1;36m[m1;32mDISCOVERm1;36m]m  ● C4REQBER v9  F<1,1,0>  [en]  DeepSeek  $0.0000  <CLOCK> DISCOVER 
 │ 90mReady for your first discoverym                                               
 │  37mType a question above and press Enterm                                       
 │ 1;36m▣ Dm  [█████████████▌░░░░░░]                                                  
 │  90mscoring hypothesesm                                                          
 │ 1;32m✦ Hypothesis  NEWm                                                            
 │  37mguides with GC content <40% have higher off-target ratesm                    
 │  90m↳ novelty: 0.87m                                                             
 │  90m↳ source: openmmm                                                            
 │ 1;34m📚 CRISPR off-target reviewm                                                  
 │  37mNature 2024 · citations 142m                                                 
 │  90mdoi: 10.1038/nature.2024.001m                                                
 │ 1;34m📚 Guide RNA design principlesm                                               
 │  37mCell 2023 · citations 87m                                                    
 │  90mdoi: 10.1016/j.cell.2023.04.012m                                             
 │ 1;34m📚 Off-target cleavage mechanismsm                                            
 │  37mScience 2024 · citations 63m                                                 
 │  90mdoi: 10.1126/science.adi1234m                                                
                                                                                
                                                                                
                                                                                
                                                                                
40m37m❯ mm40m38;5;240;40m  1 mm40m7mdmm40m38;5;240mesign a CRISPR guide RNA with minimal off-targets in T-cellsmm40m             m
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