pbcheck audit report

1. Header

pbcheck audit of 'small_pilot_cohort.h5ad'

pbcheck 0.1.0, generated 2026-09-01T12:00:00Z.

Status: design_only (fewer than the minimum donors were present in at least one group)

This is a pbcheck v0.1.0 audit of one stratum of one file. It measures how a naive per-cell test and a donor-pseudobulk test behave on this data under a donor-permutation null. It is run outside pbcheck's pre-registered Phase 0 protocol, is not a Phase 0 measurement, and makes no claim about any publication or about whether any reported result is true.

2. Read-out

No detection arms were run at this status: fewer than the minimum donors were present in at least one group.

Amendment 3 declares an operating envelope for the pseudobulk arm on synthetic oracles. For each donor-variance point it states the donor count per group at which the power target is reached, and each row says what the committed grid supports there: a point measured on the grid, or a count derived or extrapolated from it.
sigma_donor 0.2: at least 4 donors per group (power at least 0.6 at log2FC 1.0 in 200 genes; grid support 'not in the grid; Amendment 1 frontier only')
sigma_donor 0.35: at least 8 donors per group (power at least 0.6 at log2FC 1.0 in 200 genes; grid support 'ebayes power 0.793 at 8v8 (calibrated) -> n* <= 8')
sigma_donor 0.5: at least 13 donors per group (power at least 0.6 at log2FC 1.0 in 200 genes; grid support 'ebayes power 0.486 at 12v12, the largest n tested -> n* > 12')
sigma_donor 0.7: at least 23 donors per group (power at least 0.6 at log2FC 1.0 in 200 genes; grid support 'ebayes power 0.003 at 8v8 -> n* far above 8')
The arm's calibration was evaluated at one hard regime (sigma_donor 0.5, 8 against 8 donors) and nowhere else. pbcheck does not estimate sigma_donor for real data, so whether this stratum lies inside that envelope is not determined here.
Everything in this report is a diagnostic of this file: the naive arm's inflation factor and permutation floor, the pseudobulk arm's inflation factor, floor and false-positive rate as its negative control, and the bookkeeping of the shared gene universe. None of it is a Phase 0 result, and pbcheck does not rate this file against the Phase 0 decision rule.
At least one group has fewer than 8 donors: the permutation null has few distinct donor splits and the floors are coarse. Amendment 5 Change 2 of pbcheck's protocol admits floor-based quantities outside the envelope only when every group has at least 8 donors, and this run is below that in at least one group, so its floor-based numbers describe this run alone. Do not compare them with a run on another file.
No cell type was selected, so all cells were pooled into one stratum; the file has a column that looks like a cell-type annotation ('cell_type'). Pooling mixes composition shifts between conditions into the contrast; rerun with --celltype 'cell_type' --celltype-value <level> for a per-cell-type audit.

3. What these words mean

lambda: the genomic inflation factor: the ratio of observed test statistics to the null expectation, with 1.0 meaning no inflation.

permutation floor: the number of genes a test calls under donor permutation, when condition labels carry no real signal; it is the test's own false-positive baseline on this data.

donor-permutation null: the null distribution built by reassigning condition labels between donors, keeping every donor's cells together, and rerunning the test on each reassignment.

gene universe: the fixed set of genes both arms are tested and corrected over, frozen before either arm sees the real labels.

replication unit: the unit whose independent draws the statistics assume; for donor data that unit is the donor, not the cell.

thin-donor filter: the rule that drops a donor's pseudobulk profile when it is built from too few cells or too few counts, rather than keeping a noisy profile.

operating envelope: the region of donor count and donor-to-donor variability that Amendment 3 declares for the pseudobulk arm on synthetic data; each of its points states the donor count per group at which the power target is reached, on the committed grid or by the derivation the grid support of that point names.

sigma_donor: a knob of pbcheck's synthetic simulator for how much donors differ from each other; it cannot be measured on your data, which is why the envelope question is left open.

Monte-Carlo SE: the standard error of a quantity estimated from a finite number of permutations; it shrinks as more permutations are drawn.

BH convention (solo vs paired): solo BH corrects an arm's p-values over the whole gene universe on its own; paired BH corrects both arms together over the genes common to both, so their real-label counts are directly comparable.

4. Design audit

Donors per group
groupdonors (pre-filter)pseudobulk profiles (post-filter)
lupus_nephritis2n/a
healthy4n/a
Cells per donor (top 6 of 6; 0 more not shown)
donorcells
donor_00300
donor_01280
donor_02260
donor_03240
donor_04220
donor_05200

No batch columns were provided.

Design flags
FieldValue
donor nests in conditionTrue
imbalance ratio1.07
usable for pseudobulkFalse
flagstoo_few_donors
Dropped cells
FieldValue
dropped, other condition1500
dropped, other cell type600
dropped, missing donor90
dropped, missing condition40
dropped, missing cell type20

5. Counts check

Counts check: not run, because fewer than the minimum donors were present in at least one group.

6. Naive per-cell arm

Naive per-cell arm: not run, because fewer than the minimum donors were present in at least one group.

7. Donor-pseudobulk arm

Donor-pseudobulk arm: not run, because fewer than the minimum donors were present in at least one group.

8. Shared universe bookkeeping

Frozen gene universe
FieldValue
size0
minimum size200
buildern/a

Builder rule:

Thin-donor filter: not run.

9. Settings and provenance

Tool settings
settingvalue
n_perm_requested1000
n_perm_pb_requested200
seed0
top_n20
design_onlyno
naive_methodwilcoxon
naive_enginefast
pseudobulk_methodmoderated_ebayes
trendno
min_donors_per_group3
universe_min_total_count15
universe_min_prop0.5
fallback_universe_min_prop0.5
fallback_universe_min_size200
min_profiles_per_group_after_thin_filter3
Protocol constants
protocol constantvalue
alpha0.05
lambda_band[0.9, 1.1]
min_universe_size200
min_cells10
min_counts1000
Operating envelope
sigma_donormin donors per groupgrid support
0.24not in the grid; Amendment 1 frontier only
0.358ebayes power 0.793 at 8v8 (calibrated) -> n* <= 8
0.513ebayes power 0.486 at 12v12, the largest n tested -> n* > 12
0.723ebayes power 0.003 at 8v8 -> n* far above 8
Package versions
packageversion
numpy1.26.4
scipy1.13.1
pandas2.2.2
anndata0.10.7
scanpy1.10.1
statsmodels0.14.2
decoupler1.7.0
pydeseq20.4.10
Platform
FieldValue
platformWindows-10-10.0.26200
python3.12.4
Runtime by stage
stageseconds
load3.1
prepare0.4
design0.2
counts0.6
pseudobulk_build1.8
universe0.3
real_label5.2
permutation_null30.9
render0.2
The engine was measured on one synthetic oracle point (sigma_donor 0.5, 8 against 8 donors, 1500 genes), recorded in pilot/gate/synthetic_gate_2026-08-15.json; that measurement is not repeated on this file. Of the settings below, only the ones listed as protocol constants are pre-registered values taken from pbcheck.gate_config (alpha, lambda_band, min_universe_size, min_cells, min_counts); the permutation counts, the universe filter parameters, the fallback universe rule and the display settings are the tool's own and are not protocol values.

10. Footer

Generated by pbcheck 0.1.0. Protocol: docs/PHASE0_SPEC.md and docs/AMENDMENTS.md in the pbcheck repository.