
PMID- 9500320
OWN - NLM
STAT- MEDLINE
DCOM- 19980317
LR  - 20240815
IS  - 0140-6736 (Print)
IS  - 0140-6736 (Linking)
VI  - 351
IP  - 9103
DP  - 1998 Feb 28
TI  - Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive 
      developmental disorder in children.
PG  - 637-41
AB  - BACKGROUND: We investigated a consecutive series of children with chronic 
      enterocolitis and regressive developmental disorder. METHODS: 12 children (mean 
      age 6 years [range 3-10], 11 boys) were referred to a paediatric gastroenterology 
      unit with a history of normal development followed by loss of acquired skills, 
      including language, together with diarrhoea and abdominal pain. Children 
      underwent gastroenterological, neurological, and developmental assessment and 
      review of developmental records. Ileocolonoscopy and biopsy sampling, 
      magnetic-resonance imaging (MRI), electroencephalography (EEG), and lumbar 
      puncture were done under sedation. Barium follow-through radiography was done 
      where possible. Biochemical, haematological, and immunological profiles were 
      examined. FINDINGS: Onset of behavioural symptoms was associated, by the parents, 
      with measles, mumps, and rubella vaccination in eight of the 12 children, with 
      measles infection in one child, and otitis media in another. All 12 children had 
      intestinal abnormalities, ranging from lymphoid nodular hyperplasia to aphthoid 
      ulceration. Histology showed patchy chronic inflammation in the colon in 11 
      children and reactive ileal lymphoid hyperplasia in seven, but no granulomas. 
      Behavioural disorders included autism (nine), disintegrative psychosis (one), and 
      possible postviral or vaccinal encephalitis (two). There were no focal 
      neurological abnormalities and MRI and EEG tests were normal. Abnormal laboratory 
      results were significantly raised urinary methylmalonic acid compared with 
      age-matched controls (p=0.003), low haemoglobin in four children, and a low serum 
      IgA in four children. INTERPRETATION: We identified associated gastrointestinal 
      disease and developmental regression in a group of previously normal children, 
      which was generally associated in time with possible environmental triggers.
FAU - Wakefield, A J
AU  - Wakefield AJ
AD  - Inflammatory Bowel Disease Study Group, University Department of Medicine, Royal 
      Free Hospital and School of Medicine, London, UK.
FAU - Murch, S H
AU  - Murch SH
FAU - Anthony, A
AU  - Anthony A
FAU - Linnell, J
AU  - Linnell J
FAU - Casson, D M
AU  - Casson DM
FAU - Malik, M
AU  - Malik M
FAU - Berelowitz, M
AU  - Berelowitz M
FAU - Dhillon, A P
AU  - Dhillon AP
FAU - Thomson, M A
AU  - Thomson MA
FAU - Harvey, P
AU  - Harvey P
FAU - Valentine, A
AU  - Valentine A
FAU - Davies, S E
AU  - Davies SE
FAU - Walker-Smith, J A
AU  - Walker-Smith JA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Retracted Publication
PL  - England
TA  - Lancet
JT  - Lancet (London, England)
JID - 2985213R
RN  - 0 (Measles Vaccine)
RN  - 0 (Measles-Mumps-Rubella Vaccine)
RN  - 0 (Mumps Vaccine)
RN  - 0 (Rubella Vaccine)
RN  - 0 (Vaccines, Combined)
SB  - IM
CIN - Lancet. 1998 Feb 28;351(9103):611-2. doi: 10.1016/S0140-6736(05)78423-3. PMID: 
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CIN - Lancet. 1998 Mar 21;351(9106):905; author reply 908-9. PMID: 9525390
CIN - Lancet. 1998 Mar 21;351(9106):905-6; author reply 908-9. doi: 
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CIN - Lancet. 1998 Mar 21;351(9106):906; author reply 908-9. doi: 
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CIN - Lancet. 1998 Mar 21;351(9106):907; author reply 908-9. doi: 
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CIN - Lancet. 1998 Mar 21;351(9106):907; author reply 908-9. doi: 
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CIN - Lancet. 1998 Mar 21;351(9106):907-8; author reply 908-9. doi: 
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CIN - Lancet. 1998 May 2;351(9112):1355; author reply 1356. PMID: 9643815
CIN - Lancet. 1998 May 2;351(9112):1355; author reply 1356. doi: 
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CIN - Lancet. 1998 May 2;351(9112):1355-6; author reply 1356. doi: 
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CIN - Lancet. 1998 Jul 18;352(9123):234-5. doi: 10.1016/S0140-6736(05)77837-5. PMID: 
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CIN - Lancet. 2000 Jul 8;356(9224):160-1. doi: 10.1016/s0140-6736(05)73169-x. PMID: 
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CIN - Lancet. 2000 Jul 8;356(9224):161. doi: 10.1016/S0140-6736(05)73171-8. PMID: 
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CIN - Lancet. 2000 Jul 8;356(9224):161-2. doi: 10.1016/S0140-6736(05)73172-X. PMID: 
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CIN - Lancet. 2002 Jun 15;359(9323):2051-2. doi: 10.1016/S0140-6736(02)08948-1. PMID: 
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CIN - Lancet. 2004 Mar 6;363(9411):747-9. doi: 10.1016/S0140-6736(04)15714-0. PMID: 
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RIN - Lancet. 2004 Mar 6;363(9411):750. doi: 10.1016/S0140-6736(04)15715-2. PMID: 
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CIN - Lancet. 2004 Mar 6;363(9411):820-1. doi: 10.1016/S0140-6736(04)15699-7. PMID: 
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CIN - Lancet. 2004 Mar 6;363(9411):821-2. doi: 10.1016/s0140-6736(04)15708-5. PMID: 
      15022648
CIN - Lancet. 2004 Mar 6;363(9411):822-3. doi: 10.1016/S0140-6736(04)15709-7. PMID: 
      15022649
CIN - Lancet. 2004 Mar 6;363(9411):823-4. doi: 10.1016/S0140-6736(04)15710-3. PMID: 
      15022650
RIN - Lancet. 2010 Feb 6;375(9713):445. doi: 10.1016/S0140-6736(10)60175-4. PMID: 
      20137807
ECI - Eur J Gastroenterol Hepatol. 2011 Nov;23(11):1082. doi: 
      10.1097/MEG.0b013e328349d184. PMID: 21971344
MH  - Child
MH  - Child, Preschool
MH  - Developmental Disabilities/*etiology
MH  - Enterocolitis/*etiology
MH  - Female
MH  - Humans
MH  - Hyperplasia/pathology
MH  - Ileum/*pathology
MH  - Lymphoid Tissue/*pathology
MH  - Male
MH  - Measles/complications
MH  - Measles Vaccine/*adverse effects
MH  - Measles-Mumps-Rubella Vaccine
MH  - Mumps Vaccine/*adverse effects
MH  - Otitis Media/complications
MH  - Rubella Vaccine/*adverse effects
MH  - Vaccines, Combined/adverse effects
EDAT- 1998/03/21 00:00
MHDA- 1998/03/21 00:01
CRDT- 1998/03/21 00:00
PHST- 1998/03/21 00:00 [pubmed]
PHST- 1998/03/21 00:01 [medline]
PHST- 1998/03/21 00:00 [entrez]
AID - S0140673697110960 [pii]
AID - 10.1016/s0140-6736(97)11096-0 [doi]
PST - ppublish
SO  - Lancet. 1998 Feb 28;351(9103):637-41. doi: 10.1016/s0140-6736(97)11096-0.
