Model : icg_body

id icg_body meta_icg_body
nameicg_body
timemin
substancemmole
extentmmole
volumelitre
aream2
lengthm
L3V1 comp-V1

ModelDefinitions [1] name type sbo cvterm
liver ExternalModelDefinition (source=>)

Submodels [1] name model ref deletions time conversion extent conversion sbo cvterm
LI liver

Ports [54] name referenced element port ref id ref unit ref metaid ref sbo cvterm
mmole_port mmole_port mmole_port UnitDefinition: mmole mmole
min_port min_port min_port UnitDefinition: min min
m_port m_port m_port UnitDefinition: m m
m2_port m2_port m2_port UnitDefinition: m2 m2
mM_port mM_port mM_port UnitDefinition: mM mM
mmole_per_min_port mmole_per_min_port mmole_per_min_port UnitDefinition: mmole_per_min mmole_per_min
mmole_per_min_l_port mmole_per_min_l_port mmole_per_min_l_port UnitDefinition: mmole_per_min_l mmole_per_min_l
litre_per_min_port litre_per_min_port litre_per_min_port UnitDefinition: litre_per_min litre_per_min
kg_port kg_port kg_port UnitDefinition: kg kg
per_min_port per_min_port per_min_port UnitDefinition: per_min per_min
s_port s_port s_port UnitDefinition: s s
mg_port mg_port mg_port UnitDefinition: mg mg
ml_port ml_port ml_port UnitDefinition: ml ml
hr_port hr_port hr_port UnitDefinition: hr hr
per_hr_port per_hr_port per_hr_port UnitDefinition: per_hr per_hr
cm_port cm_port cm_port UnitDefinition: cm cm
mg_per_l_port mg_per_l_port mg_per_l_port UnitDefinition: mg_per_l mg_per_l
mg_per_g_port mg_per_g_port mg_per_g_port UnitDefinition: mg_per_g mg_per_g
mg_per_hr_port mg_per_hr_port mg_per_hr_port UnitDefinition: mg_per_hr mg_per_hr
l_per_min_port l_per_min_port l_per_min_port UnitDefinition: l_per_min l_per_min
l_per_hr_port l_per_hr_port l_per_hr_port UnitDefinition: l_per_hr l_per_hr
l_per_kg_port l_per_kg_port l_per_kg_port UnitDefinition: l_per_kg l_per_kg
l_per_ml_port l_per_ml_port l_per_ml_port UnitDefinition: l_per_ml l_per_ml
g_per_mole_port g_per_mole_port g_per_mole_port UnitDefinition: g_per_mole g_per_mole
m2_per_kg_port m2_per_kg_port m2_per_kg_port UnitDefinition: m2_per_kg m2_per_kg
mg_per_min_port mg_per_min_port mg_per_min_port UnitDefinition: mg_per_min mg_per_min
mmole_per_hr_port mmole_per_hr_port mmole_per_hr_port UnitDefinition: mmole_per_hr mmole_per_hr
mmole_per_l_port mmole_per_l_port mmole_per_l_port UnitDefinition: mmole_per_l mmole_per_l
mmole_per_min_kg_port mmole_per_min_kg_port mmole_per_min_kg_port UnitDefinition: mmole_per_min_kg mmole_per_min_kg
mmole_per_hr_ml_port mmole_per_hr_ml_port mmole_per_hr_ml_port UnitDefinition: mmole_per_hr_ml mmole_per_hr_ml
ml_per_s_port ml_per_s_port ml_per_s_port UnitDefinition: ml_per_s ml_per_s
ml_per_s_kg_port ml_per_s_kg_port ml_per_s_kg_port UnitDefinition: ml_per_s_kg ml_per_s_kg
ml_per_l_port ml_per_l_port ml_per_l_port UnitDefinition: ml_per_l ml_per_l
mulitre_per_g_port mulitre_per_g_port mulitre_per_g_port UnitDefinition: mulitre_per_g mulitre_per_g
mul_per_min_mg_port mul_per_min_mg_port mul_per_min_mg_port UnitDefinition: mul_per_min_mg mul_per_min_mg
min_per_hr_port min_per_hr_port min_per_hr_port UnitDefinition: min_per_hr min_per_hr
s_per_min_port s_per_min_port s_per_min_port UnitDefinition: s_per_min s_per_min
s_per_hr_port s_per_hr_port s_per_hr_port UnitDefinition: s_per_hr s_per_hr
Vgi_tissue_port Vgi_tissue_port Vgi_tissue_port Compartment: Vgi_tissue Vgi_tissue
Vgi_plasma_port Vgi_plasma_port Vgi_plasma_port Compartment: Vgi_plasma Vgi_plasma
Vli_tissue_port Vli_tissue_port Vli_tissue_port Compartment: Vli_tissue Vli_tissue
Vli_plasma_port Vli_plasma_port Vli_plasma_port Compartment: Vli_plasma Vli_plasma
Vlu_tissue_port Vlu_tissue_port Vlu_tissue_port Compartment: Vlu_tissue Vlu_tissue
Vlu_plasma_port Vlu_plasma_port Vlu_plasma_port Compartment: Vlu_plasma Vlu_plasma
Vre_tissue_port Vre_tissue_port Vre_tissue_port Compartment: Vre_tissue Vre_tissue
Vre_plasma_port Vre_plasma_port Vre_plasma_port Compartment: Vre_plasma Vre_plasma
Cgi_plasma_icg_port Cgi_plasma_icg_port Cgi_plasma_icg_port Species: Cgi_plasma_icg Cgi_plasma_icg
Cli_plasma_icg_port Cli_plasma_icg_port Cli_plasma_icg_port Species: Cli_plasma_icg Cli_plasma_icg
Clu_plasma_icg_port Clu_plasma_icg_port Clu_plasma_icg_port Species: Clu_plasma_icg Clu_plasma_icg
Cre_plasma_icg_port Cre_plasma_icg_port Cre_plasma_icg_port Species: Cre_plasma_icg Cre_plasma_icg
Car_icg_port Car_icg_port Car_icg_port Species: Car_icg Car_icg
Cve_icg_port Cve_icg_port Cve_icg_port Species: Cve_icg Cve_icg
Cpo_icg_port Cpo_icg_port Cpo_icg_port Species: Cpo_icg Cpo_icg
Chv_icg_port Chv_icg_port Chv_icg_port Species: Chv_icg Chv_icg

UnitDefinitions [38] name units sbo cvterm
mmole
ReplacedElement LI:portRef=mmole_port
10 3 mole
min
ReplacedElement LI:portRef=min_port
60 s
m
ReplacedElement LI:portRef=m_port
m
m2
ReplacedElement LI:portRef=m2_port
m 2
mM
ReplacedElement LI:portRef=mM_port
10 3 mole litre
mmole_per_min
ReplacedElement LI:portRef=mmole_per_min_port
10 3 mole 60 s
mmole_per_min_l
ReplacedElement LI:portRef=mmole_per_min_l_port
10 3 mole litre 60 s
litre_per_min
ReplacedElement LI:portRef=litre_per_min_port
litre 60 s
kg kg
per_min 1 60 s
s s
mg 10 3 g
ml meta_ml 10 3 litre
hr 3600 s
per_hr 1 3600 s
cm 10 2 m
mg_per_l 10 3 g litre
mg_per_g 10 3 g g
mg_per_hr 10 3 g 3600 s
l_per_min litre 60 s
l_per_hr litre 3600 s
l_per_kg litre 10 3 g
l_per_ml litre 10 3 litre
g_per_mole g mole
m2_per_kg m 2 10 3 g
mg_per_min 10 3 g 60 s
mmole_per_hr 10 3 mole 3600 s
mmole_per_l 10 3 mole litre
mmole_per_min_kg 10 3 mole 10 3 g 60 s
mmole_per_hr_ml 10 3 mole 10 3 litre 3600 s
ml_per_s 10 3 litre s
ml_per_s_kg 10 3 litre 10 3 g s
ml_per_l 10 3 litre litre
mulitre_per_g 10 6 litre g
mul_per_min_mg 10 6 litre 10 3 g 60 s
min_per_hr 60 s 3600 s
s_per_min meta_s_per_min 60 s 3600 s
s_per_hr s 3600 s

Compartments [18] name size constant spatial dimensions units derived units sbo cvterm
Vbi meta_Vbi
ReplacedElement LI:portRef=Vbi_port
bile 1.0 3 litre litre
Vre meta_Vre rest of body 1.0 3 litre litre
Vgi meta_Vgu gastrointestinal tract 1.0 3 litre litre
Vli meta_Vli liver 1.0 3 litre litre
Vlu meta_Vlu lung 1.0 3 litre litre
Vve meta_Vve venous plasma 1.0 3 litre litre
Var meta_Var arterial plasma 1.0 3 litre litre
Vpo meta_Vpo portal plasma 1.0 3 litre litre
Vhv meta_Vhv hepatic venous plasma 1.0 3 litre litre
Vfeces meta_Vfeces
ReplacedElement LI:portRef=Vfeces_port
feces 1.0 3 litre litre
Vgi_tissue meta_Vgi_tissue gi tissue 1.0 3 litre litre
Vgi_plasma meta_Vgi_plasma gi plasma 1.0 3 litre litre
Vli_tissue meta_Vli_tissue
ReplacedElement LI:portRef=Vli_port
li tissue 1.0 3 litre litre
Vli_plasma meta_Vli_plasma
ReplacedElement LI:portRef=Vext_port
li plasma 1.0 3 litre litre
Vlu_tissue meta_Vlu_tissue lu tissue 1.0 3 litre litre
Vlu_plasma meta_Vlu_plasma lu plasma 1.0 3 litre litre
Vre_tissue meta_Vre_tissue re tissue 1.0 3 litre litre
Vre_plasma meta_Vre_plasma re plasma 1.0 3 litre litre

Species [9] name compartment hasOnlySubstanceUnits boundaryCondition constant initialAmount initialConcentration conversionFactor units substanceUnits derivedUnits sbo cvterm
Cgi_plasma_icg meta_Cgi_plasma_icg icg (gastrointestinal tract) Vgi_plasma 0.0 mmole mmole 10 3 mole litre
Cli_plasma_icg meta_Cli_plasma_icg
ReplacedElement LI:portRef=icg_ext_port
icg (liver) Vli_plasma 0.0 mmole mmole 10 3 mole litre
Clu_plasma_icg meta_Clu_plasma_icg icg (lung) Vlu_plasma 0.0 mmole mmole 10 3 mole litre
Cre_plasma_icg meta_Cre_plasma_icg icg (rest) Vre_plasma 0.0 mmole mmole 10 3 mole litre
Car_icg meta_Car_icg icg (arterial plasma) Var 0.0 mmole mmole 10 3 mole litre
Cve_icg meta_Cve_icg icg (venous plasma) Vve 0.0 mmole mmole 10 3 mole litre
Cpo_icg meta_Cpo_icg icg (portal vein) Vpo 0.0 mmole mmole 10 3 mole litre
Chv_icg meta_Chv_icg icg (hepatic vein) Vhv 0.0 mmole mmole 10 3 mole litre
Afeces_icg meta_Afeces_icg
ReplacedElement LI:portRef=icg_feces_port
icg (feces) Vfeces 0.0 mmole mmole 10 3 mole

Parameters [75] name constant value unit derived unit sbo cvterm uncertainties
conversion_ml_per_l volume conversion factor 1000.0 ml_per_l 10 3 litre litre
conversion_l_per_ml volume conversion factor 0.001 l_per_ml litre 10 3 litre
BW body weight [kg] 75.0 kg kg
HEIGHT height [cm] 170.0 cm 10 2 m
BSA body surface area [m^2] 0.0 m2 m 2
COBW cardiac output per bodyweight [ml/s/kg] 0.833333333333333 ml_per_s_kg 10 3 litre 10 3 g s
CO cardiac output [ml/s] 100.0 ml_per_s 10 3 litre s
QC cardiac output [L/min] 6.0 l_per_min litre 60 s
Fblood blood fraction of organ volume 0.02 dimensionless None
HCT meta_HCT hematocrit 0.51 dimensionless None
FVgi gastrointestinal tract fractional tissue volume 0.0171 l_per_kg litre 10 3 g
FVbi bile fractional tissue volume 0.00071 l_per_kg litre 10 3 g
FVli liver fractional tissue volume 0.021 l_per_kg litre 10 3 g
FVlu lung fractional tissue volume 0.0076 l_per_kg litre 10 3 g
FVve venous fractional tissue volume 0.0587 l_per_kg litre 10 3 g
FVar arterial fractional tissue volume 0.0184 l_per_kg litre 10 3 g
FVpo portal fractional tissue volume 0.001 l_per_kg litre 10 3 g
FVhv hepatic venous fractional tissue volume 0.001 l_per_kg litre 10 3 g
FVre rest of body fractional tissue volume 0.0 l_per_kg litre 10 3 g
FQgi gastrointestinal tract fractional tissue blood flow 0.19 dimensionless None
FQh hepatic (venous side) fractional tissue blood flow 0.255 dimensionless None
FQlu lung fractional tissue blood flow 1.0 dimensionless None
FQre rest of body fractional tissue blood flow 0.0 dimensionless None
f_cirrhosis severity of cirrhosis [0, 0.95] 0.0 dimensionless None
f_shunts fraction of portal venous blood shunted by the liver 0.0 dimensionless None
f_tissue_loss fraction of lost parenchymal liver volume 0.0 dimensionless None
f_bloodflow fractional change of hepatic blood flow 1.0 dimensionless None
f_cardiac_output fractional change of cardiac output 1.0 dimensionless None
Mr_icg Molecular weight icg [g/mole] 774.96493 g_per_mole g mole
fup_icg fraction unbound in plasma icg 1.0 dimensionless None
IVDOSE_icg IV bolus dose icg [mg] 0.0 mg 10 3 g
ti_icg injection time icg [s] 5.0 s s
Ki_icg Ki [1/min] injection icg 0.02 per_min 1 60 s
Ri_icg Ri [mg/min] rate of infusion icg 0.0 mg_per_min 10 3 g 60 s
cum_dose_icg Cumulative dose due to infusion icg 0.0 mg 10 3 g
Qlu lung blood flow nan l_per_min litre 60 s
Qre rest of body blood flow nan l_per_min litre 60 s
Qh hepatic (venous side) blood flow nan l_per_min litre 60 s
Qgi gut blood flow nan l_per_min litre 60 s
Qpo portal blood flow nan l_per_min litre 60 s
Qha hepatic artery blood flow nan l_per_min litre 60 s
Agi_plasma_icg icg concentration (gastrointestinal tract) nan mmole 10 3 mole
Cgi_free_icg icg free concentration (gastrointestinal tract) nan mM 10 3 mole litre
Xgi_plasma_icg icg amount (gastrointestinal tract) nan mg 10 3 g
Mgi_plasma_icg icg amount (gastrointestinal tract) nan mg_per_l 10 3 g litre
Ali_plasma_icg icg concentration (liver) nan mmole 10 3 mole
Cli_free_icg icg free concentration (liver) nan mM 10 3 mole litre
Xli_plasma_icg icg amount (liver) nan mg 10 3 g
Mli_plasma_icg icg amount (liver) nan mg_per_l 10 3 g litre
Alu_plasma_icg icg concentration (lung) nan mmole 10 3 mole
Clu_free_icg icg free concentration (lung) nan mM 10 3 mole litre
Xlu_plasma_icg icg amount (lung) nan mg 10 3 g
Mlu_plasma_icg icg amount (lung) nan mg_per_l 10 3 g litre
Are_plasma_icg icg concentration (rest) nan mmole 10 3 mole
Cre_free_icg icg free concentration (rest) nan mM 10 3 mole litre
Xre_plasma_icg icg amount (rest) nan mg 10 3 g
Mre_plasma_icg icg amount (rest) nan mg_per_l 10 3 g litre
Aar_icg icg concentration (arterial plasma) nan mmole 10 3 mole
Car_free_icg icg free concentration (arterial plasma) nan mM 10 3 mole litre
Xar_icg {sname} amount ({cname}) nan mg 10 3 g
Mar_icg icg amount (arterial plasma) nan mg_per_l 10 3 g litre
Ave_icg icg concentration (venous plasma) nan mmole 10 3 mole
Cve_free_icg icg free concentration (venous plasma) nan mM 10 3 mole litre
Xve_icg {sname} amount ({cname}) nan mg 10 3 g
Mve_icg icg amount (venous plasma) nan mg_per_l 10 3 g litre
Apo_icg icg concentration (portal vein) nan mmole 10 3 mole
Cpo_free_icg icg free concentration (portal vein) nan mM 10 3 mole litre
Xpo_icg {sname} amount ({cname}) nan mg 10 3 g
Mpo_icg icg amount (portal vein) nan mg_per_l 10 3 g litre
Ahv_icg icg concentration (hepatic vein) nan mmole 10 3 mole
Chv_free_icg icg free concentration (hepatic vein) nan mM 10 3 mole litre
Xhv_icg {sname} amount ({cname}) nan mg 10 3 g
Mhv_icg icg amount (hepatic vein) nan mg_per_l 10 3 g litre
ER_icg Extraction ratio ICG nan dimensionless None
CLinfusion_icg infusion clearance (steady state) nan litre_per_min litre 60 s

Rules [65]   assignment name derived units sbo cvterm uncertainties
FVre = 1 FVbi FVgi FVli FVlu FVve FVar FVpo FVhv litre 10 3 g
FQre = 1 Qh Qlu None
BSA = 0.024265 BW 1 0.5378 HEIGHT 1 0.3964 m 2
CO = BW COBW f_cardiac_output kg 0.001 litre 1000 g s
QC = CO 1000 60 0.0166666666666667 litre s
Vbi = BW FVbi kg litre 10 3 g
Vgi = BW FVgi kg litre 10 3 g
Vli = BW FVli kg litre 10 3 g
Vlu = BW FVlu kg litre 10 3 g
Vre = BW FVre kg litre 10 3 g
Vve = 1 HCT BW FVve FVve FVar FVve FVpo FVhv BW Fblood 1 FVar FVve FVpo FVhv kg litre 1000 g
Var = 1 HCT BW FVar FVar FVar FVve FVpo FVhv BW Fblood 1 FVar FVve FVpo FVhv kg litre 1000 g
Vpo = 1 HCT BW FVpo FVpo FVar FVve FVpo FVhv BW Fblood 1 FVar FVve FVpo FVhv kg litre 1000 g
Vhv = 1 HCT BW FVhv FVhv FVar FVve FVpo FVhv BW Fblood 1 FVar FVve FVpo FVhv kg litre 1000 g
Qlu = QC FQlu litre 60 s
Qre = QC FQre litre 60 s
Qh = QC FQh f_bloodflow litre 60 s
Qgi = QC FQgi f_bloodflow litre 60 s
Qpo = Qgi litre 60 s
Qha = Qh Qpo litre 60 s
Vgi_plasma = Vgi Fblood 1 HCT litre
Vgi_tissue = Vgi 1 Fblood litre
Vli_plasma = Vli Fblood 1 HCT litre
Vli_tissue = Vli 1 f_tissue_loss 1 Fblood litre
Vlu_plasma = Vlu Fblood 1 HCT litre
Vlu_tissue = Vlu 1 Fblood litre
Vre_plasma = Vre Fblood 1 HCT litre
Vre_tissue = Vre 1 Fblood litre
Ki_icg = 0.693 ti_icg 60 1 59.9999999999999 s
Agi_plasma_icg = Cgi_plasma_icg Vgi_plasma 10 3 mole
Cgi_free_icg = Cgi_plasma_icg fup_icg 0.001 mole litre
Xgi_plasma_icg = Agi_plasma_icg Mr_icg 0.001 g
Mgi_plasma_icg = Agi_plasma_icg Vgi_plasma Mr_icg g 1000 litre
Ali_plasma_icg = Cli_plasma_icg Vli_plasma 10 3 mole
Cli_free_icg = Cli_plasma_icg fup_icg 0.001 mole litre
Xli_plasma_icg = Ali_plasma_icg Mr_icg 0.001 g
Mli_plasma_icg = Ali_plasma_icg Vli_plasma Mr_icg g 1000 litre
Alu_plasma_icg = Clu_plasma_icg Vlu_plasma 10 3 mole
Clu_free_icg = Clu_plasma_icg fup_icg 0.001 mole litre
Xlu_plasma_icg = Alu_plasma_icg Mr_icg 0.001 g
Mlu_plasma_icg = Alu_plasma_icg Vlu_plasma Mr_icg g 1000 litre
Are_plasma_icg = Cre_plasma_icg Vre_plasma 10 3 mole
Cre_free_icg = Cre_plasma_icg fup_icg 0.001 mole litre
Xre_plasma_icg = Are_plasma_icg Mr_icg 0.001 g
Mre_plasma_icg = Are_plasma_icg Vre_plasma Mr_icg g 1000 litre
Aar_icg = Car_icg Var 10 3 mole
Car_free_icg = Car_icg fup_icg 0.001 mole litre
Xar_icg = Aar_icg Mr_icg 0.001 g
Mar_icg = Aar_icg Var Mr_icg g 1000 litre
Ave_icg = Cve_icg Vve 10 3 mole
Cve_free_icg = Cve_icg fup_icg 0.001 mole litre
Xve_icg = Ave_icg Mr_icg 0.001 g
Mve_icg = Ave_icg Vve Mr_icg g 1000 litre
Apo_icg = Cpo_icg Vpo 10 3 mole
Cpo_free_icg = Cpo_icg fup_icg 0.001 mole litre
Xpo_icg = Apo_icg Mr_icg 0.001 g
Mpo_icg = Apo_icg Vpo Mr_icg g 1000 litre
Ahv_icg = Chv_icg Vhv 10 3 mole
Chv_free_icg = Chv_icg fup_icg 0.001 mole litre
Xhv_icg = Ahv_icg Mr_icg 0.001 g
Mhv_icg = Ahv_icg Vhv Mr_icg g 1000 litre
ER_icg = Car_icg 1 -7 Chv_icg 1 -7 Car_icg 1 -7 None
CLinfusion_icg = Ri_icg Mr_icg Cve_icg 1 -12 litre 60 s
d IVDOSE_icg/dt = iv_icg Mr_icg Ri_icg g 60000 s
d cum_dose_icg/dt = Ri_icg 10 3 g 60 s

Reactions [13] name equation modifiers kinetic law derived units sbo cvterm
iv_icg iv icg
➞ Cve_icg Ki_icg IVDOSE_icg Mr_icg mole 60000 s
Flow_ar_argi_icg inflow gastrointestinal tract icg
Car_icg ➞ Cgi_plasma_icg Qgi Car_icg 10 3 mole 60 s
Flow_gi_po_icg outflow gastrointestinal tract icg
Cgi_plasma_icg ➞ Cpo_icg Qgi Cgi_plasma_icg 10 3 mole 60 s
Flow_arli_li_icg arterial inflow liver icg
Car_icg ➞ Cli_plasma_icg 1 f_shunts Qha Car_icg 10 3 mole 60 s
Flow_arli_hv_icg flow arterial shunts
Car_icg ➞ Chv_icg f_shunts Qha Car_icg 10 3 mole 60 s
Flow_po_li_icg outflow po icg
Cpo_icg ➞ Cli_plasma_icg 1 f_shunts Qpo Cpo_icg 10 3 mole 60 s
Flow_po_hv_icg flow portal shunts
Cpo_icg ➞ Chv_icg f_shunts Qpo Cpo_icg 10 3 mole 60 s
Flow_li_hv_icg outflow liver icg
Cli_plasma_icg ➞ Chv_icg 1 f_shunts Qpo Qha Cli_plasma_icg 10 3 mole 60 s
Flow_hv_ve_icg outflow hepatic vein icg
Chv_icg ➞ Cve_icg Qh Chv_icg 10 3 mole 60 s
Flow_ve_lu_icg inflow lung icg
Cve_icg ➞ Clu_plasma_icg Qlu Cve_icg 10 3 mole 60 s
Flow_lu_ar_icg outflow lung icg
Clu_plasma_icg ➞ Car_icg Qlu Clu_plasma_icg 10 3 mole 60 s
Flow_ar_arre_icg inflow rest icg
Car_icg ➞ Cre_plasma_icg Qre Car_icg 10 3 mole 60 s
Flow_re_ve_icg outflow rest icg
Cre_plasma_icg ➞ Cve_icg Qre Cre_plasma_icg 10 3 mole 60 s