Disclaimer: ClawBio is a research and educational tool. It is not a medical device and does not provide clinical diagnoses. Consult a healthcare professional before making any medical decisions.

Your Medication Report

How your genes affect your medications

Summary

⛔
1 drug(s) to avoidWarfarin (Coumadin)
⚠️
20 drug(s) requiring cautionDose adjustments or alternatives may be recommended.

Drug Recommendations

DrugRecommendationEvidenceClassGenes
Warfarin (Coumadin)Avoid
Consider alternative medication.
1A ✓AnticoagulantCYP2C9:rs1799853
CYP2C9:rs1057910
VKORC1:rs9923231
Amitriptyline (Elavil)Caution
CPIC Consider 25% reduction of recommended starting dose.
1A ✓Tricyclic AntidepressantCYP2D6:rs3892097
CYP2D6:rs16947
CYP2D6:rs1065852
CYP2D6:rs28371725
Celecoxib (Celebrex)Caution
CPIC Initiate therapy with recommended starting dose.
1A ✓NSAIDCYP2C9:rs1799853
CYP2C9:rs1057910
Clomipramine (Anafranil)Caution
CPIC Consider 25% reduction of recommended starting dose.
1A ✓Tricyclic AntidepressantCYP2D6:rs3892097
CYP2D6:rs16947
CYP2D6:rs1065852
CYP2D6:rs28371725
Clopidogrel (Plavix)Caution
CPIC Avoid standard dose clopidogrel (75 mg) if possible.
1AAntiplatelet AgentCYP2C19:rs4244285
CYP2C19:rs4986893
CYP2C19:rs12248560
Codeine (Tylenol w/ Codeine)Caution
CPIC Use codeine label recommended age- or weight-specific dosing.
1AOpioid AnalgesicCYP2D6:rs3892097
CYP2D6:rs16947
CYP2D6:rs1065852
CYP2D6:rs28371725
Desipramine (Norpramin)Caution
CPIC Consider 25% reduction of recommended starting dose.
1A ✓Tricyclic AntidepressantCYP2D6:rs3892097
CYP2D6:rs16947
CYP2D6:rs1065852
CYP2D6:rs28371725
Doxepin (Sinequan)Caution
CPIC Consider 25% reduction of recommended starting dose.
1A ✓Tricyclic AntidepressantCYP2D6:rs3892097
CYP2D6:rs16947
CYP2D6:rs1065852
CYP2D6:rs28371725
Efavirenz (Sustiva)Caution
CPIC Consider initiating efavirenz with decreased dose of 400 mg/daya,b.
1A ✓AntiretroviralCYP2B6:rs3745274
Flurbiprofen (Ansaid)Caution
CPIC Initiate therapy with recommended starting dose.
1A ✓NSAIDCYP2C9:rs1799853
CYP2C9:rs1057910
Haloperidol (Haldol)Caution
Dose adjustment or monitoring may be needed.
1AAntipsychoticCYP2D6:rs3892097
CYP2D6:rs16947
CYP2D6:rs1065852
CYP2D6:rs28371725
Hydrocodone (Vicodin)Caution
CPIC Use hydrocodone label recommended age- or weight-specific dosing.
1AOpioid AnalgesicCYP2D6:rs3892097
CYP2D6:rs16947
CYP2D6:rs1065852
CYP2D6:rs28371725
Imipramine (Tofranil)Caution
CPIC Consider 25% reduction of recommended starting dose.
1A ✓Tricyclic AntidepressantCYP2D6:rs3892097
CYP2D6:rs16947
CYP2D6:rs1065852
CYP2D6:rs28371725
Meloxicam (Mobic)Caution
CPIC Initiate therapy with recommended starting dose.
1A ✓NSAIDCYP2C9:rs1799853
CYP2C9:rs1057910
Nortriptyline (Pamelor)Caution
CPIC Consider 25% reduction of recommended starting dose.
1A ✓Tricyclic AntidepressantCYP2D6:rs3892097
CYP2D6:rs16947
CYP2D6:rs1065852
CYP2D6:rs28371725
Phenytoin (Dilantin)Caution
CPIC Consider 25% reduction of recommended starting maintenance dose d.
1A ✓AntiepilepticCYP2C9:rs1799853
CYP2C9:rs1057910
Piroxicam (Feldene)Caution
CPIC Initiate therapy with recommended starting dose.
1ANSAIDCYP2C9:rs1799853
CYP2C9:rs1057910
Risperidone (Risperdal)Caution
Dose adjustment or monitoring may be needed.
1AAntipsychoticCYP2D6:rs3892097
CYP2D6:rs16947
CYP2D6:rs1065852
CYP2D6:rs28371725
Tamoxifen (Nolvadex)Caution
CPIC Consider hormonal therapy such as an aromatase inhibitor for postmenopausal women or aromatase inhibitor along with o...
CPNDS Grade B—moderate.
1A ✓SERM (Oncology)CYP2D6:rs3892097
CYP2D6:rs16947
CYP2D6:rs1065852
CYP2D6:rs28371725
Tramadol (Ultram)Caution
CPIC Use tramadol label recommended age- or weight-specific dosing.
1AOpioid AnalgesicCYP2D6:rs3892097
CYP2D6:rs16947
CYP2D6:rs1065852
CYP2D6:rs28371725
Trimipramine (Surmontil)Caution
CPIC Consider 25% reduction of recommended starting dose.
1A ✓Tricyclic AntidepressantCYP2D6:rs3892097
CYP2D6:rs16947
CYP2D6:rs1065852
CYP2D6:rs28371725
Standard Drugs (30 medications — click to expand)
DrugRecommendationEvidenceClassGenes
Aripiprazole (Abilify)Standard
Standard dosing expected to be effective.
1AAntipsychoticCYP2D6:rs3892097
CYP2D6:rs16947
CYP2D6:rs1065852
CYP2D6:rs28371725
Atazanavir (Reyataz)Standard
Standard dosing expected to be effective.
1AAntiretroviralUGT1A1:rs4148323
Atomoxetine (Strattera)Standard
CPIC Initiate with a dose of 0.5 mg/kg and increase to 1.2 mg/kg/day after 3 days If no clinical response and in the absen...
1A ✓ADHD MedicationCYP2D6:rs3892097
CYP2D6:rs16947
CYP2D6:rs1065852
CYP2D6:rs28371725
Atorvastatin (Lipitor)Standard
CPIC Prescribe desired starting dose and adjust doses based on disease-specific guidelines.
1A ✓StatinSLCO1B1:rs4149056
Azathioprine (Imuran)Standard
Standard dosing expected to be effective.
1A ✓ImmunosuppressantTPMT:rs1800460
TPMT:rs1142345
Capecitabine (Xeloda)Standard
CPIC Based on genotype, there is no indication to change dose or therapy.
SEFF/SEOM According to the data sheet.
1A ✓AntineoplasticDPYD:rs3918290
DPYD:rs67376798
Citalopram (Celexa)Standard
CPIC Initiate therapy with recommended starting dose.
1A ✓SSRI AntidepressantCYP2C19:rs4244285
CYP2C19:rs4986893
CYP2C19:rs12248560
Clozapine (Clozaril)Standard
Standard dosing expected to be effective.
3AntipsychoticCYP1A2:rs762551
CYP1A2:rs2069514
Dexlansoprazole (Dexilant)Standard
CPIC Initiate standard starting daily dose.
1A ✓Proton Pump InhibitorCYP2C19:rs4244285
CYP2C19:rs4986893
CYP2C19:rs12248560
Escitalopram (Lexapro)Standard
CPIC Initiate therapy with recommended starting dose.
1A ✓SSRI AntidepressantCYP2C19:rs4244285
CYP2C19:rs4986893
CYP2C19:rs12248560
Esomeprazole (Nexium)Standard
Standard dosing expected to be effective.
3Proton Pump InhibitorCYP2C19:rs4244285
CYP2C19:rs4986893
CYP2C19:rs12248560
Fluorouracil (5-FU)Standard
CPIC Based on genotype, there is no indication to change dose or therapy.
SEFF/SEOM According to the data sheet.
1A ✓AntineoplasticDPYD:rs3918290
DPYD:rs67376798
Fluoxetine (Prozac)Standard
CPIC No action recommended based on genotype for fluoxetine because of minimal evidence regarding the impact on efficacy o...
3SSRI AntidepressantCYP2D6:rs3892097
CYP2D6:rs16947
CYP2D6:rs1065852
CYP2D6:rs28371725
Irinotecan (Camptosar)Standard
Standard dosing expected to be effective.
1AAntineoplasticUGT1A1:rs4148323
Lansoprazole (Prevacid)Standard
CPIC Initiate standard starting daily dose.
1A ✓Proton Pump InhibitorCYP2C19:rs4244285
CYP2C19:rs4986893
CYP2C19:rs12248560
Mercaptopurine (Purinethol)Standard
Standard dosing expected to be effective.
1A ✓ImmunosuppressantTPMT:rs1800460
TPMT:rs1142345
Metoprolol (Lopressor)Standard
CPIC Initiate standard dosing.
1ABeta-BlockerCYP2D6:rs3892097
CYP2D6:rs16947
CYP2D6:rs1065852
CYP2D6:rs28371725
Omeprazole (Prilosec)Standard
CPIC Initiate standard starting daily dose.
1A ✓Proton Pump InhibitorCYP2C19:rs4244285
CYP2C19:rs4986893
CYP2C19:rs12248560
Ondansetron (Zofran)Standard
CPIC Insufficient evidence demonstrating clinical impact based on CYP2D6 genotype.
1AAntiemeticCYP2D6:rs3892097
CYP2D6:rs16947
CYP2D6:rs1065852
CYP2D6:rs28371725
Oxycodone (OxyContin)Standard
CPIC No recommendation for oxycodone therapy because of weak evidence regarding adverse events or analgesia.
2AOpioid AnalgesicCYP2D6:rs3892097
CYP2D6:rs16947
CYP2D6:rs1065852
CYP2D6:rs28371725
Pantoprazole (Protonix)Standard
CPIC Initiate standard starting daily dose.
1A ✓Proton Pump InhibitorCYP2C19:rs4244285
CYP2C19:rs4986893
CYP2C19:rs12248560
Paroxetine (Paxil)Standard
CPIC Consider a lower starting dose and slower titration schedule as compared to normal metabolizers.
1A ✓SSRI AntidepressantCYP2D6:rs3892097
CYP2D6:rs16947
CYP2D6:rs1065852
CYP2D6:rs28371725
Pravastatin (Pravachol)Standard
CPIC Prescribe desired starting dose and adjust doses based on disease-specific guidelines.
1A ✓StatinSLCO1B1:rs4149056
Rosuvastatin (Crestor)Standard
CPIC Prescribe desired starting dose and adjust doses based on disease-specific guidelines.
1A ✓StatinSLCO1B1:rs4149056
Sertraline (Zoloft)Standard
CPIC Initiate therapy with recommended starting dose.
1A ✓SSRI AntidepressantCYP2C19:rs4244285
CYP2C19:rs4986893
CYP2C19:rs12248560
Simvastatin (Zocor)Standard
CPIC Prescribe desired starting dose and adjust doses based on disease-specific guidelines.
1A ✓StatinSLCO1B1:rs4149056
Tacrolimus (Prograf)Standard
Standard dosing expected to be effective.
1A ✓ImmunosuppressantCYP3A5:rs776746
Thioguanine (Tabloid)Standard
Standard dosing expected to be effective.
1A ✓ImmunosuppressantTPMT:rs1800460
TPMT:rs1142345
Venlafaxine (Effexor)Standard
CPIC No action recommended based on genotype for venlafaxine because of minimal evidence regarding the impact on efficacy ...
1ASNRI AntidepressantCYP2D6:rs3892097
CYP2D6:rs16947
CYP2D6:rs1065852
CYP2D6:rs28371725
Voriconazole (Vfend)Standard
CPIC Initiate therapy with recommended standard of care dosing.f.
1A ✓AntifungalCYP2C19:rs4244285
CYP2C19:rs4986893
CYP2C19:rs12248560
Gene Profiles (click to expand)
GeneFull NameDiplotypePhenotype
CYP2C19Cytochrome P450 2C19*17/*2Intermediate Metabolizer
CYP2D6Cytochrome P450 2D6*2/*41Intermediate Metabolizer
CYP2C9Cytochrome P450 2C9*1/*2Intermediate Metabolizer
VKORC1Vitamin K Epoxide ReductaseTTHigh Warfarin Sensitivity
SLCO1B1Solute Carrier Organic Anion Transporter 1B1TTNormal Function
DPYDDihydropyrimidine DehydrogenaseNormal/Normal (2/3 SNPs tested)Normal Metabolizer
TPMTThiopurine S-Methyltransferase*1/*1 (2/3 SNPs tested)Normal Metabolizer
UGT1A1UDP-Glucuronosyltransferase 1A1*1/*1 (1/2 SNPs tested)Normal Metabolizer
CYP3A5Cytochrome P450 3A5*3/*3CYP3A5 Non-expressor
CYP2B6Cytochrome P450 2B6*1/*9Intermediate Metabolizer
NUDT15Nudix Hydrolase 15*1/*1 (1/2 SNPs tested)Normal Metabolizer
CYP1A2Cytochrome P450 1A2*1/*1FNormal Metabolizer
Detected Variants (click to expand)
rsIDGeneStar AlleleGenotypeEffect
rs762551CYP1A2*1FACincreased_function
rs2069514CYP1A2*1CGGdecreased_function
rs3745274CYP2B6*9GTdecreased_function
rs4244285CYP2C19*2AGno_function
rs4986893CYP2C19*3GGno_function
rs12248560CYP2C19*17CTincreased_function
rs1799853CYP2C9*2CTdecreased_function
rs1057910CYP2C9*3AAdecreased_function
rs3892097CYP2D6*4CCno_function
rs16947CYP2D6*2AGnormal_function
rs1065852CYP2D6*10CCdecreased_function
rs28371725CYP2D6*41CTdecreased_function
rs776746CYP3A5*3GGno_function
rs3918290DPYD*2ACCno_function
rs67376798DPYDD949VTTdecreased_function
rs116855232NUDT15*3CCno_function
rs4149056SLCO1B1*5TTdecreased_function
rs1800460TPMT*3BCCno_function
rs1142345TPMT*3CAAno_function
rs4148323UGT1A1*6GGdecreased_function
rs9923231VKORC1-1639G>ATTdecreased_expression
Input Details (click to expand)

Input file: demo_patient.txt

Format detected: 23andme

Checksum (SHA-256): 1e6bb1246289465a7afa7facdeb587123ed50290f4c654810c905414b9207338

Total SNPs in file: 21

Pharmacogenomic SNPs found: 21/30

Genes profiled: 12

Drugs assessed: 51

Generated by ClawBio · PharmGx Reporter v0.2.0 · 2026-03-04 22:08 UTC

Genetic data processed locally. No data was transmitted to external servers.

Disclaimer: ClawBio is a research and educational tool. It is not a medical device and does not provide clinical diagnoses. Consult a healthcare professional before making any medical decisions.