Task:
Given the Context, determine whether the chemical {{ chem }} {{ rel_type.positive_verb }} the biological effect {{ effect }}.
{{ specification_relationship_text_prompt }}

Effect synonyms:
- Treat common synonyms or equivalent terms as the same effect.
- Always map any synonym in the Context to the target effect before evaluating.

Decision rules:
- Return {{ rel_type.positive }} if the Context explicitly states that {{ chem }} {{ rel_type.positive_verb }} {{ effect }}.
- Return {{ rel_type.negative }} if the Context explicitly states that {{ chem }} {{ rel_type.negative_verb }} {{ effect }}.
- Return "none" if:
    - The chemical or the effect is not mentioned, or
    - No direct relationship is stated, or
    - The statement is speculative, conditional, or indirect (e.g., uses "may", "might", "could").
- VERY IMPORTANT: In all other cases: {{ other_topics }} relationships - return "none".

Output:
Return exactly one of the following, with no extra text:
{{ rel_type.positive }}
{{ rel_type.negative }}
none

Context:
{{ text }}
