entry created 2003-01-27 dataset Swiss-Prot modified 2023-02-22 version 149 accession Q8R2S9 accession Q9CYC4 name ARP8_MOUSE protein recommendedName fullName Actin-related-protein-8 gene name type primary Actr8 name type synonym Arp8 organism name type scientific Mus-musculus name type common Mouse dbReference id 10090 type NCBI-Taxonomy lineage taxon Eukaryota taxon Metazoa taxon Chordata taxon Craniata taxon Vertebrata taxon Euteleostomi taxon Mammalia taxon Eutheria taxon Euarchontoglires taxon Glires taxon Rodentia taxon Myomorpha taxon Muroidea taxon Muridae taxon Murinae taxon Mus taxon Mus reference key 1 citation date 2005 first 1559 last 1563 name Science type journal-article volume 309 title The-transcriptional-landscape-of-the-mammalian-genome. authorList person name Carninci-P. person name Kasukawa-T. person name Katayama-S. person name Gough-J. person name Frith-M.C. person name Maeda-N. person name Oyama-R. person name Ravasi-T. person name Lenhard-B. person name Wells-C. person name Kodzius-R. person name Shimokawa-K. person name Bajic-V.B. person name Brenner-S.E. person name Batalov-S. person name Forrest-A.R. person name Zavolan-M. person name Davis-M.J. person name Wilming-L.G. person name Aidinis-V. person name Allen-J.E. person name Ambesi-Impiombato-A. person name Apweiler-R. person name Aturaliya-R.N. person name Bailey-T.L. person name Bansal-M. person name Baxter-L. person name Beisel-K.W. person name Bersano-T. person name Bono-H. person name Chalk-A.M. person name Chiu-K.P. person name Choudhary-V. person name Christoffels-A. person name Clutterbuck-D.R. person name Crowe-M.L. person name Dalla-E. person name Dalrymple-B.P. person name de-Bono-B. person name Della-Gatta-G. person name di-Bernardo-D. person name Down-T. person name Engstrom-P. person name Fagiolini-M. person name Faulkner-G. person name Fletcher-C.F. person name Fukushima-T. person name Furuno-M. person name Futaki-S. person name Gariboldi-M. person name Georgii-Hemming-P. person name Gingeras-T.R. person name Gojobori-T. person name Green-R.E. person name Gustincich-S. person name Harbers-M. person name Hayashi-Y. person name Hensch-T.K. person name Hirokawa-N. person name Hill-D. person name Huminiecki-L. person name Iacono-M. person name Ikeo-K. person name Iwama-A. person name Ishikawa-T. person name Jakt-M. person name Kanapin-A. person name Katoh-M. person name Kawasawa-Y. person name Kelso-J. person name Kitamura-H. person name Kitano-H. person name Kollias-G. person name Krishnan-S.P. person name Kruger-A. person name Kummerfeld-S.K. person name Kurochkin-I.V. person name Lareau-L.F. person name Lazarevic-D. person name Lipovich-L. person name Liu-J. person name Liuni-S. person name McWilliam-S. person name Madan-Babu-M. person name Madera-M. person name Marchionni-L. person name Matsuda-H. person name Matsuzawa-S. person name Miki-H. person name Mignone-F. person name Miyake-S. person name Morris-K. person name Mottagui-Tabar-S. person name Mulder-N. person name Nakano-N. person name Nakauchi-H. person name Ng-P. person name Nilsson-R. person name Nishiguchi-S. person name Nishikawa-S. person name Nori-F. person name Ohara-O. person name Okazaki-Y. person name Orlando-V. person name Pang-K.C. person name Pavan-W.J. person name Pavesi-G. person name Pesole-G. person name Petrovsky-N. person name Piazza-S. person name Reed-J. person name Reid-J.F. person name Ring-B.Z. person name Ringwald-M. person name Rost-B. person name Ruan-Y. person name Salzberg-S.L. person name Sandelin-A. person name Schneider-C. person name Schoenbach-C. person name Sekiguchi-K. person name Semple-C.A. person name Seno-S. person name Sessa-L. person name Sheng-Y. person name Shibata-Y. person name Shimada-H. person name Shimada-K. person name Silva-D. person name Sinclair-B. person name Sperling-S. person name Stupka-E. person name Sugiura-K. person name Sultana-R. person name Takenaka-Y. person name Taki-K. person name Tammoja-K. person name Tan-S.L. person name Tang-S. person name Taylor-M.S. person name Tegner-J. person name Teichmann-S.A. person name Ueda-H.R. person name van-Nimwegen-E. person name Verardo-R. person name Wei-C.L. person name Yagi-K. person name Yamanishi-H. person name Zabarovsky-E. person name Zhu-S. person name Zimmer-A. person name Hide-W. person name Bult-C. person name Grimmond-S.M. person name Teasdale-R.D. person name Liu-E.T. person name Brusic-V. person name Quackenbush-J. person name Wahlestedt-C. person name Mattick-J.S. person name Hume-D.A. person name Kai-C. person name Sasaki-D. person name Tomaru-Y. person name Fukuda-S. person name Kanamori-Katayama-M. person name Suzuki-M. person name Aoki-J. person name Arakawa-T. person name Iida-J. person name Imamura-K. person name Itoh-M. person name Kato-T. person name Kawaji-H. person name Kawagashira-N. person name Kawashima-T. person name Kojima-M. person name Kondo-S. person name Konno-H. person name Nakano-K. person name Ninomiya-N. person name Nishio-T. person name Okada-M. person name Plessy-C. person name Shibata-K. person name Shiraki-T. person name Suzuki-S. person name Tagami-M. person name Waki-K. person name Watahiki-A. person name Okamura-Oho-Y. person name Suzuki-H. person name Kawai-J. person name Hayashizaki-Y. dbReference id 16141072 type PubMed dbReference id 10.1126/science.1112014 type DOI scope NUCLEOTIDE-SEQUENCE-[LARGE-SCALE-MRNA] source strain C57BL/6J tissue Embryo reference key 2 citation date 2004 first 2121 last 2127 name Genome-Res. type journal-article volume 14 title The-status,-quality,-and-expansion-of-the-NIH-full-length-cDNA-project:-the-Mammalian-Gene-Collection-(MGC). authorList consortium name The-MGC-Project-Team dbReference id 15489334 type PubMed dbReference id 10.1101/gr.2596504 type DOI scope NUCLEOTIDE-SEQUENCE-[LARGE-SCALE-MRNA] reference key 3 citation date 2010 first 619 last 625 name Biochem.-Biophys.-Res.-Commun. type journal-article volume 402 title The-mammalian-INO80-complex-is-recruited-to-DNA-damage-sites-in-an-ARP8-dependent-manner. authorList person name Kashiwaba-S. person name Kitahashi-K. person name Watanabe-T. person name Onoda-F. person name Ohtsu-M. person name Murakami-Y. dbReference id 20971067 type PubMed dbReference id 10.1016/j.bbrc.2010.10.066 type DOI scope FUNCTION comment type function text evidence 1 Plays-an-important-role-in-the-functional-organization-of-mitotic-chromosomes.-Exhibits-low-basal-ATPase-activity,-and-unable-to-polymerize-(By-similarity). comment type function text evidence 1 Proposed-core-component-of-the-chromatin-remodeling-INO80-complex-which-is-involved-in-transcriptional-regulation,-DNA-replication-and-probably-DNA-repair.-Required-for-the-recruitment-of-INO80-(and-probably-the-INO80-complex)-to-sites-of-DNA-damage-Strongly-prefer-nucleosomes-and-H3-H4-tetramers-over-H2A-H2B-dimers,-suggesting-it-may-act-as-a-nucleosome-recognition-module-within-the-complex-(By-similarity). comment type subunit text evidence 1 Component-of-the-chromatin-remodeling-INO80-complex;-specifically-part-of-a-complex-module-associated-with-the-DBINO-domain-of-INO80.-Exists-as-monomers-and-dimers,-but-the-dimer-is-most-probably-the-biologically-relevant-form-required-for-stable-interactions-with-histones-that-exploits-the-twofold-symmetry-of-the-nucleosome-core-(By-similarity). comment type subcellular-location subcellularLocation location evidence 1 Nucleus subcellularLocation location evidence 1 Chromosome text evidence 1 Specifically-localizes-to-mitotic-chromosomes. comment type similarity text evidence 4 Belongs-to-the-actin-family.-ARP8-subfamily. dbReference id AK017815 type EMBL property type protein-sequence-ID value BAB30952.1 property type molecule-type value mRNA dbReference id BC027281 type EMBL property type protein-sequence-ID value AAH27281.1 property type molecule-type value mRNA dbReference id CCDS26891.1 type CCDS dbReference id NP_081769.2 type RefSeq property type nucleotide-sequence-ID value NM_027493.3 dbReference id Q8R2S9 type AlphaFoldDB dbReference id Q8R2S9 type SMR dbReference id 207864 type BioGRID property type interactions value 2 dbReference id CPX-878 type ComplexPortal property type entry-name value INO80-chromatin-remodeling-complex dbReference id Q8R2S9 type IntAct property type interactions value 1 dbReference id Q8R2S9 type MINT dbReference id 10090.ENSMUSP00000016115 type STRING dbReference id Q8R2S9 type iPTMnet dbReference id Q8R2S9 type PhosphoSitePlus dbReference id Q8R2S9 type SwissPalm dbReference id Q8R2S9 type EPD dbReference id Q8R2S9 type jPOST dbReference id Q8R2S9 type MaxQB dbReference id Q8R2S9 type PaxDb dbReference id Q8R2S9 type PeptideAtlas dbReference id 265105 type ProteomicsDB dbReference id 31436 type Antibodypedia property type antibodies value 53-antibodies-from-15-providers dbReference id 56249 type DNASU dbReference id ENSMUST00000016115.6 type Ensembl property type protein-sequence-ID value ENSMUSP00000016115.5 property type gene-ID value ENSMUSG00000015971.6 dbReference id ENSMUST00000224797.2 type Ensembl property type protein-sequence-ID value ENSMUSP00000153076.2 property type gene-ID value ENSMUSG00000015971.6 dbReference id 56249 type GeneID dbReference id mmu:56249 type KEGG dbReference id uc007sum.2 type UCSC property type organism-name value mouse dbReference id MGI:1860775 type AGR dbReference id 93973 type CTD dbReference id MGI:1860775 type MGI property type gene-designation value Actr8 dbReference id HostDB:ENSMUSG00000015971 type VEuPathDB dbReference id KOG0797 type eggNOG property type taxonomic-scope value Eukaryota dbReference id ENSGT00390000001763 type GeneTree dbReference id CLU_006974_1_0_1 type HOGENOM dbReference id Q8R2S9 type InParanoid dbReference id CFIQESL type OMA dbReference id 11729at2759 type OrthoDB dbReference id Q8R2S9 type PhylomeDB dbReference id TF324575 type TreeFam dbReference id R-MMU-5689603 type Reactome property type pathway-name value UCH-proteinases dbReference id R-MMU-5696394 type Reactome property type pathway-name value DNA-Damage-Recognition-in-GG-NER dbReference id 56249 type BioGRID-ORCS property type hits value 18-hits-in-114-CRISPR-screens dbReference id PR:Q8R2S9 type PRO dbReference id UP000000589 type Proteomes property type component value Chromosome-14 dbReference id Q8R2S9 type RNAct property type molecule-type value protein dbReference id ENSMUSG00000015971 type Bgee property type expression-patterns value Expressed-in-embryonic-brain-and-252-other-tissues dbReference id Q8R2S9 type ExpressionAtlas property type expression-patterns value baseline-and-differential dbReference id Q8R2S9 type Genevisible property type organism-ID value MM dbReference id GO:0005813 type GO property type term value C:centrosome property type evidence value ECO:0000266 property type project value MGI dbReference id GO:0031011 type GO property type term value C:Ino80-complex property type evidence value ECO:0000266 property type project value MGI dbReference id GO:0005654 type GO property type term value C:nucleoplasm property type evidence value ECO:0000266 property type project value MGI dbReference id GO:0005634 type GO property type term value C:nucleus property type evidence value ECO:0000266 property type project value MGI dbReference id GO:0005524 type GO property type term value F:ATP-binding property type evidence value ECO:0007669 property type project value UniProtKB-KW dbReference id GO:0007049 type GO property type term value P:cell-cycle property type evidence value ECO:0007669 property type project value UniProtKB-KW dbReference id GO:0051301 type GO property type term value P:cell-division property type evidence value ECO:0007669 property type project value UniProtKB-KW dbReference id GO:0006338 type GO property type term value P:chromatin-remodeling property type evidence value ECO:0000266 property type project value MGI dbReference id GO:0006310 type GO property type term value P:DNA-recombination property type evidence value ECO:0007669 property type project value UniProtKB-KW dbReference id GO:0006302 type GO property type term value P:double-strand-break-repair property type evidence value ECO:0000318 property type project value GO_Central dbReference id GO:0045739 type GO property type term value P:positive-regulation-of-DNA-repair property type evidence value ECO:0000314 property type project value ComplexPortal dbReference id GO:0045893 type GO property type term value P:positive-regulation-of-DNA-templated-transcription property type evidence value ECO:0000266 property type project value MGI dbReference id GO:1904507 type GO property type term value P:positive-regulation-of-telomere-maintenance-in-response-to-DNA-damage property type evidence value ECO:0000315 property type project value ComplexPortal dbReference id GO:0051726 type GO property type term value P:regulation-of-cell-cycle property type evidence value ECO:0000266 property type project value MGI dbReference id GO:0033044 type GO property type term value P:regulation-of-chromosome-organization property type evidence value ECO:0000266 property type project value MGI dbReference id GO:0006282 type GO property type term value P:regulation-of-DNA-repair property type evidence value ECO:0000314 property type project value ComplexPortal dbReference id GO:0006275 type GO property type term value P:regulation-of-DNA-replication property type evidence value ECO:0000266 property type project value MGI dbReference id GO:0060382 type GO property type term value P:regulation-of-DNA-strand-elongation property type evidence value ECO:0000266 property type project value MGI dbReference id GO:0006355 type GO property type term value P:regulation-of-DNA-templated-transcription property type evidence value ECO:0000318 property type project value GO_Central dbReference id GO:0045995 type GO property type term value P:regulation-of-embryonic-development property type evidence value ECO:0000315 property type project value ComplexPortal dbReference id GO:0000723 type GO property type term value P:telomere-maintenance property type evidence value ECO:0000315 property type project value ComplexPortal dbReference id cd00012 type CDD property type entry-name value NBD_sugar-kinase_HSP70_actin property type match-status value 1 dbReference id 2.30.36.90 type Gene3D property type match-status value 1 dbReference id 3.30.420.40 type Gene3D property type match-status value 2 dbReference id IPR004000 type InterPro property type entry-name value Actin dbReference id IPR043129 type InterPro property type entry-name value ATPase_NBD dbReference id PTHR11937 type PANTHER property type entry-name value ACTIN property type match-status value 1 dbReference id PTHR11937:SF13 type PANTHER property type entry-name value ACTIN-RELATED-PROTEIN-8 property type match-status value 1 dbReference id PF00022 type Pfam property type entry-name value Actin property type match-status value 1 dbReference id SM00268 type SMART property type entry-name value ACTIN property type match-status value 1 dbReference id SSF53067 type SUPFAM property type entry-name value Actin-like-ATPase-domain property type match-status value 2 proteinExistence type evidence-at-transcript-level keyword id KW-0007 Acetylation keyword id KW-0067 ATP-binding keyword id KW-0131 Cell-cycle keyword id KW-0132 Cell-division keyword id KW-0158 Chromosome keyword id KW-0227 DNA-damage keyword id KW-0233 DNA-recombination keyword id KW-0234 DNA-repair keyword id KW-0498 Mitosis keyword id KW-0547 Nucleotide-binding keyword id KW-0539 Nucleus keyword id KW-0597 Phosphoprotein keyword id KW-1185 Reference-proteome keyword id KW-0804 Transcription keyword id KW-0805 Transcription-regulation feature description Actin-related-protein-8 id PRO_0000089124 type chain location begin position 1 end position 624 feature description Disordered evidence 3 type region-of-interest location begin position 1 end position 29 feature description Disordered evidence 3 type region-of-interest location begin position 430 end position 462 feature description Basic-and-acidic-residues evidence 3 type compositionally-biased-region location begin position 1 end position 27 feature evidence 1 type binding-site location position position 55 ligand name ATP dbReference id CHEBI:30616 type ChEBI feature evidence 1 type binding-site location position position 56 ligand name ATP dbReference id CHEBI:30616 type ChEBI feature evidence 1 type binding-site location begin position 283 end position 286 ligand name ATP dbReference id CHEBI:30616 type ChEBI feature description N-acetylmethionine evidence 2 type modified-residue location position position 1 feature description Phosphoserine evidence 2 type modified-residue location position position 132 feature description Phosphoserine evidence 2 type modified-residue location position position 412 feature description In-Ref.-1;-BAB30952. evidence 4 ref 1 type sequence-conflict original R variation G location position position 127 evidence key 1 type ECO:0000250 evidence key 2 type ECO:0000250 source dbReference id Q9H981 type UniProtKB evidence key 3 type ECO:0000256 source dbReference id MobiDB-lite type SAM evidence key 4 type ECO:0000305 sequence checksum 96B79E1119C50FEA length 624 mass 70546 modified 2002-06-01 version 1 MTQAEKGDAENGKEKGGEKEKEQRGVKRPIVPALVPESLQEQIQSNFIVVIHPGSTTLRLGRATDTLPVSVPHVIARRHKQQGQPLYKDNWLLREGLNKPESNEQRQNGLKMVDQAIWSKKMSNGTRRIPVSPEQTRSYNKQMRPAILDHCSGNKWTNTSQQPEYLVGEEALYVNPLDCYNIHWPIRRGQLNIHPGPGGSLTAVLADIEVIWSHAIQKYLEIPLKDLKYYRCILLIPDIYNKQHVKELVHMILMKMGFAGIVVHQESVCATFGSGLSSTCVVDVGDQKTSVCCVEDGVSHRNTRLCLAYGGSDVSRCFYWLMQRAGFPYRECQLTNKMDCLLLQHLKETFCHLDQDISGLQDHEFQIRHPDSPALLYQFRLGDEKLQAPMALFYPATFGIVGQKMTTLQHRSQGDPEDPHDEHYLLATQSKQEQSAKATADRKSASKPIGFEGDLRGQSSDLPERLHSQEVDLASSQGDCLMAGNESEEALTALMSRKTAISLFEGKALGLDKAILHSVDCCSSDDTKKKMYSSILVVGGGLMFHKAQEFLQHRILNKMPPSFRRIIENVDVITRPKDMDPRLIAWKGGAVLACLDTTQELWIYQREWQRFGVRMLRERAAFVW 
entry created 2003-05-30 dataset Swiss-Prot modified 2023-02-22 version 142 accession Q9CWK3 accession Q3TJX5 name CD2B2_MOUSE protein recommendedName fullName CD2-antigen-cytoplasmic-tail-binding-protein-2 shortName CD2-cytoplasmic-domain-binding-protein-2 shortName CD2-tail-binding-protein-2 gene name type primary Cd2bp2 organism name type scientific Mus-musculus name type common Mouse dbReference id 10090 type NCBI-Taxonomy lineage taxon Eukaryota taxon Metazoa taxon Chordata taxon Craniata taxon Vertebrata taxon Euteleostomi taxon Mammalia taxon Eutheria taxon Euarchontoglires taxon Glires taxon Rodentia taxon Myomorpha taxon Muroidea taxon Muridae taxon Murinae taxon Mus taxon Mus reference key 1 citation date 2005 first 1559 last 1563 name Science type journal-article volume 309 title The-transcriptional-landscape-of-the-mammalian-genome. authorList person name Carninci-P. person name Kasukawa-T. person name Katayama-S. person name Gough-J. person name Frith-M.C. person name Maeda-N. person name Oyama-R. person name Ravasi-T. person name Lenhard-B. person name Wells-C. person name Kodzius-R. person name Shimokawa-K. person name Bajic-V.B. person name Brenner-S.E. person name Batalov-S. person name Forrest-A.R. person name Zavolan-M. person name Davis-M.J. person name Wilming-L.G. person name Aidinis-V. person name Allen-J.E. person name Ambesi-Impiombato-A. person name Apweiler-R. person name Aturaliya-R.N. person name Bailey-T.L. person name Bansal-M. person name Baxter-L. person name Beisel-K.W. person name Bersano-T. person name Bono-H. person name Chalk-A.M. person name Chiu-K.P. person name Choudhary-V. person name Christoffels-A. person name Clutterbuck-D.R. person name Crowe-M.L. person name Dalla-E. person name Dalrymple-B.P. person name de-Bono-B. person name Della-Gatta-G. person name di-Bernardo-D. person name Down-T. person name Engstrom-P. person name Fagiolini-M. person name Faulkner-G. person name Fletcher-C.F. person name Fukushima-T. person name Furuno-M. person name Futaki-S. person name Gariboldi-M. person name Georgii-Hemming-P. person name Gingeras-T.R. person name Gojobori-T. person name Green-R.E. person name Gustincich-S. person name Harbers-M. person name Hayashi-Y. person name Hensch-T.K. person name Hirokawa-N. person name Hill-D. person name Huminiecki-L. person name Iacono-M. person name Ikeo-K. person name Iwama-A. person name Ishikawa-T. person name Jakt-M. person name Kanapin-A. person name Katoh-M. person name Kawasawa-Y. person name Kelso-J. person name Kitamura-H. person name Kitano-H. person name Kollias-G. person name Krishnan-S.P. person name Kruger-A. person name Kummerfeld-S.K. person name Kurochkin-I.V. person name Lareau-L.F. person name Lazarevic-D. person name Lipovich-L. person name Liu-J. person name Liuni-S. person name McWilliam-S. person name Madan-Babu-M. person name Madera-M. person name Marchionni-L. person name Matsuda-H. person name Matsuzawa-S. person name Miki-H. person name Mignone-F. person name Miyake-S. person name Morris-K. person name Mottagui-Tabar-S. person name Mulder-N. person name Nakano-N. person name Nakauchi-H. person name Ng-P. person name Nilsson-R. person name Nishiguchi-S. person name Nishikawa-S. person name Nori-F. person name Ohara-O. person name Okazaki-Y. person name Orlando-V. person name Pang-K.C. person name Pavan-W.J. person name Pavesi-G. person name Pesole-G. person name Petrovsky-N. person name Piazza-S. person name Reed-J. person name Reid-J.F. person name Ring-B.Z. person name Ringwald-M. person name Rost-B. person name Ruan-Y. person name Salzberg-S.L. person name Sandelin-A. person name Schneider-C. person name Schoenbach-C. person name Sekiguchi-K. person name Semple-C.A. person name Seno-S. person name Sessa-L. person name Sheng-Y. person name Shibata-Y. person name Shimada-H. person name Shimada-K. person name Silva-D. person name Sinclair-B. person name Sperling-S. person name Stupka-E. person name Sugiura-K. person name Sultana-R. person name Takenaka-Y. person name Taki-K. person name Tammoja-K. person name Tan-S.L. person name Tang-S. person name Taylor-M.S. person name Tegner-J. person name Teichmann-S.A. person name Ueda-H.R. person name van-Nimwegen-E. person name Verardo-R. person name Wei-C.L. person name Yagi-K. person name Yamanishi-H. person name Zabarovsky-E. person name Zhu-S. person name Zimmer-A. person name Hide-W. person name Bult-C. person name Grimmond-S.M. person name Teasdale-R.D. person name Liu-E.T. person name Brusic-V. person name Quackenbush-J. person name Wahlestedt-C. person name Mattick-J.S. person name Hume-D.A. person name Kai-C. person name Sasaki-D. person name Tomaru-Y. person name Fukuda-S. person name Kanamori-Katayama-M. person name Suzuki-M. person name Aoki-J. person name Arakawa-T. person name Iida-J. person name Imamura-K. person name Itoh-M. person name Kato-T. person name Kawaji-H. person name Kawagashira-N. person name Kawashima-T. person name Kojima-M. person name Kondo-S. person name Konno-H. person name Nakano-K. person name Ninomiya-N. person name Nishio-T. person name Okada-M. person name Plessy-C. person name Shibata-K. person name Shiraki-T. person name Suzuki-S. person name Tagami-M. person name Waki-K. person name Watahiki-A. person name Okamura-Oho-Y. person name Suzuki-H. person name Kawai-J. person name Hayashizaki-Y. dbReference id 16141072 type PubMed dbReference id 10.1126/science.1112014 type DOI scope NUCLEOTIDE-SEQUENCE-[LARGE-SCALE-MRNA] source strain C57BL/6J tissue Embryo tissue Pituitary tissue Testis reference key 2 citation date 2004 first 2121 last 2127 name Genome-Res. type journal-article volume 14 title The-status,-quality,-and-expansion-of-the-NIH-full-length-cDNA-project:-the-Mammalian-Gene-Collection-(MGC). authorList consortium name The-MGC-Project-Team dbReference id 15489334 type PubMed dbReference id 10.1101/gr.2596504 type DOI scope NUCLEOTIDE-SEQUENCE-[LARGE-SCALE-MRNA] reference key 3 citation date 2006 first 914 last 922 name Mol.-Cell.-Proteomics type journal-article volume 5 title Comprehensive-identification-of-phosphorylation-sites-in-postsynaptic-density-preparations. authorList person name Trinidad-J.C. person name Specht-C.G. person name Thalhammer-A. person name Schoepfer-R. person name Burlingame-A.L. dbReference id 16452087 type PubMed dbReference id 10.1074/mcp.t500041-mcp200 type DOI scope IDENTIFICATION-BY-MASS-SPECTROMETRY-[LARGE-SCALE-ANALYSIS] source tissue Brain reference key 4 citation date 2010 first 1174 last 1189 name Cell type journal-article volume 143 title A-tissue-specific-atlas-of-mouse-protein-phosphorylation-and-expression. authorList person name Huttlin-E.L. person name Jedrychowski-M.P. person name Elias-J.E. person name Goswami-T. person name Rad-R. person name Beausoleil-S.A. person name Villen-J. person name Haas-W. person name Sowa-M.E. person name Gygi-S.P. dbReference id 21183079 type PubMed dbReference id 10.1016/j.cell.2010.12.001 type DOI scope PHOSPHORYLATION-[LARGE-SCALE-ANALYSIS]-AT-SER-49 scope IDENTIFICATION-BY-MASS-SPECTROMETRY-[LARGE-SCALE-ANALYSIS] source tissue Kidney tissue Spleen tissue Testis reference key 5 citation date 2013 first 919 last 930 name Mol.-Cell type journal-article volume 50 title SIRT5-mediated-lysine-desuccinylation-impacts-diverse-metabolic-pathways. authorList person name Park-J. person name Chen-Y. person name Tishkoff-D.X. person name Peng-C. person name Tan-M. person name Dai-L. person name Xie-Z. person name Zhang-Y. person name Zwaans-B.M. person name Skinner-M.E. person name Lombard-D.B. person name Zhao-Y. dbReference id 23806337 type PubMed dbReference id 10.1016/j.molcel.2013.06.001 type DOI scope ACETYLATION-[LARGE-SCALE-ANALYSIS]-AT-LYS-44 scope IDENTIFICATION-BY-MASS-SPECTROMETRY-[LARGE-SCALE-ANALYSIS] source tissue Embryonic-fibroblast comment type function text evidence 1 Involved-in-pre-mRNA-splicing-as-component-of-the-U5-snRNP-complex-that-is-involved-in-spliceosome-assembly. comment type subunit text evidence 1 Component-of-the-U5-snRNP-complex-composed-of-the-U5-snRNA-and-at-least-PRPF6,-PRPF8,-SNRNP200,-EFTUD2,-SNRNP40,-DDX23,-TXNL4A-and-CD2BP2.-Interacts-directly-with-TXNL4A-and-PRPF6.-Interacts-(via-GYF-domain)-with-CD2-(via-Pro-rich-sequence-in-the-cytoplasmic-domain).-Interacts-with-PQBP1-(By-similarity). comment type subcellular-location subcellularLocation location evidence 1 Cytoplasm subcellularLocation location evidence 1 Nucleus text evidence 1 Predominantly-nuclear. dbReference id BC006920 type EMBL property type protein-sequence-ID value AAH06920.1 property type molecule-type value mRNA dbReference id AK010582 type EMBL property type protein-sequence-ID value BAB27044.1 property type molecule-type value mRNA dbReference id AK030393 type EMBL property type protein-sequence-ID value BAC26940.1 property type molecule-type value mRNA dbReference id AK031694 type EMBL property type protein-sequence-ID value BAC27518.1 property type molecule-type value mRNA dbReference id AK034689 type EMBL property type protein-sequence-ID value BAC28798.1 property type molecule-type value mRNA dbReference id AK167249 type EMBL property type protein-sequence-ID value BAE39370.1 property type molecule-type value mRNA dbReference id CCDS21859.1 type CCDS dbReference id NP_001272834.1 type RefSeq property type nucleotide-sequence-ID value NM_001285905.1 dbReference id NP_001272835.1 type RefSeq property type nucleotide-sequence-ID value NM_001285906.1 dbReference id NP_001272836.1 type RefSeq property type nucleotide-sequence-ID value NM_001285907.1 dbReference id NP_081629.1 type RefSeq property type nucleotide-sequence-ID value NM_027353.4 dbReference id XP_006508260.1 type RefSeq property type nucleotide-sequence-ID value XM_006508197.2 dbReference id XP_006508261.1 type RefSeq property type nucleotide-sequence-ID value XM_006508198.3 dbReference id Q9CWK3 type AlphaFoldDB dbReference id Q9CWK3 type SMR dbReference id 213930 type BioGRID property type interactions value 1 dbReference id 10090.ENSMUSP00000132963 type STRING dbReference id Q9CWK3 type iPTMnet dbReference id Q9CWK3 type PhosphoSitePlus dbReference id Q9CWK3 type EPD dbReference id Q9CWK3 type jPOST dbReference id Q9CWK3 type MaxQB dbReference id Q9CWK3 type PaxDb dbReference id 283747 type ProteomicsDB dbReference id 27184 type Antibodypedia property type antibodies value 200-antibodies-from-31-providers dbReference id 70233 type DNASU dbReference id ENSMUST00000035771.5 type Ensembl property type protein-sequence-ID value ENSMUSP00000044790.4 property type gene-ID value ENSMUSG00000042502.11 dbReference id ENSMUST00000166791.8 type Ensembl property type protein-sequence-ID value ENSMUSP00000132963.2 property type gene-ID value ENSMUSG00000042502.11 dbReference id ENSMUST00000205316.2 type Ensembl property type protein-sequence-ID value ENSMUSP00000145888.2 property type gene-ID value ENSMUSG00000042502.11 dbReference id ENSMUST00000206026.2 type Ensembl property type protein-sequence-ID value ENSMUSP00000146167.2 property type gene-ID value ENSMUSG00000042502.11 dbReference id 70233 type GeneID dbReference id mmu:70233 type KEGG dbReference id uc009juj.2 type UCSC property type organism-name value mouse dbReference id MGI:1917483 type AGR dbReference id 10421 type CTD dbReference id MGI:1917483 type MGI property type gene-designation value Cd2bp2 dbReference id HostDB:ENSMUSG00000042502 type VEuPathDB dbReference id KOG2950 type eggNOG property type taxonomic-scope value Eukaryota dbReference id ENSGT00390000012483 type GeneTree dbReference id CLU_062973_0_0_1 type HOGENOM dbReference id Q9CWK3 type InParanoid dbReference id VRKCGEN type OMA dbReference id 2877705at2759 type OrthoDB dbReference id Q9CWK3 type PhylomeDB dbReference id TF313042 type TreeFam dbReference id R-MMU-72163 type Reactome property type pathway-name value mRNA-Splicing---Major-Pathway dbReference id 70233 type BioGRID-ORCS property type hits value 17-hits-in-80-CRISPR-screens dbReference id Cd2bp2 type ChiTaRS property type organism-name value mouse dbReference id PR:Q9CWK3 type PRO dbReference id UP000000589 type Proteomes property type component value Chromosome-7 dbReference id Q9CWK3 type RNAct property type molecule-type value protein dbReference id ENSMUSG00000042502 type Bgee property type expression-patterns value Expressed-in-saccule-of-membranous-labyrinth-and-248-other-tissues dbReference id Q9CWK3 type ExpressionAtlas property type expression-patterns value baseline-and-differential dbReference id Q9CWK3 type Genevisible property type organism-ID value MM dbReference id GO:0005829 type GO property type term value C:cytosol property type evidence value ECO:0000266 property type project value MGI dbReference id GO:0001650 type GO property type term value C:fibrillar-center property type evidence value ECO:0000266 property type project value MGI dbReference id GO:0016607 type GO property type term value C:nuclear-speck property type evidence value ECO:0000266 property type project value MGI dbReference id GO:0005654 type GO property type term value C:nucleoplasm property type evidence value ECO:0000266 property type project value MGI dbReference id GO:0005634 type GO property type term value C:nucleus property type evidence value ECO:0000266 property type project value MGI dbReference id GO:0005682 type GO property type term value C:U5-snRNP property type evidence value ECO:0000266 property type project value MGI dbReference id GO:0043021 type GO property type term value F:ribonucleoprotein-complex-binding property type evidence value ECO:0000266 property type project value MGI dbReference id GO:0006397 type GO property type term value P:mRNA-processing property type evidence value ECO:0007669 property type project value UniProtKB-KW dbReference id GO:0008380 type GO property type term value P:RNA-splicing property type evidence value ECO:0007669 property type project value UniProtKB-KW dbReference id cd00072 type CDD property type entry-name value GYF property type match-status value 1 dbReference id 3.30.1490.40 type Gene3D property type match-status value 1 dbReference id IPR039905 type InterPro property type entry-name value CD2BP2/Lin1 dbReference id IPR003169 type InterPro property type entry-name value GYF dbReference id IPR035445 type InterPro property type entry-name value GYF-like_dom_sf dbReference id PTHR13138:SF3 type PANTHER property type entry-name value CD2-ANTIGEN-CYTOPLASMIC-TAIL-BINDING-PROTEIN-2 property type match-status value 1 dbReference id PTHR13138 type PANTHER property type entry-name value PROTEIN-LIN1 property type match-status value 1 dbReference id PF02213 type Pfam property type entry-name value GYF property type match-status value 1 dbReference id SM00444 type SMART property type entry-name value GYF property type match-status value 1 dbReference id SSF55277 type SUPFAM property type entry-name value GYF-domain property type match-status value 1 dbReference id PS50829 type PROSITE property type entry-name value GYF property type match-status value 1 proteinExistence type evidence-at-protein-level keyword id KW-0007 Acetylation keyword id KW-0963 Cytoplasm keyword id KW-1017 Isopeptide-bond keyword id KW-0507 mRNA-processing keyword id KW-0508 mRNA-splicing keyword id KW-0539 Nucleus keyword id KW-0597 Phosphoprotein keyword id KW-1185 Reference-proteome keyword id KW-0832 Ubl-conjugation feature description CD2-antigen-cytoplasmic-tail-binding-protein-2 id PRO_0000089438 type chain location begin position 1 end position 342 feature description GYF evidence 3 type domain location begin position 281 end position 339 feature description Disordered evidence 4 type region-of-interest location begin position 1 end position 64 feature description Disordered evidence 4 type region-of-interest location begin position 130 end position 150 feature description Disordered evidence 4 type region-of-interest location begin position 177 end position 200 feature description Basic-and-acidic-residues evidence 4 type compositionally-biased-region location begin position 8 end position 25 feature description N6-acetyllysine evidence 6 type modified-residue location position position 44 feature description Phosphoserine evidence 2 type modified-residue location position position 46 feature description Phosphoserine evidence 5 type modified-residue location position position 49 feature description Phosphoserine evidence 2 type modified-residue location position position 117 feature description Phosphoserine evidence 2 type modified-residue location position position 196 feature description Glycyl-lysine-isopeptide-(Lys-Gly)-(interchain-with-G-Cter-in-SUMO2) evidence 2 type cross-link location position position 26 evidence key 1 type ECO:0000250 evidence key 2 type ECO:0000250 source dbReference id O95400 type UniProtKB evidence key 3 type ECO:0000255 source dbReference id PRU00101 type PROSITE-ProRule evidence key 4 type ECO:0000256 source dbReference id MobiDB-lite type SAM evidence key 5 type ECO:0007744 source ref 3079 evidence key 6 type ECO:0007744 source ref 6337 sequence checksum 6B00FBE777A19206 length 342 mass 37694 modified 2001-06-01 version 1 MPKRKVTFQGVGDEDGEDEISVPKKKLVDPVAAAGGPGSRFKGKHSLDSDEEDDDEEGSSKYDILASEDVEGQEAATLPSEGGVRITPFNLQEEMEEGHFDADGNYFLNQDAQIRDSWLDNIDWVRIKERPPDKHQVSDSEEEDSLGQTPMSAQALLEGLLELLLPRETVAGALRRLGARGGGKGSNSKGTGRPNSPQRLDRLSGLADQMVARGNLGVYQETRERLAMRLKGLGCRAQGSHDPTPPPSLDMFAEEVAEGELETPTPTQREEAESAGDGLMDVMWEYKWENTGDAELYGPFTSAQMQTWVSEGYFPDGVYCRKLDPPGGQFYNSKRIDFELYT 
