
PMID- 42552576
OWN - NLM
STAT- Publisher
LR  - 20260805
IS  - 1538-943X (Electronic)
IS  - 1058-2916 (Linking)
DP  - 2026 Aug 5
TI  - Novel Explantation Protocol for Cardiac Recovery and Device Weaning Post-Left 
      Ventricular Assist Device Therapy: A Single-Center Experience.
LID - 10.1097/MAT.0000000000002689 [doi]
AB  - Although some patients may exhibit significant myocardial improvement after the 
      placement of a durable left ventricular assist device (LVAD), there are no 
      established guidelines on determining patients who may be eligible for 
      explantation. In this single-center case series, three patients were evaluated 
      for LVAD explantation 8-24 months after implantation using a rigorous 
      multimodality protocol along with multidisciplinary team discussions to assess 
      appropriateness for explantation. Although two of the patients have remained 
      successful device-free, the third patient ultimately underwent heart 
      transplantation 2 months post-explantation. We propose evaluating this protocol 
      more broadly in patients with durable LVADs who demonstrate improved left 
      ventricular function with the goal of ultimately developing standardized 
      guidelines to assess appropriateness for LVAD explantation.
CI  - Copyright (c) ASAIO 2026.
FAU - Kumar, Aarti
AU  - Kumar A
AD  - From the Department of Internal Medicine, University of California, Los Angeles, 
      California.
FAU - Mitchell, Ashley J
AU  - Mitchell AJ
AD  - Department of Medicine, Cedars-Sinai Kidney Transplant Program, Los Angeles, 
      California.
FAU - Shahandeh, Negeen
AU  - Shahandeh N
AD  - Division of Cardiology, University of California, Los Angeles, California.
FAU - Vucicevic, Darko
AU  - Vucicevic D
AD  - Division of Cardiology, University of California, Los Angeles, California.
FAU - Kwon, Murray H
AU  - Kwon MH
AD  - Division of Cardiac Surgery, University of California, Los Angeles, California.
FAU - Srivastava, Pratyaksh K
AU  - Srivastava PK
AD  - Division of Cardiology, University of California, Los Angeles, California.
FAU - Nsair, Ali
AU  - Nsair A
AD  - Division of Cardiology, University of California, Los Angeles, California.
FAU - Kamath, Megan Y
AU  - Kamath MY
AUID- ORCID: 0000-0002-6585-7561
AD  - Division of Cardiology, University of California, Los Angeles, California.
LA  - eng
PT  - Journal Article
DEP - 20260805
PL  - United States
TA  - ASAIO J
JT  - ASAIO journal (American Society for Artificial Internal Organs : 1992)
JID - 9204109
SB  - IM
OTO - NOTNLM
OT  - cardiac recovery
OT  - durable left ventricular assist device
OT  - heart failure
OT  - mechanical circulatory support
COIS- Disclosure: The authors have no conflicts of interest to report.
EDAT- 2026/08/05 06:42
MHDA- 2026/08/05 06:42
CRDT- 2026/08/05 00:31
PHST- 2026/08/05 06:42 [medline]
PHST- 2026/08/05 06:42 [pubmed]
PHST- 2026/08/05 00:31 [entrez]
AID - 00002480-990000000-01034 [pii]
AID - 10.1097/MAT.0000000000002689 [doi]
PST - aheadofprint
SO  - ASAIO J. 2026 Aug 5. doi: 10.1097/MAT.0000000000002689.
