OpenPKFlow — MAP Individual PK Estimation

{{ title }}

Route{{ result.route }}
Dose{{ fmt(result.dose) }}
Observations{{ result.n_observations }}
Versionv{{ version }}
Estimation Diagnostics
Converged
{{ 'Yes' if result.converged else 'No' }}
Uncertainty Reliable
{{ 'Yes' if result.uncertainty_reliable else 'No' }}
Gradient Norm
{{ "%.2e"|format(result.gradient_norm) }}
Hessian Condition
{{ "%.2e"|format(result.condition_number) }}
{% if not result.converged %}
[!] Optimizer did not converge

The MAP estimates below are NOT reliable. Do not interpret these as pharmacokinetically meaningful parameters. Review the data and prior, then retry.

{% endif %} {% if result.warnings %}
Diagnostic Warnings
    {% for w in result.warnings %}
  • {{ w }}
    • {% endfor %}
{% endif %}
MAP Parameter Estimates
{% if result.converged and result.uncertainty_reliable %}

Standard errors from inverse Hessian (delta method, natural scale).

{% elif result.converged %}

Hessian not positive-definite: standard errors suppressed.

{% endif %} {% if is_oral %} {% else %} {% endif %}
ParameterEstimateSEUnits
CL_F (apparent clearance){{ fmt(result.CL_F) }}{{ fmt(result.CL_F_se) }}L/h
Vz_F (apparent volume){{ fmt(result.Vz_F) }}{{ fmt(result.Vz_F_se) }}L
ka (absorption rate){{ fmt(result.ka) }}{{ fmt(result.ka_se) }}1/h
CL (systemic clearance){{ fmt(result.CL) }}{{ fmt(result.CL_se) }}L/h
Vz (volume of distribution){{ fmt(result.Vz) }}{{ fmt(result.Vz_se) }}L
k (elimination rate){{ fmt(result.k) }}N/A1/h
t½ (half-life){{ fmt(result.half_life) }}N/Ah
Derived PK Parameters
ParameterValueUnits
AUCinf{{ fmt(result.AUCinf) }}h * conc
Cmax{{ fmt(result.Cmax) }}conc
Tmax{{ fmt(result.Tmax) }}h
Concentration-Time Profile
MAP PK Profile
Observed vs MAP-Predicted
{% for t, obs, pred in obs_pred_rows %} {% endfor %}
Time (h)ObservedPredictedResidual
{{ "%.2f"|format(t) }} {{ "%.4g"|format(obs) }} {{ "%.4g"|format(pred) }} {{ "%.4g"|format(obs - pred) }}
Disclaimer: {{ disclaimer }}