ftp.ncbi.nih.gov/blast/matrices/
# Retrieved 2026-08-08; sections retain the published file contents.

@@ BLOSUM30
#  Matrix made by matblas from blosum30.iij
#  * column uses minimum score
#  BLOSUM Clustered Scoring Matrix in 1/5 Bit Units
#  Blocks Database = /data/blocks_5.0/blocks.dat
#  Cluster Percentage: >= 30
#  Entropy =   0.1424, Expected =  -0.1074
   A  R  N  D  C  Q  E  G  H  I  L  K  M  F  P  S  T  W  Y  V  B  Z  X  *
A  4 -1  0  0 -3  1  0  0 -2  0 -1  0  1 -2 -1  1  1 -5 -4  1  0  0  0 -7 
R -1  8 -2 -1 -2  3 -1 -2 -1 -3 -2  1  0 -1 -1 -1 -3  0  0 -1 -2  0 -1 -7 
N  0 -2  8  1 -1 -1 -1  0 -1  0 -2  0  0 -1 -3  0  1 -7 -4 -2  4 -1  0 -7 
D  0 -1  1  9 -3 -1  1 -1 -2 -4 -1  0 -3 -5 -1  0 -1 -4 -1 -2  5  0 -1 -7 
C -3 -2 -1 -3 17 -2  1 -4 -5 -2  0 -3 -2 -3 -3 -2 -2 -2 -6 -2 -2  0 -2 -7 
Q  1  3 -1 -1 -2  8  2 -2  0 -2 -2  0 -1 -3  0 -1  0 -1 -1 -3 -1  4  0 -7 
E  0 -1 -1  1  1  2  6 -2  0 -3 -1  2 -1 -4  1  0 -2 -1 -2 -3  0  5 -1 -7 
G  0 -2  0 -1 -4 -2 -2  8 -3 -1 -2 -1 -2 -3 -1  0 -2  1 -3 -3  0 -2 -1 -7 
H -2 -1 -1 -2 -5  0  0 -3 14 -2 -1 -2  2 -3  1 -1 -2 -5  0 -3 -2  0 -1 -7 
I  0 -3  0 -4 -2 -2 -3 -1 -2  6  2 -2  1  0 -3 -1  0 -3 -1  4 -2 -3  0 -7 
L -1 -2 -2 -1  0 -2 -1 -2 -1  2  4 -2  2  2 -3 -2  0 -2  3  1 -1 -1  0 -7 
K  0  1  0  0 -3  0  2 -1 -2 -2 -2  4  2 -1  1  0 -1 -2 -1 -2  0  1  0 -7 
M  1  0  0 -3 -2 -1 -1 -2  2  1  2  2  6 -2 -4 -2  0 -3 -1  0 -2 -1  0 -7 
F -2 -1 -1 -5 -3 -3 -4 -3 -3  0  2 -1 -2 10 -4 -1 -2  1  3  1 -3 -4 -1 -7 
P -1 -1 -3 -1 -3  0  1 -1  1 -3 -3  1 -4 -4 11 -1  0 -3 -2 -4 -2  0 -1 -7 
S  1 -1  0  0 -2 -1  0  0 -1 -1 -2  0 -2 -1 -1  4  2 -3 -2 -1  0 -1  0 -7 
T  1 -3  1 -1 -2  0 -2 -2 -2  0  0 -1  0 -2  0  2  5 -5 -1  1  0 -1  0 -7 
W -5  0 -7 -4 -2 -1 -1  1 -5 -3 -2 -2 -3  1 -3 -3 -5 20  5 -3 -5 -1 -2 -7 
Y -4  0 -4 -1 -6 -1 -2 -3  0 -1  3 -1 -1  3 -2 -2 -1  5  9  1 -3 -2 -1 -7 
V  1 -1 -2 -2 -2 -3 -3 -3 -3  4  1 -2  0  1 -4 -1  1 -3  1  5 -2 -3  0 -7 
B  0 -2  4  5 -2 -1  0  0 -2 -2 -1  0 -2 -3 -2  0  0 -5 -3 -2  5  0 -1 -7 
Z  0  0 -1  0  0  4  5 -2  0 -3 -1  1 -1 -4  0 -1 -1 -1 -2 -3  0  4  0 -7 
X  0 -1  0 -1 -2  0 -1 -1 -1  0  0  0  0 -1 -1  0  0 -2 -1  0 -1  0 -1 -7 
* -7 -7 -7 -7 -7 -7 -7 -7 -7 -7 -7 -7 -7 -7 -7 -7 -7 -7 -7 -7 -7 -7 -7  1

@@ BLOSUM35
#  Matrix made by matblas from blosum35.iij
#  * column uses minimum score
#  BLOSUM Clustered Scoring Matrix in 1/4 Bit Units
#  Blocks Database = /data/blocks_5.0/blocks.dat
#  Cluster Percentage: >= 35
#  Entropy =   0.2111, Expected =  -0.1550
   A  R  N  D  C  Q  E  G  H  I  L  K  M  F  P  S  T  W  Y  V  B  Z  X  *
A  5 -1 -1 -1 -2  0 -1  0 -2 -1 -2  0  0 -2 -2  1  0 -2 -1  0 -1 -1  0 -5 
R -1  8 -1 -1 -3  2 -1 -2 -1 -3 -2  2  0 -1 -2 -1 -2  0  0 -1 -1  0 -1 -5 
N -1 -1  7  1 -1  1 -1  1  1 -1 -2  0 -1 -1 -2  0  0 -2 -2 -2  4  0  0 -5 
D -1 -1  1  8 -3 -1  2 -2  0 -3 -2 -1 -3 -3 -1 -1 -1 -3 -2 -2  5  1 -1 -5 
C -2 -3 -1 -3 15 -3 -1 -3 -4 -4 -2 -2 -4 -4 -4 -3 -1 -5 -5 -2 -2 -2 -2 -5 
Q  0  2  1 -1 -3  7  2 -2 -1 -2 -2  0 -1 -4  0  0  0 -1  0 -3  0  4 -1 -5 
E -1 -1 -1  2 -1  2  6 -2 -1 -3 -1  1 -2 -3  0  0 -1 -1 -1 -2  0  5 -1 -5 
G  0 -2  1 -2 -3 -2 -2  7 -2 -3 -3 -1 -1 -3 -2  1 -2 -1 -2 -3  0 -2 -1 -5 
H -2 -1  1  0 -4 -1 -1 -2 12 -3 -2 -2  1 -3 -1 -1 -2 -4  0 -4  0 -1 -1 -5 
I -1 -3 -1 -3 -4 -2 -3 -3 -3  5  2 -2  1  1 -1 -2 -1 -1  0  4 -2 -3  0 -5 
L -2 -2 -2 -2 -2 -2 -1 -3 -2  2  5 -2  3  2 -3 -2  0  0  0  2 -2 -2  0 -5 
K  0  2  0 -1 -2  0  1 -1 -2 -2 -2  5  0 -1  0  0  0  0 -1 -2  0  1  0 -5 
M  0  0 -1 -3 -4 -1 -2 -1  1  1  3  0  6  0 -3 -1  0  1  0  1 -2 -2  0 -5 
F -2 -1 -1 -3 -4 -4 -3 -3 -3  1  2 -1  0  8 -4 -1 -1  1  3  1 -2 -3 -1 -5 
P -2 -2 -2 -1 -4  0  0 -2 -1 -1 -3  0 -3 -4 10 -2  0 -4 -3 -3 -1  0 -1 -5 
S  1 -1  0 -1 -3  0  0  1 -1 -2 -2  0 -1 -1 -2  4  2 -2 -1 -1  0  0  0 -5 
T  0 -2  0 -1 -1  0 -1 -2 -2 -1  0  0  0 -1  0  2  5 -2 -2  1 -1 -1  0 -5 
W -2  0 -2 -3 -5 -1 -1 -1 -4 -1  0  0  1  1 -4 -2 -2 16  3 -2 -3 -1 -1 -5 
Y -1  0 -2 -2 -5  0 -1 -2  0  0  0 -1  0  3 -3 -1 -2  3  8  0 -2 -1 -1 -5 
V  0 -1 -2 -2 -2 -3 -2 -3 -4  4  2 -2  1  1 -3 -1  1 -2  0  5 -2 -2  0 -5 
B -1 -1  4  5 -2  0  0  0  0 -2 -2  0 -2 -2 -1  0 -1 -3 -2 -2  5  0 -1 -5 
Z -1  0  0  1 -2  4  5 -2 -1 -3 -2  1 -2 -3  0  0 -1 -1 -1 -2  0  4  0 -5 
X  0 -1  0 -1 -2 -1 -1 -1 -1  0  0  0  0 -1 -1  0  0 -1 -1  0 -1  0 -1 -5 
* -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5  1

@@ BLOSUM40
#  Matrix made by matblas from blosum40.iij
#  * column uses minimum score
#  BLOSUM Clustered Scoring Matrix in 1/4 Bit Units
#  Blocks Database = /data/blocks_5.0/blocks.dat
#  Cluster Percentage: >= 40
#  Entropy =   0.2851, Expected =  -0.2090
   A  R  N  D  C  Q  E  G  H  I  L  K  M  F  P  S  T  W  Y  V  B  Z  X  *
A  5 -2 -1 -1 -2  0 -1  1 -2 -1 -2 -1 -1 -3 -2  1  0 -3 -2  0 -1 -1  0 -6 
R -2  9  0 -1 -3  2 -1 -3  0 -3 -2  3 -1 -2 -3 -1 -2 -2 -1 -2 -1  0 -1 -6 
N -1  0  8  2 -2  1 -1  0  1 -2 -3  0 -2 -3 -2  1  0 -4 -2 -3  4  0 -1 -6 
D -1 -1  2  9 -2 -1  2 -2  0 -4 -3  0 -3 -4 -2  0 -1 -5 -3 -3  6  1 -1 -6 
C -2 -3 -2 -2 16 -4 -2 -3 -4 -4 -2 -3 -3 -2 -5 -1 -1 -6 -4 -2 -2 -3 -2 -6 
Q  0  2  1 -1 -4  8  2 -2  0 -3 -2  1 -1 -4 -2  1 -1 -1 -1 -3  0  4 -1 -6 
E -1 -1 -1  2 -2  2  7 -3  0 -4 -2  1 -2 -3  0  0 -1 -2 -2 -3  1  5 -1 -6 
G  1 -3  0 -2 -3 -2 -3  8 -2 -4 -4 -2 -2 -3 -1  0 -2 -2 -3 -4 -1 -2 -1 -6 
H -2  0  1  0 -4  0  0 -2 13 -3 -2 -1  1 -2 -2 -1 -2 -5  2 -4  0  0 -1 -6 
I -1 -3 -2 -4 -4 -3 -4 -4 -3  6  2 -3  1  1 -2 -2 -1 -3  0  4 -3 -4 -1 -6 
L -2 -2 -3 -3 -2 -2 -2 -4 -2  2  6 -2  3  2 -4 -3 -1 -1  0  2 -3 -2 -1 -6 
K -1  3  0  0 -3  1  1 -2 -1 -3 -2  6 -1 -3 -1  0  0 -2 -1 -2  0  1 -1 -6 
M -1 -1 -2 -3 -3 -1 -2 -2  1  1  3 -1  7  0 -2 -2 -1 -2  1  1 -3 -2  0 -6 
F -3 -2 -3 -4 -2 -4 -3 -3 -2  1  2 -3  0  9 -4 -2 -1  1  4  0 -3 -4 -1 -6 
P -2 -3 -2 -2 -5 -2  0 -1 -2 -2 -4 -1 -2 -4 11 -1  0 -4 -3 -3 -2 -1 -2 -6 
S  1 -1  1  0 -1  1  0  0 -1 -2 -3  0 -2 -2 -1  5  2 -5 -2 -1  0  0  0 -6 
T  0 -2  0 -1 -1 -1 -1 -2 -2 -1 -1  0 -1 -1  0  2  6 -4 -1  1  0 -1  0 -6 
W -3 -2 -4 -5 -6 -1 -2 -2 -5 -3 -1 -2 -2  1 -4 -5 -4 19  3 -3 -4 -2 -2 -6 
Y -2 -1 -2 -3 -4 -1 -2 -3  2  0  0 -1  1  4 -3 -2 -1  3  9 -1 -3 -2 -1 -6 
V  0 -2 -3 -3 -2 -3 -3 -4 -4  4  2 -2  1  0 -3 -1  1 -3 -1  5 -3 -3 -1 -6 
B -1 -1  4  6 -2  0  1 -1  0 -3 -3  0 -3 -3 -2  0  0 -4 -3 -3  5  2 -1 -6 
Z -1  0  0  1 -3  4  5 -2  0 -4 -2  1 -2 -4 -1  0 -1 -2 -2 -3  2  5 -1 -6 
X  0 -1 -1 -1 -2 -1 -1 -1 -1 -1 -1 -1  0 -1 -2  0  0 -2 -1 -1 -1 -1 -1 -6 
* -6 -6 -6 -6 -6 -6 -6 -6 -6 -6 -6 -6 -6 -6 -6 -6 -6 -6 -6 -6 -6 -6 -6  1

@@ BLOSUM45
#  Matrix made by matblas from blosum45.iij
#  * column uses minimum score
#  BLOSUM Clustered Scoring Matrix in 1/3 Bit Units
#  Blocks Database = /data/blocks_5.0/blocks.dat
#  Cluster Percentage: >= 45
#  Entropy =   0.3795, Expected =  -0.2789
   A  R  N  D  C  Q  E  G  H  I  L  K  M  F  P  S  T  W  Y  V  B  Z  X  *
A  5 -2 -1 -2 -1 -1 -1  0 -2 -1 -1 -1 -1 -2 -1  1  0 -2 -2  0 -1 -1  0 -5 
R -2  7  0 -1 -3  1  0 -2  0 -3 -2  3 -1 -2 -2 -1 -1 -2 -1 -2 -1  0 -1 -5 
N -1  0  6  2 -2  0  0  0  1 -2 -3  0 -2 -2 -2  1  0 -4 -2 -3  4  0 -1 -5 
D -2 -1  2  7 -3  0  2 -1  0 -4 -3  0 -3 -4 -1  0 -1 -4 -2 -3  5  1 -1 -5 
C -1 -3 -2 -3 12 -3 -3 -3 -3 -3 -2 -3 -2 -2 -4 -1 -1 -5 -3 -1 -2 -3 -2 -5 
Q -1  1  0  0 -3  6  2 -2  1 -2 -2  1  0 -4 -1  0 -1 -2 -1 -3  0  4 -1 -5 
E -1  0  0  2 -3  2  6 -2  0 -3 -2  1 -2 -3  0  0 -1 -3 -2 -3  1  4 -1 -5 
G  0 -2  0 -1 -3 -2 -2  7 -2 -4 -3 -2 -2 -3 -2  0 -2 -2 -3 -3 -1 -2 -1 -5 
H -2  0  1  0 -3  1  0 -2 10 -3 -2 -1  0 -2 -2 -1 -2 -3  2 -3  0  0 -1 -5 
I -1 -3 -2 -4 -3 -2 -3 -4 -3  5  2 -3  2  0 -2 -2 -1 -2  0  3 -3 -3 -1 -5 
L -1 -2 -3 -3 -2 -2 -2 -3 -2  2  5 -3  2  1 -3 -3 -1 -2  0  1 -3 -2 -1 -5 
K -1  3  0  0 -3  1  1 -2 -1 -3 -3  5 -1 -3 -1 -1 -1 -2 -1 -2  0  1 -1 -5 
M -1 -1 -2 -3 -2  0 -2 -2  0  2  2 -1  6  0 -2 -2 -1 -2  0  1 -2 -1 -1 -5 
F -2 -2 -2 -4 -2 -4 -3 -3 -2  0  1 -3  0  8 -3 -2 -1  1  3  0 -3 -3 -1 -5 
P -1 -2 -2 -1 -4 -1  0 -2 -2 -2 -3 -1 -2 -3  9 -1 -1 -3 -3 -3 -2 -1 -1 -5 
S  1 -1  1  0 -1  0  0  0 -1 -2 -3 -1 -2 -2 -1  4  2 -4 -2 -1  0  0  0 -5 
T  0 -1  0 -1 -1 -1 -1 -2 -2 -1 -1 -1 -1 -1 -1  2  5 -3 -1  0  0 -1  0 -5 
W -2 -2 -4 -4 -5 -2 -3 -2 -3 -2 -2 -2 -2  1 -3 -4 -3 15  3 -3 -4 -2 -2 -5 
Y -2 -1 -2 -2 -3 -1 -2 -3  2  0  0 -1  0  3 -3 -2 -1  3  8 -1 -2 -2 -1 -5 
V  0 -2 -3 -3 -1 -3 -3 -3 -3  3  1 -2  1  0 -3 -1  0 -3 -1  5 -3 -3 -1 -5 
B -1 -1  4  5 -2  0  1 -1  0 -3 -3  0 -2 -3 -2  0  0 -4 -2 -3  4  2 -1 -5 
Z -1  0  0  1 -3  4  4 -2  0 -3 -2  1 -1 -3 -1  0 -1 -2 -2 -3  2  4 -1 -5 
X  0 -1 -1 -1 -2 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1  0  0 -2 -1 -1 -1 -1 -1 -5 
* -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5  1

@@ BLOSUM50
#  Matrix made by matblas from blosum50.iij
#  * column uses minimum score
#  BLOSUM Clustered Scoring Matrix in 1/3 Bit Units
#  Blocks Database = /data/blocks_5.0/blocks.dat
#  Cluster Percentage: >= 50
#  Entropy =   0.4808, Expected =  -0.3573
   A  R  N  D  C  Q  E  G  H  I  L  K  M  F  P  S  T  W  Y  V  B  Z  X  *
A  5 -2 -1 -2 -1 -1 -1  0 -2 -1 -2 -1 -1 -3 -1  1  0 -3 -2  0 -2 -1 -1 -5 
R -2  7 -1 -2 -4  1  0 -3  0 -4 -3  3 -2 -3 -3 -1 -1 -3 -1 -3 -1  0 -1 -5 
N -1 -1  7  2 -2  0  0  0  1 -3 -4  0 -2 -4 -2  1  0 -4 -2 -3  4  0 -1 -5 
D -2 -2  2  8 -4  0  2 -1 -1 -4 -4 -1 -4 -5 -1  0 -1 -5 -3 -4  5  1 -1 -5 
C -1 -4 -2 -4 13 -3 -3 -3 -3 -2 -2 -3 -2 -2 -4 -1 -1 -5 -3 -1 -3 -3 -2 -5 
Q -1  1  0  0 -3  7  2 -2  1 -3 -2  2  0 -4 -1  0 -1 -1 -1 -3  0  4 -1 -5 
E -1  0  0  2 -3  2  6 -3  0 -4 -3  1 -2 -3 -1 -1 -1 -3 -2 -3  1  5 -1 -5 
G  0 -3  0 -1 -3 -2 -3  8 -2 -4 -4 -2 -3 -4 -2  0 -2 -3 -3 -4 -1 -2 -2 -5 
H -2  0  1 -1 -3  1  0 -2 10 -4 -3  0 -1 -1 -2 -1 -2 -3  2 -4  0  0 -1 -5 
I -1 -4 -3 -4 -2 -3 -4 -4 -4  5  2 -3  2  0 -3 -3 -1 -3 -1  4 -4 -3 -1 -5 
L -2 -3 -4 -4 -2 -2 -3 -4 -3  2  5 -3  3  1 -4 -3 -1 -2 -1  1 -4 -3 -1 -5 
K -1  3  0 -1 -3  2  1 -2  0 -3 -3  6 -2 -4 -1  0 -1 -3 -2 -3  0  1 -1 -5 
M -1 -2 -2 -4 -2  0 -2 -3 -1  2  3 -2  7  0 -3 -2 -1 -1  0  1 -3 -1 -1 -5 
F -3 -3 -4 -5 -2 -4 -3 -4 -1  0  1 -4  0  8 -4 -3 -2  1  4 -1 -4 -4 -2 -5 
P -1 -3 -2 -1 -4 -1 -1 -2 -2 -3 -4 -1 -3 -4 10 -1 -1 -4 -3 -3 -2 -1 -2 -5 
S  1 -1  1  0 -1  0 -1  0 -1 -3 -3  0 -2 -3 -1  5  2 -4 -2 -2  0  0 -1 -5 
T  0 -1  0 -1 -1 -1 -1 -2 -2 -1 -1 -1 -1 -2 -1  2  5 -3 -2  0  0 -1  0 -5 
W -3 -3 -4 -5 -5 -1 -3 -3 -3 -3 -2 -3 -1  1 -4 -4 -3 15  2 -3 -5 -2 -3 -5 
Y -2 -1 -2 -3 -3 -1 -2 -3  2 -1 -1 -2  0  4 -3 -2 -2  2  8 -1 -3 -2 -1 -5 
V  0 -3 -3 -4 -1 -3 -3 -4 -4  4  1 -3  1 -1 -3 -2  0 -3 -1  5 -4 -3 -1 -5 
B -2 -1  4  5 -3  0  1 -1  0 -4 -4  0 -3 -4 -2  0  0 -5 -3 -4  5  2 -1 -5 
Z -1  0  0  1 -3  4  5 -2  0 -3 -3  1 -1 -4 -1  0 -1 -2 -2 -3  2  5 -1 -5 
X -1 -1 -1 -1 -2 -1 -1 -2 -1 -1 -1 -1 -1 -2 -2 -1  0 -3 -1 -1 -1 -1 -1 -5 
* -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5  1

@@ BLOSUM55
#  Matrix made by matblas from blosum55.iij
#  * column uses minimum score
#  BLOSUM Clustered Scoring Matrix in 1/3 Bit Units
#  Blocks Database = /data/blocks_5.0/blocks.dat
#  Cluster Percentage: >= 55
#  Entropy =   0.5637, Expected =  -0.4179
   A  R  N  D  C  Q  E  G  H  I  L  K  M  F  P  S  T  W  Y  V  B  Z  X  *
A  5 -2 -2 -2  0 -1 -1  0 -2 -2 -2 -1 -1 -3 -1  2  0 -4 -2  0 -2 -1 -1 -5 
R -2  8 -1 -2 -4  1  0 -3  0 -4 -3  3 -2 -3 -3 -1 -1 -3 -2 -3 -1  0 -1 -5 
N -2 -1  8  2 -3  0  0  0  1 -4 -4  0 -3 -4 -2  1  0 -5 -2 -4  4  0 -1 -5 
D -2 -2  2  8 -4  0  2 -2 -1 -4 -5 -1 -4 -5 -2  0 -1 -5 -3 -4  5  1 -2 -5 
C  0 -4 -3 -4 13 -4 -4 -3 -4 -2 -2 -4 -2 -3 -3 -1 -1 -4 -3 -1 -4 -4 -2 -5 
Q -1  1  0  0 -4  7  2 -2  1 -4 -3  2  0 -4 -1  0 -1 -2 -1 -3  0  4 -1 -5 
E -1  0  0  2 -4  2  7 -3 -1 -4 -4  1 -3 -4 -1  0 -1 -3 -2 -3  1  5 -1 -5 
G  0 -3  0 -2 -3 -2 -3  8 -2 -5 -5 -2 -3 -4 -3  0 -2 -3 -4 -4 -1 -3 -2 -5 
H -2  0  1 -1 -4  1 -1 -2 11 -4 -3  0 -2 -1 -3 -1 -2 -3  2 -4  0  0 -1 -5 
I -2 -4 -4 -4 -2 -4 -4 -5 -4  6  2 -4  2  0 -3 -3 -1 -3 -1  4 -4 -4 -1 -5 
L -2 -3 -4 -5 -2 -3 -4 -5 -3  2  6 -3  3  1 -4 -3 -2 -3 -1  1 -4 -3 -1 -5 
K -1  3  0 -1 -4  2  1 -2  0 -4 -3  6 -2 -4 -1  0 -1 -4 -2 -3  0  1 -1 -5 
M -1 -2 -3 -4 -2  0 -3 -3 -2  2  3 -2  8  0 -3 -2 -1 -2 -1  1 -3 -2 -1 -5 
F -3 -3 -4 -5 -3 -4 -4 -4 -1  0  1 -4  0  9 -5 -3 -3  2  4 -1 -5 -4 -2 -5 
P -1 -3 -2 -2 -3 -1 -1 -3 -3 -3 -4 -1 -3 -5 10 -1 -1 -5 -4 -3 -2 -1 -2 -5 
S  2 -1  1  0 -1  0  0  0 -1 -3 -3  0 -2 -3 -1  5  2 -4 -2 -2  0  0 -1 -5 
T  0 -1  0 -1 -1 -1 -1 -2 -2 -1 -2 -1 -1 -3 -1  2  6 -3 -2  0 -1 -1 -1 -5 
W -4 -3 -5 -5 -4 -2 -3 -3 -3 -3 -3 -4 -2  2 -5 -4 -3 15  3 -4 -5 -3 -3 -5 
Y -2 -2 -2 -3 -3 -1 -2 -4  2 -1 -1 -2 -1  4 -4 -2 -2  3  9 -2 -3 -2 -1 -5 
V  0 -3 -4 -4 -1 -3 -3 -4 -4  4  1 -3  1 -1 -3 -2  0 -4 -2  5 -4 -3 -1 -5 
B -2 -1  4  5 -4  0  1 -1  0 -4 -4  0 -3 -5 -2  0 -1 -5 -3 -4  5  2 -1 -5 
Z -1  0  0  1 -4  4  5 -3  0 -4 -3  1 -2 -4 -1  0 -1 -3 -2 -3  2  5 -1 -5 
X -1 -1 -1 -2 -2 -1 -1 -2 -1 -1 -1 -1 -1 -2 -2 -1 -1 -3 -1 -1 -1 -1 -1 -5 
* -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5  1

@@ BLOSUM60
#  Matrix made by matblas from blosum60.iij
#  * column uses minimum score
#  BLOSUM Clustered Scoring Matrix in 1/2 Bit Units
#  Blocks Database = /data/blocks_5.0/blocks.dat
#  Cluster Percentage: >= 60
#  Entropy =   0.6603, Expected =  -0.4917
   A  R  N  D  C  Q  E  G  H  I  L  K  M  F  P  S  T  W  Y  V  B  Z  X  *
A  4 -1 -1 -2  0 -1 -1  0 -2 -1 -1 -1 -1 -2 -1  1  0 -3 -2  0 -2 -1  0 -4 
R -1  5  0 -1 -3  1  0 -2  0 -3 -2  2 -1 -3 -2 -1 -1 -3 -2 -2 -1  0 -1 -4 
N -1  0  6  1 -2  0  0  0  1 -3 -3  0 -2 -3 -2  1  0 -4 -2 -3  3  0 -1 -4 
D -2 -1  1  6 -3  0  2 -1 -1 -3 -3 -1 -3 -3 -1  0 -1 -4 -3 -3  4  1 -1 -4 
C  0 -3 -2 -3  9 -3 -3 -2 -3 -1 -1 -3 -1 -2 -3 -1 -1 -2 -2 -1 -3 -3 -2 -4 
Q -1  1  0  0 -3  5  2 -2  1 -3 -2  1  0 -3 -1  0 -1 -2 -1 -2  0  3 -1 -4 
E -1  0  0  2 -3  2  5 -2  0 -3 -3  1 -2 -3 -1  0 -1 -3 -2 -2  1  4 -1 -4 
G  0 -2  0 -1 -2 -2 -2  6 -2 -3 -4 -1 -2 -3 -2  0 -2 -2 -3 -3 -1 -2 -1 -4 
H -2  0  1 -1 -3  1  0 -2  7 -3 -3 -1 -1 -1 -2 -1 -2 -2  2 -3  0  0 -1 -4 
I -1 -3 -3 -3 -1 -3 -3 -3 -3  4  2 -3  1  0 -3 -2 -1 -2 -1  3 -3 -3 -1 -4 
L -1 -2 -3 -3 -1 -2 -3 -4 -3  2  4 -2  2  0 -3 -2 -1 -2 -1  1 -3 -2 -1 -4 
K -1  2  0 -1 -3  1  1 -1 -1 -3 -2  4 -1 -3 -1  0 -1 -3 -2 -2  0  1 -1 -4 
M -1 -1 -2 -3 -1  0 -2 -2 -1  1  2 -1  5  0 -2 -1 -1 -1 -1  1 -3 -1 -1 -4 
F -2 -3 -3 -3 -2 -3 -3 -3 -1  0  0 -3  0  6 -4 -2 -2  1  3 -1 -3 -3 -1 -4 
P -1 -2 -2 -1 -3 -1 -1 -2 -2 -3 -3 -1 -2 -4  7 -1 -1 -4 -3 -2 -2 -1 -2 -4 
S  1 -1  1  0 -1  0  0  0 -1 -2 -2  0 -1 -2 -1  4  1 -3 -2 -2  0  0  0 -4 
T  0 -1  0 -1 -1 -1 -1 -2 -2 -1 -1 -1 -1 -2 -1  1  4 -2 -2  0  0 -1  0 -4 
W -3 -3 -4 -4 -2 -2 -3 -2 -2 -2 -2 -3 -1  1 -4 -3 -2 10  2 -3 -4 -2 -2 -4 
Y -2 -2 -2 -3 -2 -1 -2 -3  2 -1 -1 -2 -1  3 -3 -2 -2  2  6 -1 -2 -2 -1 -4 
V  0 -2 -3 -3 -1 -2 -2 -3 -3  3  1 -2  1 -1 -2 -2  0 -3 -1  4 -3 -2 -1 -4 
B -2 -1  3  4 -3  0  1 -1  0 -3 -3  0 -3 -3 -2  0  0 -4 -2 -3  4  1 -1 -4 
Z -1  0  0  1 -3  3  4 -2  0 -3 -2  1 -1 -3 -1  0 -1 -2 -2 -2  1  3 -1 -4 
X  0 -1 -1 -1 -2 -1 -1 -1 -1 -1 -1 -1 -1 -1 -2  0  0 -2 -1 -1 -1 -1 -1 -4 
* -4 -4 -4 -4 -4 -4 -4 -4 -4 -4 -4 -4 -4 -4 -4 -4 -4 -4 -4 -4 -4 -4 -4  1

@@ BLOSUM65
#  Matrix made by matblas from blosum65.iij
#  * column uses minimum score
#  BLOSUM Clustered Scoring Matrix in 1/2 Bit Units
#  Blocks Database = /data/blocks_5.0/blocks.dat
#  Cluster Percentage: >= 65
#  Entropy =   0.7576, Expected =  -0.5675
   A  R  N  D  C  Q  E  G  H  I  L  K  M  F  P  S  T  W  Y  V  B  Z  X  *
A  4 -1 -2 -2  0 -1 -1  0 -2 -1 -2 -1 -1 -2 -1  1  0 -3 -2  0 -2 -1 -1 -5 
R -1  6  0 -2 -4  1  0 -2  0 -3 -2  2 -2 -3 -2 -1 -1 -3 -2 -3 -1  0 -1 -5 
N -2  0  6  1 -3  0  0 -1  1 -3 -4  0 -2 -3 -2  1  0 -4 -2 -3  3  0 -1 -5 
D -2 -2  1  6 -4  0  2 -1 -1 -3 -4 -1 -3 -4 -2  0 -1 -5 -3 -3  4  1 -1 -5 
C  0 -4 -3 -4  9 -3 -4 -3 -3 -1 -1 -3 -2 -2 -3 -1 -1 -2 -2 -1 -3 -4 -2 -5 
Q -1  1  0  0 -3  6  2 -2  1 -3 -2  1  0 -3 -1  0 -1 -2 -2 -2  0  3 -1 -5 
E -1  0  0  2 -4  2  5 -2  0 -3 -3  1 -2 -3 -1  0 -1 -3 -2 -3  1  4 -1 -5 
G  0 -2 -1 -1 -3 -2 -2  6 -2 -4 -4 -2 -3 -3 -2  0 -2 -3 -3 -3 -1 -2 -2 -5 
H -2  0  1 -1 -3  1  0 -2  8 -3 -3 -1 -2 -1 -2 -1 -2 -2  2 -3  0  0 -1 -5 
I -1 -3 -3 -3 -1 -3 -3 -4 -3  4  2 -3  1  0 -3 -2 -1 -2 -1  3 -3 -3 -1 -5 
L -2 -2 -4 -4 -1 -2 -3 -4 -3  2  4 -3  2  0 -3 -3 -1 -2 -1  1 -4 -3 -1 -5 
K -1  2  0 -1 -3  1  1 -2 -1 -3 -3  5 -2 -3 -1  0 -1 -3 -2 -2  0  1 -1 -5 
M -1 -2 -2 -3 -2  0 -2 -3 -2  1  2 -2  6  0 -3 -2 -1 -2 -1  1 -3 -2 -1 -5 
F -2 -3 -3 -4 -2 -3 -3 -3 -1  0  0 -3  0  6 -4 -2 -2  1  3 -1 -3 -3 -2 -5 
P -1 -2 -2 -2 -3 -1 -1 -2 -2 -3 -3 -1 -3 -4  8 -1 -1 -4 -3 -2 -2 -1 -2 -5 
S  1 -1  1  0 -1  0  0  0 -1 -2 -3  0 -2 -2 -1  4  1 -3 -2 -2  0  0 -1 -5 
T  0 -1  0 -1 -1 -1 -1 -2 -2 -1 -1 -1 -1 -2 -1  1  5 -3 -2  0 -1 -1 -1 -5 
W -3 -3 -4 -5 -2 -2 -3 -3 -2 -2 -2 -3 -2  1 -4 -3 -3 10  2 -3 -4 -3 -2 -5 
Y -2 -2 -2 -3 -2 -2 -2 -3  2 -1 -1 -2 -1  3 -3 -2 -2  2  7 -1 -3 -2 -1 -5 
V  0 -3 -3 -3 -1 -2 -3 -3 -3  3  1 -2  1 -1 -2 -2  0 -3 -1  4 -3 -2 -1 -5 
B -2 -1  3  4 -3  0  1 -1  0 -3 -4  0 -3 -3 -2  0 -1 -4 -3 -3  4  1 -1 -5 
Z -1  0  0  1 -4  3  4 -2  0 -3 -3  1 -2 -3 -1  0 -1 -3 -2 -2  1  4 -1 -5 
X -1 -1 -1 -1 -2 -1 -1 -2 -1 -1 -1 -1 -1 -2 -2 -1 -1 -2 -1 -1 -1 -1 -1 -5 
* -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5  1

@@ BLOSUM70
#  Matrix made by matblas from blosum70.iij
#  * column uses minimum score
#  BLOSUM Clustered Scoring Matrix in 1/2 Bit Units
#  Blocks Database = /data/blocks_5.0/blocks.dat
#  Cluster Percentage: >= 70
#  Entropy =   0.8391, Expected =  -0.6313
   A  R  N  D  C  Q  E  G  H  I  L  K  M  F  P  S  T  W  Y  V  B  Z  X  *
A  4 -2 -2 -2 -1 -1 -1  0 -2 -2 -2 -1 -1 -2 -1  1  0 -3 -2  0 -2 -1 -1 -5 
R -2  6 -1 -2 -4  1  0 -3  0 -3 -3  2 -2 -3 -2 -1 -1 -3 -2 -3 -1  0 -1 -5 
N -2 -1  6  1 -3  0  0 -1  0 -4 -4  0 -2 -3 -2  0  0 -4 -2 -3  3  0 -1 -5 
D -2 -2  1  6 -4 -1  1 -2 -1 -4 -4 -1 -3 -4 -2  0 -1 -5 -4 -4  4  1 -2 -5 
C -1 -4 -3 -4  9 -3 -4 -3 -4 -1 -2 -4 -2 -2 -3 -1 -1 -3 -3 -1 -4 -4 -2 -5 
Q -1  1  0 -1 -3  6  2 -2  1 -3 -2  1  0 -3 -2  0 -1 -2 -2 -2  0  3 -1 -5 
E -1  0  0  1 -4  2  5 -2  0 -4 -3  1 -2 -4 -1  0 -1 -4 -3 -3  1  4 -1 -5 
G  0 -3 -1 -2 -3 -2 -2  6 -2 -4 -4 -2 -3 -4 -3 -1 -2 -3 -4 -4 -1 -2 -2 -5 
H -2  0  0 -1 -4  1  0 -2  8 -4 -3 -1 -2 -1 -2 -1 -2 -2  2 -3 -1  0 -1 -5 
I -2 -3 -4 -4 -1 -3 -4 -4 -4  4  2 -3  1  0 -3 -3 -1 -3 -1  3 -4 -3 -1 -5 
L -2 -3 -4 -4 -2 -2 -3 -4 -3  2  4 -3  2  0 -3 -3 -2 -2 -1  1 -4 -3 -1 -5 
K -1  2  0 -1 -4  1  1 -2 -1 -3 -3  5 -2 -3 -1  0 -1 -3 -2 -3 -1  1 -1 -5 
M -1 -2 -2 -3 -2  0 -2 -3 -2  1  2 -2  6  0 -3 -2 -1 -2 -1  1 -3 -2 -1 -5 
F -2 -3 -3 -4 -2 -3 -4 -4 -1  0  0 -3  0  6 -4 -3 -2  1  3 -1 -4 -4 -2 -5 
P -1 -2 -2 -2 -3 -2 -1 -3 -2 -3 -3 -1 -3 -4  8 -1 -1 -4 -3 -3 -2 -1 -2 -5 
S  1 -1  0  0 -1  0  0 -1 -1 -3 -3  0 -2 -3 -1  4  1 -3 -2 -2  0  0 -1 -5 
T  0 -1  0 -1 -1 -1 -1 -2 -2 -1 -2 -1 -1 -2 -1  1  5 -3 -2  0 -1 -1 -1 -5 
W -3 -3 -4 -5 -3 -2 -4 -3 -2 -3 -2 -3 -2  1 -4 -3 -3 11  2 -3 -4 -3 -3 -5 
Y -2 -2 -2 -4 -3 -2 -3 -4  2 -1 -1 -2 -1  3 -3 -2 -2  2  7 -2 -3 -2 -2 -5 
V  0 -3 -3 -4 -1 -2 -3 -4 -3  3  1 -3  1 -1 -3 -2  0 -3 -2  4 -3 -3 -1 -5 
B -2 -1  3  4 -4  0  1 -1 -1 -4 -4 -1 -3 -4 -2  0 -1 -4 -3 -3  4  0 -1 -5 
Z -1  0  0  1 -4  3  4 -2  0 -3 -3  1 -2 -4 -1  0 -1 -3 -2 -3  0  4 -1 -5 
X -1 -1 -1 -2 -2 -1 -1 -2 -1 -1 -1 -1 -1 -2 -2 -1 -1 -3 -2 -1 -1 -1 -1 -5 
* -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5  1

@@ BLOSUM75
#  Matrix made by matblas from blosum75.iij
#  * column uses minimum score
#  BLOSUM Clustered Scoring Matrix in 1/2 Bit Units
#  Blocks Database = /data/blocks_5.0/blocks.dat
#  Cluster Percentage: >= 75
#  Entropy =   0.9077, Expected =  -0.6845
   A  R  N  D  C  Q  E  G  H  I  L  K  M  F  P  S  T  W  Y  V  B  Z  X  *
A  4 -2 -2 -2 -1 -1 -1  0 -2 -2 -2 -1 -1 -3 -1  1  0 -3 -2  0 -2 -1 -1 -5 
R -2  6 -1 -2 -4  1  0 -3  0 -3 -3  2 -2 -3 -2 -1 -1 -3 -2 -3 -1  0 -1 -5 
N -2 -1  6  1 -3  0 -1 -1  0 -4 -4  0 -3 -4 -3  0  0 -4 -3 -3  3  0 -1 -5 
D -2 -2  1  6 -4 -1  1 -2 -1 -4 -4 -1 -4 -4 -2 -1 -1 -5 -4 -4  4  1 -2 -5 
C -1 -4 -3 -4  9 -3 -5 -3 -4 -1 -2 -4 -2 -2 -4 -1 -1 -3 -3 -1 -4 -4 -2 -5 
Q -1  1  0 -1 -3  6  2 -2  1 -3 -3  1  0 -4 -2  0 -1 -2 -2 -2  0  3 -1 -5 
E -1  0 -1  1 -5  2  5 -3  0 -4 -4  1 -2 -4 -1  0 -1 -4 -3 -3  1  4 -1 -5 
G  0 -3 -1 -2 -3 -2 -3  6 -2 -5 -4 -2 -3 -4 -3 -1 -2 -3 -4 -4 -1 -2 -2 -5 
H -2  0  0 -1 -4  1  0 -2  8 -4 -3 -1 -2 -2 -2 -1 -2 -2  2 -4 -1  0 -1 -5 
I -2 -3 -4 -4 -1 -3 -4 -5 -4  4  1 -3  1  0 -3 -3 -1 -3 -2  3 -4 -4 -2 -5 
L -2 -3 -4 -4 -2 -3 -4 -4 -3  1  4 -3  2  0 -3 -3 -2 -2 -1  1 -4 -3 -1 -5 
K -1  2  0 -1 -4  1  1 -2 -1 -3 -3  5 -2 -4 -1  0 -1 -4 -2 -3 -1  1 -1 -5 
M -1 -2 -3 -4 -2  0 -2 -3 -2  1  2 -2  6  0 -3 -2 -1 -2 -2  1 -3 -2 -1 -5 
F -3 -3 -4 -4 -2 -4 -4 -4 -2  0  0 -4  0  6 -4 -3 -2  1  3 -1 -4 -4 -2 -5 
P -1 -2 -3 -2 -4 -2 -1 -3 -2 -3 -3 -1 -3 -4  8 -1 -1 -5 -4 -3 -2 -2 -2 -5 
S  1 -1  0 -1 -1  0  0 -1 -1 -3 -3  0 -2 -3 -1  5  1 -3 -2 -2  0  0 -1 -5 
T  0 -1  0 -1 -1 -1 -1 -2 -2 -1 -2 -1 -1 -2 -1  1  5 -3 -2  0 -1 -1 -1 -5 
W -3 -3 -4 -5 -3 -2 -4 -3 -2 -3 -2 -4 -2  1 -5 -3 -3 11  2 -3 -5 -3 -3 -5 
Y -2 -2 -3 -4 -3 -2 -3 -4  2 -2 -1 -2 -2  3 -4 -2 -2  2  7 -2 -3 -3 -2 -5 
V  0 -3 -3 -4 -1 -2 -3 -4 -4  3  1 -3  1 -1 -3 -2  0 -3 -2  4 -4 -3 -1 -5 
B -2 -1  3  4 -4  0  1 -1 -1 -4 -4 -1 -3 -4 -2  0 -1 -5 -3 -4  4  0 -2 -5 
Z -1  0  0  1 -4  3  4 -2  0 -4 -3  1 -2 -4 -2  0 -1 -3 -3 -3  0  4 -1 -5 
X -1 -1 -1 -2 -2 -1 -1 -2 -1 -2 -1 -1 -1 -2 -2 -1 -1 -3 -2 -1 -2 -1 -1 -5 
* -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5 -5  1

@@ BLOSUM80
#  Matrix made by matblas from blosum80_3.iij
#  * column uses minimum score
#  BLOSUM Clustered Scoring Matrix in 1/3 Bit Units
#  Blocks Database = /data/blocks_5.0/blocks.dat
#  Cluster Percentage: >= 80
#  Entropy =   0.9868, Expected =  -0.7442
   A  R  N  D  C  Q  E  G  H  I  L  K  M  F  P  S  T  W  Y  V  B  Z  X  *
A  7 -3 -3 -3 -1 -2 -2  0 -3 -3 -3 -1 -2 -4 -1  2  0 -5 -4 -1 -3 -2 -1 -8 
R -3  9 -1 -3 -6  1 -1 -4  0 -5 -4  3 -3 -5 -3 -2 -2 -5 -4 -4 -2  0 -2 -8 
N -3 -1  9  2 -5  0 -1 -1  1 -6 -6  0 -4 -6 -4  1  0 -7 -4 -5  5 -1 -2 -8 
D -3 -3  2 10 -7 -1  2 -3 -2 -7 -7 -2 -6 -6 -3 -1 -2 -8 -6 -6  6  1 -3 -8 
C -1 -6 -5 -7 13 -5 -7 -6 -7 -2 -3 -6 -3 -4 -6 -2 -2 -5 -5 -2 -6 -7 -4 -8 
Q -2  1  0 -1 -5  9  3 -4  1 -5 -4  2 -1 -5 -3 -1 -1 -4 -3 -4 -1  5 -2 -8 
E -2 -1 -1  2 -7  3  8 -4  0 -6 -6  1 -4 -6 -2 -1 -2 -6 -5 -4  1  6 -2 -8 
G  0 -4 -1 -3 -6 -4 -4  9 -4 -7 -7 -3 -5 -6 -5 -1 -3 -6 -6 -6 -2 -4 -3 -8 
H -3  0  1 -2 -7  1  0 -4 12 -6 -5 -1 -4 -2 -4 -2 -3 -4  3 -5 -1  0 -2 -8 
I -3 -5 -6 -7 -2 -5 -6 -7 -6  7  2 -5  2 -1 -5 -4 -2 -5 -3  4 -6 -6 -2 -8 
L -3 -4 -6 -7 -3 -4 -6 -7 -5  2  6 -4  3  0 -5 -4 -3 -4 -2  1 -7 -5 -2 -8 
K -1  3  0 -2 -6  2  1 -3 -1 -5 -4  8 -3 -5 -2 -1 -1 -6 -4 -4 -1  1 -2 -8 
M -2 -3 -4 -6 -3 -1 -4 -5 -4  2  3 -3  9  0 -4 -3 -1 -3 -3  1 -5 -3 -2 -8 
F -4 -5 -6 -6 -4 -5 -6 -6 -2 -1  0 -5  0 10 -6 -4 -4  0  4 -2 -6 -6 -3 -8 
P -1 -3 -4 -3 -6 -3 -2 -5 -4 -5 -5 -2 -4 -6 12 -2 -3 -7 -6 -4 -4 -2 -3 -8 
S  2 -2  1 -1 -2 -1 -1 -1 -2 -4 -4 -1 -3 -4 -2  7  2 -6 -3 -3  0 -1 -1 -8 
T  0 -2  0 -2 -2 -1 -2 -3 -3 -2 -3 -1 -1 -4 -3  2  8 -5 -3  0 -1 -2 -1 -8 
W -5 -5 -7 -8 -5 -4 -6 -6 -4 -5 -4 -6 -3  0 -7 -6 -5 16  3 -5 -8 -5 -5 -8 
Y -4 -4 -4 -6 -5 -3 -5 -6  3 -3 -2 -4 -3  4 -6 -3 -3  3 11 -3 -5 -4 -3 -8 
V -1 -4 -5 -6 -2 -4 -4 -6 -5  4  1 -4  1 -2 -4 -3  0 -5 -3  7 -6 -4 -2 -8 
B -3 -2  5  6 -6 -1  1 -2 -1 -6 -7 -1 -5 -6 -4  0 -1 -8 -5 -6  6  0 -3 -8 
Z -2  0 -1  1 -7  5  6 -4  0 -6 -5  1 -3 -6 -2 -1 -2 -5 -4 -4  0  6 -1 -8 
X -1 -2 -2 -3 -4 -2 -2 -3 -2 -2 -2 -2 -2 -3 -3 -1 -1 -5 -3 -2 -3 -1 -2 -8 
* -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8  1

@@ BLOSUM85
#  Matrix made by matblas from blosum85.iij
#  * column uses minimum score
#  BLOSUM Clustered Scoring Matrix in 1/2 Bit Units
#  Blocks Database = /data/blocks_5.0/blocks.dat
#  Cluster Percentage: >= 85
#  Entropy =   1.0805, Expected =  -0.8153
   A  R  N  D  C  Q  E  G  H  I  L  K  M  F  P  S  T  W  Y  V  B  Z  X  *
A  5 -2 -2 -2 -1 -1 -1  0 -2 -2 -2 -1 -2 -3 -1  1  0 -3 -3 -1 -2 -1 -1 -6 
R -2  6 -1 -2 -4  1 -1 -3  0 -4 -3  2 -2 -4 -2 -1 -2 -4 -3 -3 -2  0 -2 -6 
N -2 -1  7  1 -4  0 -1 -1  0 -4 -4  0 -3 -4 -3  0  0 -5 -3 -4  4 -1 -2 -6 
D -2 -2  1  7 -5 -1  1 -2 -2 -5 -5 -1 -4 -4 -2 -1 -2 -6 -4 -4  4  1 -2 -6 
C -1 -4 -4 -5  9 -4 -5 -4 -5 -2 -2 -4 -2 -3 -4 -2 -2 -4 -3 -1 -4 -5 -3 -6 
Q -1  1  0 -1 -4  6  2 -3  1 -4 -3  1  0 -4 -2 -1 -1 -3 -2 -3 -1  4 -1 -6 
E -1 -1 -1  1 -5  2  6 -3 -1 -4 -4  0 -3 -4 -2 -1 -1 -4 -4 -3  0  4 -1 -6 
G  0 -3 -1 -2 -4 -3 -3  6 -3 -5 -5 -2 -4 -4 -3 -1 -2 -4 -5 -4 -1 -3 -2 -6 
H -2  0  0 -2 -5  1 -1 -3  8 -4 -3 -1 -3 -2 -3 -1 -2 -3  2 -4 -1  0 -2 -6 
I -2 -4 -4 -5 -2 -4 -4 -5 -4  5  1 -3  1 -1 -4 -3 -1 -3 -2  3 -5 -4 -2 -6 
L -2 -3 -4 -5 -2 -3 -4 -5 -3  1  4 -3  2  0 -4 -3 -2 -3 -2  0 -5 -4 -2 -6 
K -1  2  0 -1 -4  1  0 -2 -1 -3 -3  6 -2 -4 -2 -1 -1 -5 -3 -3 -1  1 -1 -6 
M -2 -2 -3 -4 -2  0 -3 -4 -3  1  2 -2  7 -1 -3 -2 -1 -2 -2  0 -4 -2 -1 -6 
F -3 -4 -4 -4 -3 -4 -4 -4 -2 -1  0 -4 -1  7 -4 -3 -3  0  3 -1 -4 -4 -2 -6 
P -1 -2 -3 -2 -4 -2 -2 -3 -3 -4 -4 -2 -3 -4  8 -1 -2 -5 -4 -3 -3 -2 -2 -6 
S  1 -1  0 -1 -2 -1 -1 -1 -1 -3 -3 -1 -2 -3 -1  5  1 -4 -2 -2  0 -1 -1 -6 
T  0 -2  0 -2 -2 -1 -1 -2 -2 -1 -2 -1 -1 -3 -2  1  5 -4 -2  0 -1 -1 -1 -6 
W -3 -4 -5 -6 -4 -3 -4 -4 -3 -3 -3 -5 -2  0 -5 -4 -4 11  2 -3 -5 -4 -3 -6 
Y -3 -3 -3 -4 -3 -2 -4 -5  2 -2 -2 -3 -2  3 -4 -2 -2  2  7 -2 -4 -3 -2 -6 
V -1 -3 -4 -4 -1 -3 -3 -4 -4  3  0 -3  0 -1 -3 -2  0 -3 -2  5 -4 -3 -1 -6 
B -2 -2  4  4 -4 -1  0 -1 -1 -5 -5 -1 -4 -4 -3  0 -1 -5 -4 -4  4  0 -2 -6 
Z -1  0 -1  1 -5  4  4 -3  0 -4 -4  1 -2 -4 -2 -1 -1 -4 -3 -3  0  4 -1 -6 
X -1 -2 -2 -2 -3 -1 -1 -2 -2 -2 -2 -1 -1 -2 -2 -1 -1 -3 -2 -1 -2 -1 -2 -6 
* -6 -6 -6 -6 -6 -6 -6 -6 -6 -6 -6 -6 -6 -6 -6 -6 -6 -6 -6 -6 -6 -6 -6  1

@@ BLOSUM90
#  Matrix made by matblas from blosum90.iij
#  * column uses minimum score
#  BLOSUM Clustered Scoring Matrix in 1/2 Bit Units
#  Blocks Database = /data/blocks_5.0/blocks.dat
#  Cluster Percentage: >= 90
#  Entropy =   1.1806, Expected =  -0.8887
   A  R  N  D  C  Q  E  G  H  I  L  K  M  F  P  S  T  W  Y  V  B  Z  X  *
A  5 -2 -2 -3 -1 -1 -1  0 -2 -2 -2 -1 -2 -3 -1  1  0 -4 -3 -1 -2 -1 -1 -6 
R -2  6 -1 -3 -5  1 -1 -3  0 -4 -3  2 -2 -4 -3 -1 -2 -4 -3 -3 -2  0 -2 -6 
N -2 -1  7  1 -4  0 -1 -1  0 -4 -4  0 -3 -4 -3  0  0 -5 -3 -4  4 -1 -2 -6 
D -3 -3  1  7 -5 -1  1 -2 -2 -5 -5 -1 -4 -5 -3 -1 -2 -6 -4 -5  4  0 -2 -6 
C -1 -5 -4 -5  9 -4 -6 -4 -5 -2 -2 -4 -2 -3 -4 -2 -2 -4 -4 -2 -4 -5 -3 -6 
Q -1  1  0 -1 -4  7  2 -3  1 -4 -3  1  0 -4 -2 -1 -1 -3 -3 -3 -1  4 -1 -6 
E -1 -1 -1  1 -6  2  6 -3 -1 -4 -4  0 -3 -5 -2 -1 -1 -5 -4 -3  0  4 -2 -6 
G  0 -3 -1 -2 -4 -3 -3  6 -3 -5 -5 -2 -4 -5 -3 -1 -3 -4 -5 -5 -2 -3 -2 -6 
H -2  0  0 -2 -5  1 -1 -3  8 -4 -4 -1 -3 -2 -3 -2 -2 -3  1 -4 -1  0 -2 -6 
I -2 -4 -4 -5 -2 -4 -4 -5 -4  5  1 -4  1 -1 -4 -3 -1 -4 -2  3 -5 -4 -2 -6 
L -2 -3 -4 -5 -2 -3 -4 -5 -4  1  5 -3  2  0 -4 -3 -2 -3 -2  0 -5 -4 -2 -6 
K -1  2  0 -1 -4  1  0 -2 -1 -4 -3  6 -2 -4 -2 -1 -1 -5 -3 -3 -1  1 -1 -6 
M -2 -2 -3 -4 -2  0 -3 -4 -3  1  2 -2  7 -1 -3 -2 -1 -2 -2  0 -4 -2 -1 -6 
F -3 -4 -4 -5 -3 -4 -5 -5 -2 -1  0 -4 -1  7 -4 -3 -3  0  3 -2 -4 -4 -2 -6 
P -1 -3 -3 -3 -4 -2 -2 -3 -3 -4 -4 -2 -3 -4  8 -2 -2 -5 -4 -3 -3 -2 -2 -6 
S  1 -1  0 -1 -2 -1 -1 -1 -2 -3 -3 -1 -2 -3 -2  5  1 -4 -3 -2  0 -1 -1 -6 
T  0 -2  0 -2 -2 -1 -1 -3 -2 -1 -2 -1 -1 -3 -2  1  6 -4 -2 -1 -1 -1 -1 -6 
W -4 -4 -5 -6 -4 -3 -5 -4 -3 -4 -3 -5 -2  0 -5 -4 -4 11  2 -3 -6 -4 -3 -6 
Y -3 -3 -3 -4 -4 -3 -4 -5  1 -2 -2 -3 -2  3 -4 -3 -2  2  8 -3 -4 -3 -2 -6 
V -1 -3 -4 -5 -2 -3 -3 -5 -4  3  0 -3  0 -2 -3 -2 -1 -3 -3  5 -4 -3 -2 -6 
B -2 -2  4  4 -4 -1  0 -2 -1 -5 -5 -1 -4 -4 -3  0 -1 -6 -4 -4  4  0 -2 -6 
Z -1  0 -1  0 -5  4  4 -3  0 -4 -4  1 -2 -4 -2 -1 -1 -4 -3 -3  0  4 -1 -6 
X -1 -2 -2 -2 -3 -1 -2 -2 -2 -2 -2 -1 -1 -2 -2 -1 -1 -3 -2 -2 -2 -1 -2 -6 
* -6 -6 -6 -6 -6 -6 -6 -6 -6 -6 -6 -6 -6 -6 -6 -6 -6 -6 -6 -6 -6 -6 -6  1

@@ PAM10
#
# This matrix was produced by "pam" Version 1.0.6 [28-Jul-93]
#
# PAM 10 substitution matrix, scale = ln(2)/2 = 0.346574
#
# Expected score = -8.27, Entropy = 3.43 bits
#
# Lowest score = -23, Highest score = 13
#
    A   R   N   D   C   Q   E   G   H   I   L   K   M   F   P   S   T   W   Y   V   B   Z   X   *
A   7 -10  -7  -6 -10  -7  -5  -4 -11  -8  -9 -10  -8 -12  -4  -3  -3 -20 -11  -5  -6  -6  -6 -23
R -10   9  -9 -17 -11  -4 -15 -13  -4  -8 -12  -2  -7 -12  -7  -6 -10  -5 -14 -11 -11  -7  -9 -23
N  -7  -9   9  -1 -17  -7  -5  -6  -2  -8 -10  -4 -15 -12  -9  -2  -5 -11  -7 -12   7  -6  -6 -23
D  -6 -17  -1   8 -21  -6   0  -6  -7 -11 -19  -8 -17 -21 -12  -7  -8 -21 -17 -11   7  -1  -9 -23
C -10 -11 -17 -21  10 -20 -20 -13 -10  -9 -21 -20 -20 -19 -11  -6 -11 -22  -7  -9 -18 -20 -13 -23
Q  -7  -4  -7  -6 -20   9  -1 -10  -2 -11  -8  -6  -7 -19  -6  -8  -9 -19 -18 -10  -6   7  -8 -23
E  -5 -15  -5   0 -20  -1   8  -7  -9  -8 -13  -7 -10 -20  -9  -7  -9 -23 -11 -10  -1   7  -8 -23
G  -4 -13  -6  -6 -13 -10  -7   7 -13 -17 -14 -10 -12 -12 -10  -4 -10 -21 -20  -9  -6  -8  -8 -23
H -11  -4  -2  -7 -10  -2  -9 -13  10 -13  -9 -10 -17  -9  -7  -9 -11 -10  -6  -9  -4  -4  -8 -23
I  -8  -8  -8 -11  -9 -11  -8 -17 -13   9  -4  -9  -3  -5 -12 -10  -5 -20  -9  -1  -9  -9  -8 -23
L  -9 -12 -10 -19 -21  -8 -13 -14  -9  -4   7 -11  -2  -5 -10 -12 -10  -9 -10  -5 -12 -10  -9 -23
K -10  -2  -4  -8 -20  -6  -7 -10 -10  -9 -11   7  -4 -20 -10  -7  -6 -18 -12 -13  -5  -6  -8 -23
M  -8  -7 -15 -17 -20  -7 -10 -12 -17  -3  -2  -4  12  -7 -11  -8  -7 -19 -17  -4 -16  -8  -9 -23
F -12 -12 -12 -21 -19 -19 -20 -12  -9  -5  -5 -20  -7   9 -13  -9 -12  -7  -1 -12 -14 -20 -12 -23
P  -4  -7  -9 -12 -11  -6  -9 -10  -7 -12 -10 -10 -11 -13   8  -4  -7 -20 -20  -9 -10  -7  -8 -23
S  -3  -6  -2  -7  -6  -8  -7  -4  -9 -10 -12  -7  -8  -9  -4   7  -2  -8 -10 -10  -4  -8  -6 -23
T  -3 -10  -5  -8 -11  -9  -9 -10 -11  -5 -10  -6  -7 -12  -7  -2   8 -19  -9  -6  -6  -9  -7 -23
W -20  -5 -11 -21 -22 -19 -23 -21 -10 -20  -9 -18 -19  -7 -20  -8 -19  13  -8 -22 -13 -21 -16 -23
Y -11 -14  -7 -17  -7 -18 -11 -20  -6  -9 -10 -12 -17  -1 -20 -10  -9  -8  10 -10  -9 -13 -11 -23
V  -5 -11 -12 -11  -9 -10 -10  -9  -9  -1  -5 -13  -4 -12  -9 -10  -6 -22 -10   8 -11 -10  -8 -23
B  -6 -11   7   7 -18  -6  -1  -6  -4  -9 -12  -5 -16 -14 -10  -4  -6 -13  -9 -11   7  -3  -8 -23
Z  -6  -7  -6  -1 -20   7   7  -8  -4  -9 -10  -6  -8 -20  -7  -8  -9 -21 -13 -10  -3   7  -8 -23
X  -6  -9  -6  -9 -13  -8  -8  -8  -8  -8  -9  -8  -9 -12  -8  -6  -7 -16 -11  -8  -8  -8  -8 -23
* -23 -23 -23 -23 -23 -23 -23 -23 -23 -23 -23 -23 -23 -23 -23 -23 -23 -23 -23 -23 -23 -23 -23   1

@@ PAM20
#
# This matrix was produced by "pam" Version 1.0.6 [28-Jul-93]
#
# PAM 20 substitution matrix, scale = ln(2)/2 = 0.346574
#
# Expected score = -6.18, Entropy = 2.95 bits
#
# Lowest score = -19, Highest score = 13
#
    A   R   N   D   C   Q   E   G   H   I   L   K   M   F   P   S   T   W   Y   V   B   Z   X   *
A   6  -8  -5  -4  -8  -5  -3  -3  -8  -6  -7  -8  -6  -9  -2  -1  -1 -16  -9  -3  -5  -4  -4 -19
R  -8   9  -7 -12  -9  -2 -11 -11  -3  -6 -10  -1  -5 -10  -5  -4  -8  -3 -11  -9  -9  -5  -7 -19
N  -5  -7   8   1 -13  -5  -3  -4  -1  -6  -8  -2 -11 -10  -7  -1  -3  -9  -5  -9   6  -4  -4 -19
D  -4 -12   1   8 -16  -4   2  -4  -5  -9 -15  -6 -13 -17  -9  -5  -6 -17 -13  -9   6   0  -7 -19
C  -8  -9 -13 -16  10 -16 -16 -11  -8  -7 -17 -16 -16 -15  -9  -4  -9 -18  -5  -7 -14 -16 -11 -19
Q  -5  -2  -5  -4 -16   9   0  -8   0  -9  -6  -4  -5 -15  -4  -6  -7 -15 -14  -8  -4   7  -6 -19
E  -3 -11  -3   2 -16   0   8  -5  -6  -6 -10  -5  -8 -16  -7  -5  -7 -19  -9  -8   0   6  -6 -19
G  -3 -11  -4  -4 -11  -8  -5   7 -10 -13 -12  -8 -10 -10  -7  -3  -7 -17 -16  -7  -4  -6  -6 -19
H  -8  -3  -1  -5  -8   0  -6 -10   9 -11  -7  -8 -13  -7  -5  -7  -8  -8  -4  -7  -2  -2  -6 -19
I  -6  -6  -6  -9  -7  -9  -6 -13 -11   9  -2  -7  -2  -3 -10  -8  -3 -16  -7   1  -7  -7  -6 -19
L  -7 -10  -8 -15 -17  -6 -10 -12  -7  -2   7  -9   0  -4  -8  -9  -8  -7  -8  -3 -10  -8  -7 -19
K  -8  -1  -2  -6 -16  -4  -5  -8  -8  -7  -9   7  -3 -16  -8  -5  -4 -14 -10 -10  -3  -5  -6 -19
M  -6  -5 -11 -13 -16  -5  -8 -10 -13  -2   0  -3  11  -5  -9  -6  -5 -15 -13  -2 -12  -6  -6 -19
F  -9 -10 -10 -17 -15 -15 -16 -10  -7  -3  -4 -16  -5   9 -11  -7 -10  -6   1  -9 -12 -16  -9 -19
P  -2  -5  -7  -9  -9  -4  -7  -7  -5 -10  -8  -8  -9 -11   8  -3  -5 -16 -16  -7  -8  -5  -6 -19
S  -1  -4  -1  -5  -4  -6  -5  -3  -7  -8  -9  -5  -6  -7  -3   7   0  -6  -8  -8  -2  -6  -4 -19
T  -1  -8  -3  -6  -9  -7  -7  -7  -8  -3  -8  -4  -5 -10  -5   0   7 -15  -7  -4  -4  -7  -5 -19
W -16  -3  -9 -17 -18 -15 -19 -17  -8 -16  -7 -14 -15  -6 -16  -6 -15  13  -6 -18 -11 -17 -13 -19
Y  -9 -11  -5 -13  -5 -14  -9 -16  -4  -7  -8 -10 -13   1 -16  -8  -7  -6  10  -8  -7 -11  -9 -19
V  -3  -9  -9  -9  -7  -8  -8  -7  -7   1  -3 -10  -2  -9  -7  -8  -4 -18  -8   7  -9  -8  -6 -19
B  -5  -9   6   6 -14  -4   0  -4  -2  -7 -10  -3 -12 -12  -8  -2  -4 -11  -7  -9   6  -1  -6 -19
Z  -4  -5  -4   0 -16   7   6  -6  -2  -7  -8  -5  -6 -16  -5  -6  -7 -17 -11  -8  -1   6  -6 -19
X  -4  -7  -4  -7 -11  -6  -6  -6  -6  -6  -7  -6  -6  -9  -6  -4  -5 -13  -9  -6  -6  -6  -6 -19
* -19 -19 -19 -19 -19 -19 -19 -19 -19 -19 -19 -19 -19 -19 -19 -19 -19 -19 -19 -19 -19 -19 -19   1

@@ PAM30
#
# This matrix was produced by "pam" Version 1.0.6 [28-Jul-93]
#
# PAM 30 substitution matrix, scale = ln(2)/2 = 0.346574
#
# Expected score = -5.06, Entropy = 2.57 bits
#
# Lowest score = -17, Highest score = 13
#
    A   R   N   D   C   Q   E   G   H   I   L   K   M   F   P   S   T   W   Y   V   B   Z   X   *
A   6  -7  -4  -3  -6  -4  -2  -2  -7  -5  -6  -7  -5  -8  -2   0  -1 -13  -8  -2  -3  -3  -3 -17
R  -7   8  -6 -10  -8  -2  -9  -9  -2  -5  -8   0  -4  -9  -4  -3  -6  -2 -10  -8  -7  -4  -6 -17
N  -4  -6   8   2 -11  -3  -2  -3   0  -5  -7  -1  -9  -9  -6   0  -2  -8  -4  -8   6  -3  -3 -17
D  -3 -10   2   8 -14  -2   2  -3  -4  -7 -12  -4 -11 -15  -8  -4  -5 -15 -11  -8   6   1  -5 -17
C  -6  -8 -11 -14  10 -14 -14  -9  -7  -6 -15 -14 -13 -13  -8  -3  -8 -15  -4  -6 -12 -14  -9 -17
Q  -4  -2  -3  -2 -14   8   1  -7   1  -8  -5  -3  -4 -13  -3  -5  -5 -13 -12  -7  -3   6  -5 -17
E  -2  -9  -2   2 -14   1   8  -4  -5  -5  -9  -4  -7 -14  -5  -4  -6 -17  -8  -6   1   6  -5 -17
G  -2  -9  -3  -3  -9  -7  -4   6  -9 -11 -10  -7  -8  -9  -6  -2  -6 -15 -14  -5  -3  -5  -5 -17
H  -7  -2   0  -4  -7   1  -5  -9   9  -9  -6  -6 -10  -6  -4  -6  -7  -7  -3  -6  -1  -1  -5 -17
I  -5  -5  -5  -7  -6  -8  -5 -11  -9   8  -1  -6  -1  -2  -8  -7  -2 -14  -6   2  -6  -6  -5 -17
L  -6  -8  -7 -12 -15  -5  -9 -10  -6  -1   7  -8   1  -3  -7  -8  -7  -6  -7  -2  -9  -7  -6 -17
K  -7   0  -1  -4 -14  -3  -4  -7  -6  -6  -8   7  -2 -14  -6  -4  -3 -12  -9  -9  -2  -4  -5 -17
M  -5  -4  -9 -11 -13  -4  -7  -8 -10  -1   1  -2  11  -4  -8  -5  -4 -13 -11  -1 -10  -5  -5 -17
F  -8  -9  -9 -15 -13 -13 -14  -9  -6  -2  -3 -14  -4   9 -10  -6  -9  -4   2  -8 -10 -13  -8 -17
P  -2  -4  -6  -8  -8  -3  -5  -6  -4  -8  -7  -6  -8 -10   8  -2  -4 -14 -13  -6  -7  -4  -5 -17
S   0  -3   0  -4  -3  -5  -4  -2  -6  -7  -8  -4  -5  -6  -2   6   0  -5  -7  -6  -1  -5  -3 -17
T  -1  -6  -2  -5  -8  -5  -6  -6  -7  -2  -7  -3  -4  -9  -4   0   7 -13  -6  -3  -3  -6  -4 -17
W -13  -2  -8 -15 -15 -13 -17 -15  -7 -14  -6 -12 -13  -4 -14  -5 -13  13  -5 -15 -10 -14 -11 -17
Y  -8 -10  -4 -11  -4 -12  -8 -14  -3  -6  -7  -9 -11   2 -13  -7  -6  -5  10  -7  -6  -9  -7 -17
V  -2  -8  -8  -8  -6  -7  -6  -5  -6   2  -2  -9  -1  -8  -6  -6  -3 -15  -7   7  -8  -6  -5 -17
B  -3  -7   6   6 -12  -3   1  -3  -1  -6  -9  -2 -10 -10  -7  -1  -3 -10  -6  -8   6   0  -5 -17
Z  -3  -4  -3   1 -14   6   6  -5  -1  -6  -7  -4  -5 -13  -4  -5  -6 -14  -9  -6   0   6  -5 -17
X  -3  -6  -3  -5  -9  -5  -5  -5  -5  -5  -6  -5  -5  -8  -5  -3  -4 -11  -7  -5  -5  -5  -5 -17
* -17 -17 -17 -17 -17 -17 -17 -17 -17 -17 -17 -17 -17 -17 -17 -17 -17 -17 -17 -17 -17 -17 -17   1

@@ PAM40
#
# This matrix was produced by "pam" Version 1.0.6 [28-Jul-93]
#
# PAM 40 substitution matrix, scale = ln(2)/2 = 0.346574
#
# Expected score = -4.27, Entropy = 2.26 bits
#
# Lowest score = -15, Highest score = 13
#
    A   R   N   D   C   Q   E   G   H   I   L   K   M   F   P   S   T   W   Y   V   B   Z   X   *
A   6  -6  -3  -3  -6  -3  -2  -1  -6  -4  -5  -6  -4  -7  -1   0   0 -12  -7  -2  -3  -2  -3 -15
R  -6   8  -5  -9  -7  -1  -8  -8  -1  -5  -8   1  -3  -8  -3  -2  -5  -1  -9  -7  -6  -3  -5 -15
N  -3  -5   7   2  -9  -3  -1  -2   1  -4  -6   0  -7  -8  -5   0  -1  -7  -4  -7   6  -2  -3 -15
D  -3  -9   2   7 -12  -2   3  -3  -3  -6 -11  -4  -9 -13  -7  -3  -4 -13 -10  -7   6   2  -5 -15
C  -6  -7  -9 -12   9 -12 -12  -8  -7  -5 -13 -12 -12 -11  -7  -2  -7 -14  -3  -5 -11 -12  -8 -15
Q  -3  -1  -3  -2 -12   8   2  -6   1  -7  -4  -2  -3 -11  -2  -4  -5 -11 -10  -6  -2   6  -4 -15
E  -2  -8  -1   3 -12   2   7  -3  -4  -5  -8  -4  -6 -12  -5  -4  -5 -15  -8  -6   2   6  -4 -15
G  -1  -8  -2  -3  -8  -6  -3   6  -8  -9  -9  -6  -7  -8  -5  -1  -5 -13 -12  -5  -2  -4  -4 -15
H  -6  -1   1  -3  -7   1  -4  -8   9  -8  -5  -5  -9  -5  -3  -5  -6  -6  -3  -6  -1   0  -4 -15
I  -4  -5  -4  -6  -5  -7  -5  -9  -8   8  -1  -5   0  -2  -7  -6  -2 -12  -5   2  -5  -5  -4 -15
L  -5  -8  -6 -11 -13  -4  -8  -9  -5  -1   7  -7   1  -2  -6  -7  -6  -5  -6  -2  -8  -6  -5 -15
K  -6   1   0  -4 -12  -2  -4  -6  -5  -5  -7   6  -1 -12  -6  -3  -2 -10  -8  -8  -2  -3  -4 -15
M  -4  -3  -7  -9 -12  -3  -6  -7  -9   0   1  -1  11  -3  -7  -5  -3 -11 -10  -1  -8  -4  -4 -15
F  -7  -8  -8 -13 -11 -11 -12  -8  -5  -2  -2 -12  -3   9  -9  -6  -8  -4   2  -7  -9 -12  -7 -15
P  -1  -3  -5  -7  -7  -2  -5  -5  -3  -7  -6  -6  -7  -9   8  -1  -3 -12 -12  -5  -6  -3  -4 -15
S   0  -2   0  -3  -2  -4  -4  -1  -5  -6  -7  -3  -5  -6  -1   6   1  -4  -6  -5  -1  -4  -2 -15
T   0  -5  -1  -4  -7  -5  -5  -5  -6  -2  -6  -2  -3  -8  -3   1   7 -11  -6  -2  -2  -5  -3 -15
W -12  -1  -7 -13 -14 -11 -15 -13  -6 -12  -5 -10 -11  -4 -12  -4 -11  13  -4 -14  -9 -13  -9 -15
Y  -7  -9  -4 -10  -3 -10  -8 -12  -3  -5  -6  -8 -10   2 -12  -6  -6  -4  10  -6  -6  -8  -7 -15
V  -2  -7  -7  -7  -5  -6  -6  -5  -6   2  -2  -8  -1  -7  -5  -5  -2 -14  -6   7  -7  -6  -4 -15
B  -3  -6   6   6 -11  -2   2  -2  -1  -5  -8  -2  -8  -9  -6  -1  -2  -9  -6  -7   6   1  -4 -15
Z  -2  -3  -2   2 -12   6   6  -4   0  -5  -6  -3  -4 -12  -3  -4  -5 -13  -8  -6   1   6  -4 -15
X  -3  -5  -3  -5  -8  -4  -4  -4  -4  -4  -5  -4  -4  -7  -4  -2  -3  -9  -7  -4  -4  -4  -4 -15
* -15 -15 -15 -15 -15 -15 -15 -15 -15 -15 -15 -15 -15 -15 -15 -15 -15 -15 -15 -15 -15 -15 -15   1

@@ PAM50
#
# This matrix was produced by "pam" Version 1.0.6 [28-Jul-93]
#
# PAM 50 substitution matrix, scale = ln(2)/2 = 0.346574
#
# Expected score = -3.70, Entropy = 2.00 bits
#
# Lowest score = -13, Highest score = 13
#
    A   R   N   D   C   Q   E   G   H   I   L   K   M   F   P   S   T   W   Y   V   B   Z   X   *
A   5  -5  -2  -2  -5  -3  -1  -1  -5  -3  -5  -5  -4  -7   0   0   0 -11  -6  -1  -2  -2  -2 -13
R  -5   8  -4  -7  -6   0  -7  -7   0  -4  -7   1  -3  -8  -3  -2  -5  -1  -8  -6  -5  -2  -4 -13
N  -2  -4   7   2  -8  -2  -1  -2   1  -4  -6   0  -6  -7  -4   1  -1  -7  -3  -6   5  -1  -2 -13
D  -2  -7   2   7 -11  -1   3  -2  -2  -6 -10  -3  -8 -12  -6  -2  -3 -12  -9  -6   6   2  -4 -13
C  -5  -6  -8 -11   9 -11 -11  -7  -6  -5 -12 -11 -11 -10  -6  -2  -6 -13  -3  -5  -9 -11  -7 -13
Q  -3   0  -2  -1 -11   8   2  -5   2  -6  -4  -2  -3 -10  -2  -4  -4 -10  -9  -5  -2   6  -3 -13
E  -1  -7  -1   3 -11   2   7  -3  -3  -4  -7  -3  -5 -11  -4  -3  -4 -13  -7  -5   2   6  -3 -13
G  -1  -7  -2  -2  -7  -5  -3   6  -7  -8  -9  -6  -7  -8  -4  -1  -4 -12 -11  -4  -2  -4  -4 -13
H  -5   0   1  -2  -6   2  -3  -7   9  -7  -5  -4  -8  -5  -3  -4  -5  -6  -2  -5   0   0  -4 -13
I  -3  -4  -4  -6  -5  -6  -4  -8  -7   8   0  -5   0  -1  -7  -5  -1 -11  -5   3  -5  -5  -3 -13
L  -5  -7  -6 -10 -12  -4  -7  -9  -5   0   6  -6   2  -1  -6  -7  -5  -5  -5  -1  -7  -5  -5 -13
K  -5   1   0  -3 -11  -2  -3  -6  -4  -5  -6   6  -1 -11  -5  -3  -2  -9  -8  -7  -1  -2  -4 -13
M  -4  -3  -6  -8 -11  -3  -5  -7  -8   0   2  -1  10  -3  -6  -4  -3 -10  -8   0  -7  -4  -4 -13
F  -7  -8  -7 -12 -10 -10 -11  -8  -5  -1  -1 -11  -3   9  -8  -5  -7  -3   3  -6  -9 -11  -6 -13
P   0  -3  -4  -6  -6  -2  -4  -4  -3  -7  -6  -5  -6  -8   8  -1  -3 -11 -11  -4  -5  -3  -4 -13
S   0  -2   1  -2  -2  -4  -3  -1  -4  -5  -7  -3  -4  -5  -1   6   1  -4  -5  -4  -1  -3  -2 -13
T   0  -5  -1  -3  -6  -4  -4  -4  -5  -1  -5  -2  -3  -7  -3   1   6 -10  -5  -2  -2  -4  -2 -13
W -11  -1  -7 -12 -13 -10 -13 -12  -6 -11  -5  -9 -10  -3 -11  -4 -10  13  -4 -12  -8 -11  -9 -13
Y  -6  -8  -3  -9  -3  -9  -7 -11  -2  -5  -5  -8  -8   3 -11  -5  -5  -4   9  -6  -5  -8  -6 -13
V  -1  -6  -6  -6  -5  -5  -5  -4  -5   3  -1  -7   0  -6  -4  -4  -2 -12  -6   7  -6  -5  -3 -13
B  -2  -5   5   6  -9  -2   2  -2   0  -5  -7  -1  -7  -9  -5  -1  -2  -8  -5  -6   5   1  -3 -13
Z  -2  -2  -1   2 -11   6   6  -4   0  -5  -5  -2  -4 -11  -3  -3  -4 -11  -8  -5   1   6  -3 -13
X  -2  -4  -2  -4  -7  -3  -3  -4  -4  -3  -5  -4  -4  -6  -4  -2  -2  -9  -6  -3  -3  -3  -4 -13
* -13 -13 -13 -13 -13 -13 -13 -13 -13 -13 -13 -13 -13 -13 -13 -13 -13 -13 -13 -13 -13 -13 -13   1

@@ PAM60
#
# This matrix was produced by "pam" Version 1.0.6 [28-Jul-93]
#
# PAM 60 substitution matrix, scale = ln(2)/2 = 0.346574
#
# Expected score = -3.21, Entropy = 1.79 bits
#
# Lowest score = -12, Highest score = 13
#
    A   R   N   D   C   Q   E   G   H   I   L   K   M   F   P   S   T   W   Y   V   B   Z   X   *
A   5  -5  -2  -2  -5  -3  -1   0  -5  -3  -4  -5  -3  -6   0   1   1 -10  -6  -1  -2  -2  -2 -12
R  -5   8  -3  -6  -6   0  -6  -7   0  -4  -6   2  -2  -7  -2  -2  -4   0  -8  -5  -5  -2  -4 -12
N  -2  -3   6   2  -7  -2   0  -1   1  -4  -5   0  -6  -6  -4   1  -1  -6  -3  -5   5  -1  -2 -12
D  -2  -6   2   7 -10  -1   3  -2  -2  -5  -9  -2  -7 -11  -5  -2  -3 -11  -8  -6   5   2  -3 -12
C  -5  -6  -7 -10   9 -10 -10  -7  -6  -4 -11 -10 -10  -9  -6  -1  -5 -12  -2  -4  -9 -10  -6 -12
Q  -3   0  -2  -1 -10   7   2  -5   2  -5  -3  -1  -2  -9  -1  -3  -4  -9  -8  -5  -1   6  -3 -12
E  -1  -6   0   3 -10   2   7  -2  -3  -4  -7  -3  -5 -10  -3  -2  -4 -12  -7  -4   2   5  -3 -12
G   0  -7  -1  -2  -7  -5  -2   6  -6  -7  -8  -5  -6  -7  -4   0  -3 -11 -10  -4  -2  -3  -3 -12
H  -5   0   1  -2  -6   2  -3  -6   8  -6  -4  -4  -7  -4  -2  -4  -5  -5  -2  -5   0   0  -3 -12
I  -3  -4  -4  -5  -4  -5  -4  -7  -6   7   0  -4   1  -1  -6  -4  -1 -10  -4   3  -4  -4  -3 -12
L  -4  -6  -5  -9 -11  -3  -7  -8  -4   0   6  -6   2  -1  -5  -6  -5  -4  -5  -1  -7  -5  -4 -12
K  -5   2   0  -2 -10  -1  -3  -5  -4  -4  -6   6   0 -10  -4  -2  -2  -8  -7  -6  -1  -2  -3 -12
M  -3  -2  -6  -7 -10  -2  -5  -6  -7   1   2   0  10  -2  -6  -4  -2  -9  -7   0  -6  -4  -3 -12
F  -6  -7  -6 -11  -9  -9 -10  -7  -4  -1  -1 -10  -2   8  -7  -5  -6  -3   3  -5  -8 -10  -5 -12
P   0  -2  -4  -5  -6  -1  -3  -4  -2  -6  -5  -4  -6  -7   7   0  -2 -10 -10  -4  -4  -2  -3 -12
S   1  -2   1  -2  -1  -3  -2   0  -4  -4  -6  -2  -4  -5   0   5   1  -4  -5  -4   0  -3  -2 -12
T   1  -4  -1  -3  -5  -4  -4  -3  -5  -1  -5  -2  -2  -6  -2   1   6  -9  -5  -1  -2  -4  -2 -12
W -10   0  -6 -11 -12  -9 -12 -11  -5 -10  -4  -8  -9  -3 -10  -4  -9  13  -3 -11  -8 -11  -8 -12
Y  -6  -8  -3  -8  -2  -8  -7 -10  -2  -4  -5  -7  -7   3 -10  -5  -5  -3   9  -5  -5  -7  -5 -12
V  -1  -5  -5  -6  -4  -5  -4  -4  -5   3  -1  -6   0  -5  -4  -4  -1 -11  -5   6  -5  -5  -3 -12
B  -2  -5   5   5  -9  -1   2  -2   0  -4  -7  -1  -6  -8  -4   0  -2  -8  -5  -5   5   1  -3 -12
Z  -2  -2  -1   2 -10   6   5  -3   0  -4  -5  -2  -4 -10  -2  -3  -4 -11  -7  -5   1   5  -3 -12
X  -2  -4  -2  -3  -6  -3  -3  -3  -3  -3  -4  -3  -3  -5  -3  -2  -2  -8  -5  -3  -3  -3  -3 -12
* -12 -12 -12 -12 -12 -12 -12 -12 -12 -12 -12 -12 -12 -12 -12 -12 -12 -12 -12 -12 -12 -12 -12   1

@@ PAM70
#
# This matrix was produced by "pam" Version 1.0.6 [28-Jul-93]
#
# PAM 70 substitution matrix, scale = ln(2)/2 = 0.346574
#
# Expected score = -2.77, Entropy = 1.60 bits
#
# Lowest score = -11, Highest score = 13
#
    A   R   N   D   C   Q   E   G   H   I   L   K   M   F   P   S   T   W   Y   V   B   Z   X   *
A   5  -4  -2  -1  -4  -2  -1   0  -4  -2  -4  -4  -3  -6   0   1   1  -9  -5  -1  -1  -1  -2 -11
R  -4   8  -3  -6  -5   0  -5  -6   0  -3  -6   2  -2  -7  -2  -1  -4   0  -7  -5  -4  -2  -3 -11
N  -2  -3   6   3  -7  -1   0  -1   1  -3  -5   0  -5  -6  -3   1   0  -6  -3  -5   5  -1  -2 -11
D  -1  -6   3   6  -9   0   3  -1  -1  -5  -8  -2  -7 -10  -4  -1  -2 -10  -7  -5   5   2  -3 -11
C  -4  -5  -7  -9   9  -9  -9  -6  -5  -4 -10  -9  -9  -8  -5  -1  -5 -11  -2  -4  -8  -9  -6 -11
Q  -2   0  -1   0  -9   7   2  -4   2  -5  -3  -1  -2  -9  -1  -3  -3  -8  -8  -4  -1   5  -2 -11
E  -1  -5   0   3  -9   2   6  -2  -2  -4  -6  -2  -4  -9  -3  -2  -3 -11  -6  -4   2   5  -3 -11
G   0  -6  -1  -1  -6  -4  -2   6  -6  -6  -7  -5  -6  -7  -3   0  -3 -10  -9  -3  -1  -3  -3 -11
H  -4   0   1  -1  -5   2  -2  -6   8  -6  -4  -3  -6  -4  -2  -3  -4  -5  -1  -4   0   1  -3 -11
I  -2  -3  -3  -5  -4  -5  -4  -6  -6   7   1  -4   1   0  -5  -4  -1  -9  -4   3  -4  -4  -3 -11
L  -4  -6  -5  -8 -10  -3  -6  -7  -4   1   6  -5   2  -1  -5  -6  -4  -4  -4   0  -6  -4  -4 -11
K  -4   2   0  -2  -9  -1  -2  -5  -3  -4  -5   6   0  -9  -4  -2  -1  -7  -7  -6  -1  -2  -3 -11
M  -3  -2  -5  -7  -9  -2  -4  -6  -6   1   2   0  10  -2  -5  -3  -2  -8  -7   0  -6  -3  -3 -11
F  -6  -7  -6 -10  -8  -9  -9  -7  -4   0  -1  -9  -2   8  -7  -4  -6  -2   4  -5  -7  -9  -5 -11
P   0  -2  -3  -4  -5  -1  -3  -3  -2  -5  -5  -4  -5  -7   7   0  -2  -9  -9  -3  -4  -2  -3 -11
S   1  -1   1  -1  -1  -3  -2   0  -3  -4  -6  -2  -3  -4   0   5   2  -3  -5  -3   0  -2  -1 -11
T   1  -4   0  -2  -5  -3  -3  -3  -4  -1  -4  -1  -2  -6  -2   2   6  -8  -4  -1  -1  -3  -2 -11
W  -9   0  -6 -10 -11  -8 -11 -10  -5  -9  -4  -7  -8  -2  -9  -3  -8  13  -3 -10  -7 -10  -7 -11
Y  -5  -7  -3  -7  -2  -8  -6  -9  -1  -4  -4  -7  -7   4  -9  -5  -4  -3   9  -5  -4  -7  -5 -11
V  -1  -5  -5  -5  -4  -4  -4  -3  -4   3   0  -6   0  -5  -3  -3  -1 -10  -5   6  -5  -4  -2 -11
B  -1  -4   5   5  -8  -1   2  -1   0  -4  -6  -1  -6  -7  -4   0  -1  -7  -4  -5   5   1  -2 -11
Z  -1  -2  -1   2  -9   5   5  -3   1  -4  -4  -2  -3  -9  -2  -2  -3 -10  -7  -4   1   5  -3 -11
X  -2  -3  -2  -3  -6  -2  -3  -3  -3  -3  -4  -3  -3  -5  -3  -1  -2  -7  -5  -2  -2  -3  -3 -11
* -11 -11 -11 -11 -11 -11 -11 -11 -11 -11 -11 -11 -11 -11 -11 -11 -11 -11 -11 -11 -11 -11 -11   1

@@ PAM80
#
# This matrix was produced by "pam" Version 1.0.6 [28-Jul-93]
#
# PAM 80 substitution matrix, scale = ln(2)/2 = 0.346574
#
# Expected score = -2.55, Entropy = 1.44 bits
#
# Lowest score = -11, Highest score = 13
#
    A   R   N   D   C   Q   E   G   H   I   L   K   M   F   P   S   T   W   Y   V   B   Z   X   *
A   4  -4  -1  -1  -4  -2  -1   0  -4  -2  -4  -4  -3  -5   0   1   1  -8  -5   0  -1  -1  -1 -11
R  -4   7  -2  -5  -5   0  -4  -6   0  -3  -5   2  -2  -6  -2  -1  -3   0  -7  -5  -3  -1  -3 -11
N  -1  -2   5   3  -6  -1   0  -1   2  -3  -5   0  -4  -5  -3   1   0  -5  -3  -4   4   0  -1 -11
D  -1  -5   3   6  -9   0   4  -1  -1  -4  -7  -2  -6  -9  -4  -1  -2 -10  -7  -5   5   2  -3 -11
C  -4  -5  -6  -9   9  -9  -9  -6  -5  -4  -9  -9  -8  -8  -5  -1  -4 -10  -2  -3  -7  -9  -5 -11
Q  -2   0  -1   0  -9   7   2  -4   2  -4  -3  -1  -2  -8  -1  -3  -3  -8  -7  -4   0   5  -2 -11
E  -1  -4   0   4  -9   2   6  -2  -2  -3  -6  -2  -4  -9  -3  -2  -3 -11  -6  -4   2   5  -2 -11
G   0  -6  -1  -1  -6  -4  -2   6  -5  -6  -7  -4  -5  -6  -3   0  -2 -10  -8  -3  -1  -2  -3 -11
H  -4   0   2  -1  -5   2  -2  -5   8  -5  -4  -3  -5  -3  -2  -3  -4  -4  -1  -4   0   1  -2 -11
I  -2  -3  -3  -4  -4  -4  -3  -6  -5   7   1  -4   1   0  -5  -4  -1  -8  -3   3  -4  -4  -2 -11
L  -4  -5  -5  -7  -9  -3  -6  -7  -4   1   6  -5   2   0  -4  -5  -4  -3  -4   0  -6  -4  -3 -11
K  -4   2   0  -2  -9  -1  -2  -4  -3  -4  -5   6   0  -9  -4  -2  -1  -7  -6  -5  -1  -1  -3 -11
M  -3  -2  -4  -6  -8  -2  -4  -5  -5   1   2   0   9  -2  -5  -3  -2  -7  -6   1  -5  -3  -2 -11
F  -5  -6  -5  -9  -8  -8  -9  -6  -3   0   0  -9  -2   8  -7  -4  -5  -2   4  -4  -7  -8  -5 -11
P   0  -2  -3  -4  -5  -1  -3  -3  -2  -5  -4  -4  -5  -7   7   0  -2  -9  -8  -3  -3  -2  -2 -11
S   1  -1   1  -1  -1  -3  -2   0  -3  -4  -5  -2  -3  -4   0   4   2  -3  -4  -3   0  -2  -1 -11
T   1  -3   0  -2  -4  -3  -3  -2  -4  -1  -4  -1  -2  -5  -2   2   5  -8  -4  -1  -1  -3  -1 -11
W  -8   0  -5 -10 -10  -8 -11 -10  -4  -8  -3  -7  -7  -2  -9  -3  -8  13  -2 -10  -7  -9  -7 -11
Y  -5  -7  -3  -7  -2  -7  -6  -8  -1  -3  -4  -6  -6   4  -8  -4  -4  -2   9  -5  -4  -6  -4 -11
V   0  -5  -4  -5  -3  -4  -4  -3  -4   3   0  -5   1  -4  -3  -3  -1 -10  -5   6  -4  -4  -2 -11
B  -1  -3   4   5  -7   0   2  -1   0  -4  -6  -1  -5  -7  -3   0  -1  -7  -4  -4   5   2  -2 -11
Z  -1  -1   0   2  -9   5   5  -2   1  -4  -4  -1  -3  -8  -2  -2  -3  -9  -6  -4   2   5  -2 -11
X  -1  -3  -1  -3  -5  -2  -2  -3  -2  -2  -3  -3  -2  -5  -2  -1  -1  -7  -4  -2  -2  -2  -3 -11
* -11 -11 -11 -11 -11 -11 -11 -11 -11 -11 -11 -11 -11 -11 -11 -11 -11 -11 -11 -11 -11 -11 -11   1

@@ PAM90
#
# This matrix was produced by "pam" Version 1.0.6 [28-Jul-93]
#
# PAM 90 substitution matrix, scale = ln(2)/2 = 0.346574
#
# Expected score = -2.26, Entropy = 1.30 bits
#
# Lowest score = -10, Highest score = 13
#
    A   R   N   D   C   Q   E   G   H   I   L   K   M   F   P   S   T   W   Y   V   B   Z   X   *
A   4  -4  -1  -1  -3  -2   0   0  -4  -2  -3  -3  -2  -5   0   1   1  -8  -5   0  -1  -1  -1 -10
R  -4   7  -2  -5  -5   0  -4  -5   1  -3  -5   2  -2  -6  -1  -1  -3   0  -6  -4  -3  -1  -2 -10
N  -1  -2   5   3  -6  -1   0  -1   2  -3  -4   1  -4  -5  -2   1   0  -5  -2  -4   4   0  -1 -10
D  -1  -5   3   6  -8   0   4  -1  -1  -4  -7  -2  -5  -8  -4  -1  -2  -9  -6  -4   5   3  -2 -10
C  -3  -5  -6  -8   9  -8  -8  -5  -5  -3  -9  -8  -8  -7  -5  -1  -4 -10  -1  -3  -7  -8  -5 -10
Q  -2   0  -1   0  -8   6   2  -3   2  -4  -3  -1  -2  -7  -1  -2  -3  -7  -6  -4   0   5  -2 -10
E   0  -4   0   4  -8   2   6  -1  -1  -3  -5  -2  -4  -8  -2  -2  -2 -10  -6  -3   2   5  -2 -10
G   0  -5  -1  -1  -5  -3  -1   5  -5  -5  -6  -4  -5  -6  -3   0  -2  -9  -8  -3  -1  -2  -2 -10
H  -4   1   2  -1  -5   2  -1  -5   8  -5  -3  -2  -5  -3  -2  -3  -3  -4  -1  -4   1   1  -2 -10
I  -2  -3  -3  -4  -3  -4  -3  -5  -5   6   1  -3   1   0  -4  -3   0  -8  -3   3  -3  -3  -2 -10
L  -3  -5  -4  -7  -9  -3  -5  -6  -3   1   6  -5   2   0  -4  -5  -3  -3  -3   0  -5  -4  -3 -10
K  -3   2   1  -2  -8  -1  -2  -4  -2  -3  -5   5   0  -8  -3  -1  -1  -6  -6  -5   0  -1  -2 -10
M  -2  -2  -4  -5  -8  -2  -4  -5  -5   1   2   0   9  -1  -4  -3  -2  -7  -6   1  -5  -3  -2 -10
F  -5  -6  -5  -8  -7  -7  -8  -6  -3   0   0  -8  -1   8  -6  -4  -5  -2   4  -4  -6  -8  -4 -10
P   0  -1  -2  -4  -5  -1  -2  -3  -2  -4  -4  -3  -4  -6   7   0  -1  -8  -8  -3  -3  -2  -2 -10
S   1  -1   1  -1  -1  -2  -2   0  -3  -3  -5  -1  -3  -4   0   4   2  -3  -4  -3   0  -2  -1 -10
T   1  -3   0  -2  -4  -3  -2  -2  -3   0  -3  -1  -2  -5  -1   2   5  -7  -4  -1  -1  -2  -1 -10
W  -8   0  -5  -9 -10  -7 -10  -9  -4  -8  -3  -6  -7  -2  -8  -3  -7  13  -2  -9  -7  -8  -6 -10
Y  -5  -6  -2  -6  -1  -6  -6  -8  -1  -3  -3  -6  -6   4  -8  -4  -4  -2   9  -4  -4  -6  -4 -10
V   0  -4  -4  -4  -3  -4  -3  -3  -4   3   0  -5   1  -4  -3  -3  -1  -9  -4   6  -4  -3  -2 -10
B  -1  -3   4   5  -7   0   2  -1   1  -3  -5   0  -5  -6  -3   0  -1  -7  -4  -4   4   2  -2 -10
Z  -1  -1   0   3  -8   5   5  -2   1  -3  -4  -1  -3  -8  -2  -2  -2  -8  -6  -3   2   5  -2 -10
X  -1  -2  -1  -2  -5  -2  -2  -2  -2  -2  -3  -2  -2  -4  -2  -1  -1  -6  -4  -2  -2  -2  -2 -10
* -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10   1

@@ PAM100
#
# This matrix was produced by "pam" Version 1.0.6 [28-Jul-93]
#
# PAM 100 substitution matrix, scale = ln(2)/2 = 0.346574
#
# Expected score = -1.99, Entropy = 1.18 bits
#
# Lowest score = -9, Highest score = 12
#
   A  R  N  D  C  Q  E  G  H  I  L  K  M  F  P  S  T  W  Y  V  B  Z  X  *
A  4 -3 -1 -1 -3 -2  0  1 -3 -2 -3 -3 -2 -5  1  1  1 -7 -4  0 -1 -1 -1 -9
R -3  7 -2 -4 -5  1 -3 -5  1 -3 -5  2 -1 -6 -1 -1 -3  1 -6 -4 -3 -1 -2 -9
N -1 -2  5  3 -5 -1  1 -1  2 -3 -4  1 -4 -5 -2  1  0 -5 -2 -3  4  0 -1 -9
D -1 -4  3  5 -7  0  4 -1 -1 -4 -6 -1 -5 -8 -3 -1 -2 -9 -6 -4  4  3 -2 -9
C -3 -5 -5 -7  9 -8 -8 -5 -4 -3 -8 -8 -7 -7 -4 -1 -4 -9 -1 -3 -6 -8 -5 -9
Q -2  1 -1  0 -8  6  2 -3  3 -4 -2  0 -2 -7 -1 -2 -2 -7 -6 -3  0  5 -2 -9
E  0 -3  1  4 -8  2  5 -1 -1 -3 -5 -1 -4 -8 -2 -1 -2 -9 -5 -3  3  4 -2 -9
G  1 -5 -1 -1 -5 -3 -1  5 -4 -5 -6 -3 -4 -6 -2  0 -2 -9 -7 -3 -1 -2 -2 -9
H -3  1  2 -1 -4  3 -1 -4  7 -4 -3 -2 -4 -3 -1 -2 -3 -4 -1 -3  1  1 -2 -9
I -2 -3 -3 -4 -3 -4 -3 -5 -4  6  1 -3  1  0 -4 -3  0 -7 -3  3 -3 -3 -2 -9
L -3 -5 -4 -6 -8 -2 -5 -6 -3  1  6 -4  3  0 -4 -4 -3 -3 -3  0 -5 -4 -3 -9
K -3  2  1 -1 -8  0 -1 -3 -2 -3 -4  5  0 -7 -3 -1 -1 -6 -6 -4  0 -1 -2 -9
M -2 -1 -4 -5 -7 -2 -4 -4 -4  1  3  0  9 -1 -4 -3 -1 -6 -5  1 -4 -2 -2 -9
F -5 -6 -5 -8 -7 -7 -8 -6 -3  0  0 -7 -1  8 -6 -4 -5 -1  4 -3 -6 -7 -4 -9
P  1 -1 -2 -3 -4 -1 -2 -2 -1 -4 -4 -3 -4 -6  7  0 -1 -7 -7 -3 -3 -1 -2 -9
S  1 -1  1 -1 -1 -2 -1  0 -2 -3 -4 -1 -3 -4  0  4  2 -3 -4 -2  0 -2 -1 -9
T  1 -3  0 -2 -4 -2 -2 -2 -3  0 -3 -1 -1 -5 -1  2  5 -7 -4  0 -1 -2 -1 -9
W -7  1 -5 -9 -9 -7 -9 -9 -4 -7 -3 -6 -6 -1 -7 -3 -7 12 -2 -9 -6 -8 -6 -9
Y -4 -6 -2 -6 -1 -6 -5 -7 -1 -3 -3 -6 -5  4 -7 -4 -4 -2  9 -4 -4 -6 -4 -9
V  0 -4 -3 -4 -3 -3 -3 -3 -3  3  0 -4  1 -3 -3 -2  0 -9 -4  5 -4 -3 -2 -9
B -1 -3  4  4 -6  0  3 -1  1 -3 -5  0 -4 -6 -3  0 -1 -6 -4 -4  4  2 -2 -9
Z -1 -1  0  3 -8  5  4 -2  1 -3 -4 -1 -2 -7 -1 -2 -2 -8 -6 -3  2  5 -2 -9
X -1 -2 -1 -2 -5 -2 -2 -2 -2 -2 -3 -2 -2 -4 -2 -1 -1 -6 -4 -2 -2 -2 -2 -9
* -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9  1

@@ PAM110
#
# This matrix was produced by "pam" Version 1.0.6 [28-Jul-93]
#
# PAM 110 substitution matrix, scale = ln(2)/2 = 0.346574
#
# Expected score = -1.81, Entropy = 1.07 bits
#
# Lowest score = -9, Highest score = 12
#
   A  R  N  D  C  Q  E  G  H  I  L  K  M  F  P  S  T  W  Y  V  B  Z  X  *
A  3 -3 -1 -1 -3 -1  0  1 -3 -1 -3 -3 -2 -4  1  1  1 -7 -4  0 -1 -1 -1 -9
R -3  7 -1 -4 -4  1 -3 -4  1 -3 -4  2 -1 -5 -1 -1 -2  1 -5 -4 -2 -1 -2 -9
N -1 -1  4  2 -5  0  1  0  2 -2 -4  1 -3 -4 -2  1  0 -5 -2 -3  3  0 -1 -9
D -1 -4  2  5 -7  1  4  0  0 -3 -6 -1 -5 -7 -3 -1 -1 -8 -5 -4  4  3 -2 -9
C -3 -4 -5 -7  9 -7 -7 -5 -4 -3 -8 -7 -7 -6 -4 -1 -3 -9 -1 -3 -6 -7 -4 -9
Q -1  1  0  1 -7  6  2 -3  3 -3 -2  0 -1 -6  0 -2 -2 -6 -6 -3  0  4 -1 -9
E  0 -3  1  4 -7  2  5 -1 -1 -3 -5 -1 -3 -7 -2 -1 -2 -9 -5 -3  3  4 -2 -9
G  1 -4  0  0 -5 -3 -1  5 -4 -4 -6 -3 -4 -5 -2  0 -2 -8 -7 -2  0 -2 -2 -9
H -3  1  2  0 -4  3 -1 -4  7 -4 -3 -2 -4 -3 -1 -2 -3 -4 -1 -3  1  1 -2 -9
I -1 -3 -2 -3 -3 -3 -3 -4 -4  6  1 -3  1  0 -4 -3  0 -7 -2  3 -3 -3 -2 -9
L -3 -4 -4 -6 -8 -2 -5 -6 -3  1  6 -4  3  0 -4 -4 -3 -3 -3  1 -5 -3 -2 -9
K -3  2  1 -1 -7  0 -1 -3 -2 -3 -4  5  0 -7 -3 -1 -1 -5 -5 -4  0 -1 -2 -9
M -2 -1 -3 -5 -7 -1 -3 -4 -4  1  3  0  8 -1 -4 -2 -1 -6 -5  1 -4 -2 -2 -9
F -4 -5 -4 -7 -6 -6 -7 -5 -3  0  0 -7 -1  8 -6 -4 -4 -1  4 -3 -6 -7 -4 -9
P  1 -1 -2 -3 -4  0 -2 -2 -1 -4 -4 -3 -4 -6  6  0 -1 -7 -7 -2 -2 -1 -2 -9
S  1 -1  1 -1 -1 -2 -1  0 -2 -3 -4 -1 -2 -4  0  3  2 -3 -3 -2  0 -1 -1 -9
T  1 -2  0 -1 -3 -2 -2 -2 -3  0 -3 -1 -1 -4 -1  2  5 -6 -3  0 -1 -2 -1 -9
W -7  1 -5 -8 -9 -6 -9 -8 -4 -7 -3 -5 -6 -1 -7 -3 -6 12 -2 -8 -6 -7 -5 -9
Y -4 -5 -2 -5 -1 -6 -5 -7 -1 -2 -3 -5 -5  4 -7 -3 -3 -2  8 -4 -3 -5 -3 -9
V  0 -4 -3 -4 -3 -3 -3 -2 -3  3  1 -4  1 -3 -2 -2  0 -8 -4  5 -3 -3 -2 -9
B -1 -2  3  4 -6  0  3  0  1 -3 -5  0 -4 -6 -2  0 -1 -6 -3 -3  4  2 -1 -9
Z -1 -1  0  3 -7  4  4 -2  1 -3 -3 -1 -2 -7 -1 -1 -2 -7 -5 -3  2  4 -2 -9
X -1 -2 -1 -2 -4 -1 -2 -2 -2 -2 -2 -2 -2 -4 -2 -1 -1 -5 -3 -2 -1 -2 -2 -9
* -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9  1

@@ PAM120
#
# This matrix was produced by "pam" Version 1.0.6 [28-Jul-93]
#
# PAM 120 substitution matrix, scale = ln(2)/2 = 0.346574
#
# Expected score = -1.64, Entropy = 0.979 bits
#
# Lowest score = -8, Highest score = 12
#
   A  R  N  D  C  Q  E  G  H  I  L  K  M  F  P  S  T  W  Y  V  B  Z  X  *
A  3 -3 -1  0 -3 -1  0  1 -3 -1 -3 -2 -2 -4  1  1  1 -7 -4  0  0 -1 -1 -8
R -3  6 -1 -3 -4  1 -3 -4  1 -2 -4  2 -1 -5 -1 -1 -2  1 -5 -3 -2 -1 -2 -8
N -1 -1  4  2 -5  0  1  0  2 -2 -4  1 -3 -4 -2  1  0 -4 -2 -3  3  0 -1 -8
D  0 -3  2  5 -7  1  3  0  0 -3 -5 -1 -4 -7 -3  0 -1 -8 -5 -3  4  3 -2 -8
C -3 -4 -5 -7  9 -7 -7 -4 -4 -3 -7 -7 -6 -6 -4  0 -3 -8 -1 -3 -6 -7 -4 -8
Q -1  1  0  1 -7  6  2 -3  3 -3 -2  0 -1 -6  0 -2 -2 -6 -5 -3  0  4 -1 -8
E  0 -3  1  3 -7  2  5 -1 -1 -3 -4 -1 -3 -7 -2 -1 -2 -8 -5 -3  3  4 -1 -8
G  1 -4  0  0 -4 -3 -1  5 -4 -4 -5 -3 -4 -5 -2  1 -1 -8 -6 -2  0 -2 -2 -8
H -3  1  2  0 -4  3 -1 -4  7 -4 -3 -2 -4 -3 -1 -2 -3 -3 -1 -3  1  1 -2 -8
I -1 -2 -2 -3 -3 -3 -3 -4 -4  6  1 -3  1  0 -3 -2  0 -6 -2  3 -3 -3 -1 -8
L -3 -4 -4 -5 -7 -2 -4 -5 -3  1  5 -4  3  0 -3 -4 -3 -3 -2  1 -4 -3 -2 -8
K -2  2  1 -1 -7  0 -1 -3 -2 -3 -4  5  0 -7 -2 -1 -1 -5 -5 -4  0 -1 -2 -8
M -2 -1 -3 -4 -6 -1 -3 -4 -4  1  3  0  8 -1 -3 -2 -1 -6 -4  1 -4 -2 -2 -8
F -4 -5 -4 -7 -6 -6 -7 -5 -3  0  0 -7 -1  8 -5 -3 -4 -1  4 -3 -5 -6 -3 -8
P  1 -1 -2 -3 -4  0 -2 -2 -1 -3 -3 -2 -3 -5  6  1 -1 -7 -6 -2 -2 -1 -2 -8
S  1 -1  1  0  0 -2 -1  1 -2 -2 -4 -1 -2 -3  1  3  2 -2 -3 -2  0 -1 -1 -8
T  1 -2  0 -1 -3 -2 -2 -1 -3  0 -3 -1 -1 -4 -1  2  4 -6 -3  0  0 -2 -1 -8
W -7  1 -4 -8 -8 -6 -8 -8 -3 -6 -3 -5 -6 -1 -7 -2 -6 12 -2 -8 -6 -7 -5 -8
Y -4 -5 -2 -5 -1 -5 -5 -6 -1 -2 -2 -5 -4  4 -6 -3 -3 -2  8 -3 -3 -5 -3 -8
V  0 -3 -3 -3 -3 -3 -3 -2 -3  3  1 -4  1 -3 -2 -2  0 -8 -3  5 -3 -3 -1 -8
B  0 -2  3  4 -6  0  3  0  1 -3 -4  0 -4 -5 -2  0  0 -6 -3 -3  4  2 -1 -8
Z -1 -1  0  3 -7  4  4 -2  1 -3 -3 -1 -2 -6 -1 -1 -2 -7 -5 -3  2  4 -1 -8
X -1 -2 -1 -2 -4 -1 -1 -2 -2 -1 -2 -2 -2 -3 -2 -1 -1 -5 -3 -1 -1 -1 -2 -8
* -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8  1

@@ PAM130
#
# This matrix was produced by "pam" Version 1.0.6 [28-Jul-93]
#
# PAM 130 substitution matrix, scale = ln(2)/2 = 0.346574
#
# Expected score = -1.48, Entropy = 0.895 bits
#
# Lowest score = -8, Highest score = 12
#
   A  R  N  D  C  Q  E  G  H  I  L  K  M  F  P  S  T  W  Y  V  B  Z  X  *
A  3 -3  0  0 -3 -1  0  1 -2 -1 -3 -2 -2 -4  1  1  1 -6 -4  0  0  0 -1 -8
R -3  6 -1 -3 -4  1 -3 -4  1 -2 -4  2 -1 -5 -1 -1 -2  1 -5 -3 -2 -1 -2 -8
N  0 -1  4  2 -4  0  1  0  2 -2 -3  1 -3 -4 -1  1  0 -4 -2 -3  3  0 -1 -8
D  0 -3  2  5 -6  1  3  0  0 -3 -5 -1 -4 -7 -2  0 -1 -7 -5 -3  4  3 -1 -8
C -3 -4 -4 -6  9 -6 -6 -4 -4 -3 -7 -6 -6 -5 -3  0 -3 -8 -1 -2 -5 -6 -4 -8
Q -1  1  0  1 -6  5  2 -2  3 -3 -2  0 -1 -6  0 -1 -2 -6 -5 -3  0  4 -1 -8
E  0 -3  1  3 -6  2  5 -1  0 -2 -4 -1 -3 -6 -2 -1 -1 -8 -5 -3  2  4 -1 -8
G  1 -4  0  0 -4 -2 -1  5 -3 -4 -5 -3 -4 -5 -2  1 -1 -7 -6 -2  0 -1 -2 -8
H -2  1  2  0 -4  3  0 -3  7 -3 -3 -1 -3 -2 -1 -2 -2 -3  0 -3  1  1 -1 -8
I -1 -2 -2 -3 -3 -3 -2 -4 -3  5  1 -2  2  0 -3 -2  0 -6 -2  3 -3 -3 -1 -8
L -3 -4 -3 -5 -7 -2 -4 -5 -3  1  5 -4  3  1 -3 -4 -2 -2 -2  1 -4 -3 -2 -8
K -2  2  1 -1 -6  0 -1 -3 -1 -2 -4  5  0 -6 -2 -1  0 -5 -5 -4  0  0 -1 -8
M -2 -1 -3 -4 -6 -1 -3 -4 -3  2  3  0  8 -1 -3 -2 -1 -5 -4  1 -3 -2 -1 -8
F -4 -5 -4 -7 -5 -6 -6 -5 -2  0  1 -6 -1  7 -5 -3 -4 -1  4 -2 -5 -6 -3 -8
P  1 -1 -1 -2 -3  0 -2 -2 -1 -3 -3 -2 -3 -5  6  1 -1 -6 -6 -2 -2 -1 -1 -8
S  1 -1  1  0  0 -1 -1  1 -2 -2 -4 -1 -2 -3  1  3  2 -2 -3 -2  0 -1 -1 -8
T  1 -2  0 -1 -3 -2 -1 -1 -2  0 -2  0 -1 -4 -1  2  4 -6 -3  0  0 -2 -1 -8
W -6  1 -4 -7 -8 -6 -8 -7 -3 -6 -2 -5 -5 -1 -6 -2 -6 12 -1 -7 -5 -7 -5 -8
Y -4 -5 -2 -5 -1 -5 -5 -6  0 -2 -2 -5 -4  4 -6 -3 -3 -1  8 -3 -3 -5 -3 -8
V  0 -3 -3 -3 -2 -3 -3 -2 -3  3  1 -4  1 -2 -2 -2  0 -7 -3  5 -3 -3 -1 -8
B  0 -2  3  4 -5  0  2  0  1 -3 -4  0 -3 -5 -2  0  0 -5 -3 -3  3  2 -1 -8
Z  0 -1  0  3 -6  4  4 -1  1 -3 -3  0 -2 -6 -1 -1 -2 -7 -5 -3  2  4 -1 -8
X -1 -2 -1 -1 -4 -1 -1 -2 -1 -1 -2 -1 -1 -3 -1 -1 -1 -5 -3 -1 -1 -1 -1 -8
* -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8  1

@@ PAM140
#
# This matrix was produced by "pam" Version 1.0.6 [28-Jul-93]
#
# PAM 140 substitution matrix, scale = ln(2)/2 = 0.346574
#
# Expected score = -1.35, Entropy = 0.820 bits
#
# Lowest score = -8, Highest score = 12
#
   A  R  N  D  C  Q  E  G  H  I  L  K  M  F  P  S  T  W  Y  V  B  Z  X  *
A  3 -2  0  0 -2 -1  0  1 -2 -1 -2 -2 -2 -4  1  1  1 -6 -4  0  0  0 -1 -8
R -2  6 -1 -3 -4  1 -2 -4  1 -2 -4  3 -1 -5 -1 -1 -2  1 -5 -3 -2 -1 -1 -8
N  0 -1  3  2 -4  0  1  0  2 -2 -3  1 -2 -4 -1  1  0 -4 -2 -2  3  1 -1 -8
D  0 -3  2  4 -6  1  3  0  0 -3 -5 -1 -4 -6 -2  0 -1 -7 -5 -3  4  3 -1 -8
C -2 -4 -4 -6  9 -6 -6 -4 -4 -3 -7 -6 -6 -5 -3  0 -3 -8 -1 -2 -5 -6 -4 -8
Q -1  1  0  1 -6  5  2 -2  3 -3 -2  0 -1 -5  0 -1 -2 -5 -5 -2  1  4 -1 -8
E  0 -2  1  3 -6  2  4 -1  0 -2 -4 -1 -3 -6 -1 -1 -1 -8 -4 -2  2  4 -1 -8
G  1 -4  0  0 -4 -2 -1  5 -3 -4 -5 -3 -3 -5 -1  1 -1 -7 -6 -2  0 -1 -1 -8
H -2  1  2  0 -4  3  0 -3  6 -3 -2 -1 -3 -2 -1 -1 -2 -3  0 -3  1  1 -1 -8
I -1 -2 -2 -3 -3 -3 -2 -4 -3  5  1 -2  2  0 -3 -2  0 -6 -2  3 -2 -2 -1 -8
L -2 -4 -3 -5 -7 -2 -4 -5 -2  1  5 -3  3  1 -3 -3 -2 -2 -2  1 -4 -3 -2 -8
K -2  3  1 -1 -6  0 -1 -3 -1 -2 -3  5  0 -6 -2 -1  0 -4 -5 -3  0  0 -1 -8
M -2 -1 -2 -4 -6 -1 -3 -3 -3  2  3  0  7 -1 -3 -2 -1 -5 -4  1 -3 -2 -1 -8
F -4 -5 -4 -6 -5 -5 -6 -5 -2  0  1 -6 -1  7 -5 -3 -4 -1  4 -2 -5 -6 -3 -8
P  1 -1 -1 -2 -3  0 -1 -1 -1 -3 -3 -2 -3 -5  6  1  0 -6 -6 -2 -2 -1 -1 -8
S  1 -1  1  0  0 -1 -1  1 -1 -2 -3 -1 -2 -3  1  3  2 -2 -3 -2  0 -1  0 -8
T  1 -2  0 -1 -3 -2 -1 -1 -2  0 -2  0 -1 -4  0  2  4 -5 -3  0  0 -1 -1 -8
W -6  1 -4 -7 -8 -5 -8 -7 -3 -6 -2 -4 -5 -1 -6 -2 -5 12 -1 -7 -5 -6 -5 -8
Y -4 -5 -2 -5 -1 -5 -4 -6  0 -2 -2 -5 -4  4 -6 -3 -3 -1  8 -3 -3 -4 -3 -8
V  0 -3 -2 -3 -2 -2 -2 -2 -3  3  1 -3  1 -2 -2 -2  0 -7 -3  5 -3 -2 -1 -8
B  0 -2  3  4 -5  1  2  0  1 -2 -4  0 -3 -5 -2  0  0 -5 -3 -3  3  2 -1 -8
Z  0 -1  1  3 -6  4  4 -1  1 -2 -3  0 -2 -6 -1 -1 -1 -6 -4 -2  2  4 -1 -8
X -1 -1 -1 -1 -4 -1 -1 -1 -1 -1 -2 -1 -1 -3 -1  0 -1 -5 -3 -1 -1 -1 -1 -8
* -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8  1

@@ PAM150
#
# This matrix was produced by "pam" Version 1.0.6 [28-Jul-93]
#
# PAM 150 substitution matrix, scale = ln(2)/2 = 0.346574
#
# Expected score = -1.25, Entropy = 0.754 bits
#
# Lowest score = -7, Highest score = 12
#
   A  R  N  D  C  Q  E  G  H  I  L  K  M  F  P  S  T  W  Y  V  B  Z  X  *
A  3 -2  0  0 -2 -1  0  1 -2 -1 -2 -2 -1 -4  1  1  1 -6 -3  0  0  0 -1 -7
R -2  6 -1 -2 -4  1 -2 -3  1 -2 -3  3 -1 -4 -1 -1 -2  1 -4 -3 -2  0 -1 -7
N  0 -1  3  2 -4  0  1  0  2 -2 -3  1 -2 -4 -1  1  0 -4 -2 -2  3  1 -1 -7
D  0 -2  2  4 -6  1  3  0  0 -3 -5 -1 -3 -6 -2  0 -1 -7 -4 -3  3  2 -1 -7
C -2 -4 -4 -6  9 -6 -6 -4 -3 -2 -6 -6 -5 -5 -3  0 -3 -7  0 -2 -5 -6 -3 -7
Q -1  1  0  1 -6  5  2 -2  3 -3 -2  0 -1 -5  0 -1 -1 -5 -4 -2  1  4 -1 -7
E  0 -2  1  3 -6  2  4 -1  0 -2 -4 -1 -2 -6 -1 -1 -1 -7 -4 -2  2  4 -1 -7
G  1 -3  0  0 -4 -2 -1  4 -3 -3 -4 -2 -3 -5 -1  1 -1 -7 -5 -2  0 -1 -1 -7
H -2  1  2  0 -3  3  0 -3  6 -3 -2 -1 -3 -2 -1 -1 -2 -3  0 -3  1  1 -1 -7
I -1 -2 -2 -3 -2 -3 -2 -3 -3  5  1 -2  2  0 -3 -2  0 -5 -2  3 -2 -2 -1 -7
L -2 -3 -3 -5 -6 -2 -4 -4 -2  1  5 -3  3  1 -3 -3 -2 -2 -2  1 -4 -3 -2 -7
K -2  3  1 -1 -6  0 -1 -2 -1 -2 -3  4  0 -6 -2 -1  0 -4 -4 -3  0  0 -1 -7
M -1 -1 -2 -3 -5 -1 -2 -3 -3  2  3  0  7 -1 -3 -2 -1 -5 -3  1 -3 -2 -1 -7
F -4 -4 -4 -6 -5 -5 -6 -5 -2  0  1 -6 -1  7 -5 -3 -3 -1  5 -2 -5 -5 -3 -7
P  1 -1 -1 -2 -3  0 -1 -1 -1 -3 -3 -2 -3 -5  6  1  0 -6 -5 -2 -2 -1 -1 -7
S  1 -1  1  0  0 -1 -1  1 -1 -2 -3 -1 -2 -3  1  2  1 -2 -3 -1  0 -1  0 -7
T  1 -2  0 -1 -3 -1 -1 -1 -2  0 -2  0 -1 -3  0  1  4 -5 -3  0  0 -1 -1 -7
W -6  1 -4 -7 -7 -5 -7 -7 -3 -5 -2 -4 -5 -1 -6 -2 -5 12 -1 -6 -5 -6 -4 -7
Y -3 -4 -2 -4  0 -4 -4 -5  0 -2 -2 -4 -3  5 -5 -3 -3 -1  8 -3 -3 -4 -3 -7
V  0 -3 -2 -3 -2 -2 -2 -2 -3  3  1 -3  1 -2 -2 -1  0 -6 -3  4 -2 -2 -1 -7
B  0 -2  3  3 -5  1  2  0  1 -2 -4  0 -3 -5 -2  0  0 -5 -3 -2  3  2 -1 -7
Z  0  0  1  2 -6  4  4 -1  1 -2 -3  0 -2 -5 -1 -1 -1 -6 -4 -2  2  4 -1 -7
X -1 -1 -1 -1 -3 -1 -1 -1 -1 -1 -2 -1 -1 -3 -1  0 -1 -4 -3 -1 -1 -1 -1 -7
* -7 -7 -7 -7 -7 -7 -7 -7 -7 -7 -7 -7 -7 -7 -7 -7 -7 -7 -7 -7 -7 -7 -7  1

@@ PAM160
#
# This matrix was produced by "pam" Version 1.0.6 [28-Jul-93]
#
# PAM 160 substitution matrix, scale = ln(2)/2 = 0.346574
#
# Expected score = -1.14, Entropy = 0.694 bits
#
# Lowest score = -7, Highest score = 12
#
   A  R  N  D  C  Q  E  G  H  I  L  K  M  F  P  S  T  W  Y  V  B  Z  X  *
A  2 -2  0  0 -2 -1  0  1 -2 -1 -2 -2 -1 -3  1  1  1 -5 -3  0  0  0  0 -7
R -2  6 -1 -2 -3  1 -2 -3  1 -2 -3  3 -1 -4 -1 -1 -1  1 -4 -3 -1  0 -1 -7
N  0 -1  3  2 -4  0  1  0  2 -2 -3  1 -2 -3 -1  1  0 -4 -2 -2  2  1  0 -7
D  0 -2  2  4 -5  1  3  0  0 -3 -4  0 -3 -6 -2  0 -1 -6 -4 -3  3  2 -1 -7
C -2 -3 -4 -5  9 -5 -5 -3 -3 -2 -6 -5 -5 -5 -3  0 -2 -7  0 -2 -4 -5 -3 -7
Q -1  1  0  1 -5  5  2 -2  2 -2 -2  0 -1 -5  0 -1 -1 -5 -4 -2  1  3 -1 -7
E  0 -2  1  3 -5  2  4  0  0 -2 -3 -1 -2 -5 -1  0 -1 -7 -4 -2  2  3 -1 -7
G  1 -3  0  0 -3 -2  0  4 -3 -3 -4 -2 -3 -4 -1  1 -1 -7 -5 -2  0 -1 -1 -7
H -2  1  2  0 -3  2  0 -3  6 -3 -2 -1 -3 -2 -1 -1 -2 -3  0 -2  1  1 -1 -7
I -1 -2 -2 -3 -2 -2 -2 -3 -3  5  2 -2  2  0 -2 -2  0 -5 -2  3 -2 -2 -1 -7
L -2 -3 -3 -4 -6 -2 -3 -4 -2  2  5 -3  3  1 -3 -3 -2 -2 -2  1 -4 -3 -2 -7
K -2  3  1  0 -5  0 -1 -2 -1 -2 -3  4  0 -5 -2 -1  0 -4 -4 -3  0  0 -1 -7
M -1 -1 -2 -3 -5 -1 -2 -3 -3  2  3  0  7  0 -2 -2 -1 -4 -3  1 -3 -2 -1 -7
F -3 -4 -3 -6 -5 -5 -5 -4 -2  0  1 -5  0  7 -4 -3 -3 -1  5 -2 -4 -5 -3 -7
P  1 -1 -1 -2 -3  0 -1 -1 -1 -2 -3 -2 -2 -4  5  1  0 -5 -5 -2 -1 -1 -1 -7
S  1 -1  1  0  0 -1  0  1 -1 -2 -3 -1 -2 -3  1  2  1 -2 -3 -1  0 -1  0 -7
T  1 -1  0 -1 -2 -1 -1 -1 -2  0 -2  0 -1 -3  0  1  3 -5 -3  0  0 -1  0 -7
W -5  1 -4 -6 -7 -5 -7 -7 -3 -5 -2 -4 -4 -1 -5 -2 -5 12 -1 -6 -5 -6 -4 -7
Y -3 -4 -2 -4  0 -4 -4 -5  0 -2 -2 -4 -3  5 -5 -3 -3 -1  8 -3 -3 -4 -3 -7
V  0 -3 -2 -3 -2 -2 -2 -2 -2  3  1 -3  1 -2 -2 -1  0 -6 -3  4 -2 -2 -1 -7
B  0 -1  2  3 -4  1  2  0  1 -2 -4  0 -3 -4 -1  0  0 -5 -3 -2  3  2 -1 -7
Z  0  0  1  2 -5  3  3 -1  1 -2 -3  0 -2 -5 -1 -1 -1 -6 -4 -2  2  3 -1 -7
X  0 -1  0 -1 -3 -1 -1 -1 -1 -1 -2 -1 -1 -3 -1  0  0 -4 -3 -1 -1 -1 -1 -7
* -7 -7 -7 -7 -7 -7 -7 -7 -7 -7 -7 -7 -7 -7 -7 -7 -7 -7 -7 -7 -7 -7 -7  1

@@ PAM170
#
# This matrix was produced by "pam" Version 1.0.6 [28-Jul-93]
#
# PAM 170 substitution matrix, scale = ln(2)/3 = 0.231049
#
# Expected score = -1.57, Entropy = 0.640 bits
#
# Lowest score = -10, Highest score = 18
#
    A   R   N   D   C   Q   E   G   H   I   L   K   M   F   P   S   T   W   Y   V   B   Z   X   *
A   3  -3   0   0  -3  -1   0   1  -3  -1  -3  -2  -2  -5   1   2   2  -8  -5   0   0   0  -1 -10
R  -3   8  -1  -3  -5   1  -2  -4   2  -3  -4   4  -1  -6  -1  -1  -2   2  -6  -4  -2   0  -2 -10
N   0  -1   4   3  -5   0   2   0   2  -3  -4   1  -3  -5  -1   1   0  -5  -3  -3   3   1  -1 -10
D   0  -3   3   6  -7   2   5   0   0  -4  -6  -1  -4  -8  -2   0  -1  -9  -6  -4   5   4  -1 -10
C  -3  -5  -5  -7  13  -8  -8  -5  -5  -3  -9  -8  -7  -6  -4   0  -3 -10   0  -3  -6  -8  -4 -10
Q  -1   1   0   2  -8   6   3  -2   4  -3  -2   0  -1  -7   0  -1  -2  -7  -6  -3   1   5  -1 -10
E   0  -2   2   5  -8   3   6   0   0  -3  -5  -1  -3  -8  -1  -1  -1 -10  -6  -3   3   5  -1 -10
G   1  -4   0   0  -5  -2   0   6  -4  -4  -6  -3  -4  -6  -2   1  -1  -9  -7  -2   0  -1  -2 -10
H  -3   2   2   0  -5   4   0  -4   9  -4  -3  -1  -4  -3  -1  -2  -2  -4   0  -3   1   2  -1 -10
I  -1  -3  -3  -4  -3  -3  -3  -4  -4   7   2  -3   2   1  -3  -2   0  -7  -2   5  -3  -3  -1 -10
L  -3  -4  -4  -6  -9  -2  -5  -6  -3   2   7  -4   4   1  -4  -4  -3  -3  -2   2  -5  -4  -2 -10
K  -2   4   1  -1  -8   0  -1  -3  -1  -3  -4   6   1  -8  -2  -1   0  -5  -6  -4   0   0  -2 -10
M  -2  -1  -3  -4  -7  -1  -3  -4  -4   2   4   1  10   0  -3  -2  -1  -6  -4   2  -4  -2  -1 -10
F  -5  -6  -5  -8  -6  -7  -8  -6  -3   1   1  -8   0  10  -6  -4  -5  -1   7  -2  -6  -7  -4 -10
P   1  -1  -1  -2  -4   0  -1  -2  -1  -3  -4  -2  -3  -6   8   1   0  -8  -7  -2  -2  -1  -1 -10
S   2  -1   1   0   0  -1  -1   1  -2  -2  -4  -1  -2  -4   1   3   2  -3  -4  -2   1  -1   0 -10
T   2  -2   0  -1  -3  -2  -1  -1  -2   0  -3   0  -1  -5   0   2   5  -7  -4   0   0  -1  -1 -10
W  -8   2  -5  -9 -10  -7 -10  -9  -4  -7  -3  -5  -6  -1  -8  -3  -7  18  -1  -9  -7  -8  -6 -10
Y  -5  -6  -3  -6   0  -6  -6  -7   0  -2  -2  -6  -4   7  -7  -4  -4  -1  12  -4  -4  -6  -4 -10
V   0  -4  -3  -4  -3  -3  -3  -2  -3   5   2  -4   2  -2  -2  -2   0  -9  -4   6  -3  -3  -1 -10
B   0  -2   3   5  -6   1   3   0   1  -3  -5   0  -4  -6  -2   1   0  -7  -4  -3   4   3  -1 -10
Z   0   0   1   4  -8   5   5  -1   2  -3  -4   0  -2  -7  -1  -1  -1  -8  -6  -3   3   5  -1 -10
X  -1  -2  -1  -1  -4  -1  -1  -2  -1  -1  -2  -2  -1  -4  -1   0  -1  -6  -4  -1  -1  -1  -2 -10
* -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10   1

@@ PAM180
#
# This matrix was produced by "pam" Version 1.0.6 [28-Jul-93]
#
# PAM 180 substitution matrix, scale = ln(2)/3 = 0.231049
#
# Expected score = -1.51, Entropy = 0.591 bits
#
# Lowest score = -10, Highest score = 18
#
    A   R   N   D   C   Q   E   G   H   I   L   K   M   F   P   S   T   W   Y   V   B   Z   X   *
A   3  -3   0   0  -3  -1   0   1  -2  -1  -3  -2  -2  -5   1   1   2  -8  -5   0   0   0  -1 -10
R  -3   8  -1  -3  -5   1  -2  -4   2  -3  -4   4  -1  -6  -1  -1  -2   2  -6  -4  -2   0  -2 -10
N   0  -1   4   3  -5   0   2   0   2  -3  -4   1  -3  -5  -1   1   0  -5  -2  -3   3   1  -1 -10
D   0  -3   3   5  -7   2   4   0   0  -3  -6   0  -4  -8  -2   0  -1  -9  -6  -3   4   3  -1 -10
C  -3  -5  -5  -7  13  -7  -7  -5  -4  -3  -8  -7  -7  -6  -4   0  -3 -10   0  -3  -6  -7  -4 -10
Q  -1   1   0   2  -7   6   3  -2   4  -3  -2   0  -1  -6   0  -1  -2  -6  -6  -3   1   5  -1 -10
E   0  -2   2   4  -7   3   5   0   0  -3  -5  -1  -3  -7  -1  -1  -1  -9  -6  -3   3   5  -1 -10
G   1  -4   0   0  -5  -2   0   6  -3  -4  -6  -3  -4  -6  -1   1  -1  -9  -7  -2   0  -1  -2 -10
H  -2   2   2   0  -4   4   0  -3   8  -4  -3  -1  -3  -3  -1  -2  -2  -4   0  -3   1   2  -1 -10
I  -1  -3  -3  -3  -3  -3  -3  -4  -4   6   2  -3   2   1  -3  -2   0  -7  -2   5  -3  -3  -1 -10
L  -3  -4  -4  -6  -8  -2  -5  -6  -3   2   7  -4   4   1  -4  -4  -3  -3  -2   2  -5  -3  -2 -10
K  -2   4   1   0  -7   0  -1  -3  -1  -3  -4   6   1  -7  -2  -1   0  -5  -6  -4   0   0  -1 -10
M  -2  -1  -3  -4  -7  -1  -3  -4  -3   2   4   1   9   0  -3  -2  -1  -6  -4   2  -3  -2  -1 -10
F  -5  -6  -5  -8  -6  -6  -7  -6  -3   1   1  -7   0  10  -6  -4  -4   0   7  -2  -6  -7  -3 -10
P   1  -1  -1  -2  -4   0  -1  -1  -1  -3  -4  -2  -3  -6   8   1   0  -7  -7  -2  -2  -1  -1 -10
S   1  -1   1   0   0  -1  -1   1  -2  -2  -4  -1  -2  -4   1   3   2  -3  -4  -2   1  -1   0 -10
T   2  -2   0  -1  -3  -2  -1  -1  -2   0  -3   0  -1  -4   0   2   4  -7  -4   0   0  -1  -1 -10
W  -8   2  -5  -9 -10  -6  -9  -9  -4  -7  -3  -5  -6   0  -7  -3  -7  18  -1  -8  -7  -8  -6 -10
Y  -5  -6  -2  -6   0  -6  -6  -7   0  -2  -2  -6  -4   7  -7  -4  -4  -1  11  -4  -4  -6  -3 -10
V   0  -4  -3  -3  -3  -3  -3  -2  -3   5   2  -4   2  -2  -2  -2   0  -8  -4   6  -3  -3  -1 -10
B   0  -2   3   4  -6   1   3   0   1  -3  -5   0  -3  -6  -2   1   0  -7  -4  -3   4   3  -1 -10
Z   0   0   1   3  -7   5   5  -1   2  -3  -3   0  -2  -7  -1  -1  -1  -8  -6  -3   3   5  -1 -10
X  -1  -2  -1  -1  -4  -1  -1  -2  -1  -1  -2  -1  -1  -3  -1   0  -1  -6  -3  -1  -1  -1  -1 -10
* -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10   1

@@ PAM190
#
# This matrix was produced by "pam" Version 1.0.6 [28-Jul-93]
#
# PAM 190 substitution matrix, scale = ln(2)/3 = 0.231049
#
# Expected score = -1.35, Entropy = 0.547 bits
#
# Lowest score = -9, Highest score = 18
#
   A  R  N  D  C  Q  E  G  H  I  L  K  M  F  P  S  T  W  Y  V  B  Z  X  *
A  3 -2  0  0 -3 -1  0  1 -2 -1 -3 -2 -2 -5  1  1  2 -7 -4  0  0  0  0 -9
R -2  8 -1 -2 -5  1 -2 -4  2 -3 -4  4 -1 -6  0 -1 -2  2 -5 -3 -1  0 -1 -9
N  0 -1  3  3 -5  1  2  0  2 -2 -4  1 -3 -4 -1  1  0 -5 -2 -3  3  1 -1 -9
D  0 -2  3  5 -7  2  4  0  0 -3 -5  0 -4 -7 -2  0 -1 -8 -5 -3  4  3 -1 -9
C -3 -5 -5 -7 13 -7 -7 -4 -4 -3 -8 -7 -7 -6 -4  0 -3 -9  0 -3 -6 -7 -4 -9
Q -1  1  1  2 -7  6  3 -2  3 -3 -2  1 -1 -6  0 -1 -1 -6 -5 -3  1  4 -1 -9
E  0 -2  2  4 -7  3  5  0  0 -3 -4 -1 -3 -7 -1  0 -1 -9 -5 -3  3  4 -1 -9
G  1 -4  0  0 -4 -2  0  6 -3 -4 -5 -3 -4 -6 -1  1 -1 -9 -7 -2  0 -1 -1 -9
H -2  2  2  0 -4  3  0 -3  8 -3 -3 -1 -3 -2 -1 -1 -2 -3  0 -3  1  2 -1 -9
I -1 -3 -2 -3 -3 -3 -3 -4 -3  6  2 -3  2  1 -3 -2  0 -7 -2  4 -3 -3 -1 -9
L -3 -4 -4 -5 -8 -2 -4 -5 -3  2  7 -4  4  2 -3 -4 -2 -3 -2  2 -5 -3 -2 -9
K -2  4  1  0 -7  1 -1 -3 -1 -3 -4  6  1 -7 -2  0  0 -5 -6 -3  0  0 -1 -9
M -2 -1 -3 -4 -7 -1 -3 -4 -3  2  4  1  9  0 -3 -2 -1 -6 -4  2 -3 -2 -1 -9
F -5 -6 -4 -7 -6 -6 -7 -6 -2  1  2 -7  0 10 -6 -4 -4  0  7 -2 -6 -7 -3 -9
P  1  0 -1 -2 -4  0 -1 -1 -1 -3 -3 -2 -3 -6  7  1  0 -7 -6 -2 -1 -1 -1 -9
S  1 -1  1  0  0 -1  0  1 -1 -2 -4  0 -2 -4  1  3  2 -3 -4 -2  1 -1  0 -9
T  2 -2  0 -1 -3 -1 -1 -1 -2  0 -2  0 -1 -4  0  2  4 -6 -3  0  0 -1  0 -9
W -7  2 -5 -8 -9 -6 -9 -9 -3 -7 -3 -5 -6  0 -7 -3 -6 18 -1 -8 -6 -7 -5 -9
Y -4 -5 -2 -5  0 -5 -5 -7  0 -2 -2 -6 -4  7 -6 -4 -3 -1 11 -3 -4 -5 -3 -9
V  0 -3 -3 -3 -3 -3 -3 -2 -3  4  2 -3  2 -2 -2 -2  0 -8 -3  6 -3 -3 -1 -9
B  0 -1  3  4 -6  1  3  0  1 -3 -5  0 -3 -6 -1  1  0 -6 -4 -3  4  2 -1 -9
Z  0  0  1  3 -7  4  4 -1  2 -3 -3  0 -2 -7 -1 -1 -1 -7 -5 -3  2  4 -1 -9
X  0 -1 -1 -1 -4 -1 -1 -1 -1 -1 -2 -1 -1 -3 -1  0  0 -5 -3 -1 -1 -1 -1 -9
* -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9  1

@@ PAM200
#
# This matrix was produced by "pam" Version 1.0.6 [28-Jul-93]
#
# PAM 200 substitution matrix, scale = ln(2)/3 = 0.231049
#
# Expected score = -1.23, Entropy = 0.507 bits
#
# Lowest score = -9, Highest score = 18
#
   A  R  N  D  C  Q  E  G  H  I  L  K  M  F  P  S  T  W  Y  V  B  Z  X  *
A  3 -2  0  0 -3 -1  0  1 -2 -1 -2 -2 -2 -4  1  1  1 -7 -4  0  0  0  0 -9
R -2  7  0 -2 -4  1 -2 -4  2 -2 -4  4 -1 -5  0 -1 -1  2 -5 -3 -1  0 -1 -9
N  0  0  3  3 -5  1  2  0  2 -2 -4  1 -2 -4 -1  1  0 -5 -2 -2  3  1  0 -9
D  0 -2  3  5 -6  2  4  0  0 -3 -5  0 -4 -7 -2  0  0 -8 -5 -3  4  3 -1 -9
C -3 -4 -5 -6 12 -7 -7 -4 -4 -3 -7 -7 -6 -6 -4  0 -3 -9  0 -2 -5 -7 -4 -9
Q -1  1  1  2 -7  5  3 -2  3 -3 -2  1 -1 -6  0 -1 -1 -6 -5 -3  1  4 -1 -9
E  0 -2  2  4 -7  3  5  0  0 -3 -4  0 -3 -7 -1  0 -1 -9 -5 -2  3  4 -1 -9
G  1 -4  0  0 -4 -2  0  6 -3 -3 -5 -2 -4 -6 -1  1  0 -8 -6 -2  0 -1 -1 -9
H -2  2  2  0 -4  3  0 -3  8 -3 -3 -1 -3 -2 -1 -1 -2 -3  0 -3  1  2 -1 -9
I -1 -2 -2 -3 -3 -3 -3 -3 -3  6  2 -2  2  1 -3 -2  0 -6 -2  4 -3 -3 -1 -9
L -2 -4 -4 -5 -7 -2 -4 -5 -3  2  7 -4  4  2 -3 -4 -2 -2 -2  2 -4 -3 -2 -9
K -2  4  1  0 -7  1  0 -2 -1 -2 -4  6  1 -7 -2  0  0 -4 -5 -3  0  0 -1 -9
M -2 -1 -2 -4 -6 -1 -3 -4 -3  2  4  1  8  0 -3 -2 -1 -5 -3  2 -3 -2 -1 -9
F -4 -5 -4 -7 -6 -6 -7 -6 -2  1  2 -7  0 10 -6 -4 -4  0  7 -2 -6 -6 -3 -9
P  1  0 -1 -2 -4  0 -1 -1 -1 -3 -3 -2 -3 -6  7  1  0 -7 -6 -2 -1 -1 -1 -9
S  1 -1  1  0  0 -1  0  1 -1 -2 -4  0 -2 -4  1  2  2 -3 -3 -1  1 -1  0 -9
T  1 -1  0  0 -3 -1 -1  0 -2  0 -2  0 -1 -4  0  2  4 -6 -3  0  0 -1  0 -9
W -7  2 -5 -8 -9 -6 -9 -8 -3 -6 -2 -4 -5  0 -7 -3 -6 18 -1 -8 -6 -7 -5 -9
Y -4 -5 -2 -5  0 -5 -5 -6  0 -2 -2 -5 -3  7 -6 -3 -3 -1 11 -3 -4 -5 -3 -9
V  0 -3 -2 -3 -2 -3 -2 -2 -3  4  2 -3  2 -2 -2 -1  0 -8 -3  5 -3 -2 -1 -9
B  0 -1  3  4 -5  1  3  0  1 -3 -4  0 -3 -6 -1  1  0 -6 -4 -3  3  2 -1 -9
Z  0  0  1  3 -7  4  4 -1  2 -3 -3  0 -2 -6 -1 -1 -1 -7 -5 -2  2  4 -1 -9
X  0 -1  0 -1 -4 -1 -1 -1 -1 -1 -2 -1 -1 -3 -1  0  0 -5 -3 -1 -1 -1 -1 -9
* -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9  1

@@ PAM210
#
# This matrix was produced by "pam" Version 1.0.6 [28-Jul-93]
#
# PAM 210 substitution matrix, scale = ln(2)/3 = 0.231049
#
# Expected score = -1.12, Entropy = 0.470 bits
#
# Lowest score = -9, Highest score = 18
#
   A  R  N  D  C  Q  E  G  H  I  L  K  M  F  P  S  T  W  Y  V  B  Z  X  *
A  2 -2  0  0 -2 -1  0  1 -2 -1 -2 -2 -1 -4  1  1  1 -7 -4  0  0  0  0 -9
R -2  7  0 -2 -4  1 -2 -3  2 -2 -4  4 -1 -5  0  0 -1  2 -5 -3 -1  0 -1 -9
N  0  0  3  2 -4  1  2  0  2 -2 -3  1 -2 -4 -1  1  0 -5 -2 -2  3  1  0 -9
D  0 -2  2  5 -6  2  4  0  1 -3 -5  0 -3 -7 -1  0  0 -8 -5 -3  4  3 -1 -9
C -2 -4 -4 -6 12 -6 -6 -4 -4 -3 -7 -6 -6 -5 -3  0 -3 -9  0 -2 -5 -6 -4 -9
Q -1  1  1  2 -6  5  3 -2  3 -3 -2  1 -1 -6  0 -1 -1 -6 -5 -2  1  4 -1 -9
E  0 -2  2  4 -6  3  5  0  0 -2 -4  0 -3 -6 -1  0 -1 -8 -5 -2  3  4 -1 -9
G  1 -3  0  0 -4 -2  0  5 -3 -3 -5 -2 -3 -5 -1  1  0 -8 -6 -2  0 -1 -1 -9
H -2  2  2  1 -4  3  0 -3  8 -3 -2  0 -3 -2  0 -1 -2 -3  0 -3  1  2 -1 -9
I -1 -2 -2 -3 -3 -3 -2 -3 -3  5  2 -2  2  1 -3 -2  0 -6 -1  4 -3 -3 -1 -9
L -2 -4 -3 -5 -7 -2 -4 -5 -2  2  7 -3  4  2 -3 -3 -2 -2 -1  2 -4 -3 -2 -9
K -2  4  1  0 -6  1  0 -2  0 -2 -3  5  1 -6 -2  0  0 -4 -5 -3  0  0 -1 -9
M -1 -1 -2 -3 -6 -1 -3 -3 -3  2  4  1  8  0 -3 -2 -1 -5 -3  2 -3 -2 -1 -9
F -4 -5 -4 -7 -5 -6 -6 -5 -2  1  2 -6  0 10 -5 -4 -4  0  7 -2 -5 -6 -3 -9
P  1  0 -1 -1 -3  0 -1 -1  0 -3 -3 -2 -3 -5  7  1  0 -7 -6 -2 -1  0 -1 -9
S  1  0  1  0  0 -1  0  1 -1 -2 -3  0 -2 -4  1  2  2 -3 -3 -1  1  0  0 -9
T  1 -1  0  0 -3 -1 -1  0 -2  0 -2  0 -1 -4  0  2  3 -6 -3  0  0 -1  0 -9
W -7  2 -5 -8 -9 -6 -8 -8 -3 -6 -2 -4 -5  0 -7 -3 -6 18 -1 -7 -6 -7 -5 -9
Y -4 -5 -2 -5  0 -5 -5 -6  0 -1 -1 -5 -3  7 -6 -3 -3 -1 11 -3 -4 -5 -3 -9
V  0 -3 -2 -3 -2 -2 -2 -2 -3  4  2 -3  2 -2 -2 -1  0 -7 -3  5 -2 -2 -1 -9
B  0 -1  3  4 -5  1  3  0  1 -3 -4  0 -3 -5 -1  1  0 -6 -4 -2  3  2 -1 -9
Z  0  0  1  3 -6  4  4 -1  2 -3 -3  0 -2 -6  0  0 -1 -7 -5 -2  2  4 -1 -9
X  0 -1  0 -1 -4 -1 -1 -1 -1 -1 -2 -1 -1 -3 -1  0  0 -5 -3 -1 -1 -1 -1 -9
* -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9  1

@@ PAM220
#
# This matrix was produced by "pam" Version 1.0.6 [28-Jul-93]
#
# PAM 220 substitution matrix, scale = ln(2)/3 = 0.231049
#
# Expected score = -1.06, Entropy = 0.437 bits
#
# Lowest score = -8, Highest score = 17
#
   A  R  N  D  C  Q  E  G  H  I  L  K  M  F  P  S  T  W  Y  V  B  Z  X  *
A  2 -2  0  0 -2 -1  0  1 -2 -1 -2 -1 -1 -4  1  1  1 -6 -4  0  0  0  0 -8
R -2  7  0 -2 -4  1 -1 -3  2 -2 -3  4 -1 -5  0  0 -1  2 -5 -3 -1  0 -1 -8
N  0  0  3  2 -4  1  2  0  2 -2 -3  1 -2 -4 -1  1  0 -4 -2 -2  2  1  0 -8
D  0 -2  2  4 -6  2  4  0  1 -3 -5  0 -3 -6 -1  0  0 -8 -5 -3  4  3 -1 -8
C -2 -4 -4 -6 12 -6 -6 -4 -4 -3 -7 -6 -6 -5 -3  0 -3 -8  0 -2 -5 -6 -3 -8
Q -1  1  1  2 -6  5  3 -2  3 -2 -2  1 -1 -5  0 -1 -1 -5 -5 -2  1  4 -1 -8
E  0 -1  2  4 -6  3  4  0  1 -2 -4  0 -2 -6 -1  0 -1 -8 -5 -2  3  4 -1 -8
G  1 -3  0  0 -4 -2  0  5 -3 -3 -5 -2 -3 -5 -1  1  0 -8 -6 -2  0 -1 -1 -8
H -2  2  2  1 -4  3  1 -3  7 -3 -2  0 -3 -2  0 -1 -2 -3  0 -3  1  2 -1 -8
I -1 -2 -2 -3 -3 -2 -2 -3 -3  5  2 -2  2  1 -2 -2  0 -6 -1  4 -2 -2 -1 -8
L -2 -3 -3 -5 -7 -2 -4 -5 -2  2  6 -3  4  2 -3 -3 -2 -2 -1  2 -4 -3 -2 -8
K -1  4  1  0 -6  1  0 -2  0 -2 -3  5  1 -6 -1  0  0 -4 -5 -3  0  0 -1 -8
M -1 -1 -2 -3 -6 -1 -2 -3 -3  2  4  1  8  0 -2 -2 -1 -5 -3  2 -3 -2 -1 -8
F -4 -5 -4 -6 -5 -5 -6 -5 -2  1  2 -6  0 10 -5 -4 -4  0  7 -2 -5 -6 -3 -8
P  1  0 -1 -1 -3  0 -1 -1  0 -2 -3 -1 -2 -5  7  1  0 -6 -6 -1 -1  0 -1 -8
S  1  0  1  0  0 -1  0  1 -1 -2 -3  0 -2 -4  1  2  2 -3 -3 -1  0  0  0 -8
T  1 -1  0  0 -3 -1 -1  0 -2  0 -2  0 -1 -4  0  2  3 -6 -3  0  0 -1  0 -8
W -6  2 -4 -8 -8 -5 -8 -8 -3 -6 -2 -4 -5  0 -6 -3 -6 17  0 -7 -6 -7 -5 -8
Y -4 -5 -2 -5  0 -5 -5 -6  0 -1 -1 -5 -3  7 -6 -3 -3  0 11 -3 -3 -5 -3 -8
V  0 -3 -2 -3 -2 -2 -2 -2 -3  4  2 -3  2 -2 -1 -1  0 -7 -3  5 -2 -2 -1 -8
B  0 -1  2  4 -5  1  3  0  1 -2 -4  0 -3 -5 -1  0  0 -6 -3 -2  3  2 -1 -8
Z  0  0  1  3 -6  4  4 -1  2 -2 -3  0 -2 -6  0  0 -1 -7 -5 -2  2  4 -1 -8
X  0 -1  0 -1 -3 -1 -1 -1 -1 -1 -2 -1 -1 -3 -1  0  0 -5 -3 -1 -1 -1 -1 -8
* -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8  1

@@ PAM230
#
# This matrix was produced by "pam" Version 1.0.6 [28-Jul-93]
#
# PAM 230 substitution matrix, scale = ln(2)/3 = 0.231049
#
# Expected score = -0.991, Entropy = 0.407 bits
#
# Lowest score = -8, Highest score = 17
#
   A  R  N  D  C  Q  E  G  H  I  L  K  M  F  P  S  T  W  Y  V  B  Z  X  *
A  2 -2  0  0 -2 -1  0  1 -2 -1 -2 -1 -1 -4  1  1  1 -6 -4  0  0  0  0 -8
R -2  7  0 -2 -4  1 -1 -3  2 -2 -3  4 -1 -5  0  0 -1  2 -5 -3 -1  0 -1 -8
N  0  0  2  2 -4  1  1  0  2 -2 -3  1 -2 -4 -1  1  0 -4 -2 -2  2  1  0 -8
D  0 -2  2  4 -6  2  4  1  1 -3 -4  0 -3 -6 -1  0  0 -7 -5 -2  3  3 -1 -8
C -2 -4 -4 -6 12 -6 -6 -4 -4 -2 -7 -6 -6 -5 -3  0 -2 -8  0 -2 -5 -6 -3 -8
Q -1  1  1  2 -6  5  3 -1  3 -2 -2  1 -1 -5  0 -1 -1 -5 -4 -2  1  4 -1 -8
E  0 -1  1  4 -6  3  4  0  1 -2 -4  0 -2 -6 -1  0 -1 -8 -5 -2  3  4 -1 -8
G  1 -3  0  1 -4 -1  0  5 -2 -3 -4 -2 -3 -5 -1  1  0 -7 -6 -2  0 -1 -1 -8
H -2  2  2  1 -4  3  1 -2  7 -3 -2  0 -2 -2  0 -1 -2 -3  0 -2  1  2 -1 -8
I -1 -2 -2 -3 -2 -2 -2 -3 -3  5  2 -2  2  1 -2 -2  0 -6 -1  4 -2 -2 -1 -8
L -2 -3 -3 -4 -7 -2 -4 -4 -2  2  6 -3  4  2 -3 -3 -2 -2 -1  2 -4 -3 -2 -8
K -1  4  1  0 -6  1  0 -2  0 -2 -3  5  0 -6 -1  0  0 -4 -5 -3  1  0 -1 -8
M -1 -1 -2 -3 -6 -1 -2 -3 -2  2  4  0  7  0 -2 -2 -1 -5 -3  2 -2 -2 -1 -8
F -4 -5 -4 -6 -5 -5 -6 -5 -2  1  2 -6  0  9 -5 -3 -3  0  7 -1 -5 -6 -3 -8
P  1  0 -1 -1 -3  0 -1 -1  0 -2 -3 -1 -2 -5  6  1  0 -6 -5 -1 -1  0 -1 -8
S  1  0  1  0  0 -1  0  1 -1 -2 -3  0 -2 -3  1  2  2 -3 -3 -1  0  0  0 -8
T  1 -1  0  0 -2 -1 -1  0 -2  0 -2  0 -1 -3  0  2  3 -6 -3  0  0 -1  0 -8
W -6  2 -4 -7 -8 -5 -8 -7 -3 -6 -2 -4 -5  0 -6 -3 -6 17  0 -7 -6 -6 -4 -8
Y -4 -5 -2 -5  0 -4 -5 -6  0 -1 -1 -5 -3  7 -5 -3 -3  0 10 -3 -3 -5 -3 -8
V  0 -3 -2 -2 -2 -2 -2 -2 -2  4  2 -3  2 -1 -1 -1  0 -7 -3  5 -2 -2 -1 -8
B  0 -1  2  3 -5  1  3  0  1 -2 -4  1 -2 -5 -1  0  0 -6 -3 -2  3  2 -1 -8
Z  0  0  1  3 -6  4  4 -1  2 -2 -3  0 -2 -6  0  0 -1 -6 -5 -2  2  4 -1 -8
X  0 -1  0 -1 -3 -1 -1 -1 -1 -1 -2 -1 -1 -3 -1  0  0 -4 -3 -1 -1 -1 -1 -8
* -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8  1

@@ PAM240
#
# This matrix was produced by "pam" Version 1.0.6 [28-Jul-93]
#
# PAM 240 substitution matrix, scale = ln(2)/3 = 0.231049
#
# Expected score = -0.923, Entropy = 0.379 bits
#
# Lowest score = -8, Highest score = 17
#
   A  R  N  D  C  Q  E  G  H  I  L  K  M  F  P  S  T  W  Y  V  B  Z  X  *
A  2 -2  0  0 -2  0  0  1 -1 -1 -2 -1 -1 -4  1  1  1 -6 -4  0  0  0  0 -8
R -2  6  0 -1 -4  1 -1 -3  2 -2 -3  3  0 -5  0  0 -1  2 -4 -3 -1  0 -1 -8
N  0  0  2  2 -4  1  1  0  2 -2 -3  1 -2 -4 -1  1  0 -4 -2 -2  2  1  0 -8
D  0 -1  2  4 -5  2  4  1  1 -2 -4  0 -3 -6 -1  0  0 -7 -4 -2  3  3 -1 -8
C -2 -4 -4 -5 12 -6 -6 -4 -4 -2 -6 -6 -5 -5 -3  0 -2 -8  0 -2 -5 -6 -3 -8
Q  0  1  1  2 -6  4  3 -1  3 -2 -2  1 -1 -5  0 -1 -1 -5 -4 -2  1  3 -1 -8
E  0 -1  1  4 -6  3  4  0  1 -2 -3  0 -2 -6 -1  0  0 -7 -4 -2  3  3 -1 -8
G  1 -3  0  1 -4 -1  0  5 -2 -3 -4 -2 -3 -5 -1  1  0 -7 -5 -1  0  0 -1 -8
H -1  2  2  1 -4  3  1 -2  7 -3 -2  0 -2 -2  0 -1 -1 -3  0 -2  1  2 -1 -8
I -1 -2 -2 -2 -2 -2 -2 -3 -3  5  2 -2  2  1 -2 -1  0 -5 -1  4 -2 -2 -1 -8
L -2 -3 -3 -4 -6 -2 -3 -4 -2  2  6 -3  4  2 -3 -3 -2 -2 -1  2 -4 -3 -1 -8
K -1  3  1  0 -6  1  0 -2  0 -2 -3  5  0 -5 -1  0  0 -4 -5 -3  1  0 -1 -8
M -1  0 -2 -3 -5 -1 -2 -3 -2  2  4  0  7  0 -2 -2 -1 -4 -3  2 -2 -2 -1 -8
F -4 -5 -4 -6 -5 -5 -6 -5 -2  1  2 -5  0  9 -5 -3 -3  0  7 -1 -5 -5 -2 -8
P  1  0 -1 -1 -3  0 -1 -1  0 -2 -3 -1 -2 -5  6  1  0 -6 -5 -1 -1  0 -1 -8
S  1  0  1  0  0 -1  0  1 -1 -1 -3  0 -2 -3  1  2  1 -3 -3 -1  0  0  0 -8
T  1 -1  0  0 -2 -1  0  0 -1  0 -2  0 -1 -3  0  1  3 -5 -3  0  0 -1  0 -8
W -6  2 -4 -7 -8 -5 -7 -7 -3 -5 -2 -4 -4  0 -6 -3 -5 17  0 -6 -5 -6 -4 -8
Y -4 -4 -2 -4  0 -4 -4 -5  0 -1 -1 -5 -3  7 -5 -3 -3  0 10 -3 -3 -4 -2 -8
V  0 -3 -2 -2 -2 -2 -2 -1 -2  4  2 -3  2 -1 -1 -1  0 -6 -3  4 -2 -2 -1 -8
B  0 -1  2  3 -5  1  3  0  1 -2 -4  1 -2 -5 -1  0  0 -5 -3 -2  3  2 -1 -8
Z  0  0  1  3 -6  3  3  0  2 -2 -3  0 -2 -5  0  0 -1 -6 -4 -2  2  3 -1 -8
X  0 -1  0 -1 -3 -1 -1 -1 -1 -1 -1 -1 -1 -2 -1  0  0 -4 -2 -1 -1 -1 -1 -8
* -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8  1

@@ PAM250
#
# This matrix was produced by "pam" Version 1.0.6 [28-Jul-93]
#
# PAM 250 substitution matrix, scale = ln(2)/3 = 0.231049
#
# Expected score = -0.844, Entropy = 0.354 bits
#
# Lowest score = -8, Highest score = 17
#
   A  R  N  D  C  Q  E  G  H  I  L  K  M  F  P  S  T  W  Y  V  B  Z  X  *
A  2 -2  0  0 -2  0  0  1 -1 -1 -2 -1 -1 -3  1  1  1 -6 -3  0  0  0  0 -8
R -2  6  0 -1 -4  1 -1 -3  2 -2 -3  3  0 -4  0  0 -1  2 -4 -2 -1  0 -1 -8
N  0  0  2  2 -4  1  1  0  2 -2 -3  1 -2 -3  0  1  0 -4 -2 -2  2  1  0 -8
D  0 -1  2  4 -5  2  3  1  1 -2 -4  0 -3 -6 -1  0  0 -7 -4 -2  3  3 -1 -8
C -2 -4 -4 -5 12 -5 -5 -3 -3 -2 -6 -5 -5 -4 -3  0 -2 -8  0 -2 -4 -5 -3 -8
Q  0  1  1  2 -5  4  2 -1  3 -2 -2  1 -1 -5  0 -1 -1 -5 -4 -2  1  3 -1 -8
E  0 -1  1  3 -5  2  4  0  1 -2 -3  0 -2 -5 -1  0  0 -7 -4 -2  3  3 -1 -8
G  1 -3  0  1 -3 -1  0  5 -2 -3 -4 -2 -3 -5  0  1  0 -7 -5 -1  0  0 -1 -8
H -1  2  2  1 -3  3  1 -2  6 -2 -2  0 -2 -2  0 -1 -1 -3  0 -2  1  2 -1 -8
I -1 -2 -2 -2 -2 -2 -2 -3 -2  5  2 -2  2  1 -2 -1  0 -5 -1  4 -2 -2 -1 -8
L -2 -3 -3 -4 -6 -2 -3 -4 -2  2  6 -3  4  2 -3 -3 -2 -2 -1  2 -3 -3 -1 -8
K -1  3  1  0 -5  1  0 -2  0 -2 -3  5  0 -5 -1  0  0 -3 -4 -2  1  0 -1 -8
M -1  0 -2 -3 -5 -1 -2 -3 -2  2  4  0  6  0 -2 -2 -1 -4 -2  2 -2 -2 -1 -8
F -3 -4 -3 -6 -4 -5 -5 -5 -2  1  2 -5  0  9 -5 -3 -3  0  7 -1 -4 -5 -2 -8
P  1  0  0 -1 -3  0 -1  0  0 -2 -3 -1 -2 -5  6  1  0 -6 -5 -1 -1  0 -1 -8
S  1  0  1  0  0 -1  0  1 -1 -1 -3  0 -2 -3  1  2  1 -2 -3 -1  0  0  0 -8
T  1 -1  0  0 -2 -1  0  0 -1  0 -2  0 -1 -3  0  1  3 -5 -3  0  0 -1  0 -8
W -6  2 -4 -7 -8 -5 -7 -7 -3 -5 -2 -3 -4  0 -6 -2 -5 17  0 -6 -5 -6 -4 -8
Y -3 -4 -2 -4  0 -4 -4 -5  0 -1 -1 -4 -2  7 -5 -3 -3  0 10 -2 -3 -4 -2 -8
V  0 -2 -2 -2 -2 -2 -2 -1 -2  4  2 -2  2 -1 -1 -1  0 -6 -2  4 -2 -2 -1 -8
B  0 -1  2  3 -4  1  3  0  1 -2 -3  1 -2 -4 -1  0  0 -5 -3 -2  3  2 -1 -8
Z  0  0  1  3 -5  3  3  0  2 -2 -3  0 -2 -5  0  0 -1 -6 -4 -2  2  3 -1 -8
X  0 -1  0 -1 -3 -1 -1 -1 -1 -1 -1 -1 -1 -2 -1  0  0 -4 -2 -1 -1 -1 -1 -8
* -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8  1

@@ PAM260
#
# This matrix was produced by "pam" Version 1.0.6 [28-Jul-93]
#
# PAM 260 substitution matrix, scale = ln(2)/3 = 0.231049
#
# Expected score = -0.794, Entropy = 0.330 bits
#
# Lowest score = -7, Highest score = 17
#
   A  R  N  D  C  Q  E  G  H  I  L  K  M  F  P  S  T  W  Y  V  B  Z  X  *
A  2 -1  0  0 -2  0  0  1 -1  0 -2 -1 -1 -3  1  1  1 -6 -3  0  0  0  0 -7
R -1  6  0 -1 -4  1 -1 -2  2 -2 -3  3  0 -4  0  0 -1  2 -4 -2 -1  0 -1 -7
N  0  0  2  2 -3  1  1  0  2 -2 -3  1 -2 -3  0  1  0 -4 -2 -2  2  1  0 -7
D  0 -1  2  4 -5  2  3  1  1 -2 -4  0 -2 -5 -1  0  0 -6 -4 -2  3  3 -1 -7
C -2 -4 -3 -5 12 -5 -5 -3 -3 -2 -6 -5 -5 -4 -3  0 -2 -7  0 -2 -4 -5 -3 -7
Q  0  1  1  2 -5  4  2 -1  3 -2 -2  1 -1 -4  0  0 -1 -5 -4 -2  1  3  0 -7
E  0 -1  1  3 -5  2  4  0  1 -2 -3  0 -2 -5  0  0  0 -7 -4 -2  3  3 -1 -7
G  1 -2  0  1 -3 -1  0  5 -2 -2 -4 -2 -3 -5  0  1  0 -7 -5 -1  1  0 -1 -7
H -1  2  2  1 -3  3  1 -2  6 -2 -2  0 -2 -2  0 -1 -1 -3  0 -2  1  2 -1 -7
I  0 -2 -2 -2 -2 -2 -2 -2 -2  4  2 -2  2  1 -2 -1  0 -5 -1  4 -2 -2 -1 -7
L -2 -3 -3 -4 -6 -2 -3 -4 -2  2  6 -3  4  2 -2 -3 -2 -2 -1  2 -3 -2 -1 -7
K -1  3  1  0 -5  1  0 -2  0 -2 -3  4  0 -5 -1  0  0 -3 -4 -2  1  0 -1 -7
M -1  0 -2 -2 -5 -1 -2 -3 -2  2  4  0  6  0 -2 -1 -1 -4 -2  2 -2 -2 -1 -7
F -3 -4 -3 -5 -4 -4 -5 -5 -2  1  2 -5  0  9 -4 -3 -3  0  7 -1 -4 -5 -2 -7
P  1  0  0 -1 -3  0  0  0  0 -2 -2 -1 -2 -4  6  1  0 -5 -5 -1 -1  0 -1 -7
S  1  0  1  0  0  0  0  1 -1 -1 -3  0 -1 -3  1  1  1 -2 -3 -1  0  0  0 -7
T  1 -1  0  0 -2 -1  0  0 -1  0 -2  0 -1 -3  0  1  2 -5 -3  0  0  0  0 -7
W -6  2 -4 -6 -7 -5 -7 -7 -3 -5 -2 -3 -4  0 -5 -2 -5 17  0 -6 -5 -6 -4 -7
Y -3 -4 -2 -4  0 -4 -4 -5  0 -1 -1 -4 -2  7 -5 -3 -3  0 10 -2 -3 -4 -2 -7
V  0 -2 -2 -2 -2 -2 -2 -1 -2  4  2 -2  2 -1 -1 -1  0 -6 -2  4 -2 -2 -1 -7
B  0 -1  2  3 -4  1  3  1  1 -2 -3  1 -2 -4 -1  0  0 -5 -3 -2  3  2  0 -7
Z  0  0  1  3 -5  3  3  0  2 -2 -2  0 -2 -5  0  0  0 -6 -4 -2  2  3 -1 -7
X  0 -1  0 -1 -3  0 -1 -1 -1 -1 -1 -1 -1 -2 -1  0  0 -4 -2 -1  0 -1 -1 -7
* -7 -7 -7 -7 -7 -7 -7 -7 -7 -7 -7 -7 -7 -7 -7 -7 -7 -7 -7 -7 -7 -7 -7  1

@@ PAM270
#
# This matrix was produced by "pam" Version 1.0.6 [28-Jul-93]
#
# PAM 270 substitution matrix, scale = ln(2)/4 = 0.173287
#
# Expected score = -0.969, Entropy = 0.309 bits
#
# Lowest score = -10, Highest score = 23
#
    A   R   N   D   C   Q   E   G   H   I   L   K   M   F   P   S   T   W   Y   V   B   Z   X   *
A   2  -2   0   0  -2   0   0   2  -2  -1  -2  -1  -1  -4   1   1   1  -7  -4   0   0   0   0 -10
R  -2   8   0  -1  -5   2  -1  -3   2  -2  -4   4  -1  -5   0   0  -1   3  -5  -3  -1   0  -1 -10
N   0   0   2   2  -4   1   2   1   2  -2  -3   1  -2  -4   0   1   1  -5  -3  -2   2   2   0 -10
D   0  -1   2   5  -6   2   4   1   1  -3  -5   0  -3  -7  -1   0   0  -8  -5  -3   4   3  -1 -10
C  -2  -5  -4  -6  16  -7  -6  -4  -4  -3  -7  -7  -6  -5  -3   0  -3 -10   1  -2  -5  -7  -4 -10
Q   0   2   1   2  -7   5   3  -1   4  -2  -2   1  -1  -6   0  -1  -1  -6  -5  -2   2   4  -1 -10
E   0  -1   2   4  -6   3   5   0   1  -2  -4   0  -3  -7  -1   0   0  -9  -5  -2   3   4  -1 -10
G   2  -3   1   1  -4  -1   0   6  -2  -3  -5  -2  -3  -6   0   1   0  -9  -6  -2   1   0  -1 -10
H  -2   2   2   1  -4   4   1  -2   8  -3  -3   0  -3  -2   0  -1  -1  -3   0  -3   1   2  -1 -10
I  -1  -2  -2  -3  -3  -2  -2  -3  -3   5   3  -2   3   1  -2  -2   0  -6  -1   5  -3  -2  -1 -10
L  -2  -4  -3  -5  -7  -2  -4  -5  -3   3   8  -3   5   2  -3  -3  -2  -2  -1   2  -4  -3  -2 -10
K  -1   4   1   0  -7   1   0  -2   0  -2  -3   6   0  -6  -1   0   0  -4  -5  -3   1   0  -1 -10
M  -1  -1  -2  -3  -6  -1  -3  -3  -3   3   5   0   8   0  -2  -2  -1  -5  -3   2  -3  -2  -1 -10
F  -4  -5  -4  -7  -5  -6  -7  -6  -2   1   2  -6   0  12  -6  -4  -4   1   9  -1  -6  -6  -3 -10
P   1   0   0  -1  -3   0  -1   0   0  -2  -3  -1  -2  -6   7   1   0  -7  -6  -1  -1   0  -1 -10
S   1   0   1   0   0  -1   0   1  -1  -2  -3   0  -2  -4   1   2   2  -3  -4  -1   1   0   0 -10
T   1  -1   1   0  -3  -1   0   0  -1   0  -2   0  -1  -4   0   2   3  -6  -3   0   0  -1   0 -10
W  -7   3  -5  -8 -10  -6  -9  -9  -3  -6  -2  -4  -5   1  -7  -3  -6  23   0  -8  -7  -7  -5 -10
Y  -4  -5  -3  -5   1  -5  -5  -6   0  -1  -1  -5  -3   9  -6  -4  -3   0  13  -3  -4  -5  -3 -10
V   0  -3  -2  -3  -2  -2  -2  -2  -3   5   2  -3   2  -1  -1  -1   0  -8  -3   5  -2  -2  -1 -10
B   0  -1   2   4  -5   2   3   1   1  -3  -4   1  -3  -6  -1   1   0  -7  -4  -2   3   3  -1 -10
Z   0   0   2   3  -7   4   4   0   2  -2  -3   0  -2  -6   0   0  -1  -7  -5  -2   3   4  -1 -10
X   0  -1   0  -1  -4  -1  -1  -1  -1  -1  -2  -1  -1  -3  -1   0   0  -5  -3  -1  -1  -1  -1 -10
* -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10   1

@@ PAM280
#
# This matrix was produced by "pam" Version 1.0.6 [28-Jul-93]
#
# PAM 280 substitution matrix, scale = ln(2)/4 = 0.173287
#
# Expected score = -0.916, Entropy = 0.289 bits
#
# Lowest score = -9, Highest score = 22
#
   A  R  N  D  C  Q  E  G  H  I  L  K  M  F  P  S  T  W  Y  V  B  Z  X  *
A  2 -2  0  0 -2  0  0  2 -1 -1 -2 -1 -1 -4  1  1  1 -7 -4  0  0  0  0 -9
R -2  7  0 -1 -4  2 -1 -3  2 -2 -3  4  0 -5  0  0 -1  3 -5 -3 -1  0 -1 -9
N  0  0  2  2 -4  1  2  1  2 -2 -3  1 -2 -4  0  1  1 -5 -3 -2  2  1  0 -9
D  0 -1  2  4 -6  2  4  1  1 -3 -5  0 -3 -7 -1  0  0 -8 -5 -2  4  3 -1 -9
C -2 -4 -4 -6 15 -6 -6 -4 -4 -3 -7 -6 -6 -5 -3  0 -3 -9  1 -2 -5 -6 -3 -9
Q  0  2  1  2 -6  4  3 -1  3 -2 -2  1 -1 -5  0  0 -1 -6 -5 -2  2  4 -1 -9
E  0 -1  2  4 -6  3  4  0  1 -2 -4  0 -2 -6  0  0  0 -8 -5 -2  3  4 -1 -9
G  2 -3  1  1 -4 -1  0  6 -2 -3 -5 -2 -3 -6  0  1  0 -8 -6 -1  1  0 -1 -9
H -1  2  2  1 -4  3  1 -2  8 -3 -2  0 -2 -2  0 -1 -1 -3  0 -3  1  2 -1 -9
I -1 -2 -2 -3 -3 -2 -2 -3 -3  5  3 -2  3  1 -2 -2  0 -6 -1  4 -2 -2 -1 -9
L -2 -3 -3 -5 -7 -2 -4 -5 -2  3  7 -3  5  2 -3 -3 -2 -2 -1  2 -4 -3 -1 -9
K -1  4  1  0 -6  1  0 -2  0 -2 -3  6  0 -6 -1  0  0 -4 -5 -3  1  1 -1 -9
M -1  0 -2 -3 -6 -1 -2 -3 -2  3  5  0  7  0 -2 -2 -1 -5 -3  2 -2 -2 -1 -9
F -4 -5 -4 -7 -5 -5 -6 -6 -2  1  2 -6  0 11 -5 -4 -4  1  9 -1 -5 -6 -3 -9
P  1  0  0 -1 -3  0  0  0  0 -2 -3 -1 -2 -5  7  1  1 -7 -6 -1 -1  0 -1 -9
S  1  0  1  0  0  0  0  1 -1 -2 -3  0 -2 -4  1  2  1 -3 -3 -1  1  0  0 -9
T  1 -1  1  0 -3 -1  0  0 -1  0 -2  0 -1 -4  1  1  3 -6 -3  0  0  0  0 -9
W -7  3 -5 -8 -9 -6 -8 -8 -3 -6 -2 -4 -5  1 -7 -3 -6 22  0 -7 -6 -7 -5 -9
Y -4 -5 -3 -5  1 -5 -5 -6  0 -1 -1 -5 -3  9 -6 -3 -3  0 13 -3 -4 -5 -3 -9
V  0 -3 -2 -2 -2 -2 -2 -1 -3  4  2 -3  2 -1 -1 -1  0 -7 -3  5 -2 -2 -1 -9
B  0 -1  2  4 -5  2  3  1  1 -2 -4  1 -2 -5 -1  1  0 -6 -4 -2  3  2 -1 -9
Z  0  0  1  3 -6  4  4  0  2 -2 -3  1 -2 -6  0  0  0 -7 -5 -2  2  4 -1 -9
X  0 -1  0 -1 -3 -1 -1 -1 -1 -1 -1 -1 -1 -3 -1  0  0 -5 -3 -1 -1 -1 -1 -9
* -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9  1

@@ PAM290
#
# This matrix was produced by "pam" Version 1.0.6 [28-Jul-93]
#
# PAM 290 substitution matrix, scale = ln(2)/4 = 0.173287
#
# Expected score = -0.877, Entropy = 0.271 bits
#
# Lowest score = -9, Highest score = 22
#
   A  R  N  D  C  Q  E  G  H  I  L  K  M  F  P  S  T  W  Y  V  B  Z  X  *
A  2 -2  0  0 -2  0  0  2 -1 -1 -2 -1 -1 -4  1  1  1 -7 -4  0  0  0  0 -9
R -2  7  0 -1 -4  2 -1 -3  2 -2 -3  4  0 -5  0  0 -1  3 -5 -3  0  0 -1 -9
N  0  0  2  2 -4  1  2  1  2 -2 -3  1 -2 -4  0  1  1 -5 -3 -2  2  1  0 -9
D  0 -1  2  4 -6  2  4  1  1 -3 -4  0 -3 -6 -1  0  0 -8 -5 -2  3  3 -1 -9
C -2 -4 -4 -6 15 -6 -6 -4 -4 -3 -7 -6 -6 -5 -3  0 -2 -9  1 -2 -5 -6 -3 -9
Q  0  2  1  2 -6  4  3 -1  3 -2 -2  1 -1 -5  0  0 -1 -5 -5 -2  2  3  0 -9
E  0 -1  2  4 -6  3  4  0  1 -2 -4  0 -2 -6  0  0  0 -8 -5 -2  3  4 -1 -9
G  2 -3  1  1 -4 -1  0  5 -2 -3 -4 -2 -3 -6  0  1  0 -8 -6 -1  1  0 -1 -9
H -1  2  2  1 -4  3  1 -2  7 -3 -2  0 -2 -2  0 -1 -1 -3  0 -2  1  2 -1 -9
I -1 -2 -2 -3 -3 -2 -2 -3 -3  5  3 -2  3  1 -2 -1  0 -6 -1  4 -2 -2 -1 -9
L -2 -3 -3 -4 -7 -2 -4 -4 -2  3  7 -3  5  3 -3 -3 -2 -2 -1  2 -4 -3 -1 -9
K -1  4  1  0 -6  1  0 -2  0 -2 -3  5  0 -6 -1  0  0 -4 -5 -3  1  1 -1 -9
M -1  0 -2 -3 -6 -1 -2 -3 -2  3  5  0  7  0 -2 -2 -1 -5 -2  2 -2 -2 -1 -9
F -4 -5 -4 -6 -5 -5 -6 -6 -2  1  3 -6  0 11 -5 -4 -3  1  9 -1 -5 -6 -3 -9
P  1  0  0 -1 -3  0  0  0  0 -2 -3 -1 -2 -5  7  1  1 -6 -6 -1 -1  0 -1 -9
S  1  0  1  0  0  0  0  1 -1 -1 -3  0 -2 -4  1  2  1 -3 -3 -1  1  0  0 -9
T  1 -1  1  0 -2 -1  0  0 -1  0 -2  0 -1 -3  1  1  3 -6 -3  0  0  0  0 -9
W -7  3 -5 -8 -9 -5 -8 -8 -3 -6 -2 -4 -5  1 -6 -3 -6 22  0 -7 -6 -7 -5 -9
Y -4 -5 -3 -5  1 -5 -5 -6  0 -1 -1 -5 -2  9 -6 -3 -3  0 13 -3 -4 -5 -2 -9
V  0 -3 -2 -2 -2 -2 -2 -1 -2  4  2 -3  2 -1 -1 -1  0 -7 -3  5 -2 -2 -1 -9
B  0  0  2  3 -5  2  3  1  1 -2 -4  1 -2 -5 -1  1  0 -6 -4 -2  3  2  0 -9
Z  0  0  1  3 -6  3  4  0  2 -2 -3  1 -2 -6  0  0  0 -7 -5 -2  2  4 -1 -9
X  0 -1  0 -1 -3  0 -1 -1 -1 -1 -1 -1 -1 -3 -1  0  0 -5 -2 -1  0 -1 -1 -9
* -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9  1

@@ PAM300
#
# This matrix was produced by "pam" Version 1.0.6 [28-Jul-93]
#
# PAM 300 substitution matrix, scale = ln(2)/4 = 0.173287
#
# Expected score = -0.835, Entropy = 0.254 bits
#
# Lowest score = -9, Highest score = 22
#
   A  R  N  D  C  Q  E  G  H  I  L  K  M  F  P  S  T  W  Y  V  B  Z  X  *
A  2 -1  0  0 -2  0  0  2 -1  0 -2 -1 -1 -4  1  1  1 -6 -4  0  0  0  0 -9
R -1  7  0 -1 -4  2 -1 -2  2 -2 -3  4  0 -5  0  0 -1  3 -5 -3  0  0 -1 -9
N  0  0  2  2 -4  1  2  1  2 -2 -3  1 -2 -4  0  1  0 -5 -2 -2  2  1  0 -9
D  0 -1  2  4 -6  2  4  1  1 -2 -4  0 -3 -6 -1  0  0 -7 -5 -2  3  3 -1 -9
C -2 -4 -4 -6 15 -6 -6 -4 -4 -3 -7 -6 -6 -5 -3  0 -2 -9  1 -2 -5 -6 -3 -9
Q  0  2  1  2 -6  4  3 -1  3 -2 -2  1 -1 -5  0  0 -1 -5 -4 -2  2  3  0 -9
E  0 -1  2  4 -6  3  4  0  1 -2 -4  0 -2 -6  0  0  0 -8 -5 -2  3  3 -1 -9
G  2 -2  1  1 -4 -1  0  5 -2 -3 -4 -2 -3 -5  0  1  0 -8 -6 -1  1  0 -1 -9
H -1  2  2  1 -4  3  1 -2  7 -2 -2  0 -2 -2  0 -1 -1 -3  0 -2  1  2  0 -9
I  0 -2 -2 -2 -3 -2 -2 -3 -2  5  3 -2  3  1 -2 -1  0 -6 -1  4 -2 -2 -1 -9
L -2 -3 -3 -4 -7 -2 -4 -4 -2  3  7 -3  4  3 -3 -3 -2 -2  0  2 -4 -3 -1 -9
K -1  4  1  0 -6  1  0 -2  0 -2 -3  5  0 -6 -1  0  0 -4 -5 -2  1  1 -1 -9
M -1  0 -2 -3 -6 -1 -2 -3 -2  3  4  0  6  1 -2 -2 -1 -5 -2  2 -2 -2 -1 -9
F -4 -5 -4 -6 -5 -5 -6 -5 -2  1  3 -6  1 11 -5 -4 -3  1  9 -1 -5 -5 -2 -9
P  1  0  0 -1 -3  0  0  0  0 -2 -3 -1 -2 -5  6  1  1 -6 -5 -1  0  0 -1 -9
S  1  0  1  0  0  0  0  1 -1 -1 -3  0 -2 -4  1  1  1 -3 -3 -1  1  0  0 -9
T  1 -1  0  0 -2 -1  0  0 -1  0 -2  0 -1 -3  1  1  2 -6 -3  0  0  0  0 -9
W -6  3 -5 -7 -9 -5 -8 -8 -3 -6 -2 -4 -5  1 -6 -3 -6 22  0 -7 -6 -6 -4 -9
Y -4 -5 -2 -5  1 -4 -5 -6  0 -1  0 -5 -2  9 -5 -3 -3  0 12 -3 -4 -5 -2 -9
V  0 -3 -2 -2 -2 -2 -2 -1 -2  4  2 -2  2 -1 -1 -1  0 -7 -3  5 -2 -2  0 -9
B  0  0  2  3 -5  2  3  1  1 -2 -4  1 -2 -5  0  1  0 -6 -4 -2  3  2  0 -9
Z  0  0  1  3 -6  3  3  0  2 -2 -3  1 -2 -5  0  0  0 -6 -5 -2  2  3 -1 -9
X  0 -1  0 -1 -3  0 -1 -1  0 -1 -1 -1 -1 -2 -1  0  0 -4 -2  0  0 -1 -1 -9
* -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9  1

@@ PAM310
#
# This matrix was produced by "pam" Version 1.0.6 [28-Jul-93]
#
# PAM 310 substitution matrix, scale = ln(2)/4 = 0.173287
#
# Expected score = -0.779, Entropy = 0.238 bits
#
# Lowest score = -9, Highest score = 22
#
   A  R  N  D  C  Q  E  G  H  I  L  K  M  F  P  S  T  W  Y  V  B  Z  X  *
A  2 -1  0  0 -2  0  0  1 -1  0 -2 -1 -1 -4  1  1  1 -6 -4  0  0  0  0 -9
R -1  6  0 -1 -4  1 -1 -2  2 -2 -3  4  0 -5  0  0 -1  3 -4 -2  0  0 -1 -9
N  0  0  2  2 -4  1  2  1  2 -2 -3  1 -2 -4  0  1  0 -4 -2 -2  2  1  0 -9
D  0 -1  2  4 -5  2  4  1  1 -2 -4  0 -2 -6 -1  0  0 -7 -5 -2  3  3 -1 -9
C -2 -4 -4 -5 15 -6 -6 -3 -4 -2 -6 -6 -6 -4 -3  0 -2 -9  1 -2 -5 -6 -3 -9
Q  0  1  1  2 -6  4  3 -1  3 -2 -2  1 -1 -5  0  0 -1 -5 -4 -2  2  3  0 -9
E  0 -1  2  4 -6  3  4  1  1 -2 -3  0 -2 -6  0  0  0 -7 -5 -2  3  3 -1 -9
G  1 -2  1  1 -3 -1  1  5 -2 -2 -4 -1 -3 -5  0  1  0 -8 -6 -1  1  0 -1 -9
H -1  2  2  1 -4  3  1 -2  7 -2 -2  0 -2 -2  0 -1 -1 -3  0 -2  1  2  0 -9
I  0 -2 -2 -2 -2 -2 -2 -2 -2  4  3 -2  3  1 -2 -1  0 -5 -1  4 -2 -2 -1 -9
L -2 -3 -3 -4 -6 -2 -3 -4 -2  3  7 -3  4  3 -3 -3 -2 -2  0  2 -3 -3 -1 -9
K -1  4  1  0 -6  1  0 -1  0 -2 -3  5  0 -5 -1  0  0 -3 -5 -2  1  1 -1 -9
M -1  0 -2 -2 -6 -1 -2 -3 -2  3  4  0  6  1 -2 -2 -1 -4 -2  2 -2 -2 -1 -9
F -4 -5 -4 -6 -4 -5 -6 -5 -2  1  3 -5  1 11 -5 -4 -3  1  9 -1 -5 -5 -2 -9
P  1  0  0 -1 -3  0  0  0  0 -2 -3 -1 -2 -5  6  1  1 -6 -5 -1  0  0  0 -9
S  1  0  1  0  0  0  0  1 -1 -1 -3  0 -2 -4  1  1  1 -3 -3 -1  1  0  0 -9
T  1 -1  0  0 -2 -1  0  0 -1  0 -2  0 -1 -3  1  1  2 -6 -3  0  0  0  0 -9
W -6  3 -4 -7 -9 -5 -7 -8 -3 -5 -2 -3 -4  1 -6 -3 -6 22  0 -7 -6 -6 -4 -9
Y -4 -4 -2 -5  1 -4 -5 -6  0 -1  0 -5 -2  9 -5 -3 -3  0 12 -2 -4 -4 -2 -9
V  0 -2 -2 -2 -2 -2 -2 -1 -2  4  2 -2  2 -1 -1 -1  0 -7 -2  4 -2 -2  0 -9
B  0  0  2  3 -5  2  3  1  1 -2 -3  1 -2 -5  0  1  0 -6 -4 -2  3  2  0 -9
Z  0  0  1  3 -6  3  3  0  2 -2 -3  1 -2 -5  0  0  0 -6 -4 -2  2  3  0 -9
X  0 -1  0 -1 -3  0 -1 -1  0 -1 -1 -1 -1 -2  0  0  0 -4 -2  0  0  0 -1 -9
* -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9  1

@@ PAM320
#
# This matrix was produced by "pam" Version 1.0.6 [28-Jul-93]
#
# PAM 320 substitution matrix, scale = ln(2)/4 = 0.173287
#
# Expected score = -0.741, Entropy = 0.224 bits
#
# Lowest score = -8, Highest score = 22
#
   A  R  N  D  C  Q  E  G  H  I  L  K  M  F  P  S  T  W  Y  V  B  Z  X  *
A  1 -1  0  1 -2  0  0  1 -1  0 -2 -1 -1 -4  1  1  1 -6 -4  0  0  0  0 -8
R -1  6  0 -1 -4  1 -1 -2  2 -2 -3  4  0 -5  0  0 -1  3 -4 -2  0  0 -1 -8
N  0  0  2  2 -4  1  2  1  2 -2 -3  1 -2 -4  0  1  0 -4 -2 -2  2  1  0 -8
D  1 -1  2  4 -5  2  3  1  1 -2 -4  0 -2 -6  0  0  0 -7 -5 -2  3  3 -1 -8
C -2 -4 -4 -5 15 -5 -5 -3 -4 -2 -6 -6 -5 -4 -3  0 -2 -8  1 -2 -4 -5 -3 -8
Q  0  1  1  2 -5  4  2 -1  3 -2 -2  1 -1 -5  0  0  0 -5 -4 -2  2  3  0 -8
E  0 -1  2  3 -5  2  4  1  1 -2 -3  0 -2 -5  0  0  0 -7 -5 -2  3  3  0 -8
G  1 -2  1  1 -3 -1  1  5 -2 -2 -4 -1 -3 -5  0  1  0 -7 -5 -1  1  0 -1 -8
H -1  2  2  1 -4  3  1 -2  6 -2 -2  0 -2 -2  0 -1 -1 -3  0 -2  1  2  0 -8
I  0 -2 -2 -2 -2 -2 -2 -2 -2  4  3 -2  2  1 -2 -1  0 -5 -1  4 -2 -2  0 -8
L -2 -3 -3 -4 -6 -2 -3 -4 -2  3  7 -3  4  3 -2 -3 -2 -2  0  2 -3 -3 -1 -8
K -1  4  1  0 -6  1  0 -1  0 -2 -3  5  0 -5 -1  0  0 -3 -5 -2  1  1 -1 -8
M -1  0 -2 -2 -5 -1 -2 -3 -2  2  4  0  6  1 -2 -1 -1 -4 -2  2 -2 -2  0 -8
F -4 -5 -4 -6 -4 -5 -5 -5 -2  1  3 -5  1 11 -5 -3 -3  1  9 -1 -5 -5 -2 -8
P  1  0  0  0 -3  0  0  0  0 -2 -2 -1 -2 -5  6  1  1 -6 -5 -1  0  0  0 -8
S  1  0  1  0  0  0  0  1 -1 -1 -3  0 -1 -3  1  1  1 -3 -3 -1  1  0  0 -8
T  1 -1  0  0 -2  0  0  0 -1  0 -2  0 -1 -3  1  1  2 -5 -3  0  0  0  0 -8
W -6  3 -4 -7 -8 -5 -7 -7 -3 -5 -2 -3 -4  1 -6 -3 -5 22  1 -6 -6 -6 -4 -8
Y -4 -4 -2 -5  1 -4 -5 -5  0 -1  0 -5 -2  9 -5 -3 -3  1 12 -2 -3 -4 -2 -8
V  0 -2 -2 -2 -2 -2 -2 -1 -2  4  2 -2  2 -1 -1 -1  0 -6 -2  4 -2 -2  0 -8
B  0  0  2  3 -4  2  3  1  1 -2 -3  1 -2 -5  0  1  0 -6 -3 -2  2  2  0 -8
Z  0  0  1  3 -5  3  3  0  2 -2 -3  1 -2 -5  0  0  0 -6 -4 -2  2  3  0 -8
X  0 -1  0 -1 -3  0  0 -1  0  0 -1 -1  0 -2  0  0  0 -4 -2  0  0  0 -1 -8
* -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8  1

@@ PAM330
#
# This matrix was produced by "pam" Version 1.0.6 [28-Jul-93]
#
# PAM 330 substitution matrix, scale = ln(2)/4 = 0.173287
#
# Expected score = -0.693, Entropy = 0.210 bits
#
# Lowest score = -8, Highest score = 22
#
   A  R  N  D  C  Q  E  G  H  I  L  K  M  F  P  S  T  W  Y  V  B  Z  X  *
A  1 -1  0  1 -2  0  0  1 -1  0 -2 -1 -1 -3  1  1  1 -6 -3  0  0  0  0 -8
R -1  6  0 -1 -4  1 -1 -2  2 -2 -3  4  0 -4  0  0 -1  3 -4 -2  0  0 -1 -8
N  0  0  2  2 -4  1  2  1  1 -2 -3  1 -1 -3  0  1  0 -4 -2 -1  2  1  0 -8
D  1 -1  2  3 -5  2  3  1  1 -2 -4  0 -2 -5  0  0  0 -7 -4 -2  3  3  0 -8
C -2 -4 -4 -5 15 -5 -5 -3 -3 -2 -6 -5 -5 -4 -3  0 -2 -8  1 -2 -4 -5 -3 -8
Q  0  1  1  2 -5  3  2 -1  3 -2 -2  1 -1 -4  0  0  0 -5 -4 -2  1  3  0 -8
E  0 -1  2  3 -5  2  3  1  1 -2 -3  0 -2 -5  0  0  0 -7 -4 -2  2  3  0 -8
G  1 -2  1  1 -3 -1  1  5 -2 -2 -4 -1 -2 -5  0  1  0 -7 -5 -1  1  0 -1 -8
H -1  2  1  1 -3  3  1 -2  6 -2 -2  0 -2 -2  0 -1 -1 -3  0 -2  1  2  0 -8
I  0 -2 -2 -2 -2 -2 -2 -2 -2  4  3 -2  2  1 -2 -1  0 -5  0  4 -2 -2  0 -8
L -2 -3 -3 -4 -6 -2 -3 -4 -2  3  6 -3  4  3 -2 -3 -1 -2  0  2 -3 -2 -1 -8
K -1  4  1  0 -5  1  0 -1  0 -2 -3  5  0 -5 -1  0  0 -3 -4 -2  1  1 -1 -8
M -1  0 -1 -2 -5 -1 -2 -2 -2  2  4  0  5  1 -2 -1  0 -4 -2  2 -2 -1  0 -8
F -3 -4 -3 -5 -4 -4 -5 -5 -2  1  3 -5  1 10 -5 -3 -3  1  9 -1 -4 -5 -2 -8
P  1  0  0  0 -3  0  0  0  0 -2 -2 -1 -2 -5  6  1  1 -6 -5 -1  0  0  0 -8
S  1  0  1  0  0  0  0  1 -1 -1 -3  0 -1 -3  1  1  1 -3 -3 -1  1  0  0 -8
T  1 -1  0  0 -2  0  0  0 -1  0 -1  0  0 -3  1  1  2 -5 -3  0  0  0  0 -8
W -6  3 -4 -7 -8 -5 -7 -7 -3 -5 -2 -3 -4  1 -6 -3 -5 22  1 -6 -5 -6 -4 -8
Y -3 -4 -2 -4  1 -4 -4 -5  0  0  0 -4 -2  9 -5 -3 -3  1 12 -2 -3 -4 -2 -8
V  0 -2 -1 -2 -2 -2 -2 -1 -2  4  2 -2  2 -1 -1 -1  0 -6 -2  4 -2 -2  0 -8
B  0  0  2  3 -4  1  2  1  1 -2 -3  1 -2 -4  0  1  0 -5 -3 -2  2  2  0 -8
Z  0  0  1  3 -5  3  3  0  2 -2 -2  1 -1 -5  0  0  0 -6 -4 -2  2  3  0 -8
X  0 -1  0  0 -3  0  0 -1  0  0 -1 -1  0 -2  0  0  0 -4 -2  0  0  0 -1 -8
* -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8  1

@@ PAM340
#
# This matrix was produced by "pam" Version 1.0.6 [28-Jul-93]
#
# PAM 340 substitution matrix, scale = ln(2)/4 = 0.173287
#
# Expected score = -0.680, Entropy = 0.198 bits
#
# Lowest score = -8, Highest score = 22
#
   A  R  N  D  C  Q  E  G  H  I  L  K  M  F  P  S  T  W  Y  V  B  Z  X  *
A  1 -1  0  1 -2  0  0  1 -1  0 -2 -1 -1 -3  1  1  1 -6 -3  0  0  0  0 -8
R -1  6  0 -1 -4  1  0 -2  2 -2 -3  4  0 -4  0  0  0  3 -4 -2  0  0 -1 -8
N  0  0  1  2 -3  1  1  1  1 -2 -3  1 -1 -3  0  1  0 -4 -2 -1  2  1  0 -8
D  1 -1  2  3 -5  2  3  1  1 -2 -4  0 -2 -5  0  0  0 -7 -4 -2  3  3  0 -8
C -2 -4 -3 -5 15 -5 -5 -3 -3 -2 -6 -5 -5 -4 -3  0 -2 -8  1 -2 -4 -5 -3 -8
Q  0  1  1  2 -5  3  2 -1  3 -2 -2  1 -1 -4  0  0  0 -5 -4 -2  1  3  0 -8
E  0  0  1  3 -5  2  3  1  1 -2 -3  0 -2 -5  0  0  0 -7 -4 -1  2  3  0 -8
G  1 -2  1  1 -3 -1  1  4 -2 -2 -4 -1 -2 -5  0  1  0 -7 -5 -1  1  0 -1 -8
H -1  2  1  1 -3  3  1 -2  6 -2 -2  0 -2 -2  0  0 -1 -2  0 -2  1  2  0 -8
I  0 -2 -2 -2 -2 -2 -2 -2 -2  4  3 -2  2  1 -2 -1  0 -5  0  3 -2 -2  0 -8
L -2 -3 -3 -4 -6 -2 -3 -4 -2  3  6 -3  4  3 -2 -2 -1 -2  0  2 -3 -2 -1 -8
K -1  4  1  0 -5  1  0 -1  0 -2 -3  4  0 -5 -1  0  0 -3 -4 -2  1  1  0 -8
M -1  0 -1 -2 -5 -1 -2 -2 -2  2  4  0  5  1 -2 -1  0 -4 -2  2 -2 -1  0 -8
F -3 -4 -3 -5 -4 -4 -5 -5 -2  1  3 -5  1 10 -4 -3 -3  1  9 -1 -4 -5 -2 -8
P  1  0  0  0 -3  0  0  0  0 -2 -2 -1 -2 -4  5  1  1 -5 -5 -1  0  0  0 -8
S  1  0  1  0  0  0  0  1  0 -1 -2  0 -1 -3  1  1  1 -3 -3 -1  1  0  0 -8
T  1  0  0  0 -2  0  0  0 -1  0 -1  0  0 -3  1  1  2 -5 -3  0  0  0  0 -8
W -6  3 -4 -7 -8 -5 -7 -7 -2 -5 -2 -3 -4  1 -5 -3 -5 22  1 -6 -5 -6 -4 -8
Y -3 -4 -2 -4  1 -4 -4 -5  0  0  0 -4 -2  9 -5 -3 -3  1 12 -2 -3 -4 -2 -8
V  0 -2 -1 -2 -2 -2 -1 -1 -2  3  2 -2  2 -1 -1 -1  0 -6 -2  4 -2 -2  0 -8
B  0  0  2  3 -4  1  2  1  1 -2 -3  1 -2 -4  0  1  0 -5 -3 -2  2  2  0 -8
Z  0  0  1  3 -5  3  3  0  2 -2 -2  1 -1 -5  0  0  0 -6 -4 -2  2  3  0 -8
X  0 -1  0  0 -3  0  0 -1  0  0 -1  0  0 -2  0  0  0 -4 -2  0  0  0 -1 -8
* -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8  1

@@ PAM350
#
# This matrix was produced by "pam" Version 1.0.6 [28-Jul-93]
#
# PAM 350 substitution matrix, scale = ln(2)/5 = 0.138629
#
# Expected score = -0.701, Entropy = 0.186 bits
#
# Lowest score = -10, Highest score = 27
#
    A   R   N   D   C   Q   E   G   H   I   L   K   M   F   P   S   T   W   Y   V   B   Z   X   *
A   2  -1   0   1  -2   0   1   2  -1   0  -2  -1  -1  -4   1   1   1  -7  -4   0   1   0   0 -10
R  -1   7   1  -1  -4   2   0  -2   2  -2  -3   4   0  -5   0   0  -1   4  -5  -3   0   1  -1 -10
N   0   1   2   2  -4   1   2   1   2  -2  -3   1  -2  -4   0   1   1  -5  -3  -2   2   2   0 -10
D   1  -1   2   4  -6   2   4   1   1  -2  -4   1  -3  -6   0   1   0  -8  -5  -2   3   3  -1 -10
C  -2  -4  -4  -6  18  -6  -6  -4  -4  -3  -7  -6  -6  -5  -3   0  -2 -10   1  -2  -5  -6  -3 -10
Q   0   2   1   2  -6   4   3  -1   3  -2  -2   1  -1  -5   1   0   0  -5  -5  -2   2   3   0 -10
E   1   0   2   4  -6   3   4   1   1  -2  -4   0  -2  -6   0   0   0  -8  -5  -2   3   3   0 -10
G   2  -2   1   1  -4  -1   1   5  -2  -2  -4  -1  -3  -6   0   1   1  -8  -6  -1   1   0  -1 -10
H  -1   2   2   1  -4   3   1  -2   7  -2  -2   1  -2  -2   0  -1  -1  -3   0  -2   1   2   0 -10
I   0  -2  -2  -2  -3  -2  -2  -2  -2   5   4  -2   3   2  -2  -1   0  -6   0   4  -2  -2   0 -10
L  -2  -3  -3  -4  -7  -2  -4  -4  -2   4   8  -3   5   3  -3  -3  -2  -2   0   3  -4  -3  -1 -10
K  -1   4   1   1  -6   1   0  -1   1  -2  -3   5   0  -6  -1   0   0  -4  -5  -2   1   1  -1 -10
M  -1   0  -2  -3  -6  -1  -2  -3  -2   3   5   0   6   1  -2  -2  -1  -5  -2   2  -2  -2   0 -10
F  -4  -5  -4  -6  -5  -5  -6  -6  -2   2   3  -6   1  13  -5  -4  -3   1  11  -1  -5  -6  -2 -10
P   1   0   0   0  -3   1   0   0   0  -2  -3  -1  -2  -5   6   1   1  -7  -6  -1   0   0   0 -10
S   1   0   1   1   0   0   0   1  -1  -1  -3   0  -2  -4   1   1   1  -3  -3  -1   1   0   0 -10
T   1  -1   1   0  -2   0   0   1  -1   0  -2   0  -1  -3   1   1   2  -6  -3   0   0   0   0 -10
W  -7   4  -5  -8 -10  -5  -8  -8  -3  -6  -2  -4  -5   1  -7  -3  -6  27   1  -7  -6  -7  -5 -10
Y  -4  -5  -3  -5   1  -5  -5  -6   0   0   0  -5  -2  11  -6  -3  -3   1  14  -2  -4  -5  -2 -10
V   0  -3  -2  -2  -2  -2  -2  -1  -2   4   3  -2   2  -1  -1  -1   0  -7  -2   5  -2  -2   0 -10
B   1   0   2   3  -5   2   3   1   1  -2  -4   1  -2  -5   0   1   0  -6  -4  -2   3   2   0 -10
Z   0   1   2   3  -6   3   3   0   2  -2  -3   1  -2  -6   0   0   0  -7  -5  -2   2   3   0 -10
X   0  -1   0  -1  -3   0   0  -1   0   0  -1  -1   0  -2   0   0   0  -5  -2   0   0   0  -1 -10
* -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10   1

@@ PAM360
#
# This matrix was produced by "pam" Version 1.0.6 [28-Jul-93]
#
# PAM 360 substitution matrix, scale = ln(2)/5 = 0.138629
#
# Expected score = -0.697, Entropy = 0.175 bits
#
# Lowest score = -9, Highest score = 27
#
   A  R  N  D  C  Q  E  G  H  I  L  K  M  F  P  S  T  W  Y  V  B  Z  X  *
A  1 -1  0  1 -2  0  1  2 -1  0 -2 -1 -1 -4  1  1  1 -7 -4  0  1  0  0 -9
R -1  6  1 -1 -4  2  0 -2  2 -2 -3  4  0 -5  0  0  0  4 -5 -2  0  1 -1 -9
N  0  1  2  2 -4  1  2  1  2 -2 -3  1 -2 -4  0  1  1 -5 -3 -2  2  2  0 -9
D  1 -1  2  4 -6  2  4  1  1 -2 -4  1 -2 -6  0  1  0 -8 -5 -2  3  3  0 -9
C -2 -4 -4 -6 18 -6 -6 -4 -4 -3 -7 -6 -6 -4 -3  0 -2 -9  1 -2 -5 -6 -3 -9
Q  0  2  1  2 -6  3  3 -1  3 -2 -2  1 -1 -5  1  0  0 -5 -4 -2  2  3  0 -9
E  1  0  2  4 -6  3  4  1  1 -2 -3  0 -2 -6  0  0  0 -8 -5 -2  3  3  0 -9
G  2 -2  1  1 -4 -1  1  5 -2 -2 -4 -1 -3 -6  0  1  1 -8 -6 -1  1  0 -1 -9
H -1  2  2  1 -4  3  1 -2  7 -2 -2  1 -2 -2  0  0 -1 -3  0 -2  1  2  0 -9
I  0 -2 -2 -2 -3 -2 -2 -2 -2  4  3 -2  3  2 -2 -1  0 -6  0  4 -2 -2  0 -9
L -2 -3 -3 -4 -7 -2 -3 -4 -2  3  7 -3  5  3 -3 -3 -2 -2  0  3 -4 -3 -1 -9
K -1  4  1  1 -6  1  0 -1  1 -2 -3  5  0 -6 -1  0  0 -4 -5 -2  1  1 -1 -9
M -1  0 -2 -2 -6 -1 -2 -3 -2  3  5  0  6  1 -2 -2 -1 -4 -2  2 -2 -2  0 -9
F -4 -5 -4 -6 -4 -5 -6 -6 -2  2  3 -6  1 12 -5 -4 -3  2 11 -1 -5 -5 -2 -9
P  1  0  0  0 -3  1  0  0  0 -2 -3 -1 -2 -5  6  1  1 -6 -5 -1  0  0  0 -9
S  1  0  1  1  0  0  0  1  0 -1 -3  0 -2 -4  1  1  1 -3 -3 -1  1  0  0 -9
T  1  0  1  0 -2  0  0  1 -1  0 -2  0 -1 -3  1  1  2 -6 -3  0  0  0  0 -9
W -7  4 -5 -8 -9 -5 -8 -8 -3 -6 -2 -4 -4  2 -6 -3 -6 27  1 -7 -6 -7 -4 -9
Y -4 -5 -3 -5  1 -4 -5 -6  0  0  0 -5 -2 11 -5 -3 -3  1 14 -2 -4 -5 -2 -9
V  0 -2 -2 -2 -2 -2 -2 -1 -2  4  3 -2  2 -1 -1 -1  0 -7 -2  4 -2 -2  0 -9
B  1  0  2  3 -5  2  3  1  1 -2 -4  1 -2 -5  0  1  0 -6 -4 -2  2  2  0 -9
Z  0  1  2  3 -6  3  3  0  2 -2 -3  1 -2 -5  0  0  0 -7 -5 -2  2  3  0 -9
X  0 -1  0  0 -3  0  0 -1  0  0 -1 -1  0 -2  0  0  0 -4 -2  0  0  0 -1 -9
* -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9  1

@@ PAM370
#
# This matrix was produced by "pam" Version 1.0.6 [28-Jul-93]
#
# PAM 370 substitution matrix, scale = ln(2)/5 = 0.138629
#
# Expected score = -0.649, Entropy = 0.165 bits
#
# Lowest score = -9, Highest score = 27
#
   A  R  N  D  C  Q  E  G  H  I  L  K  M  F  P  S  T  W  Y  V  B  Z  X  *
A  1 -1  0  1 -2  0  1  2 -1  0 -2 -1 -1 -4  1  1  1 -7 -4  0  1  0  0 -9
R -1  6  1  0 -4  2  0 -2  2 -2 -3  4  0 -5  0  0  0  3 -4 -2  0  1 -1 -9
N  0  1  2  2 -4  1  2  1  2 -2 -3  1 -2 -4  0  1  0 -5 -3 -1  2  1  0 -9
D  1  0  2  4 -5  2  3  1  1 -2 -4  1 -2 -6  0  1  0 -7 -5 -2  3  3  0 -9
C -2 -4 -4 -5 18 -6 -6 -3 -4 -2 -6 -6 -6 -4 -3  0 -2 -9  1 -2 -5 -6 -3 -9
Q  0  2  1  2 -6  3  2 -1  3 -2 -2  1 -1 -5  1  0  0 -5 -4 -2  2  3  0 -9
E  1  0  2  3 -6  2  3  1  1 -2 -3  1 -2 -6  0  0  0 -8 -5 -2  3  3  0 -9
G  2 -2  1  1 -3 -1  1  5 -2 -2 -4 -1 -3 -5  0  1  1 -8 -6 -1  1  0 -1 -9
H -1  2  2  1 -4  3  1 -2  6 -2 -2  1 -2 -2  0  0 -1 -3  0 -2  1  2  0 -9
I  0 -2 -2 -2 -2 -2 -2 -2 -2  4  3 -2  3  2 -2 -1  0 -5  0  4 -2 -2  0 -9
L -2 -3 -3 -4 -6 -2 -3 -4 -2  3  7 -3  5  3 -3 -3 -1 -2  0  3 -3 -3 -1 -9
K -1  4  1  1 -6  1  1 -1  1 -2 -3  5  0 -6 -1  0  0 -3 -5 -2  1  1  0 -9
M -1  0 -2 -2 -6 -1 -2 -3 -2  3  5  0  5  1 -2 -1  0 -4 -2  2 -2 -2  0 -9
F -4 -5 -4 -6 -4 -5 -6 -5 -2  2  3 -6  1 12 -5 -4 -3  2 11  0 -5 -5 -2 -9
P  1  0  0  0 -3  1  0  0  0 -2 -3 -1 -2 -5  6  1  1 -6 -5 -1  0  0  0 -9
S  1  0  1  1  0  0  0  1  0 -1 -3  0 -1 -4  1  1  1 -3 -3 -1  1  0  0 -9
T  1  0  0  0 -2  0  0  1 -1  0 -1  0  0 -3  1  1  2 -6 -3  0  0  0  0 -9
W -7  3 -5 -7 -9 -5 -8 -8 -3 -5 -2 -3 -4  2 -6 -3 -6 27  1 -7 -6 -6 -4 -9
Y -4 -4 -3 -5  1 -4 -5 -6  0  0  0 -5 -2 11 -5 -3 -3  1 14 -2 -4 -5 -2 -9
V  0 -2 -1 -2 -2 -2 -2 -1 -2  4  3 -2  2  0 -1 -1  0 -7 -2  4 -2 -2  0 -9
B  1  0  2  3 -5  2  3  1  1 -2 -3  1 -2 -5  0  1  0 -6 -4 -2  2  2  0 -9
Z  0  1  1  3 -6  3  3  0  2 -2 -3  1 -2 -5  0  0  0 -6 -5 -2  2  3  0 -9
X  0 -1  0  0 -3  0  0 -1  0  0 -1  0  0 -2  0  0  0 -4 -2  0  0  0 -1 -9
* -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9  1

@@ PAM380
#
# This matrix was produced by "pam" Version 1.0.6 [28-Jul-93]
#
# PAM 380 substitution matrix, scale = ln(2)/5 = 0.138629
#
# Expected score = -0.612, Entropy = 0.156 bits
#
# Lowest score = -9, Highest score = 26
#
   A  R  N  D  C  Q  E  G  H  I  L  K  M  F  P  S  T  W  Y  V  B  Z  X  *
A  1 -1  0  1 -2  0  1  2 -1  0 -2 -1 -1 -4  1  1  1 -6 -4  0  1  0  0 -9
R -1  6  1  0 -4  2  0 -2  2 -2 -3  4  0 -5  0  0  0  3 -4 -2  0  1  0 -9
N  0  1  1  2 -4  1  2  1  1 -2 -3  1 -1 -4  0  1  0 -5 -3 -1  2  1  0 -9
D  1  0  2  3 -5  2  3  1  1 -2 -4  1 -2 -6  0  1  0 -7 -5 -2  3  3  0 -9
C -2 -4 -4 -5 17 -5 -5 -3 -4 -2 -6 -6 -5 -4 -3  0 -2 -9  1 -2 -4 -5 -3 -9
Q  0  2  1  2 -5  3  2 -1  3 -2 -2  1 -1 -5  1  0  0 -5 -4 -2  2  3  0 -9
E  1  0  2  3 -5  2  3  1  1 -2 -3  1 -2 -5  0  0  0 -7 -5 -2  3  3  0 -9
G  2 -2  1  1 -3 -1  1  5 -1 -2 -4 -1 -2 -5  0  1  1 -8 -5 -1  1  0  0 -9
H -1  2  1  1 -4  3  1 -1  6 -2 -2  1 -2 -2  0  0 -1 -3  0 -2  1  2  0 -9
I  0 -2 -2 -2 -2 -2 -2 -2 -2  4  3 -2  3  2 -2 -1  0 -5  0  4 -2 -2  0 -9
L -2 -3 -3 -4 -6 -2 -3 -4 -2  3  7 -3  4  3 -2 -3 -1 -2  0  3 -3 -3 -1 -9
K -1  4  1  1 -6  1  1 -1  1 -2 -3  5  0 -5  0  0  0 -3 -5 -2  1  1  0 -9
M -1  0 -1 -2 -5 -1 -2 -2 -2  3  4  0  5  1 -2 -1  0 -4 -2  2 -2 -1  0 -9
F -4 -5 -4 -6 -4 -5 -5 -5 -2  2  3 -5  1 12 -5 -4 -3  2 10  0 -5 -5 -2 -9
P  1  0  0  0 -3  1  0  0  0 -2 -2  0 -2 -5  5  1  1 -6 -5 -1  0  0  0 -9
S  1  0  1  1  0  0  0  1  0 -1 -3  0 -1 -4  1  1  1 -3 -3 -1  1  0  0 -9
T  1  0  0  0 -2  0  0  1 -1  0 -1  0  0 -3  1  1  2 -6 -3  0  0  0  0 -9
W -6  3 -5 -7 -9 -5 -7 -8 -3 -5 -2 -3 -4  2 -6 -3 -6 26  1 -6 -6 -6 -4 -9
Y -4 -4 -3 -5  1 -4 -5 -5  0  0  0 -5 -2 10 -5 -3 -3  1 13 -2 -4 -4 -2 -9
V  0 -2 -1 -2 -2 -2 -2 -1 -2  4  3 -2  2  0 -1 -1  0 -6 -2  4 -2 -2  0 -9
B  1  0  2  3 -4  2  3  1  1 -2 -3  1 -2 -5  0  1  0 -6 -4 -2  2  2  0 -9
Z  0  1  1  3 -5  3  3  0  2 -2 -3  1 -1 -5  0  0  0 -6 -4 -2  2  3  0 -9
X  0  0  0  0 -3  0  0  0  0  0 -1  0  0 -2  0  0  0 -4 -2  0  0  0 -1 -9
* -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9  1

@@ PAM390
#
# This matrix was produced by "pam" Version 1.0.6 [28-Jul-93]
#
# PAM 390 substitution matrix, scale = ln(2)/5 = 0.138629
#
# Expected score = -0.581, Entropy = 0.147 bits
#
# Lowest score = -9, Highest score = 26
#
   A  R  N  D  C  Q  E  G  H  I  L  K  M  F  P  S  T  W  Y  V  B  Z  X  *
A  1 -1  0  1 -2  0  1  1 -1  0 -2 -1 -1 -3  1  1  1 -6 -4  0  1  0  0 -9
R -1  6  1  0 -4  1  0 -2  2 -2 -3  4  0 -5  0  0  0  3 -4 -2  0  1  0 -9
N  0  1  1  2 -4  1  2  1  1 -2 -3  1 -1 -4  0  1  0 -4 -3 -1  2  1  0 -9
D  1  0  2  3 -5  2  3  1  1 -2 -4  1 -2 -5  0  1  0 -7 -5 -2  3  3  0 -9
C -2 -4 -4 -5 17 -5 -5 -3 -4 -2 -6 -5 -5 -4 -3  0 -2 -9  1 -2 -4 -5 -3 -9
Q  0  1  1  2 -5  3  2  0  3 -2 -2  1 -1 -4  0  0  0 -5 -4 -1  2  3  0 -9
E  1  0  2  3 -5  2  3  1  1 -2 -3  1 -2 -5  0  0  0 -7 -5 -1  2  3  0 -9
G  1 -2  1  1 -3  0  1  5 -1 -2 -4 -1 -2 -5  0  1  1 -7 -5 -1  1  0  0 -9
H -1  2  1  1 -4  3  1 -1  6 -2 -2  1 -2 -2  0  0 -1 -3  0 -2  1  2  0 -9
I  0 -2 -2 -2 -2 -2 -2 -2 -2  4  3 -2  3  2 -1 -1  0 -5  0  4 -2 -2  0 -9
L -2 -3 -3 -4 -6 -2 -3 -4 -2  3  7 -3  4  3 -2 -2 -1 -2  0  3 -3 -2 -1 -9
K -1  4  1  1 -5  1  1 -1  1 -2 -3  4  0 -5  0  0  0 -3 -5 -2  1  1  0 -9
M -1  0 -1 -2 -5 -1 -2 -2 -2  3  4  0  5  1 -2 -1  0 -4 -1  2 -2 -1  0 -9
F -3 -5 -4 -5 -4 -4 -5 -5 -2  2  3 -5  1 12 -5 -3 -3  2 10  0 -5 -5 -2 -9
P  1  0  0  0 -3  0  0  0  0 -1 -2  0 -2 -5  5  1  1 -6 -5 -1  0  0  0 -9
S  1  0  1  1  0  0  0  1  0 -1 -2  0 -1 -3  1  1  1 -3 -3 -1  1  0  0 -9
T  1  0  0  0 -2  0  0  1 -1  0 -1  0  0 -3  1  1  1 -5 -3  0  0  0  0 -9
W -6  3 -4 -7 -9 -5 -7 -7 -3 -5 -2 -3 -4  2 -6 -3 -5 26  1 -6 -6 -6 -4 -9
Y -4 -4 -3 -5  1 -4 -5 -5  0  0  0 -5 -1 10 -5 -3 -3  1 13 -2 -4 -4 -2 -9
V  0 -2 -1 -2 -2 -1 -1 -1 -2  4  3 -2  2  0 -1 -1  0 -6 -2  4 -2 -1  0 -9
B  1  0  2  3 -4  2  2  1  1 -2 -3  1 -2 -5  0  1  0 -6 -4 -2  2  2  0 -9
Z  0  1  1  3 -5  3  3  0  2 -2 -2  1 -1 -5  0  0  0 -6 -4 -1  2  3  0 -9
X  0  0  0  0 -3  0  0  0  0  0 -1  0  0 -2  0  0  0 -4 -2  0  0  0 -1 -9
* -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9  1

@@ PAM400
#
# This matrix was produced by "pam" Version 1.0.6 [28-Jul-93]
#
# PAM 400 substitution matrix, scale = ln(2)/5 = 0.138629
#
# Expected score = -0.521, Entropy = 0.139 bits
#
# Lowest score = -8, Highest score = 26
#
   A  R  N  D  C  Q  E  G  H  I  L  K  M  F  P  S  T  W  Y  V  B  Z  X  *
A  1 -1  0  1 -2  0  1  1 -1  0 -2 -1 -1 -3  1  1  1 -6 -3  0  1  0  0 -8
R -1  5  1  0 -4  1  0 -2  2 -2 -3  4  0 -4  0  0  0  3 -4 -2  0  1  0 -8
N  0  1  1  2 -3  1  2  1  1 -1 -3  1 -1 -3  0  1  0 -4 -3 -1  2  1  0 -8
D  1  0  2  3 -5  2  3  1  1 -2 -3  1 -2 -5  0  1  0 -7 -4 -2  2  2  0 -8
C -2 -4 -3 -5 17 -5 -5 -3 -3 -2 -6 -5 -5 -4 -2  0 -2 -8  1 -2 -4 -5 -3 -8
Q  0  1  1  2 -5  3  2  0  3 -2 -2  1 -1 -4  0  0  0 -5 -4 -1  2  2  0 -8
E  1  0  2  3 -5  2  3  1  1 -2 -3  1 -2 -5  0  0  0 -7 -4 -1  2  3  0 -8
G  1 -2  1  1 -3  0  1  4 -1 -2 -3 -1 -2 -5  0  1  1 -7 -5 -1  1  0  0 -8
H -1  2  1  1 -3  3  1 -1  5 -2 -2  1 -1 -2  0  0 -1 -2  0 -2  1  2  0 -8
I  0 -2 -1 -2 -2 -2 -2 -2 -2  4  3 -2  2  2 -1 -1  0 -5  0  3 -2 -2  0 -8
L -2 -3 -3 -3 -6 -2 -3 -3 -2  3  7 -2  4  3 -2 -2 -1 -2  0  3 -3 -2 -1 -8
K -1  4  1  1 -5  1  1 -1  1 -2 -2  4  0 -5  0  0  0 -3 -4 -2  1  1  0 -8
M -1  0 -1 -2 -5 -1 -2 -2 -1  2  4  0  5  1 -1 -1  0 -4 -1  2 -2 -1  0 -8
F -3 -4 -3 -5 -4 -4 -5 -5 -2  2  3 -5  1 11 -4 -3 -3  2 10  0 -4 -5 -2 -8
P  1  0  0  0 -2  0  0  0  0 -1 -2  0 -1 -4  5  1  1 -6 -5 -1  0  0  0 -8
S  1  0  1  1  0  0  0  1  0 -1 -2  0 -1 -3  1  1  1 -3 -3 -1  1  0  0 -8
T  1  0  0  0 -2  0  0  1 -1  0 -1  0  0 -3  1  1  1 -5 -3  0  0  0  0 -8
W -6  3 -4 -7 -8 -5 -7 -7 -2 -5 -2 -3 -4  2 -6 -3 -5 26  1 -6 -5 -6 -4 -8
Y -3 -4 -3 -4  1 -4 -4 -5  0  0  0 -4 -1 10 -5 -3 -3  1 13 -2 -3 -4 -2 -8
V  0 -2 -1 -2 -2 -1 -1 -1 -2  3  3 -2  2  0 -1 -1  0 -6 -2  4 -1 -1  0 -8
B  1  0  2  2 -4  2  2  1  1 -2 -3  1 -2 -4  0  1  0 -5 -3 -1  2  2  0 -8
Z  0  1  1  2 -5  2  3  0  2 -2 -2  1 -1 -5  0  0  0 -6 -4 -1  2  3  0 -8
X  0  0  0  0 -3  0  0  0  0  0 -1  0  0 -2  0  0  0 -4 -2  0  0  0 -1 -8
* -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8 -8  1

@@ PAM410
#
# This matrix was produced by "pam" Version 1.0.6 [28-Jul-93]
#
# PAM 410 substitution matrix, scale = ln(2)/6 = 0.115525
#
# Expected score = -0.617, Entropy = 0.131 bits
#
# Lowest score = -10, Highest score = 31
#
    A   R   N   D   C   Q   E   G   H   I   L   K   M   F   P   S   T   W   Y   V   B   Z   X   *
A   1  -1   0   1  -2   0   1   2  -1   0  -2  -1  -1  -4   1   1   1  -7  -4   0   1   0   0 -10
R  -1   6   1   0  -4   2   0  -2   2  -2  -3   4   0  -5   0   0   0   4  -5  -2   0   1   0 -10
N   0   1   1   2  -4   1   2   1   1  -2  -3   1  -2  -4   0   1   1  -5  -3  -1   2   2   0 -10
D   1   0   2   3  -6   2   3   1   1  -2  -4   1  -2  -6   0   1   0  -8  -5  -2   3   3   0 -10
C  -2  -4  -4  -6  20  -6  -6  -4  -4  -3  -7  -6  -6  -4  -3   0  -2 -10   1  -2  -5  -6  -3 -10
Q   0   2   1   2  -6   3   2   0   3  -2  -2   1  -1  -5   1   0   0  -5  -4  -2   2   3   0 -10
E   1   0   2   3  -6   2   3   1   1  -2  -3   1  -2  -6   0   1   0  -8  -5  -2   3   3   0 -10
G   2  -2   1   1  -4   0   1   5  -1  -2  -4  -1  -3  -6   0   1   1  -8  -6  -1   1   0   0 -10
H  -1   2   1   1  -4   3   1  -1   6  -2  -2   1  -2  -2   0   0  -1  -3   0  -2   1   2   0 -10
I   0  -2  -2  -2  -3  -2  -2  -2  -2   4   4  -2   3   2  -2  -1   0  -6   0   4  -2  -2   0 -10
L  -2  -3  -3  -4  -7  -2  -3  -4  -2   4   8  -3   5   4  -3  -3  -1  -2   1   3  -3  -3  -1 -10
K  -1   4   1   1  -6   1   1  -1   1  -2  -3   5   0  -6   0   0   0  -3  -5  -2   1   1   0 -10
M  -1   0  -2  -2  -6  -1  -2  -3  -2   3   5   0   5   1  -2  -1   0  -4  -2   2  -2  -2   0 -10
F  -4  -5  -4  -6  -4  -5  -6  -6  -2   2   4  -6   1  14  -5  -4  -3   2  12   0  -5  -5  -2 -10
P   1   0   0   0  -3   1   0   0   0  -2  -3   0  -2  -5   6   1   1  -7  -5  -1   0   0   0 -10
S   1   0   1   1   0   0   1   1   0  -1  -3   0  -1  -4   1   1   1  -3  -3  -1   1   0   0 -10
T   1   0   1   0  -2   0   0   1  -1   0  -1   0   0  -3   1   1   2  -6  -3   0   0   0   0 -10
W  -7   4  -5  -8 -10  -5  -8  -8  -3  -6  -2  -3  -4   2  -7  -3  -6  31   2  -7  -6  -7  -4 -10
Y  -4  -5  -3  -5   1  -4  -5  -6   0   0   1  -5  -2  12  -5  -3  -3   2  15  -2  -4  -5  -2 -10
V   0  -2  -1  -2  -2  -2  -2  -1  -2   4   3  -2   2   0  -1  -1   0  -7  -2   4  -2  -2   0 -10
B   1   0   2   3  -5   2   3   1   1  -2  -3   1  -2  -5   0   1   0  -6  -4  -2   2   2   0 -10
Z   0   1   2   3  -6   3   3   0   2  -2  -3   1  -2  -5   0   0   0  -7  -5  -2   2   3   0 -10
X   0   0   0   0  -3   0   0   0   0   0  -1   0   0  -2   0   0   0  -4  -2   0   0   0  -1 -10
* -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10   1

@@ PAM420
#
# This matrix was produced by "pam" Version 1.0.6 [28-Jul-93]
#
# PAM 420 substitution matrix, scale = ln(2)/6 = 0.115525
#
# Expected score = -0.599, Entropy = 0.124 bits
#
# Lowest score = -10, Highest score = 31
#
    A   R   N   D   C   Q   E   G   H   I   L   K   M   F   P   S   T   W   Y   V   B   Z   X   *
A   1  -1   0   1  -2   0   1   2  -1   0  -2   0  -1  -4   1   1   1  -7  -4   0   1   0   0 -10
R  -1   6   1   0  -4   2   0  -2   2  -2  -3   4   0  -5   0   0   0   4  -5  -2   0   1   0 -10
N   0   1   1   2  -4   1   2   1   1  -2  -3   1  -1  -4   0   1   0  -5  -3  -1   2   2   0 -10
D   1   0   2   3  -5   2   3   1   1  -2  -4   1  -2  -6   0   1   0  -8  -5  -2   3   3   0 -10
C  -2  -4  -4  -5  20  -6  -6  -3  -4  -3  -7  -6  -6  -4  -3   0  -2 -10   1  -2  -5  -6  -3 -10
Q   0   2   1   2  -6   3   2   0   3  -2  -2   1  -1  -5   1   0   0  -5  -4  -2   2   3   0 -10
E   1   0   2   3  -6   2   3   1   1  -2  -3   1  -2  -6   0   1   0  -8  -5  -2   3   3   0 -10
G   2  -2   1   1  -3   0   1   5  -1  -2  -4  -1  -2  -6   0   1   1  -8  -6  -1   1   0   0 -10
H  -1   2   1   1  -4   3   1  -1   6  -2  -2   1  -2  -2   0   0  -1  -3   0  -2   1   2   0 -10
I   0  -2  -2  -2  -3  -2  -2  -2  -2   4   4  -2   3   2  -2  -1   0  -6   0   4  -2  -2   0 -10
L  -2  -3  -3  -4  -7  -2  -3  -4  -2   4   7  -3   5   4  -2  -3  -1  -2   1   3  -3  -3  -1 -10
K   0   4   1   1  -6   1   1  -1   1  -2  -3   5   0  -6   0   0   0  -3  -5  -2   1   1   0 -10
M  -1   0  -1  -2  -6  -1  -2  -2  -2   3   5   0   5   1  -2  -1   0  -4  -1   2  -2  -1   0 -10
F  -4  -5  -4  -6  -4  -5  -6  -6  -2   2   4  -6   1  13  -5  -4  -3   2  12   0  -5  -5  -2 -10
P   1   0   0   0  -3   1   0   0   0  -2  -2   0  -2  -5   5   1   1  -6  -5  -1   0   0   0 -10
S   1   0   1   1   0   0   1   1   0  -1  -3   0  -1  -4   1   1   1  -3  -3  -1   1   0   0 -10
T   1   0   0   0  -2   0   0   1  -1   0  -1   0   0  -3   1   1   1  -6  -3   0   0   0   0 -10
W  -7   4  -5  -8 -10  -5  -8  -8  -3  -6  -2  -3  -4   2  -6  -3  -6  31   2  -7  -6  -7  -4 -10
Y  -4  -5  -3  -5   1  -4  -5  -6   0   0   1  -5  -1  12  -5  -3  -3   2  15  -2  -4  -5  -2 -10
V   0  -2  -1  -2  -2  -2  -2  -1  -2   4   3  -2   2   0  -1  -1   0  -7  -2   4  -2  -2   0 -10
B   1   0   2   3  -5   2   3   1   1  -2  -3   1  -2  -5   0   1   0  -6  -4  -2   2   2   0 -10
Z   0   1   2   3  -6   3   3   0   2  -2  -3   1  -1  -5   0   0   0  -7  -5  -2   2   3   0 -10
X   0   0   0   0  -3   0   0   0   0   0  -1   0   0  -2   0   0   0  -4  -2   0   0   0  -1 -10
* -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10   1

@@ PAM430
#
# This matrix was produced by "pam" Version 1.0.6 [28-Jul-93]
#
# PAM 430 substitution matrix, scale = ln(2)/6 = 0.115525
#
# Expected score = -0.543, Entropy = 0.117 bits
#
# Lowest score = -9, Highest score = 31
#
   A  R  N  D  C  Q  E  G  H  I  L  K  M  F  P  S  T  W  Y  V  B  Z  X  *
A  1 -1  0  1 -2  0  1  2 -1  0 -2  0 -1 -4  1  1  1 -7 -4  0  1  0  0 -9
R -1  6  1  0 -4  2  0 -2  2 -2 -3  4  0 -5  0  0  0  4 -4 -2  0  1  0 -9
N  0  1  1  2 -4  1  2  1  1 -2 -3  1 -1 -4  0  1  0 -5 -3 -1  2  1  0 -9
D  1  0  2  3 -5  2  3  1  1 -2 -4  1 -2 -6  0  1  0 -7 -5 -2  3  3  0 -9
C -2 -4 -4 -5 20 -6 -5 -3 -4 -2 -6 -6 -5 -4 -3  0 -2 -9  1 -2 -4 -5 -3 -9
Q  0  2  1  2 -6  3  2  0  3 -2 -2  1 -1 -5  1  0  0 -5 -4 -1  2  3  0 -9
E  1  0  2  3 -5  2  3  1  1 -2 -3  1 -2 -6  0  1  0 -8 -5 -1  2  3  0 -9
G  2 -2  1  1 -3  0  1  5 -1 -2 -4 -1 -2 -5  0  1  1 -8 -5 -1  1  0  0 -9
H -1  2  1  1 -4  3  1 -1  5 -2 -2  1 -1 -2  0  0 -1 -3  0 -2  1  2  0 -9
I  0 -2 -2 -2 -2 -2 -2 -2 -2  4  4 -2  3  2 -1 -1  0 -5  0  4 -2 -2  0 -9
L -2 -3 -3 -4 -6 -2 -3 -4 -2  4  7 -3  5  4 -2 -2 -1 -2  1  3 -3 -3 -1 -9
K  0  4  1  1 -6  1  1 -1  1 -2 -3  4  0 -5  0  0  0 -3 -5 -2  1  1  0 -9
M -1  0 -1 -2 -5 -1 -2 -2 -1  3  5  0  5  1 -2 -1  0 -4 -1  2 -2 -1  0 -9
F -4 -5 -4 -6 -4 -5 -6 -5 -2  2  4 -5  1 13 -5 -4 -3  2 12  0 -5 -5 -2 -9
P  1  0  0  0 -3  1  0  0  0 -1 -2  0 -2 -5  5  1  1 -6 -5 -1  0  0  0 -9
S  1  0  1  1  0  0  1  1  0 -1 -2  0 -1 -4  1  1  1 -3 -3 -1  1  0  0 -9
T  1  0  0  0 -2  0  0  1 -1  0 -1  0  0 -3  1  1  1 -6 -3  0  0  0  0 -9
W -7  4 -5 -7 -9 -5 -8 -8 -3 -5 -2 -3 -4  2 -6 -3 -6 31  2 -7 -6 -6 -4 -9
Y -4 -4 -3 -5  1 -4 -5 -5  0  0  1 -5 -1 12 -5 -3 -3  2 15 -2 -4 -5 -2 -9
V  0 -2 -1 -2 -2 -1 -1 -1 -2  4  3 -2  2  0 -1 -1  0 -7 -2  4 -1 -1  0 -9
B  1  0  2  3 -4  2  2  1  1 -2 -3  1 -2 -5  0  1  0 -6 -4 -1  2  2  0 -9
Z  0  1  1  3 -5  3  3  0  2 -2 -3  1 -1 -5  0  0  0 -6 -5 -1  2  3  0 -9
X  0  0  0  0 -3  0  0  0  0  0 -1  0  0 -2  0  0  0 -4 -2  0  0  0 -1 -9
* -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9  1

@@ PAM440
#
# This matrix was produced by "pam" Version 1.0.6 [28-Jul-93]
#
# PAM 440 substitution matrix, scale = ln(2)/6 = 0.115525
#
# Expected score = -0.529, Entropy = 0.111 bits
#
# Lowest score = -9, Highest score = 30
#
   A  R  N  D  C  Q  E  G  H  I  L  K  M  F  P  S  T  W  Y  V  B  Z  X  *
A  1 -1  0  1 -2  0  1  2 -1  0 -2  0 -1 -4  1  1  1 -6 -4  0  1  0  0 -9
R -1  5  1  0 -4  2  0 -2  2 -2 -3  4  0 -5  0  0  0  4 -4 -2  0  1  0 -9
N  0  1  1  2 -4  1  2  1  1 -2 -3  1 -1 -4  0  1  0 -5 -3 -1  2  1  0 -9
D  1  0  2  3 -5  2  3  1  1 -2 -3  1 -2 -6  0  1  0 -7 -5 -2  2  2  0 -9
C -2 -4 -4 -5 20 -5 -5 -3 -4 -2 -6 -5 -5 -4 -3  0 -2 -9  1 -2 -4 -5 -3 -9
Q  0  2  1  2 -5  3  2  0  3 -2 -2  1 -1 -4  1  0  0 -5 -4 -1  2  2  0 -9
E  1  0  2  3 -5  2  3  1  1 -2 -3  1 -2 -5  0  1  0 -7 -5 -1  2  3  0 -9
G  2 -2  1  1 -3  0  1  4 -1 -2 -4 -1 -2 -5  0  1  1 -8 -5 -1  1  0  0 -9
H -1  2  1  1 -4  3  1 -1  5 -2 -2  1 -1 -2  0  0 -1 -3  0 -2  1  2  0 -9
I  0 -2 -2 -2 -2 -2 -2 -2 -2  4  4 -2  3  2 -1 -1  0 -5  0  3 -2 -2  0 -9
L -2 -3 -3 -3 -6 -2 -3 -4 -2  4  7 -3  5  4 -2 -2 -1 -2  1  3 -3 -2 -1 -9
K  0  4  1  1 -5  1  1 -1  1 -2 -3  4  0 -5  0  0  0 -3 -5 -2  1  1  0 -9
M -1  0 -1 -2 -5 -1 -2 -2 -1  3  5  0  4  1 -1 -1  0 -4 -1  2 -2 -1  0 -9
F -4 -5 -4 -6 -4 -4 -5 -5 -2  2  4 -5  1 13 -5 -4 -3  2 12  0 -5 -5 -2 -9
P  1  0  0  0 -3  1  0  0  0 -1 -2  0 -1 -5  5  1  1 -6 -5 -1  0  0  0 -9
S  1  0  1  1  0  0  1  1  0 -1 -2  0 -1 -4  1  1  1 -3 -3 -1  1  0  0 -9
T  1  0  0  0 -2  0  0  1 -1  0 -1  0  0 -3  1  1  1 -6 -3  0  0  0  0 -9
W -6  4 -5 -7 -9 -5 -7 -8 -3 -5 -2 -3 -4  2 -6 -3 -6 30  2 -6 -6 -6 -4 -9
Y -4 -4 -3 -5  1 -4 -5 -5  0  0  1 -5 -1 12 -5 -3 -3  2 15 -2 -4 -4 -2 -9
V  0 -2 -1 -2 -2 -1 -1 -1 -2  3  3 -2  2  0 -1 -1  0 -6 -2  4 -1 -1  0 -9
B  1  0  2  2 -4  2  2  1  1 -2 -3  1 -2 -5  0  1  0 -6 -4 -1  2  2  0 -9
Z  0  1  1  2 -5  2  3  0  2 -2 -2  1 -1 -5  0  0  0 -6 -4 -1  2  3  0 -9
X  0  0  0  0 -3  0  0  0  0  0 -1  0  0 -2  0  0  0 -4 -2  0  0  0 -1 -9
* -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9  1

@@ PAM450
#
# This matrix was produced by "pam" Version 1.0.6 [28-Jul-93]
#
# PAM 450 substitution matrix, scale = ln(2)/6 = 0.115525
#
# Expected score = -0.476, Entropy = 0.105 bits
#
# Lowest score = -9, Highest score = 30
#
   A  R  N  D  C  Q  E  G  H  I  L  K  M  F  P  S  T  W  Y  V  B  Z  X  *
A  1 -1  0  1 -2  0  1  1 -1  0 -2  0 -1 -3  1  1  1 -6 -4  0  1  0  0 -9
R -1  5  1  0 -4  2  0 -1  2 -2 -3  4  0 -4  0  0  0  4 -4 -2  0  1  0 -9
N  0  1  1  2 -4  1  2  1  1 -1 -2  1 -1 -4  0  1  0 -4 -3 -1  1  1  0 -9
D  1  0  2  3 -5  2  3  1  1 -2 -3  1 -2 -5  0  1  0 -7 -5 -1  2  2  0 -9
C -2 -4 -4 -5 20 -5 -5 -3 -4 -2 -6 -5 -5 -4 -2  0 -2 -9  1 -2 -4 -5 -2 -9
Q  0  2  1  2 -5  3  2  0  3 -1 -2  1 -1 -4  1  0  0 -5 -4 -1  2  2  0 -9
E  1  0  2  3 -5  2  3  1  1 -2 -3  1 -2 -5  0  1  0 -7 -5 -1  2  3  0 -9
G  1 -1  1  1 -3  0  1  4 -1 -2 -3 -1 -2 -5  0  1  1 -8 -5 -1  1  0  0 -9
H -1  2  1  1 -4  3  1 -1  5 -2 -2  1 -1 -2  0  0 -1 -2  0 -2  1  2  0 -9
I  0 -2 -1 -2 -2 -1 -2 -2 -2  4  3 -2  3  2 -1 -1  0 -5  0  3 -2 -2  0 -9
L -2 -3 -2 -3 -6 -2 -3 -3 -2  3  7 -2  4  4 -2 -2 -1 -1  1  3 -3 -2 -1 -9
K  0  4  1  1 -5  1  1 -1  1 -2 -2  4  0 -5  0  0  0 -3 -5 -2  1  1  0 -9
M -1  0 -1 -2 -5 -1 -2 -2 -1  3  4  0  4  1 -1 -1  0 -4 -1  2 -2 -1  0 -9
F -3 -4 -4 -5 -4 -4 -5 -5 -2  2  4 -5  1 13 -5 -3 -3  2 12  0 -4 -5 -2 -9
P  1  0  0  0 -2  1  0  0  0 -1 -2  0 -1 -5  5  1  1 -6 -5 -1  0  0  0 -9
S  1  0  1  1  0  0  1  1  0 -1 -2  0 -1 -3  1  1  1 -3 -3 -1  1  0  0 -9
T  1  0  0  0 -2  0  0  1 -1  0 -1  0  0 -3  1  1  1 -5 -3  0  0  0  0 -9
W -6  4 -4 -7 -9 -5 -7 -8 -2 -5 -1 -3 -4  2 -6 -3 -5 30  2 -6 -6 -6 -4 -9
Y -4 -4 -3 -5  1 -4 -5 -5  0  0  1 -5 -1 12 -5 -3 -3  2 14 -2 -4 -4 -2 -9
V  0 -2 -1 -1 -2 -1 -1 -1 -2  3  3 -2  2  0 -1 -1  0 -6 -2  3 -1 -1  0 -9
B  1  0  1  2 -4  2  2  1  1 -2 -3  1 -2 -4  0  1  0 -6 -4 -1  2  2  0 -9
Z  0  1  1  2 -5  2  3  0  2 -2 -2  1 -1 -5  0  0  0 -6 -4 -1  2  2  0 -9
X  0  0  0  0 -2  0  0  0  0  0 -1  0  0 -2  0  0  0 -4 -2  0  0  0  0 -9
* -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9  1

@@ PAM460
#
# This matrix was produced by "pam" Version 1.0.6 [28-Jul-93]
#
# PAM 460 substitution matrix, scale = ln(2)/6 = 0.115525
#
# Expected score = -0.429, Entropy = 0.0994 bits
#
# Lowest score = -9, Highest score = 30
#
   A  R  N  D  C  Q  E  G  H  I  L  K  M  F  P  S  T  W  Y  V  B  Z  X  *
A  1 -1  0  1 -2  0  1  1  0  0 -1  0 -1 -3  1  1  1 -6 -3  0  1  0  0 -9
R -1  5  1  0 -4  1  0 -1  2 -2 -2  4  0 -4  0  0  0  4 -4 -2  0  1  0 -9
N  0  1  1  2 -3  1  1  1  1 -1 -2  1 -1 -3  0  1  0 -4 -3 -1  1  1  0 -9
D  1  0  2  3 -5  2  3  1  1 -2 -3  1 -2 -5  0  1  0 -7 -4 -1  2  2  0 -9
C -2 -4 -3 -5 19 -5 -5 -3 -3 -2 -6 -5 -5 -3 -2  0 -2 -9  2 -2 -4 -5 -2 -9
Q  0  1  1  2 -5  2  2  0  2 -1 -2  1 -1 -4  1  0  0 -5 -4 -1  1  2  0 -9
E  1  0  1  3 -5  2  3  1  1 -2 -3  1 -2 -5  0  1  0 -7 -4 -1  2  2  0 -9
G  1 -1  1  1 -3  0  1  4 -1 -2 -3 -1 -2 -5  1  1  1 -7 -5 -1  1  0  0 -9
H  0  2  1  1 -3  2  1 -1  5 -2 -2  1 -1 -2  0  0  0 -2  0 -2  1  2  0 -9
I  0 -2 -1 -2 -2 -1 -2 -2 -2  3  3 -2  2  2 -1 -1  0 -5  0  3 -2 -2  0 -9
L -1 -2 -2 -3 -6 -2 -3 -3 -2  3  7 -2  4  3 -2 -2 -1 -1  1  3 -3 -2 -1 -9
K  0  4  1  1 -5  1  1 -1  1 -2 -2  4  0 -5  0  0  0 -3 -4 -2  1  1  0 -9
M -1  0 -1 -2 -5 -1 -2 -2 -1  2  4  0  4  1 -1 -1  0 -4 -1  2 -2 -1  0 -9
F -3 -4 -3 -5 -3 -4 -5 -5 -2  2  3 -5  1 12 -4 -3 -3  2 11  0 -4 -5 -2 -9
P  1  0  0  0 -2  1  0  1  0 -1 -2  0 -1 -4  4  1  1 -6 -5 -1  0  0  0 -9
S  1  0  1  1  0  0  1  1  0 -1 -2  0 -1 -3  1  1  1 -3 -3 -1  1  0  0 -9
T  1  0  0  0 -2  0  0  1  0  0 -1  0  0 -3  1  1  1 -5 -3  0  0  0  0 -9
W -6  4 -4 -7 -9 -5 -7 -7 -2 -5 -1 -3 -4  2 -6 -3 -5 30  2 -6 -6 -6 -4 -9
Y -3 -4 -3 -4  2 -4 -4 -5  0  0  1 -4 -1 11 -5 -3 -3  2 14 -2 -4 -4 -2 -9
V  0 -2 -1 -1 -2 -1 -1 -1 -2  3  3 -2  2  0 -1 -1  0 -6 -2  3 -1 -1  0 -9
B  1  0  1  2 -4  1  2  1  1 -2 -3  1 -2 -4  0  1  0 -6 -4 -1  2  2  0 -9
Z  0  1  1  2 -5  2  2  0  2 -2 -2  1 -1 -5  0  0  0 -6 -4 -1  2  2  0 -9
X  0  0  0  0 -2  0  0  0  0  0 -1  0  0 -2  0  0  0 -4 -2  0  0  0  0 -9
* -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9  1

@@ PAM470
#
# This matrix was produced by "pam" Version 1.0.6 [28-Jul-93]
#
# PAM 470 substitution matrix, scale = ln(2)/7 = 0.0990210
#
# Expected score = -0.520, Entropy = 0.0942 bits
#
# Lowest score = -10, Highest score = 35
#
    A   R   N   D   C   Q   E   G   H   I   L   K   M   F   P   S   T   W   Y   V   B   Z   X   *
A   1  -1   1   1  -2   0   1   2  -1   0  -2   0  -1  -4   1   1   1  -7  -4   0   1   0   0 -10
R  -1   6   1   0  -4   2   0  -1   2  -2  -3   4   0  -5   0   0   0   4  -5  -2   0   1   0 -10
N   1   1   1   2  -4   1   2   1   1  -2  -3   1  -1  -4   0   1   0  -5  -3  -1   2   1   0 -10
D   1   0   2   3  -5   2   3   1   1  -2  -4   1  -2  -6   0   1   0  -8  -5  -2   3   3   0 -10
C  -2  -4  -4  -5  22  -6  -5  -3  -4  -2  -6  -6  -6  -4  -3   0  -2 -10   2  -2  -5  -6  -3 -10
Q   0   2   1   2  -6   3   2   0   3  -2  -2   1  -1  -5   1   0   0  -5  -4  -1   2   2   0 -10
E   1   0   2   3  -5   2   3   1   1  -2  -3   1  -2  -6   0   1   0  -8  -5  -1   2   3   0 -10
G   2  -1   1   1  -3   0   1   5  -1  -2  -4  -1  -2  -6   1   1   1  -8  -6  -1   1   1   0 -10
H  -1   2   1   1  -4   3   1  -1   5  -2  -2   1  -1  -2   0   0   0  -3   0  -2   1   2   0 -10
I   0  -2  -2  -2  -2  -2  -2  -2  -2   4   4  -2   3   2  -1  -1   0  -5   0   3  -2  -2   0 -10
L  -2  -3  -3  -4  -6  -2  -3  -4  -2   4   8  -3   5   4  -2  -2  -1  -2   1   3  -3  -3  -1 -10
K   0   4   1   1  -6   1   1  -1   1  -2  -3   4   0  -5   0   0   0  -3  -5  -2   1   1   0 -10
M  -1   0  -1  -2  -6  -1  -2  -2  -1   3   5   0   4   1  -1  -1   0  -4  -1   2  -2  -1   0 -10
F  -4  -5  -4  -6  -4  -5  -6  -6  -2   2   4  -5   1  14  -5  -4  -3   3  13   0  -5  -5  -2 -10
P   1   0   0   0  -3   1   0   1   0  -1  -2   0  -1  -5   5   1   1  -6  -5  -1   0   1   0 -10
S   1   0   1   1   0   0   1   1   0  -1  -2   0  -1  -4   1   1   1  -4  -3  -1   1   0   0 -10
T   1   0   0   0  -2   0   0   1   0   0  -1   0   0  -3   1   1   1  -6  -3   0   0   0   0 -10
W  -7   4  -5  -8 -10  -5  -8  -8  -3  -5  -2  -3  -4   3  -6  -4  -6  35   2  -7  -6  -7  -4 -10
Y  -4  -5  -3  -5   2  -4  -5  -6   0   0   1  -5  -1  13  -5  -3  -3   2  16  -2  -4  -5  -2 -10
V   0  -2  -1  -2  -2  -1  -1  -1  -2   3   3  -2   2   0  -1  -1   0  -7  -2   4  -1  -1   0 -10
B   1   0   2   3  -5   2   2   1   1  -2  -3   1  -2  -5   0   1   0  -6  -4  -1   2   2   0 -10
Z   0   1   1   3  -6   2   3   1   2  -2  -3   1  -1  -5   1   0   0  -7  -5  -1   2   3   0 -10
X   0   0   0   0  -3   0   0   0   0   0  -1   0   0  -2   0   0   0  -4  -2   0   0   0   0 -10
* -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10   1

@@ PAM480
#
# This matrix was produced by "pam" Version 1.0.6 [28-Jul-93]
#
# PAM 480 substitution matrix, scale = ln(2)/7 = 0.0990210
#
# Expected score = -0.494, Entropy = 0.0893 bits
#
# Lowest score = -10, Highest score = 35
#
    A   R   N   D   C   Q   E   G   H   I   L   K   M   F   P   S   T   W   Y   V   B   Z   X   *
A   1  -1   1   1  -2   0   1   2   0   0  -2   0  -1  -4   1   1   1  -7  -4   0   1   0   0 -10
R  -1   5   1   0  -4   2   0  -1   2  -2  -3   4   0  -5   0   0   0   4  -4  -2   0   1   0 -10
N   1   1   1   2  -4   1   2   1   1  -1  -3   1  -1  -4   0   1   0  -5  -3  -1   2   1   0 -10
D   1   0   2   3  -5   2   3   1   1  -2  -3   1  -2  -6   0   1   0  -7  -5  -1   2   2   0 -10
C  -2  -4  -4  -5  22  -5  -5  -3  -4  -2  -6  -6  -5  -4  -3   0  -2 -10   2  -2  -4  -5  -3 -10
Q   0   2   1   2  -5   3   2   0   3  -2  -2   1  -1  -5   1   0   0  -5  -4  -1   2   2   0 -10
E   1   0   2   3  -5   2   3   1   1  -2  -3   1  -2  -5   0   1   0  -8  -5  -1   2   3   0 -10
G   2  -1   1   1  -3   0   1   4  -1  -2  -4  -1  -2  -5   1   1   1  -8  -5  -1   1   1   0 -10
H   0   2   1   1  -4   3   1  -1   5  -2  -2   1  -1  -2   0   0   0  -3   0  -2   1   2   0 -10
I   0  -2  -1  -2  -2  -2  -2  -2  -2   4   4  -2   3   2  -1  -1   0  -5   0   3  -2  -2   0 -10
L  -2  -3  -3  -3  -6  -2  -3  -4  -2   4   7  -3   5   4  -2  -2  -1  -2   1   3  -3  -3  -1 -10
K   0   4   1   1  -6   1   1  -1   1  -2  -3   4   0  -5   0   0   0  -3  -5  -2   1   1   0 -10
M  -1   0  -1  -2  -5  -1  -2  -2  -1   3   5   0   4   1  -1  -1   0  -4  -1   2  -2  -1   0 -10
F  -4  -5  -4  -6  -4  -5  -5  -5  -2   2   4  -5   1  14  -5  -4  -3   3  13   0  -5  -5  -2 -10
P   1   0   0   0  -3   1   0   1   0  -1  -2   0  -1  -5   5   1   1  -6  -5  -1   0   1   0 -10
S   1   0   1   1   0   0   1   1   0  -1  -2   0  -1  -4   1   1   1  -3  -3  -1   1   0   0 -10
T   1   0   0   0  -2   0   0   1   0   0  -1   0   0  -3   1   1   1  -6  -3   0   0   0   0 -10
W  -7   4  -5  -7 -10  -5  -8  -8  -3  -5  -2  -3  -4   3  -6  -3  -6  35   2  -7  -6  -6  -4 -10
Y  -4  -4  -3  -5   2  -4  -5  -5   0   0   1  -5  -1  13  -5  -3  -3   2  16  -2  -4  -5  -2 -10
V   0  -2  -1  -1  -2  -1  -1  -1  -2   3   3  -2   2   0  -1  -1   0  -7  -2   3  -1  -1   0 -10
B   1   0   2   2  -4   2   2   1   1  -2  -3   1  -2  -5   0   1   0  -6  -4  -1   2   2   0 -10
Z   0   1   1   2  -5   2   3   1   2  -2  -3   1  -1  -5   1   0   0  -6  -5  -1   2   2   0 -10
X   0   0   0   0  -3   0   0   0   0   0  -1   0   0  -2   0   0   0  -4  -2   0   0   0   0 -10
* -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10 -10   1

@@ PAM490
#
# This matrix was produced by "pam" Version 1.0.6 [28-Jul-93]
#
# PAM 490 substitution matrix, scale = ln(2)/7 = 0.0990210
#
# Expected score = -0.431, Entropy = 0.0847 bits
#
# Lowest score = -9, Highest score = 34
#
   A  R  N  D  C  Q  E  G  H  I  L  K  M  F  P  S  T  W  Y  V  B  Z  X  *
A  1 -1  0  1 -2  0  1  2  0  0 -1  0 -1 -3  1  1  1 -6 -4  0  1  0  0 -9
R -1  5  1  0 -4  2  0 -1  2 -2 -3  4  0 -5  0  0  0  4 -4 -2  0  1  0 -9
N  0  1  1  2 -4  1  2  1  1 -1 -2  1 -1 -4  0  1  0 -5 -3 -1  1  1  0 -9
D  1  0  2  3 -5  2  3  1  1 -2 -3  1 -2 -5  0  1  0 -7 -5 -1  2  2  0 -9
C -2 -4 -4 -5 22 -5 -5 -3 -4 -2 -6 -5 -5 -4 -3  0 -2 -9  2 -2 -4 -5 -2 -9
Q  0  2  1  2 -5  2  2  0  2 -1 -2  1 -1 -4  1  0  0 -5 -4 -1  2  2  0 -9
E  1  0  2  3 -5  2  3  1  1 -2 -3  1 -2 -5  0  1  0 -7 -5 -1  2  2  0 -9
G  2 -1  1  1 -3  0  1  4 -1 -2 -3 -1 -2 -5  1  1  1 -8 -5 -1  1  1  0 -9
H  0  2  1  1 -4  2  1 -1  5 -2 -2  1 -1 -2  0  0  0 -3  0 -2  1  2  0 -9
I  0 -2 -1 -2 -2 -1 -2 -2 -2  3  4 -2  3  2 -1 -1  0 -5  0  3 -2 -2  0 -9
L -1 -3 -2 -3 -6 -2 -3 -3 -2  4  7 -2  5  4 -2 -2 -1 -1  1  3 -3 -2 -1 -9
K  0  4  1  1 -5  1  1 -1  1 -2 -2  4  0 -5  0  0  0 -3 -5 -2  1  1  0 -9
M -1  0 -1 -2 -5 -1 -2 -2 -1  3  5  0  4  1 -1 -1  0 -4 -1  2 -2 -1  0 -9
F -3 -5 -4 -5 -4 -4 -5 -5 -2  2  4 -5  1 14 -5 -4 -3  3 13  0 -5 -5 -2 -9
P  1  0  0  0 -3  1  0  1  0 -1 -2  0 -1 -5  4  1  1 -6 -5 -1  0  1  0 -9
S  1  0  1  1  0  0  1  1  0 -1 -2  0 -1 -4  1  1  1 -3 -3 -1  1  0  0 -9
T  1  0  0  0 -2  0  0  1  0  0 -1  0  0 -3  1  1  1 -6 -3  0  0  0  0 -9
W -6  4 -5 -7 -9 -5 -7 -8 -3 -5 -1 -3 -4  3 -6 -3 -6 34  2 -6 -6 -6 -4 -9
Y -4 -4 -3 -5  2 -4 -5 -5  0  0  1 -5 -1 13 -5 -3 -3  2 15 -2 -4 -4 -2 -9
V  0 -2 -1 -1 -2 -1 -1 -1 -2  3  3 -2  2  0 -1 -1  0 -6 -2  3 -1 -1  0 -9
B  1  0  1  2 -4  2  2  1  1 -2 -3  1 -2 -5  0  1  0 -6 -4 -1  2  2  0 -9
Z  0  1  1  2 -5  2  2  1  2 -2 -2  1 -1 -5  1  0  0 -6 -4 -1  2  2  0 -9
X  0  0  0  0 -2  0  0  0  0  0 -1  0  0 -2  0  0  0 -4 -2  0  0  0  0 -9
* -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9  1

@@ PAM500
#
# This matrix was produced by "pam" Version 1.0.6 [28-Jul-93]
#
# PAM 500 substitution matrix, scale = ln(2)/7 = 0.0990210
#
# Expected score = -0.401, Entropy = 0.0803 bits
#
# Lowest score = -9, Highest score = 34
#
   A  R  N  D  C  Q  E  G  H  I  L  K  M  F  P  S  T  W  Y  V  B  Z  X  *
A  1 -1  0  1 -2  0  1  1  0  0 -1  0 -1 -3  1  1  1 -6 -3  0  1  0  0 -9
R -1  5  1  0 -4  2  0 -1  2 -2 -2  4  0 -4  0  0  0  4 -4 -2  0  1  0 -9
N  0  1  1  2 -3  1  1  1  1 -1 -2  1 -1 -4  0  1  0 -5 -3 -1  1  1  0 -9
D  1  0  2  3 -5  2  3  1  1 -2 -3  1 -2 -5  0  1  0 -7 -5 -1  2  2  0 -9
C -2 -4 -3 -5 22 -5 -5 -3 -4 -2 -6 -5 -5 -3 -2  0 -2 -9  2 -2 -4 -5 -2 -9
Q  0  2  1  2 -5  2  2  0  2 -1 -2  1 -1 -4  1  0  0 -5 -4 -1  2  2  0 -9
E  1  0  1  3 -5  2  3  1  1 -2 -3  1 -1 -5  0  1  0 -7 -5 -1  2  2  0 -9
G  1 -1  1  1 -3  0  1  4 -1 -2 -3  0 -2 -5  1  1  1 -8 -5 -1  1  1  0 -9
H  0  2  1  1 -4  2  1 -1  4 -2 -2  1 -1 -2  0  0  0 -2  0 -2  1  2  0 -9
I  0 -2 -1 -2 -2 -1 -2 -2 -2  3  4 -2  3  2 -1 -1  0 -5  0  3 -2 -2  0 -9
L -1 -2 -2 -3 -6 -2 -3 -3 -2  4  7 -2  4  4 -2 -2 -1 -1  1  3 -3 -2 -1 -9
K  0  4  1  1 -5  1  1  0  1 -2 -2  4  0 -5  0  0  0 -3 -5 -2  1  1  0 -9
M -1  0 -1 -2 -5 -1 -1 -2 -1  3  4  0  4  1 -1 -1  0 -4 -1  2 -1 -1  0 -9
F -3 -4 -4 -5 -3 -4 -5 -5 -2  2  4 -5  1 13 -4 -3 -3  3 13  0 -4 -5 -2 -9
P  1  0  0  0 -2  1  0  1  0 -1 -2  0 -1 -4  4  1  1 -6 -5 -1  0  1  0 -9
S  1  0  1  1  0  0  1  1  0 -1 -2  0 -1 -3  1  1  1 -3 -3 -1  1  0  0 -9
T  1  0  0  0 -2  0  0  1  0  0 -1  0  0 -3  1  1  1 -6 -3  0  0  0  0 -9
W -6  4 -5 -7 -9 -5 -7 -8 -2 -5 -1 -3 -4  3 -6 -3 -6 34  2 -6 -6 -6 -4 -9
Y -3 -4 -3 -5  2 -4 -5 -5  0  0  1 -5 -1 13 -5 -3 -3  2 15 -1 -4 -4 -2 -9
V  0 -2 -1 -1 -2 -1 -1 -1 -2  3  3 -2  2  0 -1 -1  0 -6 -1  3 -1 -1  0 -9
B  1  0  1  2 -4  2  2  1  1 -2 -3  1 -1 -4  0  1  0 -6 -4 -1  2  2  0 -9
Z  0  1  1  2 -5  2  2  1  2 -2 -2  1 -1 -5  1  0  0 -6 -4 -1  2  2  0 -9
X  0  0  0  0 -2  0  0  0  0  0 -1  0  0 -2  0  0  0 -4 -2  0  0  0  0 -9
* -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9 -9  1

@@ IDENTITY
  A  R  N  B  D  C  Q  Z  E  G  H  I  L  K  M  F  P  S  T  W  Y  V  X  *
A  1 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000
R -10000  1 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000
N -10000 -10000  1 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000
B -10000 -10000 -10000  1 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000
D -10000 -10000 -10000 -10000  1 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000
C -10000 -10000 -10000 -10000 -10000  1 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000
Q -10000 -10000 -10000 -10000 -10000 -10000  1 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000
Z -10000 -10000 -10000 -10000 -10000 -10000 -10000  1 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000
E -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000  1 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000
G -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000  1 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000
H -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000  1 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000
I -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000  1 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000
L -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000  1 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000
K -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000  1 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000
M -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000  1 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000
F -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000  1 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000
P -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000  1 -10000 -10000 -10000 -10000 -10000 -10000 -10000
S -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000  1 -10000 -10000 -10000 -10000 -10000 -10000
T -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000  1 -10000 -10000 -10000 -10000 -10000
W -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000  1 -10000 -10000 -10000 -10000
Y -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000  1 -10000 -10000 -10000
V -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000  1 -10000 -10000
X -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000  0 -10000
* -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000 -10000  0

@@ NUC.4.4
#
# This matrix was created by Todd Lowe   12/10/92
#
# Uses ambiguous nucleotide codes, probabilities rounded to
#  nearest integer
#
# Lowest score = -4, Highest score = 5
#
    A   T   G   C   S   W   R   Y   K   M   B   V   H   D   N
A   5  -4  -4  -4  -4   1   1  -4  -4   1  -4  -1  -1  -1  -2
T  -4   5  -4  -4  -4   1  -4   1   1  -4  -1  -4  -1  -1  -2
G  -4  -4   5  -4   1  -4   1  -4   1  -4  -1  -1  -4  -1  -2
C  -4  -4  -4   5   1  -4  -4   1  -4   1  -1  -1  -1  -4  -2
S  -4  -4   1   1  -1  -4  -2  -2  -2  -2  -1  -1  -3  -3  -1
W   1   1  -4  -4  -4  -1  -2  -2  -2  -2  -3  -3  -1  -1  -1
R   1  -4   1  -4  -2  -2  -1  -4  -2  -2  -3  -1  -3  -1  -1
Y  -4   1  -4   1  -2  -2  -4  -1  -2  -2  -1  -3  -1  -3  -1
K  -4   1   1  -4  -2  -2  -2  -2  -1  -4  -1  -3  -3  -1  -1
M   1  -4  -4   1  -2  -2  -2  -2  -4  -1  -3  -1  -1  -3  -1
B  -4  -1  -1  -1  -1  -3  -3  -1  -1  -3  -1  -2  -2  -2  -1
V  -1  -4  -1  -1  -1  -3  -1  -3  -3  -1  -2  -1  -2  -2  -1
H  -1  -1  -4  -1  -3  -1  -3  -1  -3  -1  -2  -2  -1  -2  -1  
D  -1  -1  -1  -4  -3  -1  -1  -3  -1  -3  -2  -2  -2  -1  -1
N  -2  -2  -2  -2  -1  -1  -1  -1  -1  -1  -1  -1  -1  -1  -1

