Phenotype-Similarity Gene Network of

Phenotypic metrics
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Effect size is not displayed when phenotype evaluation is binary (presence/absence).
Phenotypes similarity:
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Effect size:
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Biological annotations
Genotype
Sex
Life stage
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Early: -16w, Interval: 17-48w, Late: 49w-
Network structure
Module size
Node count:
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Show modules whose number of visible nodes is within this range.
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Recenter and fit the current network in view.
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Arrange modules into a grid to avoid overlap and fit on screen.
Highlight
Markup
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Human Disease annotations use IMPC Disease Models. Genes associated with human diseases are highlighted with a red border. If a gene also matches a selected phenotype, a larger red outer ring is shown around the blue phenotype border.
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Phenotype choices combine genotype, life-stage, and sex variants. Use Biological annotations to refine them. Genes with a selected phenotype are highlighted with a blue border. If a gene also has a Human Disease annotation, the blue border remains inside a larger red outer ring.
Centrality
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'Normalized' options divide the centrality score by the number of phenotypes observed in KO mice
Visualization
Layout
Node repulsion
Scale:
Size & Width
Font size:
Line width:
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Default is 1 for Gene Symbol and 5 for Phenotype or Gene List. Increase this value to make network edges thicker.
Few Many

Similarity of accessory phenotypes

Low High

Effect size of target phenotype

Export
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GraphML can be used for visualization in other network analysis tools.